CL2017000180A1 - Tablet formulation of 2-fluor-n-methyl-4- [7- (quinolin-6-ylmethyl) imidazo [1,2-b] [1,2,4] triazin-2-yl] benzamide. - Google Patents

Tablet formulation of 2-fluor-n-methyl-4- [7- (quinolin-6-ylmethyl) imidazo [1,2-b] [1,2,4] triazin-2-yl] benzamide.

Info

Publication number
CL2017000180A1
CL2017000180A1 CL2017000180A CL2017000180A CL2017000180A1 CL 2017000180 A1 CL2017000180 A1 CL 2017000180A1 CL 2017000180 A CL2017000180 A CL 2017000180A CL 2017000180 A CL2017000180 A CL 2017000180A CL 2017000180 A1 CL2017000180 A1 CL 2017000180A1
Authority
CL
Chile
Prior art keywords
triazin
quinolin
imidazo
methyl
fluor
Prior art date
Application number
CL2017000180A
Other languages
Spanish (es)
Inventor
Elisabete Goncalves
Christian Tauchmann
Shau-Fong Yen
Sudha Vippagunta
Zhixin Zong
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53762251&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017000180(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2017000180A1 publication Critical patent/CL2017000180A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN SE RELACIONA CON TABLETAS QUE COMPRENDEN 2-FLUORO-N-METIL-4-[7-(QUINOLIN-6-ILMETIL)IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-IL]BENZAMIDA, PROCESOS PARA LA PRODUCCIÓN DE LOS MISMOS, Y USOS EN EL TRATAMIENTO DE CIERTOS TIPOS DE CÁNCER.</p><p> THIS INVENTION IS RELATED TO TABLETS THAT INCLUDE 2-FLUORO-N-METHYL-4- [7- (QUINOLIN-6-ILMETIL) IMIDAZO [1,2-B] [1,2,4] TRIAZIN-2 -IL] BENZAMIDA, PROCESSES FOR THE PRODUCTION OF THE SAME, AND USES IN THE TREATMENT OF CERTAIN TYPES OF CANCER. </p>

CL2017000180A 2014-07-25 2017-01-24 Tablet formulation of 2-fluor-n-methyl-4- [7- (quinolin-6-ylmethyl) imidazo [1,2-b] [1,2,4] triazin-2-yl] benzamide. CL2017000180A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462028865P 2014-07-25 2014-07-25

Publications (1)

Publication Number Publication Date
CL2017000180A1 true CL2017000180A1 (en) 2017-09-15

Family

ID=53762251

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000180A CL2017000180A1 (en) 2014-07-25 2017-01-24 Tablet formulation of 2-fluor-n-methyl-4- [7- (quinolin-6-ylmethyl) imidazo [1,2-b] [1,2,4] triazin-2-yl] benzamide.

Country Status (31)

Country Link
US (5) US10085993B2 (en)
EP (2) EP3848376A1 (en)
JP (3) JP6770946B2 (en)
KR (2) KR20230136693A (en)
CN (2) CN115364061A (en)
AR (1) AR101286A1 (en)
AU (4) AU2015293539A1 (en)
CA (1) CA2954840A1 (en)
CL (1) CL2017000180A1 (en)
CO (1) CO2017000586A2 (en)
DK (1) DK3172209T3 (en)
EA (2) EA202191301A1 (en)
EC (1) ECSP17011672A (en)
ES (1) ES2857523T3 (en)
FR (1) FR22C1058I2 (en)
GT (1) GT201700007A (en)
HU (2) HUE053346T2 (en)
IL (1) IL250166B (en)
JO (1) JO3618B1 (en)
MX (2) MX379279B (en)
MY (1) MY187276A (en)
NL (1) NL301208I2 (en)
NO (1) NO2022058I1 (en)
PE (1) PE20170523A1 (en)
PH (1) PH12017500121A1 (en)
PL (1) PL3172209T3 (en)
PT (1) PT3172209T (en)
SG (2) SG10201900648SA (en)
SI (1) SI3172209T1 (en)
TW (2) TWI724993B (en)
WO (1) WO2016012963A1 (en)

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PH12017500121A1 (en) 2017-05-29
FR22C1058I1 (en) 2023-01-06
NO2022058I1 (en) 2022-12-16
AU2018207947A1 (en) 2018-08-09
JO3618B1 (en) 2020-08-27
US20250339440A1 (en) 2025-11-06
MY187276A (en) 2021-09-17
GT201700007A (en) 2018-12-18
MX2017001177A (en) 2017-05-01
HUS2200054I1 (en) 2023-01-28
JP7002587B2 (en) 2022-01-20
CN115364061A (en) 2022-11-22
SI3172209T1 (en) 2021-03-31
MX379279B (en) 2025-03-11
JP2022046659A (en) 2022-03-23
CA2954840A1 (en) 2016-01-28
EA201790259A1 (en) 2017-06-30
EP3172209B1 (en) 2020-12-02
EP3848376A1 (en) 2021-07-14
US10596178B2 (en) 2020-03-24
JP2020114852A (en) 2020-07-30
US20170231997A1 (en) 2017-08-17
AU2021202500A1 (en) 2021-05-20
NZ728089A (en) 2024-01-26
AR101286A1 (en) 2016-12-07
EA202191301A1 (en) 2021-11-30
US20210113569A1 (en) 2021-04-22
TW201613595A (en) 2016-04-16
KR20170039211A (en) 2017-04-10
AU2020200912A1 (en) 2020-02-27
WO2016012963A1 (en) 2016-01-28
BR112017000953A2 (en) 2017-11-14
KR20230136693A (en) 2023-09-26
JP2017521469A (en) 2017-08-03
AU2015293539A1 (en) 2017-02-02
CO2017000586A2 (en) 2017-06-20
MX2021000595A (en) 2021-04-13
IL250166A0 (en) 2017-03-30
SG10201900648SA (en) 2019-02-27
US20190015418A1 (en) 2019-01-17
NL301208I2 (en) 2025-03-20
EA039220B1 (en) 2021-12-20
HUE053346T2 (en) 2021-06-28
US12208101B2 (en) 2025-01-28
US20220249498A1 (en) 2022-08-11
AU2020200912B2 (en) 2021-01-28
CN106714784A (en) 2017-05-24
TW202200148A (en) 2022-01-01
PL3172209T3 (en) 2021-06-14
KR102581121B1 (en) 2023-09-21
SG11201700147SA (en) 2017-02-27
PE20170523A1 (en) 2017-05-17
FR22C1058I2 (en) 2023-11-17
US10085993B2 (en) 2018-10-02
PT3172209T (en) 2021-02-11
EP3172209A1 (en) 2017-05-31
DK3172209T3 (en) 2021-02-22
TWI724993B (en) 2021-04-21
JP6770946B2 (en) 2020-10-21
ECSP17011672A (en) 2018-03-31
IL250166B (en) 2021-01-31
ES2857523T3 (en) 2021-09-29

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