CL2017000200A1 - Célula huésped mejorada para producir proteinas - Google Patents

Célula huésped mejorada para producir proteinas

Info

Publication number
CL2017000200A1
CL2017000200A1 CL2017000200A CL2017000200A CL2017000200A1 CL 2017000200 A1 CL2017000200 A1 CL 2017000200A1 CL 2017000200 A CL2017000200 A CL 2017000200A CL 2017000200 A CL2017000200 A CL 2017000200A CL 2017000200 A1 CL2017000200 A1 CL 2017000200A1
Authority
CL
Chile
Prior art keywords
host cell
produce proteins
enhanced host
cell
peptides
Prior art date
Application number
CL2017000200A
Other languages
English (en)
Inventor
Cédric Szpirer
Jonathan Cavrenne
Benjamin Michel
Original Assignee
Delphi Genetics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delphi Genetics filed Critical Delphi Genetics
Publication of CL2017000200A1 publication Critical patent/CL2017000200A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07006—DNA-directed RNA polymerase (2.7.7.6)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN SE RELACIONA CON UNA CÉLULA HOSPEDERA PARA PRODUCIR UN PÉPTIDO. POLIPÉPTIDO O PROTEÍNA RECOMBINANTE DE INTERÉS, EN DONDE DICHA CÉLULA HOSPEDERA COMPRENDE AL MENOS 2 COPIAS DE UNA SECUENCIA DE ÁCIDO NUCLÉICO QUE CODIFICA UNA PROTEÍNA VENENO: Y AL USO DE LA MISMA PARA LA PRODUCCIÓN DE PÉPTIDOS, POLIPÉPTIDOS O PROTEÍNAS DE INTERÉS.</p>
CL2017000200A 2014-07-25 2017-01-25 Célula huésped mejorada para producir proteinas CL2017000200A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14178656 2014-07-25
EP14182341 2014-08-26

Publications (1)

Publication Number Publication Date
CL2017000200A1 true CL2017000200A1 (es) 2017-07-14

Family

ID=53718025

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000200A CL2017000200A1 (es) 2014-07-25 2017-01-25 Célula huésped mejorada para producir proteinas

Country Status (9)

Country Link
US (1) US10718001B2 (es)
EP (1) EP3172334B1 (es)
JP (3) JP7126824B2 (es)
CN (1) CN106715681B (es)
AU (1) AU2015293825B2 (es)
BR (1) BR112017001463A2 (es)
CL (1) CL2017000200A1 (es)
ES (1) ES2903413T3 (es)
WO (1) WO2016012607A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017147507A1 (en) * 2016-02-24 2017-08-31 Xycrobe Therapeutics, Inc. Skin probiotic formulation
US11180541B2 (en) * 2017-09-28 2021-11-23 Geltor, Inc. Recombinant collagen and elastin molecules and uses thereof
EP3953380A4 (en) 2019-04-12 2023-01-25 Geltor, Inc. RECOMBINATION ELASTIN AND ASSOCIATED PRODUCTION
CN110373422B (zh) * 2019-07-12 2022-05-10 扬州大学 重组裂解猪霍乱沙门菌及其构建方法和应用
DK4010500T3 (da) * 2019-08-05 2025-05-05 Wacker Chemie Ag Bakteriestamme til frigivelse af et rekombinant protein i en fermenteringsfremgangsmåde
WO2022020748A1 (en) * 2020-07-24 2022-01-27 Duke University Methods and compositions for the production of acetyl-coa derived products
CN114540394A (zh) * 2020-11-25 2022-05-27 中国科学院深圳先进技术研究院 一种噬菌体相关的基因诱导表达系统
JP2024540917A (ja) * 2021-10-18 2024-11-06 モデルナティエックス インコーポレイテッド 組み換えタンパク質生産のためのカスタム株
CN118374547A (zh) * 2023-01-13 2024-07-23 上海吉量医药工程有限公司 一种无抗微质粒及其制备方法和应用
JP2026503706A (ja) 2023-01-25 2026-01-29 ノベル バイオテクノロジー ユーエスエー インコーポレイテッド 産物製造のための発現システム
GB202304540D0 (en) 2023-03-28 2023-05-10 Univ Tartu Method of biosynthesis
CN117187281A (zh) * 2023-09-11 2023-12-08 云舟生物科技(广州)股份有限公司 一种无抗性质粒生产系统及其应用
CN121343851A (zh) * 2024-07-16 2026-01-16 上海吉量医药工程有限公司 一种无抗质粒生产菌株及其应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
CA2327387C (en) 1998-05-07 2012-07-03 Gx Biosystems A/S Cytotoxin-based biological containment
US6355412B1 (en) 1999-07-09 2002-03-12 The European Molecular Biology Laboratory Methods and compositions for directed cloning and subcloning using homologous recombination
EP1111061A1 (en) * 1999-12-20 2001-06-27 Universite Libre De Bruxelles Double selection vector
WO2002066657A1 (en) * 2001-02-23 2002-08-29 Universite Libre De Bruxelles Method for the selection of recombinant clones comprising a sequence encoding an antidote protein to a toxic molecule
WO2003037504A1 (en) 2001-11-02 2003-05-08 Japan Techno Co., Ltd. Vibratory stirrer for sterilization and sterilizer and sterilization method employing vibratory stirrer
CA2477194A1 (en) 2002-03-19 2003-09-25 Universite Libre De Bruxelles Poison/antidote genetic systems for the selection of genetically modified eucaryote cells or organisms
WO2004022745A2 (en) * 2002-09-03 2004-03-18 Universite Libre De Bruxelles Reversible, parallel and multitask cloning method and kit
GB0609124D0 (en) * 2006-05-09 2006-06-21 Univ Birmingham Plasmid curing
JP2010187541A (ja) 2007-05-29 2010-09-02 Ajinomoto Co Inc Ｌ−リジンの製造法
CA2730741C (en) * 2008-07-18 2016-10-25 Regis Sodoyer Self-replicating vector lacking an antibiotic-resistance gene
JP5729702B2 (ja) 2009-03-23 2015-06-03 国立研究開発法人産業技術総合研究所 コウジ酸の産生に必須の遺伝子を利用してコウジ酸の産生量を向上する方法
NZ596453A (en) * 2009-05-22 2013-09-27 Merial Ltd Antibiotic-free plasmid
CA2868113A1 (en) * 2011-03-22 2012-09-27 Opx Biotechnologies, Inc. Microbial production of chemical products and related compositions, methods and systems
US9920323B2 (en) 2011-07-07 2018-03-20 Delphi Genetics Genetically modified phage and use thereof
US20140147890A1 (en) * 2011-07-07 2014-05-29 Delphi Genetics Genetically modified phage and use thereof
EP2729563B1 (en) * 2011-07-07 2018-09-12 Delphi Genetics Genetically modified phage and use thereof
EP2570134A1 (en) * 2011-09-15 2013-03-20 De la Cueva-Mendez, Guillermo Systems and methods for diminishing cell growth and including selective killing of target cells
US9657310B2 (en) 2012-04-27 2017-05-23 Jcr Pharmaceuticals Co., Ltd. Expression vector
DE102012213206A1 (de) * 2012-07-26 2014-01-30 Trumpf Laser- Und Systemtechnik Gmbh Vorrichtung zum Drehen eines Laserbearbeitungskopfes mittels eines Torque-Motors
JP2014057546A (ja) 2012-09-18 2014-04-03 Osaka Univ トキシン−アンチトキシン系を利用したベクター

Also Published As

Publication number Publication date
CN106715681B (zh) 2021-08-24
BR112017001463A2 (pt) 2018-02-20
ES2903413T3 (es) 2022-04-01
US20170211118A1 (en) 2017-07-27
JP2020202828A (ja) 2020-12-24
WO2016012607A1 (en) 2016-01-28
JP7126824B2 (ja) 2022-08-29
AU2015293825B2 (en) 2019-06-13
JP2022162124A (ja) 2022-10-21
EP3172334B1 (en) 2021-11-10
US10718001B2 (en) 2020-07-21
CN106715681A (zh) 2017-05-24
JP7194711B2 (ja) 2022-12-22
AU2015293825A1 (en) 2017-02-16
JP2017523780A (ja) 2017-08-24
EP3172334A1 (en) 2017-05-31
CA2956107A1 (en) 2016-01-28

Similar Documents

Publication Publication Date Title
CL2017000200A1 (es) Célula huésped mejorada para producir proteinas
CL2018000226A1 (es) Mezcla de péptidos (divisional solicitud 201601405)
EA202190906A1 (ru) Рекомбинантное получение препаратов пептидов коллагена и их применение
EA201691111A1 (ru) Химерные белки фактора viii и их применение
MX377692B (es) Peptidos anti-inflamatorios y usos de los mismos.
MX2023007211A (es) Anticuerpos antimiostatina y metodos de uso.
BR112019007369A2 (pt) anticorpos anti-lag-3 e métodos de uso dos mesmos
MX2017006866A (es) Pares de unión para producción de péptidos.
PE20171111A1 (es) Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso
UY40283A (es) Método para alterar una propiedad de una planta
EA202091166A1 (ru) ПОЛИПЕПТИДЫ, СОДЕРЖАЩИЕ Fc С ИЗМЕНЕННЫМ ГЛИКОЗИЛИРОВАНИЕМ И СНИЖЕННОЙ ЭФФЕКТОРНОЙ ФУНКЦИЕЙ
EA201891420A1 (ru) Антитела к миостатину, полипептиды, содержащие варианты fc-областей, и способы их применения
EA201690299A1 (ru) СТАБИЛИЗАЦИЯ Fc-СОДЕРЖАЩИХ ПОЛИПЕПТИДОВ
MX2017008817A (es) Composiciones y metodos para la glicosilacion de proteinas.
MX387560B (es) Procedimiento para mejorar la solubilidad de proteínas y péptidos usando un enlace del fragmento fc de inmunoglobulina.
EA201491049A1 (ru) Противораковый слитый белок
MX2017004664A (es) Conjugados de farmacos de anticuerpos modificados mediante glicoingenieria.
EA201792651A1 (ru) Аденовирусные полинуклеотиды и полипептиды
BR112013008407A2 (pt) antígenos de clostridium difficile
EA201790976A1 (ru) Терапевтические вакцины против hpv16
EA201491277A1 (ru) Противораковый слитый белок
ES2722773T3 (es) Polipéptidos de fHbp meningocócicos modificados
EA201390820A1 (ru) Слитый белок против рака
BR112016026842A2 (pt) preparação compreendendo fator viii e peptídeos de fator de von willebrand
EA201892325A1 (ru) Композиции и способы детектирования белков клетки-хозяина