CL2017000317A1 - Terapia adjuntiva con 25-hidroxi vitamina d - Google Patents

Terapia adjuntiva con 25-hidroxi vitamina d

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Publication number
CL2017000317A1
CL2017000317A1 CL2017000317A CL2017000317A CL2017000317A1 CL 2017000317 A1 CL2017000317 A1 CL 2017000317A1 CL 2017000317 A CL2017000317 A CL 2017000317A CL 2017000317 A CL2017000317 A CL 2017000317A CL 2017000317 A1 CL2017000317 A1 CL 2017000317A1
Authority
CL
Chile
Prior art keywords
adjunctive therapy
hydroxy vitamin
hypocalcemia
agent
vitamin
Prior art date
Application number
CL2017000317A
Other languages
English (en)
Inventor
Jay A White
Joel Z Melnick
P Martin Petkovich
Samir P Tabash
Charles W Bishop
Susan H Peers
Stephen A Strugnell
Original Assignee
Opko Ireland Global Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53783233&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017000317(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Opko Ireland Global Holdings Ltd filed Critical Opko Ireland Global Holdings Ltd
Publication of CL2017000317A1 publication Critical patent/CL2017000317A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
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    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/4841—Filling excipients; Inactive ingredients
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    • A—HUMAN NECESSITIES
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
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    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Diabetes (AREA)
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  • Endocrinology (AREA)
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  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
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  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
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  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

<p>MÉTODOS, COMPOSICIONES, Y KITS PARA LA TERAPIA ADJUNTIVA USANDO LA 25-HIDROXI VITAMINA D SON REVELADOS. LA 25- HIDROXI VITAMINA D PUEDE SER ADMINISTRADA CON UN AGENTE QUE INCREMENTA EL RIESGO DE UNA HIPOCALCEMIA Y/O UN AGENTE ANTI CANCERÍGENO. LA TERAPIA ADJUNTIVA ES EFECTIVA EN EL TRATAMIENTO Y EN LA PREVENCIÓN DE LA HIPOCALCEMIA IATROGÉNICA Y/O EL HIPERPARATIROIDISMO SECUNDARIO, ASÍ COMO EN EL RETRASO DEL PROGRESO DEL CÁNCER Y EL TIEMPO PARA UN EVENTO RELACIONADO CON EL ESQUELETO POSTERIOR AL TRATAMIENTO.</p>
CL2017000317A 2014-08-07 2017-02-07 Terapia adjuntiva con 25-hidroxi vitamina d CL2017000317A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462034604P 2014-08-07 2014-08-07

Publications (1)

Publication Number Publication Date
CL2017000317A1 true CL2017000317A1 (es) 2017-10-20

Family

ID=53783233

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000317A CL2017000317A1 (es) 2014-08-07 2017-02-07 Terapia adjuntiva con 25-hidroxi vitamina d

Country Status (21)

Country Link
US (2) US20180085381A1 (es)
EP (1) EP3193925A2 (es)
JP (5) JP2017523220A (es)
KR (2) KR20170047265A (es)
CN (2) CN114681468A (es)
AU (2) AU2015298858A1 (es)
BR (1) BR112017002526A2 (es)
CA (1) CA2957240A1 (es)
CL (1) CL2017000317A1 (es)
CO (2) CO2018004206A2 (es)
CR (2) CR20210577A (es)
EA (1) EA201790332A1 (es)
EC (1) ECSP17014159A (es)
IL (1) IL250462A0 (es)
MX (1) MX2017001751A (es)
MY (1) MY203284A (es)
PE (1) PE20170392A1 (es)
PH (2) PH12017500228A1 (es)
SG (2) SG10201911274TA (es)
TW (2) TW202241453A (es)
WO (1) WO2016020508A2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12133917B2 (en) 2018-08-31 2024-11-05 Eirgen Pharma Ltd. Pediatric dosage forms, methods of making and using

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2882048C (en) 2006-02-03 2020-03-24 Opko Renal, Llc Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3
HUE037309T2 (hu) 2006-06-21 2018-08-28 Opko Ireland Global Holdings Ltd Terápia D-vitamin telítési szer alkalmazásával és D-vitamin hormon helyettesítõ szer
ES2401205T3 (es) 2007-04-25 2013-04-17 Cytochroma Inc. Composiciones de orales de liberación controlada que comprende un compuesto de vitamina D y un soporte céreo
WO2009047644A2 (en) 2007-04-25 2009-04-16 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
CN103037902A (zh) 2010-03-29 2013-04-10 赛特克罗公司 用于降低甲状旁腺水平的方法和组合物
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
EP4596045A3 (en) 2016-03-28 2025-10-15 EirGen Pharma Ltd. Methods of vitamin d treatment
ES2893753T3 (es) * 2016-05-20 2022-02-10 Christoph Karl Composiciones farmacéuticas con ácido zoledrónico, calcio y vitamina D, adecuadas para el tratamiento y/o la profilaxis de enfermedades del metabolismo óseo y de efectos secundarios inducidos por la terapia, tales como hipocalcemias
DE202017007720U1 (de) * 2016-05-20 2025-02-11 Christoph Karl Pharmazeutische Zusammensetzungen mit Anti-RANKL-Antikörpern, Kalzium und Vitamin D, geeignet zur Behandlung und/oder Prophylaxe von Erkrankungen des Knochenstoffwechsels und von therapiebedingten Nebenwirkungen wie Hypokalzämien
CN108519448B (zh) * 2018-04-04 2021-04-13 北京市心肺血管疾病研究所 25-羟基维生素d在制备大动脉炎患者疾病活动性评判试剂盒中的应用
US20210308151A1 (en) * 2020-04-06 2021-10-07 Eirgen Pharma Ltd. Activating endogenous antimicrobials to treat sars-cov-2 infection
WO2025094144A1 (en) 2023-11-02 2025-05-08 Eirgen Pharma Ltd. Controlling loss of kidney function

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2845342B2 (ja) * 1990-04-28 1999-01-13 大正製薬株式会社 ビタミンｄ▲下３▼誘導体含有固形製剤組成物
AU2003226148A1 (en) * 2002-04-05 2003-10-27 Merck & Co., Inc. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
NZ536267A (en) * 2002-04-10 2007-06-29 Fred H Miller Multi-phase, multi-compartment and multi-ingredient capsular system
TWI336260B (en) * 2002-07-25 2011-01-21 Glaxo Group Ltd Dosage form suitable for retaining drug substance
DE20321698U1 (de) * 2002-12-16 2008-12-24 Teva Pharmaceutical Industries Ltd. Medikament zur Erhöhung der Bioverfügbarkeit von Alendronat oder einem anderen Bisphosphonat durch Verabreichen einer Vordosis eines Vitamin-D-Derivats
WO2008116133A1 (en) * 2007-03-21 2008-09-25 Duke University Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture
ES2401205T3 (es) * 2007-04-25 2013-04-17 Cytochroma Inc. Composiciones de orales de liberación controlada que comprende un compuesto de vitamina D y un soporte céreo
CA2683514C (en) * 2007-04-25 2019-07-09 Proventiv Therapeutics, Llc Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease
CA2684778C (en) * 2007-04-25 2017-09-05 Cytochroma Inc. Methods and compounds for vitamin d therapy
WO2009047644A2 (en) * 2007-04-25 2009-04-16 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
AU2009214052B2 (en) * 2008-02-13 2015-05-07 Dsm Ip Assets B.V. Combined use of 25-hydroxy-vitamin D3 and vitamin D3 for improving bone mineral density and for treating osteoporosis
KR20120005228A (ko) * 2010-07-08 2012-01-16 주식회사 네비팜 골다공증 치료용 비스포스폰산 함유 장용 약학조성물 및 그의 제조방법
US20130085121A1 (en) * 2011-09-30 2013-04-04 Jianguo Wang Pharmaceutical compositions comprising phosphate binder, calcium receptor-active compound and/or active vitamin d
KR101847947B1 (ko) * 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12133917B2 (en) 2018-08-31 2024-11-05 Eirgen Pharma Ltd. Pediatric dosage forms, methods of making and using
US12433842B2 (en) 2018-08-31 2025-10-07 Eirgen Pharma Ltd. Pediatric dosage forms, methods of making and using

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ECSP17014159A (es) 2017-05-31
PH12017500228A1 (en) 2017-07-03
US20200253988A1 (en) 2020-08-13
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CO2017002081A2 (es) 2017-07-19
KR20170047265A (ko) 2017-05-04
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WO2016020508A3 (en) 2016-03-31
TW202241453A (zh) 2022-11-01
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CA2957240A1 (en) 2016-02-11

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