CL2017000533A1 - Pirrolopirimidinas para uso en la infección por el virus de la gripe - Google Patents

Pirrolopirimidinas para uso en la infección por el virus de la gripe

Info

Publication number
CL2017000533A1
CL2017000533A1 CL2017000533A CL2017000533A CL2017000533A1 CL 2017000533 A1 CL2017000533 A1 CL 2017000533A1 CL 2017000533 A CL2017000533 A CL 2017000533A CL 2017000533 A CL2017000533 A CL 2017000533A CL 2017000533 A1 CL2017000533 A1 CL 2017000533A1
Authority
CL
Chile
Prior art keywords
pyrrolopyrimidines
influenza virus
virus infection
flu
influences
Prior art date
Application number
CL2017000533A
Other languages
English (en)
Inventor
Gowan David Craig Mc
Pierre Jean-Marie Bernard Raboisson
Werner Constant Johan Embrechts
Tim Hugo Maria Jonckers
Jerôme Émile Georges Guillemont
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of CL2017000533A1 publication Critical patent/CL2017000533A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

<p>LA INVENCIÓN SE REFIERE A COMPUESTOS QUE TIENEN LA ESTRUCTURA DE FORMULA (I) QUE SE PUEDEN UTILIZAR PARA EL TRATAMIENTO DE INFECCIONES DE LA GRIPE O CONTRA ESTAS.</p>
CL2017000533A 2014-09-08 2017-03-06 Pirrolopirimidinas para uso en la infección por el virus de la gripe CL2017000533A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14183984 2014-09-08

Publications (1)

Publication Number Publication Date
CL2017000533A1 true CL2017000533A1 (es) 2017-10-06

Family

ID=51535336

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000533A CL2017000533A1 (es) 2014-09-08 2017-03-06 Pirrolopirimidinas para uso en la infección por el virus de la gripe

Country Status (22)

Country Link
US (1) US9932346B2 (es)
EP (1) EP3191489B1 (es)
JP (1) JP6718451B2 (es)
KR (1) KR102531340B1 (es)
CN (1) CN106661036B (es)
AU (1) AU2015314394A1 (es)
BR (1) BR112017004524A2 (es)
CA (1) CA2957475A1 (es)
CL (1) CL2017000533A1 (es)
DK (1) DK3191489T3 (es)
EA (1) EA201790571A1 (es)
ES (1) ES2860688T3 (es)
HR (1) HRP20210038T1 (es)
HU (1) HUE053595T2 (es)
IL (1) IL250955A0 (es)
LT (1) LT3191489T (es)
MX (1) MX2017002972A (es)
PH (1) PH12017500393A1 (es)
SG (1) SG11201701621YA (es)
SI (1) SI3191489T1 (es)
WO (1) WO2016037953A1 (es)
ZA (1) ZA201701643B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3141252T (lt) 2009-06-17 2018-11-12 Vertex Pharmaceuticals Inc. Gripo virusų replikacijos inhibitoriai
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
EP3294735B8 (en) 2015-05-13 2022-01-05 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
SG11201804225PA (en) 2015-12-09 2018-06-28 Sunshine Lake Pharma Co Ltd Inhibitors of influenza virus replication, application methods and uses thereof
DK3400225T3 (da) * 2016-01-07 2022-01-03 Janssen Sciences Ireland Unlimited Co Pentansyrederivater substitueret med pyrrolo-[2,3-b]pyrimidinpyridiner til behandling af influenzavirusinfektioner
WO2017133665A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh 6,7-diazaindazole and 6,7-diazaindole derivatives and use in treatment, amelioration or prevention of influenza thereof
WO2017133669A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh 5, 7-diazaindole and 5, 7-diazaindazole derivatives and their use in the treatment, amelioration or prevention of influenza
WO2018033082A1 (en) 2016-08-16 2018-02-22 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
CN106316886A (zh) * 2016-08-24 2017-01-11 泰州精英化成医药科技有限公司 顺式‑3‑（叔丁氧羰基氨基）环己烷甲酸的制备方法
WO2018041091A1 (en) * 2016-08-30 2018-03-08 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
JP7034162B2 (ja) 2016-12-15 2022-03-11 サンシャイン・レイク・ファーマ・カンパニー・リミテッド インフルエンザウイルス複製の阻害剤及びその使用
CA3047404A1 (en) * 2016-12-23 2018-06-28 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use
CN108276401B (zh) 2017-01-05 2020-12-22 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
WO2018157830A1 (en) * 2017-03-02 2018-09-07 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
TWI778052B (zh) 2017-04-24 2022-09-21 美商共結晶製藥公司 流感病毒複製之抑制劑
CN108727369B (zh) * 2017-04-25 2023-06-09 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
WO2025119372A2 (zh) * 2023-12-08 2025-06-12 武汉人福创新药物研发中心有限公司 Mrgprx2拮抗剂及用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200802685B (en) 2005-09-30 2009-10-28 Vertex Pharma Deazapurines useful as inhibitors of janus kinases
LT3141252T (lt) * 2009-06-17 2018-11-12 Vertex Pharmaceuticals Inc. Gripo virusų replikacijos inhibitoriai
PE20140146A1 (es) * 2010-11-19 2014-02-06 Incyte Corp Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
CN103562205A (zh) * 2010-12-16 2014-02-05 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
RU2013132681A (ru) * 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
UA118010C2 (uk) * 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу

Also Published As

Publication number Publication date
HUE053595T2 (hu) 2021-07-28
EP3191489A1 (en) 2017-07-19
ES2860688T8 (es) 2022-01-18
KR102531340B1 (ko) 2023-05-10
US20170253600A1 (en) 2017-09-07
US9932346B2 (en) 2018-04-03
MX2017002972A (es) 2017-05-30
LT3191489T (lt) 2021-01-25
IL250955A0 (en) 2017-04-30
EA201790571A1 (ru) 2017-08-31
SI3191489T1 (sl) 2021-02-26
CN106661036A (zh) 2017-05-10
SG11201701621YA (en) 2017-03-30
CN106661036B (zh) 2022-03-15
EP3191489B1 (en) 2021-01-06
WO2016037953A1 (en) 2016-03-17
AU2015314394A1 (en) 2017-03-02
JP6718451B2 (ja) 2020-07-08
DK3191489T3 (da) 2021-03-29
ES2860688T3 (es) 2021-10-05
CA2957475A1 (en) 2016-03-17
JP2017527619A (ja) 2017-09-21
ZA201701643B (en) 2018-12-19
BR112017004524A2 (pt) 2017-12-05
HRP20210038T1 (hr) 2021-03-05
KR20170054420A (ko) 2017-05-17
PH12017500393A1 (en) 2017-07-17

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