CL2017003235A1 - New peptides and new combinations of peptides for use in immunotherapy and methods for creating supports for use against pancreatic cancer and other types of cancer - Google Patents

New peptides and new combinations of peptides for use in immunotherapy and methods for creating supports for use against pancreatic cancer and other types of cancer

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Publication number
CL2017003235A1
CL2017003235A1 CL2017003235A CL2017003235A CL2017003235A1 CL 2017003235 A1 CL2017003235 A1 CL 2017003235A1 CL 2017003235 A CL2017003235 A CL 2017003235A CL 2017003235 A CL2017003235 A CL 2017003235A CL 2017003235 A1 CL2017003235 A1 CL 2017003235A1
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CL
Chile
Prior art keywords
peptides
new
cancer
immunotherapy
methods
Prior art date
Application number
CL2017003235A
Other languages
Spanish (es)
Inventor
Toni Weinschenk
Jens Fritsche
Andrea Mahr
Oliver Schoor
Harpreet Singh
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1510771.7A external-priority patent/GB201510771D0/en
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of CL2017003235A1 publication Critical patent/CL2017003235A1/en

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN SE REFIERE A PÉPTIDOS, PROTEÍNAS, ÁCIDOS NUCLÉICOS Y CÉLULAS DESTINADOS A LA UTILIZACIÓN EN MÉTODOS INMUNOTERAPÉUTICOS. EN PARTICULAR, LA PRESENTE INVENCIÓN SE REFIERE A LA INMUNOTERAPIA CONTRA EL CÁNCER. LA PRESENTE INVENCIÓN SE REFIERE ASIMISMO A EPÍTOPOS PEPTÍDICOS PARA LINFOCITOS T ASOCIADOS A TUMORES, SOLOS O EN COMBINACIÓN CON OTROS PÉPTIDOS ASOCIADOS A TUMORES QUE, POR EJEMPLO, PUEDEN SERVIR COMO PRINCIPIOS ACTIVOS FARMACÉUTICOS EN COMPOSICIONES VACUNALES DESTINADAS A ESTIMULAR RESPUESTAS INMUNITARIAS ANTITUMORALES, O A ESTIMULAR EX VIVO LINFOCITOS T QUE DESPUÉS SERÁN TRANSFERIDOS A LOS PACIENTES. LOS PÉPTIDOS UNIDOS A MOLÉCULAS DEL COMPLEJO MAYOR DE HISTOCOMPATIBILIDAD (MHC), O LOS PÉPTIDOS COMO TALES, TAMBIÉN PUEDEN SER DIANAS DE ANTICUERPOS, DE RECEPTORES DE LINFOCITOS T SOLUBLES, Y DE OTRAS MOLÉCULAS DE UNIÓN.</p><p> THIS INVENTION REFERS TO PEPTIDES, PROTEINS, NUCLETIC ACIDS AND CELLS FOR USE IN IMMUNOTHERAPEUTIC METHODS. IN PARTICULAR, THE PRESENT INVENTION REFERS TO IMMUNOTHERAPY AGAINST CANCER. THE PRESENT INVENTION REFERS ASYMISM TO PEPTIDE EPITHOPES FOR LYMPHOCYTES ASSOCIATED WITH TUMORS, ONLY OR IN COMBINATION WITH OTHER PEPTIDES ASSOCIATED WITH TUMORS WHICH, FOR EXAMPLE, MAY SERVE AS EXPERIMENTAL COMPARTMENT COMPARTMENT EXTERNAL COMPARTMENTS. I LIVE LYMPHOCYTES THAT WILL BE TRANSFERRED TO PATIENTS. PEPTIDES UNITED TO MOLECULES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC), OR PEPTIDES AS SUCH, MAY ALSO BE A TARGET OF ANTIBODIES, OF RECEIVERS OF T SOLUBLE LYMPHOCYTES, AND OF OTHER MOLECULES.

CL2017003235A 2015-06-19 2017-12-15 New peptides and new combinations of peptides for use in immunotherapy and methods for creating supports for use against pancreatic cancer and other types of cancer CL2017003235A1 (en)

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