CL2018000327A1 - Sistemas de tratamiento de aloinjerto rápido y métodos - Google Patents
Sistemas de tratamiento de aloinjerto rápido y métodosInfo
- Publication number
- CL2018000327A1 CL2018000327A1 CL2018000327A CL2018000327A CL2018000327A1 CL 2018000327 A1 CL2018000327 A1 CL 2018000327A1 CL 2018000327 A CL2018000327 A CL 2018000327A CL 2018000327 A CL2018000327 A CL 2018000327A CL 2018000327 A1 CL2018000327 A1 CL 2018000327A1
- Authority
- CL
- Chile
- Prior art keywords
- fabric
- methods
- processing
- acoustic energy
- resonant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/16—Physical preservation processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/362—Skin, e.g. dermal papillae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
<p>SE PROPORCIONAN SISTEMAS Y MÉTODOS PARA EL TRATAMIENTO O PROCESAMIENTO DE TEJIDO, Y PRODUCTOS DE TEJIDO HECHOS USANDO TALES SISTEMAS Y MÉTODOS. LOS MÉTODOS INVOLUCRAN COMBINAR EL TEJIDO CON UNA SOLUCIÓN DE PROCESAMIENTO EN UN RECIPIENTE DE PROCESAMIENTO Y APLICAR ENERGÍA ACÚSTICA RESONANTE A ESTE. EN ALGUNOS CASOS, EL TEJIDO ES PROCESADO EN AUSENCIA DE SOLUCIÓN DE PROCESAMIENTO. LA ENERGÍA ACÚSTICA RESONANTE AGITA RÁPIDAMENTE EL TEJIDO CON LA SOLUCIÓN DE PROCESAMIENTO POR MEDIO DE VIBRACIÓN. EL MÉTODO GENERAL PROPORCIONADO ES AMPLIAMENTE APLICABLE A UNA VARIEDAD DE MÉTODOS DE PROCESAMIENTO DE TEJIDOS, LA SOLUCIÓN DE PROCESAMIENTO Y CARACTERÍSTICAS DE LA ENERGÍA ACÚSTICA RESONANTE SIENDO SELECCIONADAS EN BASE AL TIPO DE TEJIDO A SER PROCESADO Y LA NATURALEZA DEL PROCESAMIENTO PUEDA SER REALIZADA. MÉTODOS EJEMPLARES INCLUYEN MÉTODOS DE DESMINERALIZACIÓN DE HUESO, DESCELULARIZACIÓN TISULAR, CRIOPRESERVACIÓN TISULAR, PRODUCCIÓN DE LA FRACCIÓN VASCULAR ESTROMAL, HOMOGENIZACIÓN DE TEJIDO, LIMPIEZA DE TEJIDO Y DESCONTAMINACIÓN DEL TEJIDO, Y EVALUACIÓN DE LA CARGA MICROBIANA. AL APLICAR ENERGÍA ACÚSTICA RESONANTE AL TEJIDO DURANTE EL PROCESAMIENTO, LA TASA O EFICIENCIA DE PROCESAMIENTO, O AMBAS PUEDEN SER MEJORADAS.</p>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562202661P | 2015-08-07 | 2015-08-07 | |
| US201562218289P | 2015-09-14 | 2015-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018000327A1 true CL2018000327A1 (es) | 2018-07-27 |
Family
ID=57984439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018000327A CL2018000327A1 (es) | 2015-08-07 | 2018-02-05 | Sistemas de tratamiento de aloinjerto rápido y métodos |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20170035937A1 (es) |
| EP (1) | EP3331984B1 (es) |
| KR (2) | KR20250151572A (es) |
| AU (1) | AU2016304809B2 (es) |
| CA (1) | CA2992594A1 (es) |
| CL (1) | CL2018000327A1 (es) |
| WO (1) | WO2017027481A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10900876B2 (en) * | 2016-03-10 | 2021-01-26 | Becton, Dickinson And Company | Methods and devices for producing cellular suspensions from tissue samples |
| WO2018157456A1 (zh) * | 2017-03-03 | 2018-09-07 | 北京博辉瑞进生物科技有限公司 | 一种生物组织基质材料、制备方法及在耳科修复材料中的应用 |
| US11452796B2 (en) | 2017-06-30 | 2022-09-27 | Allosource | Cellular bone grafts, and methods of manufacture and use |
| AU2018406738B2 (en) * | 2018-01-31 | 2024-10-10 | Rokit Healthcare Inc. | Bioink composition for cartilage regeneration, method for manufacturing customized scaffold for cartilage regeneration using same, and customized scaffold for cartilage regeneration manufactured using manufacturing method |
| CN109876189B (zh) * | 2018-05-28 | 2022-02-18 | 聂云飞 | 一种利用超声波高效制备脂肪源生物材料的方法 |
| CA3108928A1 (en) * | 2018-08-23 | 2020-02-27 | Theracell Consulting Sprl | Automated process for the treatment of a biological tissue to produce a tissue matrix |
| CN114206406A (zh) * | 2019-12-09 | 2022-03-18 | 爱恩斯生物科技(昆山)有限公司 | 利用脂肪组织源细胞外基质的支架及其制造方法 |
| CN111069149A (zh) * | 2019-12-20 | 2020-04-28 | 河北鑫康辰生物技术有限公司 | 一种医用同种骨清洗方法 |
| US11896736B2 (en) | 2020-07-13 | 2024-02-13 | Globus Medical, Inc | Biomaterial implants and methods of making the same |
| CN113118075B (zh) * | 2021-04-07 | 2023-06-30 | 南京尚磐信息科技有限公司 | 一种碳纤维肋骨的碳颗粒凝结脱落系统及其脱落方法 |
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| US5118512A (en) * | 1990-01-23 | 1992-06-02 | Osteotech, Inc. (A Delaware Corp.) | Process for cryopreserving biological materials and materials prepared thereby |
| US5879939A (en) * | 1995-05-17 | 1999-03-09 | Neocrin Company | Isolation of cells from organ tissue using sonication |
| US5977432A (en) * | 1997-06-09 | 1999-11-02 | Life Net Research Foundation | Process for cleaning bone grafts using centrifugal force and bone grafts produced thereby |
| US6820726B1 (en) | 1998-12-22 | 2004-11-23 | Otis Elevator Company | Traction enhanced controlled pressure flexible flat tension member termination device |
| MXPA01002610A (es) * | 1998-09-11 | 2002-04-08 | Berkshire Lab Inc | Metodo para utilizar energia acustica resonante y/o energia acusto-em resonante para detectar y/o afectar estructuras. |
| US20050059953A1 (en) * | 1999-09-03 | 2005-03-17 | Lifenet | Apparatus for demineralizing osteoinductive bone |
| US7188993B1 (en) | 2003-01-27 | 2007-03-13 | Harold W Howe | Apparatus and method for resonant-vibratory mixing |
| WO2006046955A1 (en) | 2003-10-28 | 2006-05-04 | Allosource | Methods for determining microbial contamination of allograft products |
| US7658888B2 (en) | 2006-01-10 | 2010-02-09 | Allosource | Apparatus for treating allograft products |
| US7776291B2 (en) | 2006-01-10 | 2010-08-17 | Allosource, Inc. | Apparatus for treating allograft products |
| KR100816395B1 (ko) * | 2006-09-21 | 2008-03-27 | (주)필미아젠 | 세포 유래 세포외기질막의 제조방법 |
| US8574825B2 (en) * | 2007-06-01 | 2013-11-05 | Bacterin International, Inc. | Process for demineralization of bone matrix with preservation of natural growth factors |
| JP5325779B2 (ja) | 2007-06-14 | 2013-10-23 | 株式会社ポーラファルマ | 医薬組成物 |
| CA2690457C (en) * | 2007-06-15 | 2018-02-20 | Osteotech, Inc. | Bone matrix compositions and methods |
| US20090024224A1 (en) * | 2007-07-16 | 2009-01-22 | Chen Silvia S | Implantation of cartilage |
| US9358320B2 (en) | 2008-04-25 | 2016-06-07 | Allosource | Multi-layer tissue patches |
| US9480549B2 (en) | 2008-04-25 | 2016-11-01 | Allosource | Multi-layer tissue patches |
| US9192695B2 (en) | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
| US8216808B2 (en) * | 2008-12-09 | 2012-07-10 | Donndelinger Thomas M | Methods for accelerating tissue processing |
| KR100978562B1 (ko) * | 2008-12-31 | 2010-08-27 | 주식회사 코리아본뱅크 | 스폰지형 골 이식재 및 이를 제조하는 방법 |
| US8636402B2 (en) * | 2009-05-20 | 2014-01-28 | Xyleco, Inc. | Processing biomass |
| US8486344B2 (en) | 2009-05-22 | 2013-07-16 | Allosource, Inc. | Apparatus and methods for treating allograft products |
| KR101123869B1 (ko) * | 2009-07-07 | 2012-03-15 | (주)에어프라임 | 포장용 에어완충재 제조장치 |
| US20140024115A1 (en) | 2009-11-04 | 2014-01-23 | Allosource | Methods of combining mesenchymal stem cells and cartilage containing allografts, and products of combined mesenchymal stem cells and cartilage containing allografts |
| EA024470B1 (ru) * | 2010-06-28 | 2016-09-30 | Ббс-Биоэктив Боун Сабститьютс Ой | Способ получения препарата костного белка и препарат костного белка |
| US20130156863A1 (en) * | 2010-06-30 | 2013-06-20 | Tissuetech, Inc. | Methods of preparing chorion tissue and products derived therefrom |
| AU2011352928B2 (en) * | 2010-12-27 | 2017-02-02 | Stroma Cell Therapeutics, Llc | Ultrasonic cavitation derived stromal or mesenchymal vascular extracts and cells derived therefrom obtained from adipose tissue and use thereof |
| US20140079741A1 (en) | 2011-03-18 | 2014-03-20 | Katholieke Universiteit Leuven Ku Leuven Research & Development | Inhibition and treatment of biofilms |
| US9155607B2 (en) * | 2011-11-16 | 2015-10-13 | Purdue Research Foundation | Compositions and methods for repair or regeneration of soft tissue |
| JP2015525122A (ja) | 2012-05-31 | 2015-09-03 | レゾダイン・コーポレイション | 材料を流動化し、混合し、塗布し、乾燥し、結合し、化学反応し、分離する機械的システム |
| CA2881796A1 (en) | 2012-08-17 | 2014-02-20 | Allosource | Adipose composition systems and methods |
| EP2919794B1 (en) | 2012-11-15 | 2021-01-20 | AlloSource | Minced cartilage systems and methods |
| CA2894750C (en) | 2013-02-22 | 2021-12-14 | Allosource | Cartilage mosaic compositions and methods |
| AU2014225458A1 (en) | 2013-03-07 | 2015-07-09 | Allosource | Consistent calcium content bone allograft systems and methods |
| AU2014248873B2 (en) | 2013-03-13 | 2017-03-23 | Allosource | Fascia fibrous compositions and methods for their use and manufacture |
| AU2014236705B2 (en) | 2013-03-15 | 2018-04-12 | Allosource | Perforated osteochondral allograft compositions |
| CA2899713C (en) | 2013-03-15 | 2022-07-19 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
-
2016
- 2016-08-08 KR KR1020257032717A patent/KR20250151572A/ko active Pending
- 2016-08-08 WO PCT/US2016/046070 patent/WO2017027481A1/en not_active Ceased
- 2016-08-08 EP EP16835767.1A patent/EP3331984B1/en active Active
- 2016-08-08 KR KR1020187006146A patent/KR102867973B1/ko active Active
- 2016-08-08 CA CA2992594A patent/CA2992594A1/en active Pending
- 2016-08-08 AU AU2016304809A patent/AU2016304809B2/en active Active
- 2016-08-08 US US15/231,586 patent/US20170035937A1/en active Pending
-
2018
- 2018-02-05 CL CL2018000327A patent/CL2018000327A1/es unknown
-
2022
- 2022-02-04 US US17/649,989 patent/US20220160937A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3331984A1 (en) | 2018-06-13 |
| EP3331984B1 (en) | 2021-09-22 |
| AU2016304809A1 (en) | 2018-02-01 |
| AU2016304809B2 (en) | 2020-09-24 |
| WO2017027481A1 (en) | 2017-02-16 |
| KR20180037232A (ko) | 2018-04-11 |
| EP3331984A4 (en) | 2019-04-03 |
| CA2992594A1 (en) | 2017-02-16 |
| KR20250151572A (ko) | 2025-10-21 |
| US20220160937A1 (en) | 2022-05-26 |
| KR102867973B1 (ko) | 2025-10-10 |
| US20170035937A1 (en) | 2017-02-09 |
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