CL2018001733A1 - Analogos cortistatinos y usos relacionados. - Google Patents

Analogos cortistatinos y usos relacionados.

Info

Publication number
CL2018001733A1
CL2018001733A1 CL2018001733A CL2018001733A CL2018001733A1 CL 2018001733 A1 CL2018001733 A1 CL 2018001733A1 CL 2018001733 A CL2018001733 A CL 2018001733A CL 2018001733 A CL2018001733 A CL 2018001733A CL 2018001733 A1 CL2018001733 A1 CL 2018001733A1
Authority
CL
Chile
Prior art keywords
related uses
cortistatin analogues
cortistatin
analogues
Prior art date
Application number
CL2018001733A
Other languages
English (en)
Inventor
Matthew D Shair
Henry Efrem Pelish
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of CL2018001733A1 publication Critical patent/CL2018001733A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CL2018001733A 2015-12-23 2018-06-22 Analogos cortistatinos y usos relacionados. CL2018001733A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562387246P 2015-12-23 2015-12-23
US201662297494P 2016-02-19 2016-02-19

Publications (1)

Publication Number Publication Date
CL2018001733A1 true CL2018001733A1 (es) 2018-11-09

Family

ID=59091204

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018001733A CL2018001733A1 (es) 2015-12-23 2018-06-22 Analogos cortistatinos y usos relacionados.

Country Status (17)

Country Link
US (1) US20180298024A1 (es)
EP (1) EP3394072A4 (es)
JP (1) JP2019508368A (es)
KR (1) KR20180095051A (es)
CN (1) CN108699085A (es)
AU (1) AU2016377678A1 (es)
BR (1) BR112018012647A2 (es)
CA (1) CA3009324A1 (es)
CL (1) CL2018001733A1 (es)
CO (1) CO2018007535A2 (es)
EA (1) EA201891511A1 (es)
IL (1) IL260123A (es)
MX (1) MX2018007804A (es)
PH (1) PH12018501351A1 (es)
RU (1) RU2018126984A (es)
SG (1) SG11201805092WA (es)
WO (1) WO2017112815A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI763630B (zh) 2015-07-02 2022-05-11 瑞士商赫孚孟拉羅股份公司 雙環內醯胺及其使用方法
EP3526219B1 (en) 2016-10-17 2021-12-15 F. Hoffmann-La Roche AG Bicyclic pyridone lactams and methods of use thereof
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
WO2019204537A1 (en) 2018-04-20 2019-10-24 Genentech, Inc. N-[4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol e-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs)
CN113677346A (zh) * 2018-11-01 2021-11-19 希洛斯医药品股份有限公司 周期蛋白依赖性激酶7(cdk7)的抑制剂
US20240180921A1 (en) * 2021-03-25 2024-06-06 University Of South Carolina Cdk8/19 inhibitors for the treatment of cytokine storm

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009137335A1 (en) * 2008-05-05 2009-11-12 The Scripps Research Institute Synthesis of (+) corstistatin a and related compounds
EP2334686B1 (en) * 2008-08-28 2019-02-27 President and Fellows of Harvard College Cortistatin analogues and syntheses therof
US20130217014A1 (en) * 2012-02-17 2013-08-22 Genentech, Inc. Methods of using cdk8 antagonists
WO2014123900A1 (en) * 2013-02-05 2014-08-14 Sirenas Marine Discovery Anti-cancer and anti-hiv compounds
SG11201605178WA (en) * 2013-12-24 2016-07-28 Harvard College Cortistatin analogues and syntheses and uses thereof

Also Published As

Publication number Publication date
CN108699085A (zh) 2018-10-23
CO2018007535A2 (es) 2018-07-31
EA201891511A1 (ru) 2018-12-28
AU2016377678A1 (en) 2018-07-12
MX2018007804A (es) 2019-07-04
BR112018012647A2 (pt) 2018-12-04
IL260123A (en) 2018-07-31
US20180298024A1 (en) 2018-10-18
EP3394072A4 (en) 2019-05-29
PH12018501351A1 (en) 2019-02-27
JP2019508368A (ja) 2019-03-28
CA3009324A1 (en) 2017-06-29
SG11201805092WA (en) 2018-07-30
EP3394072A1 (en) 2018-10-31
KR20180095051A (ko) 2018-08-24
WO2017112815A1 (en) 2017-06-29
RU2018126984A (ru) 2020-01-23

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