CL2018002654A1 - Bencenosulfonilureas asimétricas y usos médicos de las mismas. - Google Patents

Bencenosulfonilureas asimétricas y usos médicos de las mismas.

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Publication number
CL2018002654A1
CL2018002654A1 CL2018002654A CL2018002654A CL2018002654A1 CL 2018002654 A1 CL2018002654 A1 CL 2018002654A1 CL 2018002654 A CL2018002654 A CL 2018002654A CL 2018002654 A CL2018002654 A CL 2018002654A CL 2018002654 A1 CL2018002654 A1 CL 2018002654A1
Authority
CL
Chile
Prior art keywords
grelina
compounds
document
asymmetric
benzenesulfonylureas
Prior art date
Application number
CL2018002654A
Other languages
English (en)
Inventor
Antoine Daina
Claudio Pietra
Claudio Giuliano
Original Assignee
Helsinn Healthcare Sa
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Filing date
Publication date
Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Publication of CL2018002654A1 publication Critical patent/CL2018002654A1/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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Abstract

EN EL PRESENTE DOCUMENTO, SE DIVULGAN NUEVAS BENCENOSULFONILUREAS ASIMÉTRICAS, QUE CORRESPONDEN A LAS FÓRMULAS GENERALES (I) A (IV), Y SALES FARMACÉUTICAMENTE ACEPTABLES DE LAS MISMAS, CUYAS ESTRUCTURAS Y SUSTITUYENTES SE DETALLAN EN LA MEMORIA DESCRIPTIVA. EN LA PRESENTE DIVULGACIÓN, SE DESCRIBEN PROCEDIMIENTOS PARA LA SÍNTESIS DE ESTOS COMPUESTOS. LOS COMPUESTOS SON ACTIVOS SOBRE LOS RECEPTORES DE GRELINA, EN PARTICULAR TIENEN ACTIVIDAD AGONISTA INVERSA, Y SON ÚTILES PARA PREVENIR Y/O TRATAR ENFERMEDADES MEDIADAS FISIOPATOLÓGICAMENTE POR EL RECEPTOR DE GRELINA, COMO POR EJEMPLO, OBESIDAD, DIABETES Y ABUSO DE SUSTANCIAS. TAMBIÉN SE DESCRIBEN COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN UN COMPUESTO DESCRITO EN EL PRESENTE DOCUMENTO Y UN PORTADOR O VEHÍCULO FARMACÉUTICAMENTE ACEPTABLE.
CL2018002654A 2016-03-22 2018-09-14 Bencenosulfonilureas asimétricas y usos médicos de las mismas. CL2018002654A1 (es)

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