CL2018003391A1 - Beta-horquilla peptidomimética con actividad inhibidora de elastasa y formas de dosificación en aerosol de la misma. - Google Patents
Beta-horquilla peptidomimética con actividad inhibidora de elastasa y formas de dosificación en aerosol de la misma.Info
- Publication number
- CL2018003391A1 CL2018003391A1 CL2018003391A CL2018003391A CL2018003391A1 CL 2018003391 A1 CL2018003391 A1 CL 2018003391A1 CL 2018003391 A CL2018003391 A CL 2018003391A CL 2018003391 A CL2018003391 A CL 2018003391A CL 2018003391 A1 CL2018003391 A1 CL 2018003391A1
- Authority
- CL
- Chile
- Prior art keywords
- pro
- fork
- refers
- pharmaceutical
- activity
- Prior art date
Links
- 239000000443 aerosol Substances 0.000 title abstract 2
- 239000002552 dosage form Substances 0.000 title 1
- 230000002849 elastaseinhibitory effect Effects 0.000 title 1
- 239000000816 peptidomimetic Substances 0.000 title 1
- 201000003883 Cystic fibrosis Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 210000004072 lung Anatomy 0.000 abstract 2
- 239000008249 pharmaceutical aerosol Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 108010028275 Leukocyte Elastase Proteins 0.000 abstract 1
- 102000016799 Leukocyte elastase Human genes 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A AEROSOLES FARMACÉUTICOS QUE COMPRENDEN UNA ß-HORQUILLA PEPTIDOMIMÉTICA DE FÓRMULA CICLO(-OCTG-GLU-THR-ALA-SER-ILE-PRO-PRO-GLN-LYS-TYR-DPRO-PRO-), O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO, QUE TIENE ACTIVIDAD INHIBIDORA CONTRA ELASTASA DE NEUTRÓFILO HUMANA. ADEMÁS, SE REFIERE A COMPOSICIONES FARMACÉUTICAS SÓLIDAS O LÍQUIDAS Y KITS PARA PREPARAR Y ADMINISTRAR TALES AEROSOLES. LA INVENCIÓN SE PUEDE UTILIZAR PARA LA PREVENCIÓN, MANEJO O TRATAMIENTO DE ENFERMEDADES PULMONARES, TAL COMO LA DEFICIENCIA DE ANTITRIPSINA ALFA-1 (AATD), FIBROSIS QUÍSTICA (CF), BRONQUIACTASIA FIBROSA NO QUÍSTICA (NCFB) O ENFERMEDAD PULMONAR OBSTRUCTIVA CRÓNICA (COPD), O INFECCIONES, O ENFERMEDADES O AFECCIONES DE LOS PULMONES, QUE SON MEDIADAS O QUE RESULTAN DE LA ACTIVIDAD DE LA ELASTASA DE NEUTRÓFILO HUMANA. POR LO TANTO, LA INVENCIÓN SE REFIERE ADEMÁS A UNA COMPOSICIÓN FARMACÉUTICA O UN AEROSOL FARMACÉUTICO QUE COMPRENDE EL COMPUESTO ACTIVO CICLO(-OCTG-GLU-THR-ALA-SER-ILE-PRO-PRO-GLN-LYS-TYR-DPRO-PRO-), O CUALQUIER SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO, PARA USO EN UN MÉTODO PARA LA PREVENCIÓN, MANEJO O TRATAMIENTO DE ENFERMEDADES O AFECCIONES DE LOS PULMONES QUE SON MEDIADAS O QUE RESULTAN DE LA ACTIVIDAD DE LA ELASTASA DE NEUTRÓFILO EN UN SUJETO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16020210 | 2016-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018003391A1 true CL2018003391A1 (es) | 2019-05-03 |
Family
ID=56108445
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018003391A CL2018003391A1 (es) | 2016-05-31 | 2018-11-28 | Beta-horquilla peptidomimética con actividad inhibidora de elastasa y formas de dosificación en aerosol de la misma. |
| CL2018003390A CL2018003390A1 (es) | 2016-05-31 | 2018-11-28 | Beta-horquilla peptidomimética con actividad inhibidora de elastasa y formas de dosificación en aerosol de la misma. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018003390A CL2018003390A1 (es) | 2016-05-31 | 2018-11-28 | Beta-horquilla peptidomimética con actividad inhibidora de elastasa y formas de dosificación en aerosol de la misma. |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US11235023B2 (es) |
| EP (2) | EP3463281B1 (es) |
| JP (4) | JP7286319B6 (es) |
| KR (2) | KR102480800B1 (es) |
| CN (3) | CN109195580A (es) |
| AU (2) | AU2017273508B2 (es) |
| BR (2) | BR112018074532B1 (es) |
| CA (2) | CA3024522C (es) |
| CL (2) | CL2018003391A1 (es) |
| DK (2) | DK3463280T3 (es) |
| EA (2) | EA039603B1 (es) |
| ES (2) | ES2927948T3 (es) |
| HR (2) | HRP20221185T1 (es) |
| HU (2) | HUE060119T2 (es) |
| IL (2) | IL263112B2 (es) |
| LT (2) | LT3463281T (es) |
| MA (2) | MA45168A (es) |
| MX (2) | MX393629B (es) |
| PH (2) | PH12018502522A1 (es) |
| PL (2) | PL3463281T3 (es) |
| PT (2) | PT3463281T (es) |
| RS (2) | RS63622B1 (es) |
| SG (3) | SG11201810137UA (es) |
| SM (2) | SMT202200405T1 (es) |
| UA (2) | UA125899C2 (es) |
| WO (2) | WO2017207117A1 (es) |
| ZA (2) | ZA201807772B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX393629B (es) * | 2016-05-31 | 2025-03-24 | Polyphor Ag | Beta-horquilla peptidomimetica con actividad inhibidora de elastasa y formas de dosificacion en aerosol de la misma. |
| JP2022544834A (ja) * | 2019-08-23 | 2022-10-21 | ピーエイチ・ファーマ・カンパニー・リミテッド | 肺疾患における好中球エラスターゼ阻害剤の使用 |
| BR112022014861A2 (pt) * | 2020-01-30 | 2022-09-20 | Vertex Pharma | Métodos de tratamento para deficiência de alfa-1 antittripsina |
| WO2021203014A1 (en) | 2020-04-03 | 2021-10-07 | Vertex Pharmaceuticals Incorporated | Pyrano[4,3-b]l ndole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd) |
| EP4126863A1 (en) | 2020-04-03 | 2023-02-08 | Vertex Pharmaceuticals Incorporated | 1 h-pyrazolo[4,3-g]isoquinoline and 1 h-pyrazolo[4,3-g]quinoline derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd) |
| JP2023549971A (ja) * | 2020-11-23 | 2023-11-29 | スペクシス アーゲー | ベータヘアピン型ペプチド模倣物の組成物及びそのエアロゾル投与形態 |
| CN116421704A (zh) * | 2023-02-20 | 2023-07-14 | 成都佩德生物医药有限公司 | 多肽pd-dp-005在制备治疗肺部疾病药物中的应用及其药物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998019694A1 (en) | 1996-11-01 | 1998-05-14 | Xoma Corporation | Therapeutic uses of bpi protein products in cystic fibrosis patients |
| US20060188555A1 (en) * | 2005-01-21 | 2006-08-24 | Micheal Cormier | Therapeutic peptide formulations with improved stability |
| CA2598360C (en) * | 2005-02-17 | 2016-12-20 | Universitat Zurich | Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity |
| EP1712220A1 (en) * | 2005-04-15 | 2006-10-18 | PARI GmbH Spezialisten für effektive Inhalation | Pharmaceutical aerosol composition |
| PT1981572E (pt) * | 2006-02-09 | 2013-02-26 | Pari Pharma Gmbh | Distribuição pulmonar de inibidor de alfa-i proteinase |
| JP2009526003A (ja) * | 2006-02-10 | 2009-07-16 | パーリ・ファルマ・ゲーエムベーハー | 吸入療法用噴霧状抗生物質 |
| WO2008025560A1 (en) | 2006-09-01 | 2008-03-06 | Pari Pharma Gmbh | Methods for taste masking of nebulised compositions for nasal and pulmonary inhalation therapy |
| EP1927373B1 (en) * | 2006-11-30 | 2012-08-22 | PARI Pharma GmbH | Inhalation nebulizer |
| PL2567691T3 (pl) * | 2011-09-12 | 2015-05-29 | Meiji Seika Pharma Co Ltd | Kompozycje wodne obejmujące arbekacynę |
| WO2015096672A1 (zh) | 2013-12-23 | 2015-07-02 | 石家庄铁道大学 | 测试装置 |
| JP6431486B2 (ja) | 2013-12-26 | 2018-11-28 | 株式会社カネカ | 太陽電池のｉ‐ｖ測定方法、太陽電池のｉ‐ｖ測定装置、太陽電池の製造方法、太陽電池モジュールの製造方法、および太陽電池モジュール |
| NZ722025A (en) * | 2013-12-27 | 2019-06-28 | Polyphor Ag | Beta-hairpin peptidomimetics as selective elastase inhibitors |
| EA034910B1 (ru) * | 2013-12-27 | 2020-04-06 | Полифор Аг | Бета-шпилечные пептидомиметики в качестве селективных ингибиторов эластазы |
| MX393629B (es) * | 2016-05-31 | 2025-03-24 | Polyphor Ag | Beta-horquilla peptidomimetica con actividad inhibidora de elastasa y formas de dosificacion en aerosol de la misma. |
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2017
- 2017-05-31 MX MX2018014752A patent/MX393629B/es unknown
- 2017-05-31 EP EP17733738.3A patent/EP3463281B1/en active Active
- 2017-05-31 PT PT177337383T patent/PT3463281T/pt unknown
- 2017-05-31 ES ES17733737T patent/ES2927948T3/es active Active
- 2017-05-31 CN CN201780033187.7A patent/CN109195580A/zh active Pending
- 2017-05-31 KR KR1020187036054A patent/KR102480800B1/ko active Active
- 2017-05-31 RS RS20220923A patent/RS63622B1/sr unknown
- 2017-05-31 WO PCT/EP2017/025156 patent/WO2017207117A1/en not_active Ceased
- 2017-05-31 UA UAA201812929A patent/UA125899C2/uk unknown
- 2017-05-31 DK DK17733737.5T patent/DK3463280T3/da active
- 2017-05-31 CA CA3024522A patent/CA3024522C/en active Active
- 2017-05-31 BR BR112018074532-4A patent/BR112018074532B1/pt not_active IP Right Cessation
- 2017-05-31 MA MA045168A patent/MA45168A/fr unknown
- 2017-05-31 SG SG11201810137UA patent/SG11201810137UA/en unknown
- 2017-05-31 PT PT177337375T patent/PT3463280T/pt unknown
- 2017-05-31 HR HRP20221185TT patent/HRP20221185T1/hr unknown
- 2017-05-31 KR KR1020187036055A patent/KR102511284B1/ko active Active
- 2017-05-31 HU HUE17733737A patent/HUE060119T2/hu unknown
- 2017-05-31 EA EA201892818A patent/EA039603B1/ru unknown
- 2017-05-31 JP JP2018562561A patent/JP7286319B6/ja active Active
- 2017-05-31 ES ES17733738T patent/ES2928050T3/es active Active
- 2017-05-31 BR BR112018074551-0A patent/BR112018074551B1/pt not_active IP Right Cessation
- 2017-05-31 IL IL263112A patent/IL263112B2/en unknown
- 2017-05-31 AU AU2017273508A patent/AU2017273508B2/en not_active Ceased
- 2017-05-31 RS RS20220922A patent/RS63639B1/sr unknown
- 2017-05-31 SM SM20220405T patent/SMT202200405T1/it unknown
- 2017-05-31 SM SM20220404T patent/SMT202200404T1/it unknown
- 2017-05-31 US US16/305,518 patent/US11235023B2/en not_active Expired - Fee Related
- 2017-05-31 DK DK17733738.3T patent/DK3463281T3/da active
- 2017-05-31 MA MA045167A patent/MA45167A/fr unknown
- 2017-05-31 LT LTEPPCT/EP2017/025157T patent/LT3463281T/lt unknown
- 2017-05-31 HU HUE17733738A patent/HUE060393T2/hu unknown
- 2017-05-31 MX MX2018014425A patent/MX2018014425A/es unknown
- 2017-05-31 US US16/305,714 patent/US11235024B2/en not_active Expired - Fee Related
- 2017-05-31 CN CN202211636345.7A patent/CN116159024A/zh active Pending
- 2017-05-31 HR HRP20221194TT patent/HRP20221194T1/hr unknown
- 2017-05-31 WO PCT/EP2017/025157 patent/WO2017207118A1/en not_active Ceased
- 2017-05-31 PL PL17733738.3T patent/PL3463281T3/pl unknown
- 2017-05-31 SG SG10202113280XA patent/SG10202113280XA/en unknown
- 2017-05-31 CA CA3024521A patent/CA3024521C/en active Active
- 2017-05-31 CN CN201780033188.1A patent/CN109310613A/zh active Pending
- 2017-05-31 SG SG11201810138XA patent/SG11201810138XA/en unknown
- 2017-05-31 AU AU2017273507A patent/AU2017273507B2/en not_active Ceased
- 2017-05-31 EA EA201892819A patent/EA201892819A1/ru unknown
- 2017-05-31 PL PL17733737.5T patent/PL3463280T3/pl unknown
- 2017-05-31 UA UAA201812930A patent/UA125900C2/uk unknown
- 2017-05-31 IL IL263114A patent/IL263114B2/en unknown
- 2017-05-31 LT LTEPPCT/EP2017/025156T patent/LT3463280T/lt unknown
- 2017-05-31 EP EP17733737.5A patent/EP3463280B1/en active Active
- 2017-05-31 JP JP2018562549A patent/JP7544466B2/ja active Active
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2018
- 2018-11-19 ZA ZA2018/07772A patent/ZA201807772B/en unknown
- 2018-11-19 ZA ZA2018/07773A patent/ZA201807773B/en unknown
- 2018-11-28 CL CL2018003391A patent/CL2018003391A1/es unknown
- 2018-11-28 CL CL2018003390A patent/CL2018003390A1/es unknown
- 2018-11-29 PH PH12018502522A patent/PH12018502522A1/en unknown
- 2018-11-29 PH PH12018502521A patent/PH12018502521A1/en unknown
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2021
- 2021-10-06 US US17/495,137 patent/US11844823B2/en active Active
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2022
- 2022-01-04 JP JP2022000083A patent/JP2022078013A/ja active Pending
- 2022-10-20 JP JP2022168582A patent/JP2023017793A/ja not_active Withdrawn
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