CL2018003604A1 - Composiciones farmacéuticas para terapia combinada (divisional solicitud 201701983) - Google Patents
Composiciones farmacéuticas para terapia combinada (divisional solicitud 201701983)Info
- Publication number
- CL2018003604A1 CL2018003604A1 CL2018003604A CL2018003604A CL2018003604A1 CL 2018003604 A1 CL2018003604 A1 CL 2018003604A1 CL 2018003604 A CL2018003604 A CL 2018003604A CL 2018003604 A CL2018003604 A CL 2018003604A CL 2018003604 A1 CL2018003604 A1 CL 2018003604A1
- Authority
- CL
- Chile
- Prior art keywords
- combination
- agonist
- ppar
- bili
- prevention
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA PRESENTE INVENCIÓN SE RELACIONA CON UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE UNA COMBINACIÓN DE UN AGONISTA DE FXR Y POR LO MENOS UN AGENTE REDUCTOR DE LÍPIDOS (POR EJEMPLO, UN AGONISTA DE PPAR-ALFA, AGONISTA DE PPAR-DELTA, AGONISTA DUAL DE PPAR-ALFA Y DELTA, Y/O ESTATINA). TAMBIÉN SE DESCRIBE EL USO DE LA COMBINACIÓN PARA EL TRATAMIENTO O PREVENCIÓN DE UNA ENFERMEDAD O AFECCIÓN MEDIADA POR FXR, TAL COMO CIRROSIS BILIAR PRIMARIA (PBC), COLANGITIS ESCLEROSANTE PRIMARIA (PSC), HIPERTENSIÓN PORTAL, DIARREA POR ÁCIDOS BILIARES, NAFLD (ENFERMEDAD DE HÍGADO GRASO NO ALCOHÓLICA), NASH (ESTEATOHEPATITIS NO INDUCIDA POR ALCOHOL), Y OTRAS ENFERMEDADES HEPÁTICAS CRÓNICAS. LA COMBINACIÓN DE LA PRESENTE INVENCIÓN ES ÚTIL PARA EL TRATAMIENTO O PREVENCIÓN DE AFECCIONES RELACIONADAS CON NIVELES ELEVADOS DE LÍPIDOS Y ENZIMAS HEPÁTICAS. LA PRESENTE INVENCIÓN TAMBIÉN SE RELACIONA CON ENVASES O KITS QUE INCLUYEN LA COMBINACIÓN FARMACÉUTICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562113134P | 2015-02-06 | 2015-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018003604A1 true CL2018003604A1 (es) | 2019-02-22 |
Family
ID=56564878
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001983A CL2017001983A1 (es) | 2015-02-06 | 2017-08-03 | Composiciones farmacéuticas para terapia combinada. |
| CL2018001006A CL2018001006A1 (es) | 2015-02-06 | 2018-04-19 | Composiciones farmacéuticas para terapia combinada (sol. divisional de n° 201701983) |
| CL2018003604A CL2018003604A1 (es) | 2015-02-06 | 2018-12-14 | Composiciones farmacéuticas para terapia combinada (divisional solicitud 201701983) |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001983A CL2017001983A1 (es) | 2015-02-06 | 2017-08-03 | Composiciones farmacéuticas para terapia combinada. |
| CL2018001006A CL2018001006A1 (es) | 2015-02-06 | 2018-04-19 | Composiciones farmacéuticas para terapia combinada (sol. divisional de n° 201701983) |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US11311557B2 (es) |
| EP (2) | EP4035665A1 (es) |
| JP (2) | JP7306791B2 (es) |
| KR (1) | KR20170115071A (es) |
| CN (1) | CN107405325B (es) |
| AR (1) | AR103624A1 (es) |
| AU (2) | AU2016215179B2 (es) |
| BR (1) | BR112017016766B1 (es) |
| CA (1) | CA2976056C (es) |
| CL (3) | CL2017001983A1 (es) |
| CO (1) | CO2017007959A2 (es) |
| CR (1) | CR20170356A (es) |
| DK (1) | DK3253382T3 (es) |
| EA (1) | EA036404B1 (es) |
| EC (1) | ECSP17057848A (es) |
| ES (1) | ES2905872T3 (es) |
| GT (1) | GT201700174A (es) |
| IL (2) | IL253719B (es) |
| MA (1) | MA40814A1 (es) |
| MX (1) | MX388508B (es) |
| NI (1) | NI201700100A (es) |
| PE (1) | PE20180027A1 (es) |
| PH (1) | PH12017501384A1 (es) |
| SG (1) | SG11201706347SA (es) |
| SV (1) | SV2017005512A (es) |
| TN (1) | TN2017000344A1 (es) |
| TW (1) | TW201628625A (es) |
| UA (1) | UA125744C2 (es) |
| WO (1) | WO2016127019A2 (es) |
| ZA (1) | ZA201706007B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TN2017000344A1 (en) | 2015-02-06 | 2019-01-16 | Intercept Pharmaceuticals Inc | Pharmaceutical compositions for combination therapy |
| US10894054B2 (en) * | 2015-04-07 | 2021-01-19 | Intercept Pharmaceuticals, Inc. | FXR agonist compositions for combination therapy |
| CN108350020A (zh) * | 2015-09-24 | 2018-07-31 | 英特塞普特医药品公司 | 用于制备胆汁酸衍生物的方法和中间体 |
| US12053445B2 (en) | 2016-03-31 | 2024-08-06 | Genfit | Methods of treatment of cholestatic diseases |
| US11331292B2 (en) | 2016-03-31 | 2022-05-17 | Genfit | Methods of treatment of cholestatic diseases |
| PT3435996T (pt) * | 2016-03-31 | 2025-05-13 | Genfit | Elafibranor para utilização no tratamento de colangite biliar primária |
| US20180243263A1 (en) | 2016-12-09 | 2018-08-30 | Cadila Healthcare Ltd. | Treatment for primary biliary cholangitis |
| AU2018223146B2 (en) * | 2017-02-21 | 2023-12-21 | Genfit | Combination of a PPAR agonist with a FXR agonist |
| CN111093705A (zh) * | 2017-09-13 | 2020-05-01 | 诺华股份有限公司 | 包含fxr激动剂的组合 |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| CN113677336B (zh) * | 2019-04-10 | 2024-04-30 | 基恩菲特公司 | 包含式(i)化合物和glp-1受体激动剂的组合疗法 |
| EA202193334A1 (ru) * | 2019-05-30 | 2022-03-14 | Интерсепт Фармасьютикалз, Инк. | Фармацевтические композиции, содержащие агонист fxr и фибрат, для применения при лечении холестатического заболевания печени |
| CN110287493B (zh) * | 2019-06-28 | 2023-04-18 | 中国科学技术信息研究所 | 风险短语识别方法、装置、电子设备及存储介质 |
| AU2020312735A1 (en) * | 2019-07-18 | 2021-12-16 | Enyo Pharma | Method for decreasing adverse-effects of interferon |
| JP2022548725A (ja) * | 2019-09-20 | 2022-11-21 | レネオ ファーマシューティカルズ，インク． | 腎臓病の治療におけるｐｐａｒデルタアゴニストの使用 |
| WO2021102251A1 (en) * | 2019-11-22 | 2021-05-27 | Avolynt | Use of sglt2 inhibitors to treat primary billiary cholangitis |
| CN111690731B (zh) * | 2020-05-22 | 2021-09-28 | 河南大学 | Fxr激动剂在治疗肝性脑病中的应用 |
| WO2022043367A1 (en) | 2020-08-26 | 2022-03-03 | Genfit | Compositions and methods for the treatment of primary biliary cholangitis |
| CN112885471B (zh) * | 2021-03-12 | 2023-01-24 | 上海中医药大学附属岳阳中西医结合医院 | 基于贝叶斯网络最大熵自学习扩展集对分析的银屑病疗效评价系统 |
| WO2023147141A1 (en) * | 2022-01-28 | 2023-08-03 | Intercept Pharmaceuticals, Inc. | Combination therapy |
| WO2024132001A1 (en) * | 2022-12-21 | 2024-06-27 | Charles University, Faculty Of Pharmacy In Hradec Kralove | Multitarget nuclear receptor ligands based on 2-(4-(quinolin-2-yloxy)phenoxy)propanoic acid and 2-(4-(quinoxalin-2-yloxy)phenoxy)propanoic acid for the treatment of metabolic and liver diseases |
| WO2025250918A1 (en) * | 2024-05-30 | 2025-12-04 | Intercept Pharmaceuticals, Inc. | Novel compositions |
| EP4725479A1 (en) * | 2024-10-09 | 2026-04-15 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Ppar agonists for treatment of diseases associated with aatd |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB860303A (en) | 1958-06-20 | 1961-02-01 | Ici Ltd | Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª |
| US3262580A (en) | 1964-06-23 | 1966-07-26 | Mcdowell Wellman Eng Co | Slewable gantry crane |
| FR1498459A (es) | 1965-07-30 | 1968-01-08 | ||
| US3674836A (en) | 1968-05-21 | 1972-07-04 | Parke Davis & Co | 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof |
| US4058552A (en) | 1969-01-31 | 1977-11-15 | Orchimed Sa | Esters of p-carbonylphenoxy-isobutyric acids |
| FI52570C (fi) | 1969-04-16 | 1977-10-10 | Sumitomo Chemical Co | Menetelmä veren kolesteroli- tai lipoidipitoisuutta alentavien fenoxia lifaattisten karboksyylihappoyhdisteiden ja -esteriyhdisteiden valmist amiseksi. |
| AT296986B (de) | 1969-08-13 | 1972-03-10 | Merz & Co | Verfahren zur Herstellung von neuen α-Halogenphenoxy-isobutyroyl-β-nicotinoyl-glykolen |
| DE2230383C3 (de) | 1971-10-01 | 1981-12-03 | Boehringer Mannheim Gmbh, 6800 Mannheim | Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben |
| JPS5118954B2 (es) | 1972-02-04 | 1976-06-14 | ||
| US3948973A (en) | 1972-08-29 | 1976-04-06 | Sterling Drug Inc. | Halocyclopropyl substituted phenoxyalkanoic acids |
| DE2308826C3 (de) | 1973-02-22 | 1980-03-27 | Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren | Phenoxyalkancarbonsäureester von Oxyalkyltheophyllinen, Verfahren zu ihrer Herstellung und Arzneimittel |
| FR2244511B1 (es) | 1973-07-05 | 1977-07-15 | Roussel Uclaf | |
| ES488665A0 (es) | 1980-02-15 | 1980-12-16 | Especialidades Farmaco Terape | Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| EP0607536B1 (en) | 1992-12-08 | 2001-01-24 | Ss Pharmaceutical Co., Ltd. | Arylamide derivatives |
| TW438587B (en) | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| AU5928898A (en) | 1997-01-24 | 1998-08-18 | Regents Of The University Of California, The | Use of fxr, pparalpha and lxralpha activators to restore barrier function, promote epidermal differentiation and inhibit proliferation |
| TR200000562T2 (tr) * | 1997-08-29 | 2000-08-21 | Pfizer Products Inc. | Amlodifin ve bir statin bileşiği içeren bileşim terapisi |
| AU749505B2 (en) | 1997-10-27 | 2002-06-27 | Dr. Reddy's Laboratories Limited | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
| US20030109467A1 (en) | 2001-11-15 | 2003-06-12 | Isis Pharmaceuticals Inc. | Antisense modulation of human FXR expression |
| WO2000037057A2 (en) | 1998-12-18 | 2000-06-29 | Abbott Laboratories | Novel formulations comprising lipid-regulating agents |
| ES2326850T3 (es) | 1998-12-23 | 2009-10-20 | Glaxo Group Limited | Ensayos para ligandos de receptores nucleares. |
| AU2409600A (en) | 1999-01-07 | 2000-07-24 | Tularik Inc. | Fxr receptor-mediated modulation of cholesterol metabolism |
| US6071955A (en) * | 1999-02-25 | 2000-06-06 | The Regents Of The University Of California | FXR, PPARA and LXRA activators to treat acne/acneiform conditions |
| US20020132223A1 (en) | 1999-03-26 | 2002-09-19 | City Of Hope | Methods for modulating activity of the FXR nuclear receptor |
| AR028023A1 (es) | 2000-04-19 | 2003-04-23 | Borody Thomas J | Una composicion farmaceutica para el tratamiento de la hiperlipidemia y el uso de dicha composicion para la preparacion de medicamentos |
| US6777446B2 (en) | 2000-09-05 | 2004-08-17 | Tularik, Inc. | FXR modulators |
| US20040072868A1 (en) | 2000-09-18 | 2004-04-15 | Collins Jon Loren | Substitued aminopropoxyaryl derivatives useful as agonists for lxr |
| ATE303399T1 (de) | 2001-03-12 | 2005-09-15 | Intercept Pharmaceuticals Inc | Steroide als agonisten für fxr |
| EP1285914B1 (en) | 2001-08-13 | 2007-12-19 | PheneX Pharmaceuticals AG | Nr1h4 nuclear receptor binding compounds |
| US7259186B2 (en) | 2002-12-17 | 2007-08-21 | Abbott Laboratories | Salts of fenofibric acid and pharmaceutical formulations thereof |
| EP1568706A1 (en) | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
| GB0405349D0 (en) * | 2004-03-10 | 2004-04-21 | Univ Birmingham | Cancer therapy and medicaments therefor |
| PL1734970T3 (pl) | 2004-03-12 | 2015-05-29 | Intercept Pharmaceuticals Inc | Leczenie zwłóknienia z zastosowaniem ligandów FXR |
| PE20060315A1 (es) * | 2004-05-24 | 2006-05-15 | Irm Llc | Compuestos de tiazol como moduladores de ppar |
| US20060252670A1 (en) * | 2004-10-14 | 2006-11-09 | Intercept Pharmaceuticals Inc. | Method of reducing drug-induced adverse side effects in a patient |
| WO2006121861A2 (en) | 2005-05-05 | 2006-11-16 | Microbia, Inc. | Biphenylazetidinone cholesterol absorption inhibitors |
| ITMI20050912A1 (it) | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| WO2007095174A2 (en) | 2006-02-14 | 2007-08-23 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions |
| US20070197606A1 (en) | 2006-02-22 | 2007-08-23 | Burczynski Frank J | Use of ppar agonists as anti-oxidants |
| WO2007111992A2 (en) * | 2006-03-22 | 2007-10-04 | President And Fellows Of Harvard College | Methods and compositions for treating hypercholesterolemia and atherosclerosis |
| AU2007267692B2 (en) | 2006-05-24 | 2012-06-14 | Eli Lilly And Company | Compounds and methods for modulating FXR |
| DK2029547T3 (da) | 2006-05-24 | 2010-07-26 | Lilly Co Eli | FXR-agonister |
| CN101522703B (zh) | 2006-06-27 | 2013-04-17 | 英特塞普特医药品公司 | 胆酸派生物及其在制备预防或治疗fxr介导的疾病或状况的药物中的应用 |
| AU2006346853A1 (en) | 2006-08-04 | 2008-02-07 | Aska Pharmaceutical Co., Ltd. | Drug formulation containing fibrate medicament and process for producing the same |
| EP1886685A1 (en) | 2006-08-11 | 2008-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition |
| EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
| EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
| WO2008039829A2 (en) | 2006-09-26 | 2008-04-03 | Ironwood Pharmaceuticals, Inc. | Diphenylheterocycle cholesterol absorption inhibitors |
| CL2007003035A1 (es) * | 2006-10-24 | 2008-05-16 | Smithkline Beechman Corp | Compuestos derivados de isoxazol sustituidos, agonistas de receptores farnesoid x; procedimiento de preparacion; composicion farmaceutica que lo comprende; y uso del compuesto en el tratamiento de la obesidad, diabetes mellitus, fibrosis en organos, |
| WO2008073825A1 (en) | 2006-12-08 | 2008-06-19 | Exelixis, Inc. | Lxr and fxr modulators |
| US20080299118A1 (en) | 2007-06-01 | 2008-12-04 | Wyeth | FXR Agonists for the Treatment of Malignancies |
| US20080300235A1 (en) | 2007-06-01 | 2008-12-04 | Wyeth | FXR Agonists for Reducing LOX-1 Expression |
| TW200906823A (en) | 2007-07-16 | 2009-02-16 | Lilly Co Eli | Compounds and methods for modulating FXR |
| US8338628B2 (en) | 2007-08-28 | 2012-12-25 | City Of Hope | Method of synthesizing alkylated bile acid derivatives |
| US20090163474A1 (en) | 2007-10-19 | 2009-06-25 | Wyeth | FXR Agonists for the Treatment of Nonalcoholic Fatty Liver and Cholesterol Gallstone Diseases |
| US20090215748A1 (en) | 2007-12-20 | 2009-08-27 | Wyeth | FXR agonists for treating vitamin D associated diseases |
| EP2110374A1 (en) | 2008-04-18 | 2009-10-21 | Merck Sante | Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators |
| EP2289883A1 (en) | 2009-08-19 | 2011-03-02 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| AU2010323066B2 (en) * | 2009-11-26 | 2014-12-11 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
| PT3336097T (pt) | 2012-06-19 | 2020-10-29 | Intercept Pharmaceuticals Inc | Preparação da forma não cristalina de ácido obeticólico |
| HUE036887T2 (hu) | 2012-10-26 | 2018-08-28 | Intercept Pharmaceuticals Inc | Eljárás epesav-származékok elõállítására |
| CA2912139C (en) | 2013-05-14 | 2021-04-20 | Roberto Pellicciari | 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators |
| US10077268B2 (en) * | 2014-03-13 | 2018-09-18 | Salk Institute For Biological Studies | FXR agonists and methods for making and using |
| TN2017000344A1 (en) | 2015-02-06 | 2019-01-16 | Intercept Pharmaceuticals Inc | Pharmaceutical compositions for combination therapy |
| EA202193334A1 (ru) | 2019-05-30 | 2022-03-14 | Интерсепт Фармасьютикалз, Инк. | Фармацевтические композиции, содержащие агонист fxr и фибрат, для применения при лечении холестатического заболевания печени |
-
2016
- 2016-02-05 TN TNP/2017/000344A patent/TN2017000344A1/en unknown
- 2016-02-05 DK DK16747312.3T patent/DK3253382T3/da active
- 2016-02-05 AU AU2016215179A patent/AU2016215179B2/en active Active
- 2016-02-05 JP JP2017541334A patent/JP7306791B2/ja active Active
- 2016-02-05 AR ARP160100332A patent/AR103624A1/es unknown
- 2016-02-05 EP EP21208443.8A patent/EP4035665A1/en active Pending
- 2016-02-05 US US15/548,537 patent/US11311557B2/en active Active
- 2016-02-05 CA CA2976056A patent/CA2976056C/en active Active
- 2016-02-05 WO PCT/US2016/016694 patent/WO2016127019A2/en not_active Ceased
- 2016-02-05 KR KR1020177024607A patent/KR20170115071A/ko not_active Ceased
- 2016-02-05 UA UAA201708864A patent/UA125744C2/uk unknown
- 2016-02-05 CN CN201680015586.6A patent/CN107405325B/zh active Active
- 2016-02-05 ES ES16747312T patent/ES2905872T3/es active Active
- 2016-02-05 PE PE2017001322A patent/PE20180027A1/es unknown
- 2016-02-05 CR CR20170356A patent/CR20170356A/es unknown
- 2016-02-05 TW TW105104019A patent/TW201628625A/zh unknown
- 2016-02-05 EP EP16747312.3A patent/EP3253382B1/en not_active Revoked
- 2016-02-05 BR BR112017016766-2A patent/BR112017016766B1/pt active IP Right Grant
- 2016-02-05 MA MA40814A patent/MA40814A1/fr unknown
- 2016-02-05 MX MX2017010131A patent/MX388508B/es unknown
- 2016-02-05 SG SG11201706347SA patent/SG11201706347SA/en unknown
- 2016-02-05 EA EA201791770A patent/EA036404B1/ru unknown
-
2017
- 2017-07-30 IL IL253719A patent/IL253719B/en unknown
- 2017-08-01 PH PH12017501384A patent/PH12017501384A1/en unknown
- 2017-08-03 CL CL2017001983A patent/CL2017001983A1/es unknown
- 2017-08-04 GT GT201700174A patent/GT201700174A/es unknown
- 2017-08-04 CO CONC2017/0007959A patent/CO2017007959A2/es unknown
- 2017-08-04 NI NI201700100A patent/NI201700100A/es unknown
- 2017-08-07 SV SV2017005512A patent/SV2017005512A/es unknown
- 2017-08-31 EC ECIEPI201757848A patent/ECSP17057848A/es unknown
- 2017-09-04 ZA ZA2017/06007A patent/ZA201706007B/en unknown
-
2018
- 2018-04-19 CL CL2018001006A patent/CL2018001006A1/es unknown
- 2018-12-14 CL CL2018003604A patent/CL2018003604A1/es unknown
-
2021
- 2021-02-17 AU AU2021201015A patent/AU2021201015A1/en not_active Abandoned
- 2021-10-11 JP JP2021166629A patent/JP2022000483A/ja not_active Withdrawn
-
2022
- 2022-02-23 IL IL290823A patent/IL290823A/en unknown
- 2022-03-21 US US17/700,392 patent/US20220280534A1/en not_active Abandoned
- 2022-03-21 US US17/700,317 patent/US12337003B2/en active Active
-
2025
- 2025-06-10 US US19/233,923 patent/US20250367217A1/en active Pending
- 2025-06-10 US US19/233,916 patent/US20250367216A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GT201700174A (es) | Composiciones farmaceuticas para terapia combinada | |
| CL2017001488A1 (es) | Benzamidas sustituidas con 1,3–tiazol–2–ilo | |
| EP4306168A3 (en) | Isoxazoline compositions and use thereof in the prevention or treatment of parasite infestations in animals | |
| CL2012002319A1 (es) | Compuestos derivados de amino-tienopirimidinas que contienen un grupo alquilo sustituido, inhibidores de mnk| o mnk2; composición farmacéutica; y su uso para la profilaxis o la terapia de enfermedades metabólicas, trastornos hematopoyéticos, enfermedades neurodegenerativas, cáncer, entre otras. | |
| BR112015023922A2 (pt) | composição farmacêutica compreendendo um ativador de ampk e um agente serotonérgico e métodos de uso destes | |
| MX2025003620A (es) | Composiciones de ester de acido cannabinoide y sus usos | |
| MX2014005440A (es) | Inhibidores de nicotinamida adenina dinucleotido difosfato oxidasa-4 y uso de los mismos. | |
| BR112016027041A8 (pt) | combinações farmacêuticas para tratamento do câncer | |
| AR105493A1 (es) | Inhibidor de la isocitrato deshidrogenasa mutada idh1 r132h | |
| MX2022002183A (es) | Composiciones de éster de ácido cannabinoide y sus usos. | |
| MX2016015437A (es) | Combinacion que comprende un glucocorticoide y edo-s101. | |
| BR112015022092A8 (pt) | derivado de di-hidropiridazina-3,5-diona, seu uso e agente preventivo e/ou terapêutico comprendendo o mesmo | |
| BR112016024020A8 (pt) | composição farmacêutica | |
| SV2017005466A (es) | Pirazolpiridinaminas como inhibidores de mknk1 y mknk2 | |
| PH12020551412A1 (en) | Pharmaceutical composition including sodium alkyl sulfate | |
| EP3760626A4 (en) | INNOVATIVE COMPOSITION AND COMPOSITION WITH IT AS AN ACTIVE INGREDIENT FOR THE PREVENTION, IMPROVEMENT OR TREATMENT OF FIBROSIS OR NON-ALCOHOLIC STEATOHEPATITIS | |
| MX2019012522A (es) | Compuestos y metodos terapeuticos. | |
| CR20190391A (es) | Derivados de pirazol como inhibidores de bromodominio | |
| BR112018077350A2 (pt) | composições de fosfolipídio | |
| MX2015005734A (es) | Metodos de tratamiento de enfermedades hepaticas. | |
| MX2016004267A (es) | Combinacion. | |
| EA202090788A1 (ru) | Жидкая композиция для использования в качестве противовоспалительного средства | |
| MX2017006747A (es) | Amidas de acidos grasos para la prevencion y/o tratamiento de la esteatohepatitis. | |
| BR112022004489A2 (pt) | Composto ou composição para uso | |
| BR112019024785A2 (pt) | composto de bifenila ou sal do mesmo, composição farmacêutica, agente antineoplásico e uso |