CL2019001380A1 - Unidad de tejido nervioso y utilización de una unidad de este tipo para la implantación en el sistema nervioso de un mamífero. - Google Patents

Unidad de tejido nervioso y utilización de una unidad de este tipo para la implantación en el sistema nervioso de un mamífero.

Info

Publication number
CL2019001380A1
CL2019001380A1 CL2019001380A CL2019001380A CL2019001380A1 CL 2019001380 A1 CL2019001380 A1 CL 2019001380A1 CL 2019001380 A CL2019001380 A CL 2019001380A CL 2019001380 A CL2019001380 A CL 2019001380A CL 2019001380 A1 CL2019001380 A1 CL 2019001380A1
Authority
CL
Chile
Prior art keywords
unit
nervous tissue
nervous
implantation
mammal
Prior art date
Application number
CL2019001380A
Other languages
English (en)
Inventor
Maxime Feyeux
Kevin Alessandri
Pierre Nassoy
Laurent Cognet
Erwan Bezard
Abdelhamid Benazzouz
Original Assignee
Centre Nat Rech Scient
Univ Bordeaux
Inst Doptique Theorique Et Appliquee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Univ Bordeaux, Inst Doptique Theorique Et Appliquee filed Critical Centre Nat Rech Scient
Publication of CL2019001380A1 publication Critical patent/CL2019001380A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3675—Nerve tissue, e.g. brain, spinal cord, nerves, dura mater
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)

Abstract

LA INVENCIÓN SE REFIERE A UNA UNIDAD DE TEJIDO NERVIOSO PARA SU UTILIZACIÓN PARA UNA IMPLANTACIÓN EN EL SISTEMA NERVIOSO DE UN MAMÍFERO HUMANO O NO HUMANO, EN LA QUE DICHA UNIDAD DE TEJIDO NERVIOSO CONTIENE CÉLULAS NEURONALES POSTMITÓTICAS DIFERENCIADAS, EN UNA MATRIZ EXTRACELULAR, DICHA UNIDAD OBTENIÉNDOSE A PARTIR DE UN MICROCOMPARTIMENTO CELULAR COMPRENDIENDO UNA CÁPSULA DE HIDROGEL QUE RODEA DICHA UNIDAD DE TEJIDO NERVIOSO Y DICHA CÁPSULA DE HIDROGEL ESTANDO AL MENOS PARCIALMENTE ELIMINADA ANTES DE LA UTILIZACIÓN DE LA UNIDAD DE TEJIDO NERVIOSO. LA INVENCIÓN SE REFIERE IGUALMENTE A UN PROCEDIMIENTO DE PREPARACIÓN DE UNA UNIDAD DE TEJIDO NERVIOSO DE ESTE TIPO.
CL2019001380A 2016-11-23 2019-05-22 Unidad de tejido nervioso y utilización de una unidad de este tipo para la implantación en el sistema nervioso de un mamífero. CL2019001380A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1661378A FR3058892B1 (fr) 2016-11-23 2016-11-23 Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere

Publications (1)

Publication Number Publication Date
CL2019001380A1 true CL2019001380A1 (es) 2019-12-27

Family

ID=58992917

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019001380A CL2019001380A1 (es) 2016-11-23 2019-05-22 Unidad de tejido nervioso y utilización de una unidad de este tipo para la implantación en el sistema nervioso de un mamífero.

Country Status (20)

Country Link
US (3) US12448601B2 (es)
EP (2) EP3544619B1 (es)
JP (3) JP7209300B2 (es)
KR (2) KR102372929B1 (es)
CN (2) CN110730667B (es)
AU (2) AU2017365847B2 (es)
BR (1) BR112019010514A2 (es)
CA (1) CA3042113C (es)
CL (1) CL2019001380A1 (es)
CY (1) CY1124892T1 (es)
DK (2) DK3903795T3 (es)
ES (2) ES2976483T3 (es)
FI (1) FI3903795T3 (es)
FR (1) FR3058892B1 (es)
IL (2) IL295963B2 (es)
LT (2) LT3903795T (es)
MX (1) MX389000B (es)
PL (1) PL3544619T3 (es)
PT (2) PT3903795T (es)
WO (1) WO2018096278A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12599670B2 (en) 2014-12-12 2026-04-14 The Trustees Of The University Of Pennsylvania Composition comprising three-dimensional astrocyte bundles of bi-polar and aligned astrocyte processes and a method of making thereof
AU2017248756B2 (en) 2016-04-14 2022-08-04 The Trustees Of The University Of Pennsylvania Implantable living electrodes and methods for use thereof
FR3059009B1 (fr) 2016-11-23 2018-12-07 Universite de Bordeaux Microcompartiment cellulaire et procedes de preparation
FR3058892B1 (fr) * 2016-11-23 2021-04-09 Univ Bordeaux Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere
EP3395942A1 (en) * 2017-04-25 2018-10-31 IMBA-Institut für Molekulare Biotechnologie GmbH Bi- or multi-differentiated organoid
US20220257662A1 (en) * 2018-10-26 2022-08-18 Tessara Therapeutics Pty Ltd Nervous system cell therapy
FR3099882A1 (fr) * 2019-08-12 2021-02-19 Treefrog Therapeutics Unité tridimensionnelle creuse de tissu rétinien et utilisation dans le traitement des rétinopathies
CN114729323B (zh) 2019-11-22 2024-09-17 诺和诺德股份有限公司 旋转聚集的神经微球及其应用
JP2024509088A (ja) * 2021-02-24 2024-02-29 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 脳への聴覚入力を回復または増強するための事前形成された神経組織
FR3164725A1 (fr) * 2024-07-21 2026-01-23 Treefrog Therapeutics Unité de tissu neural et utilisation d’une telle unité comme médicament
WO2026022106A1 (fr) * 2024-07-21 2026-01-29 Treefrog Therapeutics Unité de tissu neural et utilisation d'une telle unité comme médicament

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7250294B2 (en) * 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
CN1367245A (zh) * 2001-08-10 2002-09-04 谢佐平 一种诱导神经干细胞转化为多巴胺能神经元的技术
ZA200401646B (en) * 2003-03-12 2004-06-07 Reliance Life Sciences Pvt Ltd Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells.
SE0301974D0 (sv) * 2003-07-03 2003-07-03 Astra Tech Ab A device for promoting regeneration of an injured nerve, a kit and a biodegredable sheet for preparing such a device
US7691629B2 (en) * 2004-11-17 2010-04-06 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions
US20060171935A1 (en) * 2005-01-31 2006-08-03 Asa Abeliovich Protecting cell therapy for neurological disorders including Parkinson's disease
PL1998690T3 (pl) * 2006-03-29 2019-12-31 Swenora Biotech Ab Sposób wytwarzania urządzenia do regeneracji nerwów
EP2028268A1 (en) * 2007-08-20 2009-02-25 Université Libre De Bruxelles Generation of neuronal cells from pluripotent stem cells
US9057053B2 (en) * 2010-01-19 2015-06-16 The Board Of Trustees Of The Leland Stanford Junior University Direct conversion of cells to cells of other lineages
SG10201805199RA (en) * 2011-06-02 2018-07-30 Harvard College Methods and Uses for Ex Vivo Tissue Culture Systems
CN113528442A (zh) * 2011-11-04 2021-10-22 纪念斯隆-凯特琳癌症中心 用于植入的中脑多巴胺（da）神经元
EP2743345A1 (en) * 2012-12-13 2014-06-18 IMBA-Institut für Molekulare Biotechnologie GmbH Three dimensional heterogeneously differentiated tissue culture
JP2015047140A (ja) 2013-09-03 2015-03-16 国立大学法人京都大学 移植後の生着能を有する神経細胞と固体３次元マトリックスとの複合体
US20160250385A1 (en) * 2013-11-04 2016-09-01 The Trustees Of The University Of Pennsylvania Neuronal replacement and reestablishment of axonal connections
US11198850B2 (en) * 2013-11-22 2021-12-14 Riken Method for manufacturing telencephalon or progenitor tissue thereof
EP3261446A4 (en) * 2015-02-26 2018-12-05 The McLean Hospital Corporation Methods and compositions for the treatment or prevention of parkinson's disease
WO2016140716A1 (en) * 2015-03-02 2016-09-09 The Trustees Of Columbia University In The City Of New York Injectable microtissue systems, devices, and methods
LU92845B1 (en) * 2015-10-08 2017-05-02 Univ Du Luxembourg Campus Belval Means and methods for generating midbrain organoids
US10597623B2 (en) * 2015-11-13 2020-03-24 The Johns Hopkins University Multiwell cell culture system having rotating shafts for mixing culture media and method of use thereof
FR3059009B1 (fr) 2016-11-23 2018-12-07 Universite de Bordeaux Microcompartiment cellulaire et procedes de preparation
FR3058892B1 (fr) * 2016-11-23 2021-04-09 Univ Bordeaux Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere

Also Published As

Publication number Publication date
FI3903795T3 (en) 2024-04-04
PT3903795T (pt) 2024-04-04
CA3042113A1 (fr) 2018-05-31
LT3903795T (lt) 2024-04-25
CN110730667A (zh) 2020-01-24
JP2025060950A (ja) 2025-04-10
LT3544619T (lt) 2022-01-10
KR20220036988A (ko) 2022-03-23
EP3903795B1 (fr) 2024-01-03
AU2017365847A1 (en) 2019-05-16
EP3544619B1 (fr) 2021-09-15
US12435307B2 (en) 2025-10-07
MX389000B (es) 2025-03-20
IL266773A (en) 2019-07-31
EP3544619A1 (fr) 2019-10-02
IL295963A (en) 2022-10-01
CY1124892T1 (el) 2023-01-05
IL295963B1 (en) 2025-12-01
AU2022202869B2 (en) 2025-04-24
ES2976483T3 (es) 2024-08-02
PT3544619T (pt) 2021-11-03
IL266773B2 (en) 2023-02-01
KR102372929B1 (ko) 2022-03-11
DK3544619T3 (da) 2021-11-08
JP2019535485A (ja) 2019-12-12
CN117286107A (zh) 2023-12-26
KR102636762B1 (ko) 2024-02-14
US20200063099A1 (en) 2020-02-27
AU2022202869C1 (en) 2025-07-17
FR3058892B1 (fr) 2021-04-09
US20230257699A1 (en) 2023-08-17
IL295963B2 (en) 2026-04-01
EP3903795A1 (fr) 2021-11-03
AU2017365847B2 (en) 2022-02-10
DK3903795T3 (da) 2024-04-08
JP7209300B2 (ja) 2023-01-20
AU2022202869A1 (en) 2022-05-19
FR3058892A1 (fr) 2018-05-25
JP2023052084A (ja) 2023-04-11
BR112019010514A2 (pt) 2019-09-17
PL3544619T3 (pl) 2022-02-07
CA3042113C (fr) 2023-01-03
WO2018096278A1 (fr) 2018-05-31
MX2019006048A (es) 2019-12-09
KR20190106997A (ko) 2019-09-18
IL266773B (en) 2022-10-01
NZ752938A (en) 2025-07-25
US20260002125A1 (en) 2026-01-01
ES2898837T3 (es) 2022-03-09
CN110730667B (zh) 2023-10-03
US12448601B2 (en) 2025-10-21

Similar Documents

Publication Publication Date Title
MX2019006048A (es) Unidad de tejido nervioso y utilizacion de una unidad de este tipo para la implantacion en el sistema nervioso de un mamifero.
CL2017002066A1 (es) Proteasas de cisteína
CL2019002251A1 (es) Anticuerpos contra triptasa, composiciones de estos y usos de estos.
CR20150021A (es) Método para convertir insectos o gusanos en flujos de nutrientes y composiciones obtenidas de esta manera
UY35427A (es) Compuestos y sus usos en la modulación de la hemoglobina
UY35425A (es) Compuestos y sus usos en la modulación de la hemoglobina
UY35426A (es) Compuestos y sus usos en la modulación de la hemoglobina
EA201792307A1 (ru) Способы репарации и регенерации тканей
MX2016016301A (es) Procesos de siembra en serie y usos de los mismos.
CL2017002020A1 (es) Dispositivo de apriete y procedimiento para el montaje de un módulo solar
EA201692241A1 (ru) Контейнер, индикаторное устройство и небулайзер
BR112017005504A2 (pt) composições que compreendem células recombinantes de bacillus e um inseticida.
CL2018001775A1 (es) Unidades de administración de agroquímicos de liberación controlada, su fabricación y uso
CY1122615T1 (el) Θεραπεια με βλαστοκυτταρα σε παθολογιες τουενδομητριου
EP3640320A4 (en) CRYOPRESERVATION TEMPLATE FOR THE CRYOPRESERVATION OF CELLS OR TISSUES
AR099500A1 (es) Composición para el desmucilaginado enzimático de aceite
NZ721835A (en) An osseointegrable device
CL2016002380A1 (es) Dispositivo de limpieza para instrumentos médicos y métodos relacionados de utilización.
CO2017013361A2 (es) Angiogénesis usando células madre placentarias estimuladas
GT201400151A (es) Cucurbitáceas androicas, procedimientos de obtención y utilizaciones de estas cucurbitáceas
ES2514140B1 (es) Uso del inhibidor de sulfatasas esteroideas STX64 para el tratamiento del envejecimiento
BR112015024877A2 (pt) vacinas que compreendem polipeptídeos de leishmania para o tratamento e diagnóstico de leishmaniose
MX2019010941A (es) Receptores de antigeno y usos de los mismos.
MX2017003949A (es) Derivados peptidicos novedosos y sus usos.
AR101442A1 (es) Método para la expansión de células madre de adultos de sangre