CL2020002205A1 - Método para la rápida obtención de nanopartículas de albúmina cargadas con nanopartículas magnéticas - Google Patents

Método para la rápida obtención de nanopartículas de albúmina cargadas con nanopartículas magnéticas

Info

Publication number
CL2020002205A1
CL2020002205A1 CL2020002205A CL2020002205A CL2020002205A1 CL 2020002205 A1 CL2020002205 A1 CL 2020002205A1 CL 2020002205 A CL2020002205 A CL 2020002205A CL 2020002205 A CL2020002205 A CL 2020002205A CL 2020002205 A1 CL2020002205 A1 CL 2020002205A1
Authority
CL
Chile
Prior art keywords
nanoparticles
loaded
albumin
magnetic
rapid obtaining
Prior art date
Application number
CL2020002205A
Other languages
English (en)
Inventor
Fernando Vargas Cantin Patricio
Susana Diaz Saldivar Patricia
Original Assignee
Univ Santiago Chile
Univ Tecnica Federico Santa Maria Utfsm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Santiago Chile, Univ Tecnica Federico Santa Maria Utfsm filed Critical Univ Santiago Chile
Priority to CL2020002205A priority Critical patent/CL2020002205A1/es
Publication of CL2020002205A1 publication Critical patent/CL2020002205A1/es
Priority to CN202180070646.5A priority patent/CN116685354A/zh
Priority to PCT/CL2021/050079 priority patent/WO2022040822A1/es
Priority to US18/023,313 priority patent/US20240016755A1/en
Priority to EP21859483.6A priority patent/EP4205731A4/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/47—Magnetic materials; Paramagnetic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Power Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a un método para la rápida obtención de nanopartículas de albúmina cargadas con nanopartículas magnéticas, que comprende etapas con agitación a ultra altas velocidades. Este método permite obtener dichas nanopartículas en menos de 45 minutos con eficiencia de encapsulación superior al 90%.
CL2020002205A 2020-08-26 2020-08-26 Método para la rápida obtención de nanopartículas de albúmina cargadas con nanopartículas magnéticas CL2020002205A1 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CL2020002205A CL2020002205A1 (es) 2020-08-26 2020-08-26 Método para la rápida obtención de nanopartículas de albúmina cargadas con nanopartículas magnéticas
CN202180070646.5A CN116685354A (zh) 2020-08-26 2021-08-27 用于快速获得负载有磁性纳米颗粒的白蛋白纳米颗粒的方法
PCT/CL2021/050079 WO2022040822A1 (es) 2020-08-26 2021-08-27 Método para la rápida obtención de nanopartículas de albúmina cargadas con nanopartículas magnéticas
US18/023,313 US20240016755A1 (en) 2020-08-26 2021-08-27 Method for rapidly obtaining albumin nanoparticles loaded with magnetic nanoparticles
EP21859483.6A EP4205731A4 (en) 2020-08-26 2021-08-27 Method for rapidly obtaining albumin nanoparticles loaded with magnetic nanoparticles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CL2020002205A CL2020002205A1 (es) 2020-08-26 2020-08-26 Método para la rápida obtención de nanopartículas de albúmina cargadas con nanopartículas magnéticas

Publications (1)

Publication Number Publication Date
CL2020002205A1 true CL2020002205A1 (es) 2020-10-02

Family

ID=73047998

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020002205A CL2020002205A1 (es) 2020-08-26 2020-08-26 Método para la rápida obtención de nanopartículas de albúmina cargadas con nanopartículas magnéticas

Country Status (5)

Country Link
US (1) US20240016755A1 (es)
EP (1) EP4205731A4 (es)
CN (1) CN116685354A (es)
CL (1) CL2020002205A1 (es)
WO (1) WO2022040822A1 (es)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG126676A1 (en) 2001-05-09 2007-01-30 Nanomaterials Tech Pte Ltd Process for the controlled production of organic particles
CA2923748C (en) * 2005-03-21 2017-06-20 The Regents Of The University Of California Functionalized magnetic nanoparticles and methods of use thereof
KR101125232B1 (ko) * 2009-09-29 2012-03-21 서울대학교산학협력단 초상자성 산화철 나노입자 탑재 고분자 미세구의 제조 방법
CN103611172B (zh) * 2013-12-02 2015-06-03 东南大学 载纳米雄黄磁性白蛋白纳米球及制备方法
CN104546741A (zh) * 2014-12-26 2015-04-29 郑州大学 一种2-甲氧基雌二醇白蛋白纳米冻干剂制备方法及其应用
CN106124758B (zh) * 2016-06-12 2018-06-26 华中科技大学 一种水溶性微球的制备方法及其应用
RU2659949C1 (ru) * 2017-11-09 2018-07-04 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский технологический университет "МИСиС" Способ получения препарата на основе магнитных наночастиц (МНЧ) оксида железа для МРТ-диагностики новообразований
JP7373207B2 (ja) * 2018-03-01 2023-11-02 バー‐イラン、ユニバーシティー 眼の状態の矯正に使用するためのシステム、方法、及び材料組成物

Also Published As

Publication number Publication date
EP4205731A1 (en) 2023-07-05
CN116685354A (zh) 2023-09-01
US20240016755A1 (en) 2024-01-18
EP4205731A4 (en) 2024-10-16
WO2022040822A1 (es) 2022-03-03

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