CL2020002465A1 - Método de tratamiento de enfermedad fibrótica - Google Patents

Método de tratamiento de enfermedad fibrótica

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Publication number
CL2020002465A1
CL2020002465A1 CL2020002465A CL2020002465A CL2020002465A1 CL 2020002465 A1 CL2020002465 A1 CL 2020002465A1 CL 2020002465 A CL2020002465 A CL 2020002465A CL 2020002465 A CL2020002465 A CL 2020002465A CL 2020002465 A1 CL2020002465 A1 CL 2020002465A1
Authority
CL
Chile
Prior art keywords
treatment method
disease treatment
fibrotic disease
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methods
Prior art date
Application number
CL2020002465A
Other languages
English (en)
Inventor
Brad Owen Buckman
Prabha Ibrahim
P T Ravi Rajagopalan
Original Assignee
Blade Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Blade Therapeutics Inc filed Critical Blade Therapeutics Inc
Publication of CL2020002465A1 publication Critical patent/CL2020002465A1/es

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

En la presente se describen métodos para tratar trastornos fibróticos por la administración de compuestos selectivos para CAPN1, CAPN2, y/o CAPN9 tal que se reduzcan al mínimo los efectos secundarios, interacciones fuera de ruta, y/o toxicidades. Estos métodos pueden, por ejemplo, reducir al mínimo los efectos no deseados de compuestos terapéuticos al proporcionar dosificación y formas de dosificación que reducen al mínimo el nivel de fármaco no unido dentro de los tejidos pertinentes de un paciente que se somete a tratamiento.
CL2020002465A 2018-03-28 2020-09-24 Método de tratamiento de enfermedad fibrótica CL2020002465A1 (es)

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AU2019295763A1 (en) * 2018-06-28 2021-01-21 Blade Therapeutics, Inc. Methods of treating liver fibrosis using calpain inhibitors
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