CL2021001024A1 - Calibración automática y mantenimiento automático de modelos espectroscópicos de raman para predicciones en tiempo real - Google Patents

Calibración automática y mantenimiento automático de modelos espectroscópicos de raman para predicciones en tiempo real

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Publication number
CL2021001024A1
CL2021001024A1 CL2021001024A CL2021001024A CL2021001024A1 CL 2021001024 A1 CL2021001024 A1 CL 2021001024A1 CL 2021001024 A CL2021001024 A CL 2021001024A CL 2021001024 A CL2021001024 A CL 2021001024A CL 2021001024 A1 CL2021001024 A1 CL 2021001024A1
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CL
Chile
Prior art keywords
data sets
biopharmaceutical
automatic
real
data
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CL2021001024A
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English (en)
Inventor
Aditya Tulsyan
Original Assignee
Amgen Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=70331744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2021001024(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CL2021001024A1 publication Critical patent/CL2021001024A1/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00—Computing arrangements using knowledge-based models
    • G06N5/04—Inference or reasoning models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N2021/8411—Application to online plant, process monitoring
    • G01N2021/8416—Application to online plant, process monitoring and process controlling, not otherwise provided for
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/127—Calibration; base line adjustment; drift compensation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Software Systems (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Data Mining & Analysis (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Computing Systems (AREA)
  • Mathematical Physics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Evolutionary Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Computational Linguistics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioethics (AREA)

Abstract

Un método para monitorizar y/o controlar un proceso biofarmacéutico incluye determinar un punto de consulta asociado con la exploración del proceso mediante un sistema de espectroscopía (por ejemplo, un sistema de espectroscopía de Raman), y consultar una base de datos de observación que contiene conjuntos de datos de observación asociados con observaciones pasadas de procesos biofarmacéuticos. Cada uno de los conjuntos de datos de observación incluye datos espectrales y una medición analítica real correspondiente. Consultar la base de datos de observación incluye seleccionar como datos de entrenamiento, de entre los conjuntos de datos de observación, los conjuntos de datos que satisfacen uno o más criterios de relevancia con respecto al punto de consulta. El método también incluye usar los datos de entrenamiento seleccionados para calibrar un modelo local específico para el proceso biofarmacéutico. El modelo local (por ejemplo, un modelo de proceso gaussiano) se entrena para predecir mediciones analíticas basándose en entradas de datos espectrales. El método también incluye usar el modelo local para predecir una medición analítica del proceso biofarmacéutico.
CL2021001024A 2018-10-23 2021-04-22 Calibración automática y mantenimiento automático de modelos espectroscópicos de raman para predicciones en tiempo real CL2021001024A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862749359P 2018-10-23 2018-10-23
US201962833044P 2019-04-12 2019-04-12
US201962864565P 2019-06-21 2019-06-21

Publications (1)

Publication Number Publication Date
CL2021001024A1 true CL2021001024A1 (es) 2021-09-24

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CL2021001024A CL2021001024A1 (es) 2018-10-23 2021-04-22 Calibración automática y mantenimiento automático de modelos espectroscópicos de raman para predicciones en tiempo real

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Country Link
US (1) US20220128474A1 (es)
EP (1) EP3870957B1 (es)
JP (1) JP7601760B2 (es)
KR (1) KR20210078531A (es)
CN (1) CN112912716B (es)
AU (2) AU2019365102A1 (es)
CA (1) CA3115296A1 (es)
CL (1) CL2021001024A1 (es)
DK (1) DK3870957T3 (es)
ES (1) ES3041713T3 (es)
FI (1) FI3870957T3 (es)
HU (1) HUE072452T2 (es)
IL (1) IL281977B2 (es)
LT (1) LT3870957T (es)
MX (1) MX2021004510A (es)
PL (1) PL3870957T3 (es)
PT (1) PT3870957T (es)
SG (1) SG11202103232WA (es)
SI (1) SI3870957T1 (es)
TW (1) TWI844570B (es)
WO (1) WO2020086635A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120795059A (zh) 2018-08-27 2025-10-17 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
EP3980895A2 (en) * 2019-06-10 2022-04-13 Waters Technologies Ireland Limited Techniques for analytical instrument performance diagnostics
US20220414613A1 (en) * 2019-11-26 2022-12-29 Thermo Finnigan Llc Remote monitoring, troubleshooting and service scheduling of analytical apparatuses
CN116457453A (zh) * 2020-10-01 2023-07-18 美国安进公司 细胞培养的预测建模和控制
US20220138557A1 (en) * 2020-11-04 2022-05-05 Adobe Inc. Deep Hybrid Graph-Based Forecasting Systems
US20210117841A1 (en) * 2020-12-23 2021-04-22 Intel Corporation Methods, apparatus, and articles of manufacture to improve automated machine learning
DE102021100531B3 (de) * 2021-01-13 2022-03-31 BioThera Institut GmbH Apparatur zum Steuern eines Prozesses sowie zugehöriges Steuerungsverfahren
US20240271078A1 (en) * 2021-06-09 2024-08-15 Amgen Inc. Assessing packed cell volume for cell cultures
US20240287436A1 (en) * 2021-06-20 2024-08-29 The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Raman spectroscopy method and system for monitoring invasive species in algal bioreactors
WO2023053585A1 (ja) * 2021-09-30 2023-04-06 富士フイルム株式会社 学習用データの取得方法、学習用データ取得システム、ソフトセンサの構築方法、ソフトセンサ、学習用データ
AR127458A1 (es) 2021-10-27 2024-01-24 Amgen Inc Predicción basada en aprendizaje profundo usando espectroscopia
CN118284802A (zh) * 2021-11-22 2024-07-02 富士胶片株式会社 信息处理装置、信息处理装置的工作方法、信息处理装置的工作程序、校准完毕状态预测模型的生成方法以及校准完毕状态预测模型
JP7783091B2 (ja) * 2022-02-25 2025-12-09 株式会社日立製作所 評価システム及び評価方法
TW202346567A (zh) * 2022-03-01 2023-12-01 美商安進公司 用於控制細胞培養之混合預測建模
CN115308102B (zh) * 2022-05-19 2025-07-01 芬欧汇川(中国)有限公司 纸张透气度测量方法以及纸张透气度测量系统
EP4562408A1 (en) * 2022-07-26 2025-06-04 Thermo Scientific Portable Analytical Instruments Inc. Autochemometric scientific instrument support systems
CA3265250A1 (en) * 2022-08-29 2024-03-07 Amgen Inc. PREDICTIVE MODEL FOR EVALUATING PROCESSING TIME IMPACTS
EP4581349A1 (en) * 2022-08-29 2025-07-09 Büchi Labortechnik AG Methods for providing a predictive model for spectroscopy and calibrating a spectroscopic device
JP2025534958A (ja) 2022-09-14 2025-10-22 アムジエン・インコーポレーテツド 細胞培養プロセスの監視及び／又は制御のための変分オートエンコーダによるジャストインタイムラーニング
EP4634646A1 (en) * 2022-12-12 2025-10-22 Genentech Inc. Real-time automated monitoring and control of ultrafiltration/diafiltration (uf/df) conditioning and dilution processes
WO2024188962A1 (en) * 2023-03-14 2024-09-19 Katholieke Universiteit Leuven Spectrum prediction methods for chemical processes
EP4672128A4 (en) 2023-03-31 2026-05-20 Fujifilm Corp QUALITY MONITORING DEVICE, METHOD FOR OPERATION OF A QUALITY MONITORING DEVICE, AND PROGRAM FOR OPERATION OF A QUALITY MONITORING DEVICE
KR20250023079A (ko) 2023-08-09 2025-02-18 주식회사 엘지화학 발효공정의 생성량 예측 시스템 및 방법
CN117571684A (zh) * 2023-11-20 2024-02-20 无锡药明生物技术股份有限公司 细胞培养液代谢物浓度确定方法、装置、设备和介质
WO2025114830A1 (en) * 2023-11-27 2025-06-05 Avant Meats Company Limited Control system and method for a perpetual automated bioprocessing system
WO2025132566A1 (en) 2023-12-21 2025-06-26 Boehringer Ingelheim International Gmbh Measuring arrangement and method for analyzing a fluidic sample
CN118819056B (zh) * 2024-09-19 2024-12-31 天津医学高等专科学校(天津市护士学校) 一种黄芩细胞悬浮培养优化控制系统
CN118820281B (zh) * 2024-09-19 2024-12-31 之江实验室 光谱数据库查询模型构建方法以及光谱数据库查询方法
EP4715492A1 (en) * 2024-09-20 2026-03-25 Sartorius Stedim Data Analytics AB Monitoring and/or controlling a chemical and/or biological process
CN119223939B (zh) * 2024-11-28 2025-04-01 合肥金星智控科技股份有限公司 基于libs的物料检测模型的自适应校准方法及装置

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319494B1 (en) 1990-12-14 2001-11-20 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US5862060A (en) * 1996-11-22 1999-01-19 Uop Llc Maintenance of process control by statistical analysis of product optical spectrum
KR100508289B1 (ko) 1998-04-21 2005-08-17 마이크로메트 에이지 Ｃｄ１９×ｃｄ３ 특이 폴리펩티드 및 그의 용도
US7398119B2 (en) * 1998-07-13 2008-07-08 Childrens Hospital Los Angeles Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US20070192035A1 (en) * 2005-06-09 2007-08-16 Chem Image Corporation Forensic integrated search technology
EP1558374A2 (en) * 2002-10-28 2005-08-03 BP Corporation North America Inc. Process and method for chemical manufacturing using transformation of on-line instrumentation data
KR20110086881A (ko) 2002-12-20 2011-08-01 암겐 인코포레이티드 미오스타틴을 저해하는 결합제
JP4745959B2 (ja) * 2003-05-12 2011-08-10 リバー・ダイアグノスティクス・ビー．・ブイ． 微生物の自動特徴づけおよび分類
ZA200601699B (en) 2003-10-16 2007-05-30 Micromet Ag Multispecific deimmunized CD3-binders
NZ554258A (en) * 2007-03-29 2009-01-31 Khipu Systems Ltd Predictive model implementation system and methodology
SG10201808730VA (en) 2007-04-03 2018-11-29 Amgen Res Munich Gmbh Cross-species-specific binding domain
US7961312B2 (en) * 2007-08-13 2011-06-14 C8 Medisensors Inc. Calibrated analyte concentration measurements in mixtures
US8311955B2 (en) * 2007-10-30 2012-11-13 Exxonmobil Research And Engineering Company Bootstrap method for oil property prediction
AU2008318505A1 (en) * 2007-11-02 2009-05-07 Ceres, Inc. Materials and methods for use in biomass processing
US8725667B2 (en) * 2008-03-08 2014-05-13 Tokyo Electron Limited Method and system for detection of tool performance degradation and mismatch
GB2466442A (en) * 2008-12-18 2010-06-23 Dublin Inst Of Technology A system to analyze a sample on a slide using Raman spectroscopy on an identified area of interest
CN101825567A (zh) * 2010-04-02 2010-09-08 南开大学 一种近红外光谱和拉曼光谱波长的筛选方法
ES2680151T3 (es) 2012-03-01 2018-09-04 Amgen Research (Munich) Gmbh Moléculas de unión de polipéptidos de larga duración
EP2648133A1 (fr) * 2012-04-04 2013-10-09 Biomerieux Identification de microorganismes par spectrometrie et classification structurée
US20130311136A1 (en) * 2012-05-18 2013-11-21 Mustard Tree Instruments, Llc Rule-Based Sample Verification and Chemical Monitoring Methodology
GB2513343A (en) * 2013-04-23 2014-10-29 Univ Singapore Methods related to instrument-independent measurements for quantitative analysis of fiber-optic Raman spectroscopy
US20140114676A1 (en) * 2012-10-23 2014-04-24 Theranos, Inc. Drug Monitoring and Regulation Systems and Methods
US20140308285A1 (en) 2013-03-15 2014-10-16 Amgen Inc. Heterodimeric bispecific antibodies
EP2970449B1 (en) 2013-03-15 2019-09-25 Amgen Research (Munich) GmbH Single chain binding molecules comprising n-terminal abp
MX357011B (es) 2013-03-15 2018-06-22 Amgen Inc Anticuerpos biespecificos heterodimericos.
US20140302037A1 (en) 2013-03-15 2014-10-09 Amgen Inc. BISPECIFIC-Fc MOLECULES
CN104215623B (zh) * 2013-05-31 2018-09-25 欧普图斯(苏州)光学纳米科技有限公司 面向多行业检测的激光拉曼光谱智能化辨识方法及系统
EP3049440B1 (en) 2013-09-25 2020-03-25 Amgen Inc. V-c-fc-v-c antibody
EP3164481A4 (en) * 2014-07-02 2018-03-21 Biogen MA Inc. Cross-scale modeling of bioreactor cultures using raman spectroscopy
EP3303561A2 (en) * 2015-05-29 2018-04-11 Biogen MA Inc. Cell culture methods and systems
WO2017015568A1 (en) * 2015-07-22 2017-01-26 Vinogradova Ekaterina Lable-free detection of sialic acid using surface-enhanced raman scattering microscopy
EA039859B1 (ru) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
US20170127983A1 (en) * 2015-11-10 2017-05-11 Massachusetts Institute Of Technology Systems and methods for sampling calibration of non-invasive analyte measurements
DK3291038T3 (da) 2016-08-31 2021-10-18 Sartorius Stedim Biotech Gmbh Kontrol og overvågning af en proces til fremstilling af et kemisk, farmaceutisk eller bioteknologisk produkt
SG11202001127TA (en) * 2017-10-16 2020-03-30 Regeneron Pharma In situ raman spectroscopy systems and methods for controlling process variables in cell cultures
US10810408B2 (en) * 2018-01-26 2020-10-20 Viavi Solutions Inc. Reduced false positive identification for spectroscopic classification

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TWI844570B (zh) 2024-06-11
HUE072452T2 (hu) 2025-11-28
IL281977B2 (en) 2025-03-01
JP2022512775A (ja) 2022-02-07
ES3041713T3 (en) 2025-11-13
KR20210078531A (ko) 2021-06-28
DK3870957T3 (da) 2025-09-29
SG11202103232WA (en) 2021-05-28
JP7601760B2 (ja) 2024-12-17
EP3870957B1 (en) 2025-07-16
FI3870957T3 (fi) 2025-09-30
PT3870957T (pt) 2025-09-01
PL3870957T3 (pl) 2025-11-17
CN112912716A (zh) 2021-06-04
MX2021004510A (es) 2021-06-08
AU2025205401A1 (en) 2025-07-31
WO2020086635A1 (en) 2020-04-30
EP3870957A1 (en) 2021-09-01
BR112021007611A2 (pt) 2021-07-27
AU2019365102A1 (en) 2021-04-29
SI3870957T1 (sl) 2025-10-30
US20220128474A1 (en) 2022-04-28
IL281977A (en) 2021-05-31
TW202033949A (zh) 2020-09-16
IL281977B1 (en) 2024-11-01
CN112912716B (zh) 2025-04-11
CA3115296A1 (en) 2020-04-30
LT3870957T (lt) 2025-10-10

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