CL2023003003A1 - Tratamiento y diagnóstico de trastornos inflamatorios - Google Patents

Tratamiento y diagnóstico de trastornos inflamatorios

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Publication number
CL2023003003A1
CL2023003003A1 CL2023003003A CL2023003003A CL2023003003A1 CL 2023003003 A1 CL2023003003 A1 CL 2023003003A1 CL 2023003003 A CL2023003003 A CL 2023003003A CL 2023003003 A CL2023003003 A CL 2023003003A CL 2023003003 A1 CL2023003003 A1 CL 2023003003A1
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CL
Chile
Prior art keywords
subject
inflammatory disorder
diagnosis
treatment
inflammatory disorders
Prior art date
Application number
CL2023003003A
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English (en)
Inventor
Zhu Zhenglun
Gao Hong
Original Assignee
Zhu Zhenglun
Gao Hong
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Publication date
Application filed by Zhu Zhenglun, Gao Hong filed Critical Zhu Zhenglun
Publication of CL2023003003A1 publication Critical patent/CL2023003003A1/es

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    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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Abstract

Método para tratar un trastorno inflamatorio en un sujeto, que comprende administrar al sujeto que lo necesita una molécula de ácido nucleico para inhibir la expresión de Hom-1. Específicamente, la molécula de ácido nucleico es un agente de ARNi o un oligonucleótido morfolino antisentido. Además, se describe un método para seleccionar un agente terapéutico para un trastorno inflamatorio en un sujeto, o monitorear la eficacia de un agente terapéutico para un trastorno inflamatorio en un sujeto, que comprende detectar el nivel de expresión de Hom-1 en una muestra de tejido inflamado obtenida del sujeto.
CL2023003003A 2016-02-04 2023-10-06 Tratamiento y diagnóstico de trastornos inflamatorios CL2023003003A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662291271P 2016-02-04 2016-02-04

Publications (1)

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CL2023003003A1 true CL2023003003A1 (es) 2024-04-19

Family

ID=59499992

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2018002097A CL2018002097A1 (es) 2016-02-04 2018-08-03 Tratamiento y diagnóstico de desórdenes inflamatorios
CL2021003543A CL2021003543A1 (es) 2016-02-04 2021-12-29 Tratamiento y diagnóstico de desórdenes inflamatorios (divisional de la solicitud no. 201802097)
CL2023003003A CL2023003003A1 (es) 2016-02-04 2023-10-06 Tratamiento y diagnóstico de trastornos inflamatorios

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Application Number Title Priority Date Filing Date
CL2018002097A CL2018002097A1 (es) 2016-02-04 2018-08-03 Tratamiento y diagnóstico de desórdenes inflamatorios
CL2021003543A CL2021003543A1 (es) 2016-02-04 2021-12-29 Tratamiento y diagnóstico de desórdenes inflamatorios (divisional de la solicitud no. 201802097)

Country Status (13)

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US (3) US11268095B2 (es)
EP (1) EP3411479A4 (es)
JP (3) JP2019512018A (es)
KR (1) KR20180109985A (es)
CN (1) CN108779461A (es)
AU (2) AU2017213744B2 (es)
CA (1) CA3013898A1 (es)
CL (3) CL2018002097A1 (es)
IL (2) IL311968A (es)
MX (2) MX2018009542A (es)
MY (2) MY203831A (es)
SG (2) SG10201913129QA (es)
WO (1) WO2017136322A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018009542A (es) 2016-02-04 2018-11-09 Zhu Zhenglun Tratamiento y diagnostico de trastornos inflamatorios.
AU2020271894A1 (en) 2019-04-11 2021-12-02 Enclear Therapies, Inc. Methods of amelioration of cerebrospinal fluid and devices and systems therefor
CN111528842B (zh) * 2020-05-26 2023-01-03 复嶂环洲生物科技(上海)有限公司 基于生理和行为指标的帕金森病症状定量化评估方法
US12329930B2 (en) 2020-09-29 2025-06-17 Enclear Therapies, Inc. Subarachnoid fluid management method and system
AU2022297513A1 (en) * 2021-06-23 2024-01-18 Enclear Therapies, Inc. Method of regulating gene expression

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2709309B1 (fr) 1993-08-25 1995-11-10 Centre Nat Rech Scient Compositions cellulaires, préparation et utilisations thérapeutiques.
US5583153A (en) 1994-10-06 1996-12-10 Regents Of The University Of California Use of taxol in the treatment of rheumatoid arthritis
US20030035790A1 (en) 1999-01-15 2003-02-20 Shu-Hsia Chen Combination therapy for the prevention or treatment of cancer, inflammatory disorders or infectious diseases in a subject
EP1222933A1 (en) 2001-01-15 2002-07-17 Academisch Ziekenhuis Leiden h.o.d.n., Leids Universitair Medisch Centrum Generation and/or reduction of new lung tissue in an affected lung, by modulation of the Wnt-pathway
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
JP2006519008A (ja) 2003-02-10 2006-08-24 独立行政法人産業技術総合研究所 哺乳動物細胞の調節
JPWO2005070964A1 (ja) 2004-01-27 2008-01-17 株式会社医学生物学研究所 単球の単離方法
US20070248535A1 (en) 2005-02-07 2007-10-25 The Trustees Of Columbia University In The City Of New York Methods to treat or prevent hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity
WO2007051077A2 (en) 2005-10-28 2007-05-03 The Regents Of The University Of California Methods and compounds for lymphoma cell detection and isolation
US20070161031A1 (en) 2005-12-16 2007-07-12 The Board Of Trustees Of The Leland Stanford Junior University Functional arrays for high throughput characterization of gene expression regulatory elements
JP2009519710A (ja) 2005-12-16 2009-05-21 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 遺伝子発現調節エレメントのハイスループットでの特徴付けのための機能性アレイ
CN101505780B (zh) * 2006-02-22 2017-06-13 朱正崙 发育相关疾病的治疗
CN102575250B (zh) * 2009-07-15 2014-05-28 朱正仑 治疗和诊断免疫系统疾病的药物和制剂及其用途
WO2012071513A2 (en) 2010-11-24 2012-05-31 Hong Gao Expanding hematopoietic stem cells
US10066272B2 (en) 2011-06-10 2018-09-04 Zhenglun Zhu Human homeobox gene ventx and macrophage terminal differentiation and activation, compositions and methods thereof
US20150297679A1 (en) 2012-12-14 2015-10-22 The Brigham And Women's Hospital, Inc. Methods and assays relating to macrophage differentiation
WO2014169086A1 (en) * 2013-04-10 2014-10-16 Zhenglun Zhu Homeobox transcription factor ventx regulates differentiation and maturation of human dendritic cells
US9428748B2 (en) * 2013-06-17 2016-08-30 Hong Gao Method of expanding hematopoietic stem cells
EP3347026A4 (en) 2015-09-09 2019-05-08 Seattle Children's Hospital (DBA Seattle Children's Research Institute) GENEMANIPULATION OF MACROPHAGES FOR IMMUNOTHERAPY
AU2016353064B2 (en) 2015-11-11 2022-12-22 Zhenglun Zhu Method of modifying macrophage differentiation and immunity
MX2018009542A (es) 2016-02-04 2018-11-09 Zhu Zhenglun Tratamiento y diagnostico de trastornos inflamatorios.
EP3601539A4 (en) 2017-03-28 2021-01-13 Zhenglun Zhu METHODS OF TREATING NEOPLASIC DISEASES

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Publication number Publication date
US11268095B2 (en) 2022-03-08
US12146138B2 (en) 2024-11-19
CN108779461A (zh) 2018-11-09
JP2022180437A (ja) 2022-12-06
KR20180109985A (ko) 2018-10-08
EP3411479A4 (en) 2019-09-18
JP2024170560A (ja) 2024-12-10
US20220177892A1 (en) 2022-06-09
AU2023233180A1 (en) 2023-12-14
IL260987B1 (en) 2024-05-01
JP2019512018A (ja) 2019-05-09
US20190085336A1 (en) 2019-03-21
MX2022010890A (es) 2022-09-27
AU2017213744B2 (en) 2023-06-22
CA3013898A1 (en) 2017-08-10
IL260987B2 (en) 2024-09-01
JP7635939B2 (ja) 2025-02-26
EP3411479A1 (en) 2018-12-12
CL2018002097A1 (es) 2018-12-21
SG10201913129QA (en) 2020-02-27
MX2018009542A (es) 2018-11-09
IL311968A (en) 2024-06-01
AU2023233180B2 (en) 2026-03-26
AU2017213744A1 (en) 2018-08-30
CL2021003543A1 (es) 2022-08-19
SG11201806636SA (en) 2018-09-27
MY203831A (en) 2024-07-19
MY194135A (en) 2022-11-14
IL260987A (en) 2018-09-20
WO2017136322A1 (en) 2017-08-10
US20250188474A1 (en) 2025-06-12

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