CL2025001234A1 - Compuestos heterocíclicos como antagonistas de sting - Google Patents

Compuestos heterocíclicos como antagonistas de sting

Info

Publication number
CL2025001234A1
CL2025001234A1 CL2025001234A CL2025001234A CL2025001234A1 CL 2025001234 A1 CL2025001234 A1 CL 2025001234A1 CL 2025001234 A CL2025001234 A CL 2025001234A CL 2025001234 A CL2025001234 A CL 2025001234A CL 2025001234 A1 CL2025001234 A1 CL 2025001234A1
Authority
CL
Chile
Prior art keywords
disease
syndrome
heart failure
sting
interferonopathies
Prior art date
Application number
CL2025001234A
Other languages
English (en)
Inventor
Mayer Camilla
Dahmann Georg
Ruth Handschuh Sandra
Nar Herbert
Oost Thorsten
Gross Patrick
Hoffmann Matthias
Brambilla Marta
Li Jun
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2025001234A1 publication Critical patent/CL2025001234A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se relaciona a compuestos de fórmula 1; y su uso como antagonistas de STING, por ejemplo para el tratamiento de una enfermedad que se selecciona entre el grupo que consiste en: lupus eritematoso sistémico (SLE), interferonopatías (monogénicas y digénicas) (incluyendo a la vasculopatía asociada a STING con inicio en la infancia (SAVI), síndrome de Aicardi-Goutières (AGS), síndrome COPA, y perniosis lúpica familiar), interferonopatías de tipo 1 con mutaciones en los genes DNASE2 o ATAD3A, degeneración macular relacionada con la edad (AMD), retinopatía, glaucoma, esclerosis lateral amiotrófica (ALS), diabetes, obesidad, enfermedad inflamatoria intestinal (IBD), enfermedad pulmonar obstructiva crónica (EPOC), síndrome de Bloom, síndrome de Sjogren, enfermedad de Parkinson, insuficiencia cardíaca y cáncer, esclerosis sistémica (SSc), dermatomiositis, enfermedad del hígado graso no alcohólico (NAFLD), esteatohepatitis no alcohólica (NASH), insuficiencia hepática aguda o crónica (ACLF), enfermedad pulmonar intersticial (ILD), fibrosis pulmonar idiopática (IPF), envejecimiento/trastornos musculares, septicemia, insuficiencia cardíaca, artritis reumatoide y osteoartritis.
CL2025001234A 2022-10-28 2025-04-24 Compuestos heterocíclicos como antagonistas de sting CL2025001234A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263381349P 2022-10-28 2022-10-28
EP22210157 2022-11-29

Publications (1)

Publication Number Publication Date
CL2025001234A1 true CL2025001234A1 (es) 2025-08-29

Family

ID=88600218

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2025001234A CL2025001234A1 (es) 2022-10-28 2025-04-24 Compuestos heterocíclicos como antagonistas de sting

Country Status (16)

Country Link
EP (1) EP4608830A1 (es)
JP (1) JP2026510538A (es)
KR (1) KR20250096817A (es)
CN (1) CN119998286A (es)
AU (1) AU2023368953A1 (es)
CA (1) CA3269346A1 (es)
CL (1) CL2025001234A1 (es)
CO (1) CO2025003882A2 (es)
CR (1) CR20250111A (es)
DO (1) DOP2025000092A (es)
IL (1) IL319947A (es)
JO (1) JOP20250093A1 (es)
MX (1) MX2025004817A (es)
PE (1) PE20251576A1 (es)
TW (1) TW202434213A (es)
WO (1) WO2024089155A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025228900A1 (en) * 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Arylamide substituted indazoles and the use thereof as medicament

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE028588T2 (hu) * 2005-12-13 2016-12-28 Incyte Holdings Corp Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
US11377440B2 (en) 2017-10-05 2022-07-05 Glaxosmithkline Intellectual Property Development Limited Modulators of stimulator of interferon genes (STING)
WO2019122202A1 (en) 2017-12-20 2019-06-27 Ecole Polytechnique Federale De Lausanne (Epfl) Sting inhibitors
EP3813784B1 (en) * 2018-06-07 2024-01-10 The Regents Of The University Of Michigan Prc1 inhibitors and prc1 inhibitors for use in methods of treatment therewith
PY2089151A (es) * 2019-12-31 2022-05-11 Ifm Due Inc Compuestos y composiciones para tratar afecciones asociadas con la actividad de sting
US12065427B2 (en) * 2021-04-29 2024-08-20 Boehringer Ingelheim International Gmbh Heterocyclic compounds capable of activating STING

Also Published As

Publication number Publication date
CN119998286A (zh) 2025-05-13
PE20251576A1 (es) 2025-06-12
MX2025004817A (es) 2025-06-02
JOP20250093A1 (ar) 2025-04-27
EP4608830A1 (en) 2025-09-03
CO2025003882A2 (es) 2025-05-08
AU2023368953A1 (en) 2025-03-27
CR20250111A (es) 2025-05-05
TW202434213A (zh) 2024-09-01
IL319947A (en) 2025-05-01
WO2024089155A1 (en) 2024-05-02
KR20250096817A (ko) 2025-06-27
DOP2025000092A (es) 2025-05-15
JP2026510538A (ja) 2026-04-08
CA3269346A1 (en) 2024-05-02

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