CN100450505C - Chinese medicinal ointment for treating beriberi - Google Patents
Chinese medicinal ointment for treating beriberi Download PDFInfo
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- CN100450505C CN100450505C CNB2006100465841A CN200610046584A CN100450505C CN 100450505 C CN100450505 C CN 100450505C CN B2006100465841 A CNB2006100465841 A CN B2006100465841A CN 200610046584 A CN200610046584 A CN 200610046584A CN 100450505 C CN100450505 C CN 100450505C
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- Prior art keywords
- beriberi
- ointment
- cream
- make
- drug
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- 206010047601 Vitamin B1 deficiency Diseases 0.000 title claims abstract description 24
- 208000002894 beriberi Diseases 0.000 title claims abstract description 24
- 239000002674 ointment Substances 0.000 title abstract description 11
- 239000003814 drug Substances 0.000 claims abstract description 38
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000001035 drying Methods 0.000 claims abstract description 9
- 239000000758 substrate Substances 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000004140 cleaning Methods 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims description 21
- 239000006071 cream Substances 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 235000021395 porridge Nutrition 0.000 claims description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- 229910000831 Steel Inorganic materials 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
- 235000010233 benzoic acid Nutrition 0.000 claims description 3
- 239000004202 carbamide Substances 0.000 claims description 3
- 235000013877 carbamide Nutrition 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 238000007710 freezing Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 229940041616 menthol Drugs 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 3
- 229960004889 salicylic acid Drugs 0.000 claims description 3
- 239000010959 steel Substances 0.000 claims description 3
- 239000011593 sulfur Substances 0.000 claims description 3
- 229910052717 sulfur Inorganic materials 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 230000003628 erosive effect Effects 0.000 abstract description 3
- 239000012535 impurity Substances 0.000 abstract description 3
- 239000000843 powder Substances 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 3
- 238000010298 pulverizing process Methods 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- VWDXGKUTGQJJHJ-UHFFFAOYSA-N Catenarin Natural products C1=C(O)C=C2C(=O)C3=C(O)C(C)=CC(O)=C3C(=O)C2=C1O VWDXGKUTGQJJHJ-UHFFFAOYSA-N 0.000 abstract description 2
- 239000010282 Emodin Substances 0.000 abstract description 2
- RBLJKYCRSCQLRP-UHFFFAOYSA-N Emodin-dianthron Natural products O=C1C2=CC(C)=CC(O)=C2C(=O)C2=C1CC(=O)C=C2O RBLJKYCRSCQLRP-UHFFFAOYSA-N 0.000 abstract description 2
- YOOXNSPYGCZLAX-UHFFFAOYSA-N Helminthosporin Natural products C1=CC(O)=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O YOOXNSPYGCZLAX-UHFFFAOYSA-N 0.000 abstract description 2
- NTGIIKCGBNGQAR-UHFFFAOYSA-N Rheoemodin Natural products C1=C(O)C=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1O NTGIIKCGBNGQAR-UHFFFAOYSA-N 0.000 abstract description 2
- 244000052616 bacterial pathogen Species 0.000 abstract description 2
- LQGUBLBATBMXHT-UHFFFAOYSA-N chrysophanol Chemical compound C1=CC=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O LQGUBLBATBMXHT-UHFFFAOYSA-N 0.000 abstract description 2
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 abstract description 2
- VASFLQKDXBAWEL-UHFFFAOYSA-N emodin Natural products OC1=C(OC2=C(C=CC(=C2C1=O)O)O)C1=CC=C(C=C1)O VASFLQKDXBAWEL-UHFFFAOYSA-N 0.000 abstract description 2
- 230000035876 healing Effects 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- PKUBGLYEOAJPEG-UHFFFAOYSA-N physcion Natural products C1=C(C)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O PKUBGLYEOAJPEG-UHFFFAOYSA-N 0.000 abstract description 2
- 241000223229 Trichophyton rubrum Species 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000002386 leaching Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 206010048768 Dermatosis Diseases 0.000 description 4
- 208000017520 skin disease Diseases 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 206010005913 Body tinea Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 201000010618 Tinea cruris Diseases 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 230000000629 anti-dermatophyte Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- BITYAPCSNKJESK-UHFFFAOYSA-N potassiosodium Chemical compound [Na].[K] BITYAPCSNKJESK-UHFFFAOYSA-N 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 201000003875 tinea corporis Diseases 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a Chinese medicinal ointment for treating beriberi, which is characterized in that wild or planted japanese dock root is processed by the steps of impurity removing, cleaning, slicing, pulverizing, drying, ethanol leaching, concentrating, powder preparing by freeze drying, ointment medicine preparing, gruel substrate preparing by adding auxiliary materials, medicinal ointment preparing, sterilizing and packaging. The Chinese medicinal ointment for treating beriberi inhibits and kills trichophyton rubrum and other pathogenic bacteria by mainly utilizing ingredients, such as emodin, rumicin, etc., in the root part of the japanese dock root and achieves the purpose of healing beriberi, and beriberi is not apt to relapse after a long time. The Chinese medicinal ointment for treating beriberi is externally used and has the advantages of convenient use, simple preparation process and low cost. The clinical trial of the ointment is completed, and clinical application of the ointment is carried out to 5000 patients with erosive type, water blister type, chap type and foot odor diseases. Effectual rate reaches more than 95 percent, and total effective rate is more than 99 percent.
Description
Technical field
The present invention is a field of pharmaceutical technology, relates to the beriberic Chinese medicine beriberi paste of a kind of treatment.
Background technology
The dermatosis of beriberi class is the dermatosis that a kind of fungal infection is propagated, and is a kind of commonly encountered diseases, frequently-occurring disease.Traditional method that is used for the treatment of beriberi is to be applied to the affected part outside medicine is direct, and medicine is treated in the tissue of human body by dermal osmosis.Common on the market have various medicines that anti-dermatophytes such as beriberi, tinea cruris, tinea corporis infect that are used for the treatment of, as zinci undecylenatis compositum, JIAOXIAN YICIJING etc.Be used for the treatment of beriberi footwear, shoe pad, socks etc. in addition, these methods are because its antibiotic composition deficiency can't be killed the skin corium courses of infection and have defectives such as the length course of treatment, weak curative effect, disease relapse rate height, and clinical effectiveness is undesirable.
Summary of the invention
The present invention is in order to overcome the defective that said medicine treatment beriberi class dermatosis etc. exists, purpose is more effective treatment beriberi class dermatosis, provide a kind of can to erosive type, vesicle type, the type of chapping and foot odor be cured and the Chinese medicine unguentum that do not recur, offend again for a long time.
The present invention is the beriberic Chinese medicine beriberi paste of a kind of treatment, its content Description:
The beriberic Chinese medicine beriberi paste of a kind of treatment of the present invention, it is characterized in that: it is by Radix Rumicis Crispi wild or plantation, makes medicated porridge shape thing substrate → make ointment → sterilization, pack through removing impurity → cleanings → section, pulverizing → drying → ethanol lixiviate → concentrate → be lyophilized into powder → make cream drug → add adjuvant;
It prepares with the following method to treat beriberic Chinese medicine beriberi paste:
(1), with the bright Radix Rumicis Crispi cleaning of wild or plantation, cut into slices shape or fritter shape after drying;
(2), with dried bright Radix Rumicis Japonici heel piece or piece, be contained in the rustless steel container, add concentration and be 70～80% ethanol, soaked 7～10 days, under 30～50 ℃ of temperature conditions, carry out homogenizing about the repeated multiple times, make standby lixiviate medicinal liquid;
(3), will make standby lixiviating solution through vacuum extraction, the temperature in the container is 40～65 ℃, and ethanol is all taken out, water takes out about 50%, remainder is spissated cream drug;
(4), spissated cream drug placed quick-freezing under-35～-40 ℃ the temperature, drying, lyophilizing in 15～20 hours is a powdered drug;
(5), get by weight: powdered drug 20%, distilled water 40%, sodium carboxymethyl cellulose 2%, stir after the mixing, make cream drug;
(6), get by weight: salicylic acid 3%, sulfur 3%, benzoic acid 5%, dimethyl sulfoxide 6%, menthol 1%, glycerol 5%, carbamide 15%, mix, grind well, make medicated porridge shape thing substrate;
(7), cream drug and the medicated porridge shape thing substrate of making is mixed, stir, make cream;
(8), cream is sterilized, packed.
The present invention is the beriberic Chinese medicine beriberi paste of a kind of treatment, mainly be compositions such as the emodin that utilizes the Radix Rumicis Crispi root contained, rumicin, suppress, kill trichophyton and other pathogenic bacterium, and reach the beriberic purpose of healing, and be difficult for recurrence, major criminal for a long time.The Chinese medicine beriberi paste is an externally used paste, easy to use, preparation technology is simple, with low cost.Clinical trial of the present invention is finished, and routine erosive type, vesicle type, the type of chapping and smelly foot patient surplus 5000 have been carried out clinical practice, and obvious effective rate reaches more than 95%; Always effectively be more than 99%.
The specific embodiment
The beriberic Chinese medicine beriberi paste of a kind of treatment of the present invention, be to realize like this, it is by Radix Rumicis Crispi wild or plantation, makes medicated porridge shape thing substrate → make ointment → sterilization, pack through removing impurity → cleanings → section, pulverizing → drying → ethanol lixiviate → concentrate → be lyophilized into powder → make cream drug → add adjuvant.
Follow these steps to finish:
(1), with the bright Radix Rumicis Crispi cleaning of wild or plantation, cut into slices shape or fritter shape after drying;
(2), with dried bright Radix Rumicis Japonici heel piece or piece, be contained in the rustless steel container, add concentration and be 70～80% ethanol, soaked 7～10 days, under 30～50 ℃ of temperature conditions, carry out homogenizing about the repeated multiple times, make standby lixiviate medicinal liquid;
(3), will make standby lixiviating solution through vacuum extraction, the temperature in the container is 40～65 ℃, and ethanol is all taken out, water takes out about 50%, remainder is spissated cream drug;
(4), spissated cream drug placed quick-freezing under-35～-40 ℃ the temperature, drying, lyophilizing in 15～20 hours is a powdered drug;
(5), every 10g dress of preparation is prepared by following method for the Chinese medicine beriberi paste of example:
Get major ingredient: powdered drug 2g, distilled water 4g, carboxylic potassio sodium cellulosate 0.2g, stir after the mixing, make cream drug;
Get adjuvant: salicylic acid 0.3g, sulfur 0.3g, benzoic acid 0.5g, dimethyl sulfoxide 0.6g, menthol 0.1g, glycerol 0.5g, carbamide 1.5g, mix, grind well, make medicated porridge shape thing substrate;
Cream drug of making and medicated porridge shape thing substrate mix, and stir, and make the Chinese medicine beriberi paste; Sterilize, pack.
Using method: will treat after beriberic Chinese medicine beriberi paste is applied to the affected part, and rub repeatedly and put on the skin, and take effect about a week every day 1～2 time, and be difficult for recurrence, major criminal for a long time.
Claims (1)
1, the beriberic Chinese medicine beriberi paste of a kind of treatment, it is characterized in that: it prepares with the following method:
(1), with the bright Radix Rumicis Crispi cleaning of wild or plantation, cut into slices shape or fritter shape after drying;
(2), with dried bright Radix Rumicis Japonici heel piece or piece, be contained in the rustless steel container, add concentration and be 70～80% ethanol, soaked 7～10 days, under 30～50 ℃ of temperature conditions, carry out homogenizing about the repeated multiple times, make standby lixiviate medicinal liquid;
(3), will make standby lixiviating solution through vacuum extraction, the temperature in the container is 40～65 ℃, and ethanol is all taken out, water takes out about 50%, remainder is spissated cream drug;
(4), spissated cream drug placed quick-freezing under-35～-40 ℃ the temperature, drying, lyophilizing in 15～20 hours is a powdered drug;
(5), get by weight: powdered drug 20%, distilled water 40%, sodium carboxymethyl cellulose 2%, stir after the mixing, make cream drug;
(6), get by weight: salicylic acid 3%, sulfur 3%, benzoic acid 5%, dimethyl sulfoxide 6%, menthol 1%, glycerol 5%, carbamide 15%, mix, grind well, make medicated porridge shape thing substrate;
(7), cream drug and the medicated porridge shape thing substrate of making is mixed, stir, make cream;
(8), cream is sterilized, packed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100465841A CN100450505C (en) | 2006-05-18 | 2006-05-18 | Chinese medicinal ointment for treating beriberi |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100465841A CN100450505C (en) | 2006-05-18 | 2006-05-18 | Chinese medicinal ointment for treating beriberi |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1883568A CN1883568A (en) | 2006-12-27 |
| CN100450505C true CN100450505C (en) | 2009-01-14 |
Family
ID=37581950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100465841A Expired - Fee Related CN100450505C (en) | 2006-05-18 | 2006-05-18 | Chinese medicinal ointment for treating beriberi |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100450505C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107455387A (en) * | 2017-07-25 | 2017-12-12 | 佛山市南海建诺鞋业有限公司 | A kind of formula of PU bactericidal creams and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615967A (en) * | 2004-09-13 | 2005-05-18 | 满书岐 | Chinese herbal medicine for treating beri-beri |
-
2006
- 2006-05-18 CN CNB2006100465841A patent/CN100450505C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615967A (en) * | 2004-09-13 | 2005-05-18 | 满书岐 | Chinese herbal medicine for treating beri-beri |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1883568A (en) | 2006-12-27 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090114 Termination date: 20120518 |