CN101128444A - 用于治疗呼吸系统疾病的新药物 - Google Patents

用于治疗呼吸系统疾病的新药物 Download PDF

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Publication number
CN101128444A
CN101128444A CNA2006800060256A CN200680006025A CN101128444A CN 101128444 A CN101128444 A CN 101128444A CN A2006800060256 A CNA2006800060256 A CN A2006800060256A CN 200680006025 A CN200680006025 A CN 200680006025A CN 101128444 A CN101128444 A CN 101128444A
Authority
CN
China
Prior art keywords
compound
ethyl
hydroxyl
dimethyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800060256A
Other languages
English (en)
Chinese (zh)
Inventor
英戈·科内茨基
蒂里·布伊索
菲利普·勒斯滕伯格
安德烈亚斯·施纳普
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CN101128444A publication Critical patent/CN101128444A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
CNA2006800060256A 2005-02-24 2006-02-16 用于治疗呼吸系统疾病的新药物 Pending CN101128444A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005008921.6 2005-02-24
DE102005008921A DE102005008921A1 (de) 2005-02-24 2005-02-24 Neue Arzneimittel zur Behandlung von Atemwegserkrankungen

Publications (1)

Publication Number Publication Date
CN101128444A true CN101128444A (zh) 2008-02-20

Family

ID=36179764

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800060256A Pending CN101128444A (zh) 2005-02-24 2006-02-16 用于治疗呼吸系统疾病的新药物

Country Status (26)

Country Link
US (3) US20060189605A1 (pt)
EP (1) EP1856070B1 (pt)
JP (1) JP4950075B2 (pt)
KR (1) KR20070110386A (pt)
CN (1) CN101128444A (pt)
AR (1) AR055562A1 (pt)
AT (1) ATE517877T1 (pt)
AU (1) AU2006218010B2 (pt)
BR (1) BRPI0607258A2 (pt)
CA (1) CA2598914A1 (pt)
DE (1) DE102005008921A1 (pt)
DK (1) DK1856070T3 (pt)
EA (1) EA012439B1 (pt)
ES (1) ES2370653T3 (pt)
IL (1) IL185444A0 (pt)
MX (1) MX2007010363A (pt)
MY (1) MY146802A (pt)
NO (1) NO20073176L (pt)
NZ (1) NZ561743A (pt)
PE (1) PE20061097A1 (pt)
PL (1) PL1856070T3 (pt)
TW (1) TWI369988B (pt)
UA (1) UA90504C2 (pt)
UY (1) UY29394A1 (pt)
WO (1) WO2006089859A1 (pt)
ZA (1) ZA200704727B (pt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107406488A (zh) * 2014-12-24 2017-11-28 凯思生物技术公司 用于治疗呼吸系统疾病的新型PI3Kγ抑制剂肽
CN110179987A (zh) * 2012-09-28 2019-08-30 加的夫大学学院咨询有限公司 用于治疗炎性肺病的治疗剂

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005008921A1 (de) * 2005-02-24 2006-08-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von Atemwegserkrankungen
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
PE20080610A1 (es) * 2006-08-22 2008-07-15 Boehringer Ingelheim Int Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos
UY30552A1 (es) * 2006-08-22 2008-03-31 Boehringer Ingelheim Int Combinaciones farmacologiicas en base a derivados sustituidos de la n-(5-{2-[1,1-dimetil-propilamino]-1-hidroxi-metil}-2-hidroxi-fenil)-metansulfonamida y aplicaciones
EP2056836A1 (en) * 2006-08-22 2009-05-13 Boehringer Ingelheim International GmbH Powder formulations for inhalation containing enantiomerically pure beta-agonists
PE20080425A1 (es) * 2006-08-22 2008-06-16 Boehringer Ingelheim Int Formulacion aerosol para la inhalacion de beta-agonistas
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3026534A1 (de) * 1980-07-12 1982-03-18 C.H. Boehringer Sohn, 6507 Ingelheim 3,1-benzoxazin-2-one, ihre herstellung und verwendung
US4460581A (en) * 1982-10-12 1984-07-17 Boehringer Ingelheim Kg (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
US4570630A (en) * 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
DE3609152A1 (de) * 1986-03-19 1987-09-24 Bayer Ag Verfahren zur herstellung des (-)-antipoden des (e)-1-cyclohexyl-4,4-dimethyl- 3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ens
AU2004226824B2 (en) * 2003-04-04 2008-05-01 Novartis Ag Quinoline-2-one-derivatives for the treatment of airways diseases
DE102004003428A1 (de) * 2004-01-23 2005-08-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Beta-2-Agonisten, und deren Verwendung als Arzneimittel
US7220742B2 (en) * 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102005008921A1 (de) * 2005-02-24 2006-08-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von Atemwegserkrankungen
US7423146B2 (en) * 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
UY30552A1 (es) * 2006-08-22 2008-03-31 Boehringer Ingelheim Int Combinaciones farmacologiicas en base a derivados sustituidos de la n-(5-{2-[1,1-dimetil-propilamino]-1-hidroxi-metil}-2-hidroxi-fenil)-metansulfonamida y aplicaciones
PE20080425A1 (es) * 2006-08-22 2008-06-16 Boehringer Ingelheim Int Formulacion aerosol para la inhalacion de beta-agonistas

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110179987A (zh) * 2012-09-28 2019-08-30 加的夫大学学院咨询有限公司 用于治疗炎性肺病的治疗剂
CN107406488A (zh) * 2014-12-24 2017-11-28 凯思生物技术公司 用于治疗呼吸系统疾病的新型PI3Kγ抑制剂肽

Also Published As

Publication number Publication date
AU2006218010B2 (en) 2013-02-14
EP1856070A1 (de) 2007-11-21
NO20073176L (no) 2007-09-17
ES2370653T3 (es) 2011-12-21
IL185444A0 (en) 2008-01-06
US20110053926A1 (en) 2011-03-03
PE20061097A1 (es) 2006-11-14
WO2006089859A1 (de) 2006-08-31
MX2007010363A (es) 2007-09-25
EA200701615A1 (ru) 2008-02-28
EA012439B1 (ru) 2009-10-30
KR20070110386A (ko) 2007-11-16
AU2006218010A1 (en) 2006-08-31
TWI369988B (en) 2012-08-11
ATE517877T1 (de) 2011-08-15
CA2598914A1 (en) 2006-08-31
NZ561743A (en) 2009-09-25
PL1856070T3 (pl) 2011-12-30
EP1856070B1 (de) 2011-07-27
MY146802A (en) 2012-09-28
US20090105236A1 (en) 2009-04-23
UA90504C2 (ru) 2010-05-11
JP2008531518A (ja) 2008-08-14
DE102005008921A1 (de) 2006-08-31
JP4950075B2 (ja) 2012-06-13
TW200640465A (en) 2006-12-01
DK1856070T3 (da) 2011-09-26
BRPI0607258A2 (pt) 2009-08-25
UY29394A1 (es) 2006-10-02
AR055562A1 (es) 2007-08-22
ZA200704727B (en) 2008-09-25
US20060189605A1 (en) 2006-08-24

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