CN101208101B - 免疫原性组合物 - Google Patents

免疫原性组合物 Download PDF

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Publication number
CN101208101B
CN101208101B CN2006800230577A CN200680023057A CN101208101B CN 101208101 B CN101208101 B CN 101208101B CN 2006800230577 A CN2006800230577 A CN 2006800230577A CN 200680023057 A CN200680023057 A CN 200680023057A CN 101208101 B CN101208101 B CN 101208101B
Authority
CN
China
Prior art keywords
hib
immunogenic composition
kda
glycoconjugate
vaccine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2006800230577A
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English (en)
Chinese (zh)
Other versions
CN101208101A (zh
Inventor
R·L·比曼斯
D·布特里奥
C·卡皮奥
P·德内尔
P·迪维维耶
J·普尔曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Biologicals SA
Original Assignee
GlaxoSmithKline Biologicals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0513071.1A external-priority patent/GB0513071D0/en
Priority claimed from GB0515556A external-priority patent/GB0515556D0/en
Priority claimed from GB0524204A external-priority patent/GB0524204D0/en
Priority claimed from GB0526040A external-priority patent/GB0526040D0/en
Priority claimed from GB0526041A external-priority patent/GB0526041D0/en
Application filed by GlaxoSmithKline Biologicals SA filed Critical GlaxoSmithKline Biologicals SA
Priority claimed from PCT/EP2006/006220 external-priority patent/WO2007000327A1/en
Publication of CN101208101A publication Critical patent/CN101208101A/zh
Application granted granted Critical
Publication of CN101208101B publication Critical patent/CN101208101B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/116—Polyvalent bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN2006800230577A 2005-06-27 2006-06-23 免疫原性组合物 Active CN101208101B (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
GB0513071.1 2005-06-27
GBGB0513069.5A GB0513069D0 (en) 2005-06-27 2005-06-27 Immunogenic composition
GBGB0513071.1A GB0513071D0 (en) 2005-06-27 2005-06-27 Immunogenic composition
GB0513069.5 2005-06-27
GB0515556.9 2005-07-28
GB0515556A GB0515556D0 (en) 2005-07-28 2005-07-28 Immunogenic composition
GB0524204.5 2005-11-28
GB0524204A GB0524204D0 (en) 2005-11-28 2005-11-28 Immunogenic composition
GB0526041.9 2005-12-21
GB0526040A GB0526040D0 (en) 2005-12-21 2005-12-21 Immunogenic composition
GB0526040.1 2005-12-21
GB0526041A GB0526041D0 (en) 2005-12-21 2005-12-21 Immunogenic composition
PCT/EP2006/006220 WO2007000327A1 (en) 2005-06-27 2006-06-23 Immunogenic composition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2011101438611A Division CN102218138A (zh) 2005-06-27 2006-06-23 免疫原性组合物

Publications (2)

Publication Number Publication Date
CN101208101A CN101208101A (zh) 2008-06-25
CN101208101B true CN101208101B (zh) 2013-01-02

Family

ID=34856207

Family Applications (4)

Application Number Title Priority Date Filing Date
CN2006800230577A Active CN101208101B (zh) 2005-06-27 2006-06-23 免疫原性组合物
CN200680023149.5A Active CN101222935B (zh) 2005-06-27 2006-06-23 免疫原性组合物
CN2006800311786A Active CN101247827B (zh) 2005-06-27 2006-06-23 疫苗生产方法
CN2006800233344A Active CN101208103B (zh) 2005-06-27 2006-06-23 免疫原性组合物

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN200680023149.5A Active CN101222935B (zh) 2005-06-27 2006-06-23 免疫原性组合物
CN2006800311786A Active CN101247827B (zh) 2005-06-27 2006-06-23 疫苗生产方法
CN2006800233344A Active CN101208103B (zh) 2005-06-27 2006-06-23 免疫原性组合物

Country Status (8)

Country Link
CN (4) CN101208101B (2)
BE (1) BE2021C560I2 (2)
ES (1) ES2367918T5 (2)
FR (1) FR12C0060I2 (2)
GB (1) GB0513069D0 (2)
NO (2) NO2021022I1 (2)
UA (1) UA97233C2 (2)
ZA (3) ZA200710853B (2)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2809349T3 (da) * 2012-01-30 2019-02-18 Serum Institute Of India Pvt Ltd Immunogen sammensætning
SI2885007T1 (sl) * 2012-08-16 2018-12-31 Pfizer Inc. Postopki in kompozicije glikokonjugacij
KR102906912B1 (ko) * 2016-09-02 2026-01-05 사노피 파스퇴르 인크 네이세리아 메닌기티디스 백신
JP7165468B2 (ja) * 2016-11-25 2022-11-04 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ｎＯＭＶ－抗原コンジュゲート及びその使用
CN109879967A (zh) * 2017-12-15 2019-06-14 苏州和锐生物科技有限公司 一种乙酰氨基葡萄糖偶联物的制备方法及应用
CN110251667A (zh) * 2018-05-11 2019-09-20 武汉博沃生物科技有限公司 一种免疫组合制剂及其制备方法和应用
US12533418B2 (en) * 2019-11-22 2026-01-27 Glaxosmithkline Biologicals Sa Dosage and administration of a bacterial saccharide glycoconjugate vaccine
CN115819616B (zh) * 2021-07-28 2025-04-11 江苏瑞科生物技术股份有限公司 一种基因重组vzv融合蛋白及其制备方法和应用
CN115721709A (zh) * 2021-08-27 2023-03-03 康希诺生物股份公司 一种肺炎球菌结合疫苗制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1449293A (zh) * 2000-06-29 2003-10-15 史密丝克莱恩比彻姆生物有限公司 多价疫苗组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180815A (en) * 1988-04-13 1993-01-19 Fuji Photo Film Co., Ltd. Modified protein for carrying hapten
EP1372707A1 (en) * 2001-04-06 2004-01-02 Institut Pasteur Conjugate vaccine composed of the polysaccharide moiety of the lipopolysaccharide of vibrio cholerae 0139 bound to tetanus toxoid
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
CN1401328A (zh) * 2002-10-18 2003-03-12 北京绿竹生物技术有限责任公司 流行性脑脊髓膜炎多糖－蛋白结合疫苗
ES2461350T3 (es) * 2003-01-30 2014-05-19 Novartis Ag Vacunas inyectables contra múltiples serogrupos de meningococos

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1449293A (zh) * 2000-06-29 2003-10-15 史密丝克莱恩比彻姆生物有限公司 多价疫苗组合物

Also Published As

Publication number Publication date
UA97233C2 (uk) 2012-01-25
FR12C0060I1 (2) 2012-12-14
CN101222935A (zh) 2008-07-16
BE2021C560I2 (2) 2026-02-02
FR12C0060I2 (fr) 2017-01-06
GB0513069D0 (en) 2005-08-03
CN101208103B (zh) 2013-04-24
ZA200710909B (en) 2009-04-29
ES2367918T5 (es) 2014-11-21
NO2021022I1 (no) 2021-05-25
CN101208101A (zh) 2008-06-25
CN101247827A (zh) 2008-08-20
CN101247827B (zh) 2013-07-17
ES2367918T3 (es) 2011-11-10
NO2025018I1 (no) 2025-04-08
CN101208103A (zh) 2008-06-25
ZA200710853B (en) 2009-04-29
CN101222935B (zh) 2015-07-29
ZA200711074B (en) 2009-07-29

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