CN101212902A - Fungicidal mixtures based on 3, 5-disubstituted pyrazole carboxylic acid biphenylamides - Google Patents
Fungicidal mixtures based on 3, 5-disubstituted pyrazole carboxylic acid biphenylamides Download PDFInfo
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本发明涉及杀真菌混合物，其以协同有效量包含如下化合物作为活性组分：The present invention relates to fungicidal mixtures comprising the following compounds as active ingredients in synergistically effective amounts:
1)至少一种式I的3，5-二取代的N-联苯基吡唑甲酰胺：1) At least one 3,5-disubstituted N-biphenylpyrazole carboxamide of the formula I:
其中各取代基如下所定义：Wherein each substituent is defined as follows:
X为氧或硫；X is oxygen or sulfur;
R1和R2相互独立地为氰基、硝基、卤素、C1-C6烷基、C1-C6卤代烷基、甲氧基、二氟甲氧基或三氟甲氧基；R 1 and R 2 are independently cyano, nitro, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, methoxy, difluoromethoxy or trifluoromethoxy;
R3为卤素、C1-C4烷基或C1-C4卤代烷基；R 3 is halogen, C 1 -C 4 alkyl or C 1 -C 4 haloalkyl;
R4为氢或卤素；R 4 is hydrogen or halogen;
和and
2)至少一种选自A)-F)组的活性化合物II：2) At least one active compound II selected from groups A)-F):
A)选自如下的唑类：双苯三唑醇(bitertanol)、糠菌唑(bromuconazole)、环唑醇(cyproconazole)、醚唑(difenoconazole)、烯唑醇(diniconazole)、烯菌灵(enilconazole)、氧唑菌(epoxiconazole)、喹唑菌酮(fluquinconazole)、腈苯唑(fenbuconazole)、氟硅唑(flusilazole)、粉唑醇(flutriafol)、己唑醇(hexaconazole)、酰胺唑(imibenconazole)、环戊唑醇(ipconazole)、环戊唑菌(metconazole)、腈菌唑(myclobutanil)、戊菌唑(penconazole)、丙环唑(propiconazole)、丙硫菌唑(prothioconazole)、硅氟唑(simeconazole)、三唑酮(triadimefon)、唑菌醇(triadimenol)、戊唑醇(tebuconazole)、氟醚唑(tetraconazole)、戊叉唑菌(triticonazole)、丙氯灵(prochloraz)、稻瘟酯(pefurazoate)、烯菌灵(imazalil)、氟菌唑(triflumizole)、氰霜唑(cyazofamid)、苯菌灵(benomyl)、多菌灵(carbendazim)、涕必灵(thiabendazole)、麦穗宁(fuberidazole)、噻唑菌胺(ethaboxam)、氯唑灵(etridiazole)和土菌消(hymexazole)；A) azoles selected from the group consisting of: bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, dimethendazole ( enilconazole), epoxiconazole, fluquinconazole, fenbuconazole, flusilazole, flutriafol, hexaconazole, imibenconazole ), ipconazole, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, silfluazole (simeconazole), triadimefon, triadimenol, tebuconazole, tetraconazole, triticonazole, prochloraz, blastic ester (pefurazoate), imazalil, triflumizole, cyazofamid, benomyl, carbendazim, thiabendazole, wheat suingin ( fuberidazole), ethaboxam, etridiazole and hymexazole;
B)选自如下的嗜球果伞素类(strobilurins)：腈嘧菌酯(azoxystrobin)、醚菌胺(dimoxystrobin)、烯肟菌酯(enestroburin)、氟嘧菌酯(fluoxastrobin)、亚胺菌(kresoxim-methyl)、叉氨苯酰胺(methominostrobin)、肟醚菌胺(orysastrobin)、啶氧菌酯(picoxystrobin)、唑菌胺酯(pyraclostrobin)、肟菌酯(trifloxystrobin)、烯肟菌酯(enestroburin)、(2-氯-5-[1-(3-甲基苄氧基亚氨基)乙基]苄基)氨基甲酸甲酯、(2-氯-5-[1-(6-甲基吡啶-2-基甲氧基亚氨基)乙基]苄基)氨基甲酸甲酯和2-(邻-(2，5-二甲基苯氧基亚甲基)苯基)-3-甲氧基丙烯酸甲酯；B) strobilurins selected from the group consisting of: azoxystrobin, dimoxystrobin, enestroburin, fluoxastrobin, iminobacterium (kresoxim-methyl), methominostrobin, orysastrobin, picoxystrobin, pyraclostrobin, trifloxystrobin, erythoxystrobin ( enestroburin), (2-chloro-5-[1-(3-methylbenzyloxyimino)ethyl]benzyl)methyl carbamate, (2-chloro-5-[1-(6-methyl Pyridin-2-ylmethoxyimino)ethyl]benzyl)methyl carbamate and 2-(o-(2,5-dimethylphenoxymethylene)phenyl)-3-methoxy Methyl acrylate;
C)选自如下的羧酰胺：萎锈灵(carboxin)、苯霜灵(benalaxyl)、啶酰菌胺(boscalid)、环酰菌胺(fenhexamid)、氟酰胺(flutolanil)、呋吡唑灵(furametpyr)、丙氧灭绣胺(mepronil)、甲霜灵(metalaxyl)、精甲霜灵(mefenoxam)、甲呋酰胺(ofurace)、霜灵(oxadixyl)、氧化萎锈灵(oxycarboxin)、吡噻菌胺(penthiopyrad)、溴氟唑菌(thifluzamide)、噻酰菌胺(tiadinil)、3，4-二氯-N-(2-氰基苯基)异噻唑-5-甲酰胺、烯酰吗啉(dimethomorph)、氟吗啉(flumorph)、氟联苯菌(flumetover)、氟吡菌胺((flu opicolide)picobenzamid)、苯酰菌胺(zoxamide)、氯环丙酰胺(carpropamid)、双氯氰菌胺(diclocymet)、双炔酰菌胺(mandipropamid)、N-(2-(4-[3-(4-氯苯基)丙-2-炔基氧基]-3-甲氧基苯基)乙基)-2-甲磺酰氨基-3-甲基丁酰胺、N-(2-(4-[3-(4-氯苯基)丙-2-炔基氧基]-3-甲氧基苯基)乙基)-2-乙磺酰氨基-3-甲基丁酰胺、3-(4-氯苯基)-3-(2-异丙氧羰基氨基-3-甲基丁酰氨基)丙酸甲酯、式III化合物：C) Carboxamides selected from the group consisting of carboxin, benalaxyl, boscalid, fenhexamid, flutolanil, furazolin ( furametpyr), mepronil, metalaxyl, mefenoxam, ofurace, oxadixyl, oxycarboxin, pyridoxine Penthiopyrad, thifluzamide, tiadinil, 3,4-dichloro-N-(2-cyanophenyl)isothiazole-5-carboxamide, enoyl Dimethomorph, flumorph, flumetover, fluopicolide picobenzomid, zoxamide, carpropamid, bis diclocymet, mandipropamid, N-(2-(4-[3-(4-chlorophenyl)prop-2-ynyloxy]-3-methoxy Phenyl)ethyl)-2-methanesulfonylamino-3-methylbutanamide, N-(2-(4-[3-(4-chlorophenyl)prop-2-ynyloxy]-3 -Methoxyphenyl)ethyl)-2-ethanesulfonylamino-3-methylbutanamide, 3-(4-chlorophenyl)-3-(2-isopropoxycarbonylamino-3-methyl Butyrylamino) methyl propionate, compound of formula III:
其中R5为甲基或乙基，Wherein R 5 is methyl or ethyl,
N-(4’-溴联苯-2-基)-4-二氟甲基-2-甲基噻唑-5-甲酰胺、N-(4’-三氟甲基联苯-2-基)-4-二氟甲基-2-甲基噻唑-5-甲酰胺、N-(4’-氯-3’-氟联苯-2-基)-4-二氟甲基-2-甲基噻唑-5-甲酰胺、N-(3’，4’-二氯-4-氟联苯-2-基)-3-二氟甲基-1-甲基吡唑-4-甲酰胺和N-(2-氰基苯基)-3，4-二氯异噻唑-5-甲酰胺；N-(4'-bromobiphenyl-2-yl)-4-difluoromethyl-2-methylthiazole-5-carboxamide, N-(4'-trifluoromethylbiphenyl-2-yl) -4-Difluoromethyl-2-methylthiazole-5-carboxamide, N-(4'-chloro-3'-fluorobiphenyl-2-yl)-4-difluoromethyl-2-methyl Thiazole-5-carboxamide, N-(3',4'-dichloro-4-fluorobiphenyl-2-yl)-3-difluoromethyl-1-methylpyrazole-4-carboxamide and N -(2-cyanophenyl)-3,4-dichloroisothiazole-5-carboxamide;
D)选自如下的杂环化合物：氟啶胺(fluazinam)、啶斑肟(pyrifenox)、磺嘧菌灵(bupirimate)、环丙嘧啶(cyprodinil)、异嘧菌醇(fenarimol)、嘧菌腙(ferimzone)、嘧菌胺(mepanipyrim)、氟苯嘧啶醇(nuarimol)、二甲嘧菌胺(pyrimethanil)、嗪氨灵(triforine)、拌种咯(fenpiclonil)、氟菌(fludioxonil)、aldimorph(4-十二烷基-2，6-二甲基吗啉)、吗菌灵(dodemorph)、丁苯吗啉(fenpropimorph)、克啉菌(tridemorph)、苯锈啶(fenpropidin)、异丙定(iprodione)、杀菌利(procymidone)、烯菌酮(vinclozolin)、唑酮菌(famoxadone)、咪唑菌酮(fenamidone)、异噻菌酮(octhilinone)、噻菌灵(probenazole)、5-氯-7-(4-甲基哌啶-1-基)-6-(2，4，6-三氟苯基)[1，2，4]三唑并[1，5-a]嘧啶、敌菌灵(anilazine)、哒菌清(diclomezine)、咯喹酮(pyroquilon)、丙氧喹啉(proquinazid)、三环唑(tricyclazole)、式IV化合物(2-丁氧基-6-碘-3-丙基苯并吡喃-4-酮)：D) Heterocyclic compounds selected from the group consisting of fluazinam, pyrifenox, bupirimate, cyprodinil, fenarimol, pyrizone (ferimzone), mepanipyrim, nuarimol, pyrimethanil, triforine, fenpiclonil, fludioxonil, aldimorph (4-dodecyl-2,6-dimethylmorpholine), dodemorph, fenpropimorph, tridemorph, fenpropidin, isopropyl iprodione, procymidone, vinclozolin, famoxadone, fenamidone, octhilinone, probenazole, 5- Chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine, Anilazine, diclomezine, pyroquilon, proquinazid, tricyclazole, compound of formula IV (2-butoxy-6-iodo- 3-Propylbenzopyran-4-one):
噻二唑素(acibenzolar-S-methyl)、敌菌丹(captafol)、克菌丹(captan)、棉隆(dazomet)、灭菌丹(folpet)、氰菌胺(fenoxanil)、喹氧灵(quinoxyfen)和式V的N，N-二甲基-3-(3-溴-6-氟-2-甲基吲哚-1-磺酰基)-[1，2，4]三唑-1-磺酰胺：Thiadiazole (acibenzolar-S-methyl), captafol, captan, dazomet, folpet, fenoxanil, quinoxyfen ( quinoxyfen) and N,N-dimethyl-3-(3-bromo-6-fluoro-2-methylindole-1-sulfonyl)-[1,2,4]triazole-1- Sulfonamide:
E)选自如下的氨基甲酸盐类：代森锰锌(mancozeb)、代森锰(maneb)、威百亩(metam)、代森联(metiram)、福美铁(ferbam)、甲基代森锌(propineb)、福美双(thiram)、代森锌(zineb)、福美锌(ziram)、乙霉威(diethofencarb)、异丙菌胺(iprovalicarb)、苯噻菌胺(flubenthiavalicarb)、百维灵(propamocarb)、N-(1-(1-(4-氰基苯基)乙磺酰基)丁-2-基)氨基甲酸4-氟苯基酯、式VI的3-(4-氯苯基)-3-(2-异丙氧羰基氨基-3-甲基丁酰氨基)丙酸甲酯：E) Carbamates selected from the group consisting of mancozeb, maneb, metam, metiram, ferbam, methyl Zinc (propineb), thiram, zineb, ziram, diethofencarb, iprovalicarb, flubenthiavalicarb, Proverb (propamocarb), 4-fluorophenyl N-(1-(1-(4-cyanophenyl)ethanesulfonyl)but-2-yl)carbamate, 3-(4-chlorophenyl of formula VI )-3-(2-isopropoxycarbonylamino-3-methylbutyrylamino)propanoic acid methyl ester:
和式VII的氨基甲酸酯肟醚：and carbamate oxime ethers of formula VII:
其中Z为N或CH；Where Z is N or CH;
F)选自如下的其他杀真菌剂：F) Other fungicides selected from the group consisting of:
胍类：多果定(dodine)、双胍辛醋酸盐(iminoctadine)、双胍盐(guazatine)，抗菌素类：春雷霉素(kasugamycin)、链霉素(streptomycin)、多氧霉素(polyoxins)、有效霉素(validamycin A)，Guanidines: dodine, iminoctadine, guazatine, antibiotics: kasugamycin, streptomycin, polyoxins, validamycin A,
硝基苯基衍生物：乐杀螨(binapacryl)、敌螨普(dinocap)、敌螨通(dinobuton)，Nitrophenyl derivatives: binapacryl, dinocap, dinobuton,
含硫的杂环基化合物：二噻农(dithianon)、稻瘟灵(isoprothiolane)，有机金属化合物：三苯锡基盐，如薯瘟锡(fentin acetate)，有机磷化合物：克瘟散(edifenphos)、异稻瘟净(iprobenfos)、藻菌磷(fosetyl)、乙磷铝(fosetyl-aluminum)、亚磷酸及其盐、定菌磷(pyrazophos)、甲基立枯磷(tolclofos-methyl)，Sulfur-containing heterocyclic compounds: dithianon, isoprothiolane, organometallic compounds: triphenyltin-based salts, such as fentin acetate, organophosphorus compounds: edifenphos ), iprobenfos, fosetyl, fosetyl-aluminum, phosphorous acid and its salts, pyrazophos, tolclofos-methyl,
有机氯化合物：百菌清(chlorothalonil)、抑菌灵(dichlofluanid)、磺菌胺(flusulfamide)、六氯苯(hexachlorobenzene)、四氯苯酞(phthalide)、戊菌隆(pencycuron)、五氯硝基苯(quintozene)、甲基托布津(thiophanate-methyl)、对甲抑菌灵(tolylfluanid)，Organochlorine compounds: chlorothalonil, dichlorofluanid, flusulfamide, hexachlorobenzene, phthalide, pencycuron, pentachloride Quintozene, thiophanate-methyl, tolylfluanid,
无机活性化合物：波尔多液(Bordeaux混合物)、醋酸铜、氢氧化铜、王铜、碱式硫酸铜、硫，Inorganic active compounds: Bordeaux mixture (Bordeaux mixture), copper acetate, copper hydroxide, king copper, basic copper sulfate, sulfur,
其他：环氟菌胺(cyflufenamid)、清菌脲(cymoxanil)、甲菌定(dimethirimol)、乙菌定(ethirimol)、呋氨丙灵(furalaxyl)、苯菌酮(metrafenone)和螺茂胺(spiroxamine)。Others: cyflufenamid, cymoxanil, dimethirimol, ethirimol, furalaxyl, metrafenone, and spiroxanil (spiroxamine).
此外，本发明涉及一种使用至少一种化合物I和至少一种活性化合物II的混合物防治有害真菌的方法，化合物I和II在制备该类混合物中的用途以及包含这些混合物的组合物和种子。Furthermore, the invention relates to a method for controlling harmful fungi using a mixture of at least one compound I and at least one active compound II, the use of compounds I and II for the preparation of such mixtures and compositions and seeds comprising these mixtures.
式I的取代联苯基酰胺由EP-A 589 301已知，该文献还公开了一种制备它们的方法以及选自杀真菌剂、杀菌剂、杀螨剂、杀线虫剂或杀虫剂的可能混合配对组分。The substituted biphenylamides of formula I are known from EP-A 589 301, which also discloses a process for their preparation and the possibility of selecting from fungicides, bactericides, acaricides, nematocides or insecticides Mix and match components.
取代的联苯基酰胺也由WO 01/42223已知；然而，这些化合物仅在联苯基上单取代。Substituted biphenyl amides are also known from WO 01/42223; however, these compounds are only monosubstituted on the biphenyl.
JP-A 09/132567公开了在苯基环上被三氟甲基取代的二取代联苯基酰替苯胺。JP-A 09/132567 discloses disubstituted biphenylanilides substituted with a trifluoromethyl group on the phenyl ring.
WO 2005/34628尤其公开了吡唑甲酰胺和各种其他杀真菌活性化合物的混合物。该公布中提到的吡唑甲酰胺与本发明化合物I的不同尤其在于在联苯基上的取代方式。WO 2005/34628 discloses inter alia mixtures of pyrazole carboxamides and various other fungicidally active compounds. The pyrazole carboxamides mentioned in this publication differ from the compounds I according to the invention especially in the manner of substitution on the biphenyl group.
2，4-二取代的N-联苯基酰胺由WO 2005/123689和WO 2005/123690已知，而3，5-二取代的联苯基酰胺由在先的德国申请第102005007160.0号已知。2,4-Disubstituted N-biphenylamides are known from WO 2005/123689 and WO 2005/123690, whereas 3,5-disubstituted biphenylamides are known from the earlier German application No. 102005007160.0.
然而，所述联苯基酰胺和已知的混合物尤其在低施用率下并不完全令人满意。However, the biphenylamides and the known mixtures are not entirely satisfactory, especially at low application rates.
作为组分2)的上述活性化合物II、其制备及其对有害真菌的作用通常是已知的(例如参见http://www.hclrss.demon.co.uk/index.html)；它们可以市购。The abovementioned active compounds II as component 2), their preparation and their action against harmful fungi are generally known (see for example http://www.hclrss.demon.co.uk/index.html ); they are available on the market purchase.
苯霜灵，N-(苯基乙酰基)-N-(2，6-二甲苯基)-DL-丙氨酸甲酯(DE 29 03 612)；甲霜灵，N-(甲氧基乙酰基)-N-(2，6-二甲苯基)-DL-丙氨酸甲酯(GB 15 00 581)；甲呋酰胺，(RS)-α-(2-氯-N-2，6-二甲苯基乙酰胺基)-γ-丁内酯[CAS RN58810-48-3]；Benalaxyl, N-(phenylacetyl)-N-(2,6-xylyl)-DL-alanine methyl ester (DE 29 03 612); metalaxyl, N-(methoxyacetyl Base)-N-(2,6-xylyl)-DL-alanine methyl ester (GB 15 00 581); Mefuramide, (RS)-α-(2-chloro-N-2,6- Xylylacetamido)-γ-butyrolactone [CAS RN58810-48-3];
霜灵，N-(2，6-二甲基苯基)-2-甲氧基-N-(2-氧代-3-唑烷基)乙酰胺(GB20 58 059)；Faxyl, N-(2,6-dimethylphenyl)-2-methoxy-N-(2-oxo-3-oxazolidinyl)acetamide (GB20 58 059);
aldimorph，包含65-75％2，6-二甲基吗啉和25-35％2，5-二甲基吗啉的“4-烷基-2，5(或2，6)-二甲基吗啉”，包含超过85％的4-十二烷基-2，5(或2，6)-二甲基吗啉，且其中“烷基”还包括辛基、癸基、十四烷基和十六烷基，以及其中顺/反比为1∶1[CAS RN 91315-15-0]；aldimorph, a "4-alkyl-2,5 (or 2,6)-dimethyl Morpholine", containing more than 85% 4-dodecyl-2,5 (or 2,6)-dimethylmorpholine, and where "alkyl" also includes octyl, decyl, tetradecyl and hexadecyl, and where the cis/trans ratio is 1:1 [CAS RN 91315-15-0];
多果定，1-十二烷基胍乙酸盐(Plant Dis.Rep.第41卷，第1029页(1957))；吗菌灵，4-环十二烷基-2，6-二甲基吗啉(DE-A 1198125)；Docidine, 1-dodecylguanidine acetate (Plant Dis. Rep. Vol. 41, p. 1029 (1957)); Mobendazim, 4-cyclododecyl-2,6-dimethyl Morpholine (DE-A 1198125);
丁苯吗啉，(RS)-顺式-4-[3-(4-叔丁基苯基)-2-甲基丙基]-2，6-二甲基吗啉(DE-A 27 52 096)；Fenpropimorph, (RS)-cis-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine (DE-A 27 52 096);
苯锈啶，(RS)-1-[3-(4-叔丁基苯基)-2-甲基丙基]哌啶(DE-A 27 52 096)；双胍盐，由工业级亚氨基二(八亚甲基)二胺的酰胺化得到的反应产物的混合物，包含各种胍和多胺[CAS RN 108173-90-6]；Fenpropidin, (RS)-1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine (DE-A 27 52 096); Mixtures of reaction products resulting from the amidation of (octamethylene)diamines, containing various guanidines and polyamines [CAS RN 108173-90-6];
双胍辛醋酸盐，1，1′-亚氨基二(八亚甲基)双胍(Congr.Plant Pathol.1.第27页(1968))；Biguanide octyl acetate, 1,1'-iminobis(octamethylene)biguanide (Congr. Plant Pathol. 1. p. 27 (1968));
螺茂胺，(8-叔丁基-1，4-二氧杂螺[4.5]癸-2-基)二乙基胺(EP-A 281 842)；克啉菌，2，6-二甲基-4-十三烷基吗啉(DE-A 11 64 152)；Spirooxamine, (8-tert-butyl-1,4-dioxaspiro[4.5]dec-2-yl)diethylamine (EP-A 281 842); Methyl-4-tridecylmorpholine (DE-A 11 64 152);
二甲嘧菌胺，4，6-二甲基嘧啶-2-基苯基胺(DD-A 151 404)；pyrimethanil, 4,6-dimethylpyrimidin-2-ylphenylamine (DD-A 151 404);
嘧菌胺，(4-甲基-6-丙-1-炔基嘧啶-2-基)苯基胺(EP-A 224 339)；Azoxystrobin, (4-methyl-6-prop-1-ynylpyrimidin-2-yl)phenylamine (EP-A 224 339);
环丙嘧啶，(4-环丙基-6-甲基嘧啶-2-基)苯基胺(EP-A 310 550)；Cyclopyridine, (4-cyclopropyl-6-methylpyrimidin-2-yl)phenylamine (EP-A 310 550);
放线菌酮，4-{(2R)-2-[(1S，3S，5S)-3，5-二甲基-2-氧代环己基]-2-羟基乙基}哌啶-2，6-二酮[CAS RN 66-81-9]；Cycloheximide, 4-{(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2, 6-diketone [CAS RN 66-81-9];
灰黄霉素(griseofulvin)，7-氯-2’，4，6-三甲氧基-6’-甲基螺[苯并呋喃-2(3H)，1’-环己-2’-烯]-3，4’-二酮[CAS RN 126-07-8]；Griseofulvin, 7-chloro-2', 4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H), 1'-cyclohex-2'-ene] -3,4'-dione [CAS RN 126-07-8];
春雷霉素，3-O-[2-氨基-4-[(羧基亚氨基甲基)氨基]-2，3，4，6-四脱氧-α-D-阿拉伯吡喃己糖基]-D-手性肌醇[CAS RN 6980-18-3]；Kasugamycin, 3-O-[2-amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-α-D-arabinohexopyranosyl]-D - Chiral inositol [CAS RN 6980-18-3];
多马霉素，(8E，14E，16E，18E，20E)-(1R，3S，5R，7R，12R，22R，24S，25R，26S)-22-(3-氨基-3，6-二脱氧-β-D-吡喃甘露糖氧基)-1，3，26-三羟基-12-甲基-10-氧代-6，11，28-三氧杂三环[22.3.1.05，7]二十八碳-8，14，16，18，20-五烯-25-甲酸[CASRN 7681-93-8]；Domamycin, (8E, 14E, 16E, 18E, 20E)-(1R, 3S, 5R, 7R, 12R, 22R, 24S, 25R, 26S)-22-(3-amino-3,6-dideoxy -β-D-mannopyranosyloxy)-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[ 22.3.1.05,7 ] Octaca-8,14,16,18,20-pentaene-25-carboxylic acid [CASRN 7681-93-8];
多氧霉素，5-(2-氨基-5-O-氨基甲酰基-2-脱氧-L-木质酰胺基)-1-(5-羧基-1，2，3，4-四氢-2，4-二氧代嘧啶-1-基)-1，5-二脱氧-β-D-呋喃阿洛糖醛酸[CASRN 22976-86-9]；Polyoxin, 5-(2-Amino-5-O-carbamoyl-2-deoxy-L-lignylamido)-1-(5-carboxy-1,2,3,4-tetrahydro-2 , 4-dioxopyrimidin-1-yl)-1,5-dideoxy-β-D-furanoaluronic acid [CASRN 22976-86-9];
链霉素，1，1′-{1-L-(1，3，5/2，4，6)-4-[5-脱氧-2-O-(2-脱氧-2-甲基氨基-α-L-吡喃葡糖基)-3-C-甲酰基-α-L-呋喃来苏糖基氧基]-2，5，6-三羟基亚环己-1，3-基}双胍(J.Am.Chem.Soc.第69卷，第1234页(1947))；Streptomycin, 1,1'-{1-L-(1,3,5/2,4,6)-4-[5-deoxy-2-O-(2-deoxy-2-methylamino- α-L-glucopyranosyl)-3-C-formyl-α-L-lyxofuranosyloxy]-2,5,6-trihydroxycyclohexylene-1,3-yl}biguanide (J. Am. Chem. Soc. Vol. 69, p. 1234 (1947));
双苯三唑醇，β-([1，1’-联苯]-4-基氧基)-α-(1，1-二甲基乙基)-1H-1，2，4-三唑-1-乙醇(DE 23 24 020)；Bisbenzotriazole, β-([1,1'-biphenyl]-4-yloxy)-α-(1,1-dimethylethyl)-1H-1,2,4-triazole -1-Ethanol (DE 23 24 020);
糠菌唑，1-[[4-溴-2-(2，4-二氯苯基)四氢-2-呋喃基]甲基]-1H-[1，2，4]-三唑(Proc.1990 Br.Crop.Prot.Conf.-Pests Dis.第1卷，第459页)；Fuconazole, 1-[[4-bromo-2-(2,4-dichlorophenyl)tetrahydro-2-furyl]methyl]-1H-[1,2,4]-triazole (Proc .1990 Br.Crop.Prot.Conf.-Pests Dis. Vol. 1, p. 459);
环唑醇，2-(4-氯苯基)-3-环丙基-1-[1，2，4]三唑-1-基丁-2-醇(US 4 664 696)；醚唑，1-{2-[2-氯-4-(4-氯苯氧基)苯基]-4-甲基-[1，3]二氧戊环-2-基甲基}-1H-[1，2，4]三唑(GB-A 2 098 607)；Cycloconazole, 2-(4-chlorophenyl)-3-cyclopropyl-1-[1,2,4]triazol-1-ylbutan-2-ol (US 4 664 696); oxetazole , 1-{2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-[1,3]dioxolan-2-ylmethyl}-1H-[ 1,2,4]triazole (GB-A 2 098 607);
烯唑醇，(βE)-β-[(2，4-二氯苯基)亚甲基]-α-(1，1-二甲基乙基)-1H-1，2，4-三唑-1-乙醇(Noyaku Kagaku，1983，第8卷，第575页)；Diniconazole, (βE)-β-[(2,4-dichlorophenyl)methylene]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole -1-Ethanol (Noyaku Kagaku, 1983, Vol. 8, p. 575);
烯菌灵，1-[2-(2，4-二氯苯基)-2-(2-丙烯氧基)乙基]-1H-咪唑(Fruits，1973，第28卷，第545页)；Diphenazim, 1-[2-(2,4-dichlorophenyl)-2-(2-propenyloxy)ethyl]-1H-imidazole (Fruits, 1973, Vol. 28, p. 545);
氧唑菌，(2RS，3SR)-1-[3-(2-氯苯基)-2，3-环氧-2-(4-氟苯基)丙基]-1H-1，2，4-三唑(EP-A 196 038)；Oxaconazole, (2RS, 3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1H-1,2,4 - triazoles (EP-A 196 038);
腈苯唑，α-[2-(4-氯苯基)乙基]-α-苯基-1H-1，2，4-三唑-1-丙腈(Proc.1988 Br.Crop Prot.Conf.-Pests Dis.第1卷，第33页)；Nibazole, α-[2-(4-chlorophenyl)ethyl]-α-phenyl-1H-1,2,4-triazole-1-propionitrile (Proc.1988 Br.Crop Prot.Conf .-Pests Dis. Vol. 1, p. 33);
喹唑菌酮，3-(2，4-二氯苯基)-6-氟-2-[1，2，4]三唑-1-基-3H-喹唑啉-4-酮(Proc.Br.Crop Prot.Conf.-Pests Dis.5-3，411(1992))；Quinaconazole, 3-(2,4-dichlorophenyl)-6-fluoro-2-[1,2,4]triazol-1-yl-3H-quinazolin-4-one (Proc. Br. Crop Prot. Conf.-Pests Dis.5-3, 411(1992));
氟硅唑，1-{[二(4-氟苯基)甲基甲硅烷基]甲基}-1H-[1，2，4]三唑(Proc.Br.Crop Prot.Conf.-Pests Dis.1，413(1 984))；Fluorosilazole, 1-{[bis(4-fluorophenyl)methylsilyl]methyl}-1H-[1,2,4]triazole (Proc.Br.Crop Prot.Conf.-Pests Dis .1,413(1 984));
粉唑醇，α-(2-氟苯基)-α-(4-氟苯基)-1H-1，2，4-三唑-1-乙醇(EP-A 15 756)；己唑醇，2-(2，4-二氯苯基)-1-[1，2，4]三唑-1-基己-2-醇(CAS RN 79983-71-4)；环戊唑醇，2-[(4-氯苯基)甲基]-5-(1-甲基乙基)-1-(1H-1，2，4-三唑-1-基甲基)环戊醇(EP-A 267 778)；Triazolol, α-(2-fluorophenyl)-α-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol (EP-A 15 756); Hexaconazole, 2-(2,4-Dichlorophenyl)-1-[1,2,4]triazol-1-ylhexan-2-ol (CAS RN 79983-71-4); Tebuconazole, 2- [(4-Chlorophenyl)methyl]-5-(1-methylethyl)-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol (EP-A 267 778);
环戊唑菌，5-(4-氯苄基)-2，2-二甲基-1-[1，2，4]三唑-1-基甲基环戊醇(GB 857383)；Meconazole, 5-(4-chlorobenzyl)-2,2-dimethyl-1-[1,2,4]triazol-1-ylmethylcyclopentanol (GB 857383);
腈菌唑，2-(4-氯苯基)-2-[1，2，4]三唑-1-基甲基戊腈(CAS RN 88671-89-0)；戊菌唑，1-[2-(2，4-二氯苯基)戊基]-1H-[1，2，4]三唑(Pesticide Manual，第12版(2000)，第712页)；Myclobutanil, 2-(4-chlorophenyl)-2-[1,2,4]triazol-1-ylmethylvaleronitrile (CAS RN 88671-89-0); Penconazole, 1-[ 2-(2,4-Dichlorophenyl)pentyl]-1H-[1,2,4]triazole (Pesticide Manual, 12th Edition (2000), p. 712);
丙环唑，1-[[2-(2，4-二氯苯基)-4-丙基-1，3-二氧戊环-2-基]甲基]-1H-1，2，4-三唑(BE 835 579)；Propiconazole, 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4 - triazole (BE 835 579);
丙氯灵，N-(丙基-[2-(2，4，6-三氯苯氧基)乙基])咪唑-1-甲酰胺(US 3 991 071)；丙硫菌唑，2-[2-(1-氯环丙基)-3-(2-氯苯基)-2-羟基丙基]-2，4-二氢[1，2，4]三唑-3-硫酮(WO 96/16048)；Prochloraz, N-(propyl-[2-(2,4,6-trichlorophenoxy)ethyl])imidazole-1-carboxamide (US 3 991 071); prothioconazole, 2- [2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro[1,2,4]triazole-3-thione ( WO 96/16048);
硅氟唑，α-(4-氟苯基)-α-(三甲基甲硅烷基)甲基]-1H-1，2，4-三唑-1-乙醇[CAS RN 149508-90-7]，Silfluazole, α-(4-fluorophenyl)-α-(trimethylsilyl)methyl]-1H-1,2,4-triazole-1-ethanol [CAS RN 149508-90-7 ],
戊唑醇，1-(4-氯苯基)-4，4-二甲基-3-[1，2，4]三唑-1-基甲基戊-3-醇(EP-A 40345)；Tebuconazole, 1-(4-chlorophenyl)-4,4-dimethyl-3-[1,2,4]triazol-1-ylmethylpentan-3-ol (EP-A 40345) ;
氟醚唑，1-[2-(2，4-二氯苯基)-3-(1，1，2，2-四氟乙氧基)丙基]-1H-1，2，4-三唑(EP-A 234 242)；Fluetherazole, 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1H-1,2,4-tri Azole (EP-A 234 242);
三唑酮，1-(4-氯苯氧基)-3，3-二甲基-1-(1H-1，2，4-三唑-1-基)-2-丁酮(BE 793867)；Triazolone, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone (BE 793867) ;
唑菌醇，β-(4-氯苯氧基)-α-(1，1-二甲基乙基)-1H-1，2，4-三唑-1-乙醇(DE-A 2324 010)；pyraclostrobin, β-(4-chlorophenoxy)-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol (DE-A 2324 010) ;
氟菌唑，(4-氯-2-三氟甲基苯基)-(2-丙氧基-1-[1，2，4]三唑-1-基亚乙基)胺(JP-A 79/119 462)；Fluconazole, (4-chloro-2-trifluoromethylphenyl)-(2-propoxy-1-[1,2,4]triazol-1-ylethylene)amine (JP-A 79/119 462);
戊叉唑菌，(5E)-5-[(4-氯苯基)亚甲基]-2，2-二甲基-1-(1H-1，2，4-三唑-1-基甲基)环戊醇(FR 26 41 277)；Triconazole, (5E)-5-[(4-chlorophenyl)methylene]-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl base) cyclopentanol (FR 26 41 277);
异丙定，N-异丙基-3-(3，5-二氯苯基)-2，4-二氧代咪唑烷-1-甲酰胺(GB 13 12536)；Isopropyldine, N-isopropyl-3-(3,5-dichlorophenyl)-2,4-dioxoimidazolidine-1-carboxamide (GB 13 12536);
甲菌利，(RS)-3-(3，5-二氯苯基)-5-甲氧基甲基-5-甲基-1，3-唑烷-2，4-二酮[CAS RN 54864-61-8]；Triclozolin, (RS)-3-(3,5-dichlorophenyl)-5-methoxymethyl-5-methyl-1,3-oxazolidine-2,4-dione [CAS RN 54864-61-8];
杀菌利，N-(3，5-二氯苯基)-1，2-二甲基环丙烷-1，2-二甲酰亚胺(US 3 903090)；Cyclopropane, N-(3,5-dichlorophenyl)-1,2-dimethylcyclopropane-1,2-dicarboximide (US 3 903090);
烯菌酮，3-(3，5-二氯苯基)-5-甲基-5-乙烯基唑烷-2，4-二酮(DE-A22 07 576)；Vinyloxazolidine, 3-(3,5-dichlorophenyl)-5-methyl-5-vinyloxazolidine-2,4-dione (DE-A22 07 576);
福美铁，二甲基二硫代氨基甲酸铁(3+)(US 1 972 961)；Ferbam, iron (3+) dimethyldithiocarbamate (US 1 972 961);
代森钠，亚乙基二(二硫代氨基甲酸)二钠(US 2 317 765)；Disen sodium, disodium ethylene bis(dithiocarbamate) (US 2 317 765);
代森锰，亚乙基二(二硫代氨基甲酸)锰(US 2 504 404)；Maneb, manganese ethylene bis(dithiocarbamate) (US 2 504 404);
代森锰锌，亚乙基二(二硫代氨基甲酸)锰聚合物锌盐配合物(GB 996 264)；Mancozeb, ethylene bis(dithiocarbamate) manganese polymer zinc salt complex (GB 996 264);
威百亩，甲基二硫代氨基甲酸(US 2 791 605)；Metabam, methyl dithiocarbamate (US 2 791 605);
代森联，亚乙基二(二硫代氨基甲酸)锌氨合物(US 3 248 400)；Disenlian, ethylene bis(dithiocarbamate) zinc ammonium compound (US 3 248 400);
甲基代森锌，亚丙基二(二硫代氨基甲酸)锌聚合物(BE 611 960)；Zinc methyl, propylene bis(dithiocarbamate) zinc polymer (BE 611 960);
福代锌，二(二甲基二硫代氨基甲酸根合-κS，κS′)[μ-[[1，2-亚乙基二[二硫代氨基甲酸根合-κS，κS′]](2-)]]二[锌][CAS RN 64440-88-6]；Fordai zinc, bis(dimethyldithiocarbamoato-κS,κS′) [μ-[[1,2-ethylenebis[dithiocarbamoato-κS,κS′]] (2-)]] di[zinc][CAS RN 64440-88-6];
福美双，二(二甲基硫代氨基甲酰基)二硫化物(DE-A 642 532)；Thiram, bis(dimethylthiocarbamoyl) disulfide (DE-A 642 532);
福美锌，二甲基二硫代氨基甲酸盐[CAS RN 137-30-4]；Dimethazin, Dimethyldithiocarbamate [CAS RN 137-30-4];
代森锌，亚乙基二(二硫代氨基甲酸)锌(US 2 457 674)；Zinc zinc, ethylene bis(dithiocarbamate) zinc (US 2 457 674);
敌菌灵，4，6-二氯-N-(2-氯苯基)-1，3，5-三嗪-2-胺(US 2 720 480)；Difenazol, 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine (US 2 720 480);
苯菌灵，N-丁基-2-乙酰氨基苯并咪唑-1-甲酰胺(US 3 631 176)；Benomyl, N-butyl-2-acetamidobenzimidazole-1-carboxamide (US 3 631 176);
啶酰菌胺，2-氯-N-(4’-氯联苯-2-基)烟酰胺(EP-A 545 099)；Boscalid, 2-chloro-N-(4’-chlorobiphenyl-2-yl)nicotinamide (EP-A 545 099);
多菌灵，(1H-苯并咪唑-2-基)氨基甲酸甲酯(US 3 657 443)；Carbendazim, methyl (1H-benzimidazol-2-yl)carbamate (US 3 657 443);
萎锈灵，5，6-二氢-2-甲基-N-苯基-1，4-氧硫杂环己二烯-3-甲酰胺(US 3 249499)；Carboxamide, 5,6-dihydro-2-methyl-N-phenyl-1,4-oxathione-3-carboxamide (US 3 249499);
氧化萎锈灵，5，6-二氢-2-甲基-1，4-氧硫杂环己二烯-3-甲酰苯胺4，4-二氧化物(US 3 399 214)；Oxyprofen, 5,6-dihydro-2-methyl-1,4-oxathione-3-carboxanilide 4,4-dioxide (US 3 399 214);
氰霜唑，4-氯-2-氰基-N，N-二甲基-5-(4-甲基苯基)-1H-咪唑-1-磺酰胺(CASRN 120116-88-3)；Cyazofamid, 4-chloro-2-cyano-N,N-dimethyl-5-(4-methylphenyl)-1H-imidazole-1-sulfonamide (CASRN 120116-88-3);
棉隆，3，5-二甲基-1，3，5-噻二嗪-2-硫酮(Bull.Soc.Chim.Fr.第15卷，第891页(1897))；Dimenon, 3,5-dimethyl-1,3,5-thiadiazine-2-thione (Bull. Soc. Chim. Fr. Vol. 15, p. 891 (1897));
二氟吡隆(diflufenzopyr)，2-{1-[4-(3，5-二氟苯基)脲亚氨基]乙基}烟酸[CASRN 109293-97-2]；Diflufenzopyr, 2-{1-[4-(3,5-difluorophenyl)ureidimino]ethyl}nicotinic acid [CASRN 109293-97-2];
二噻农，5，10-二氧代-5，10-二氢萘并[2，3-b][1，4]二噻英-2，3-二甲腈(GB857 383)；Dithianon, 5,10-dioxo-5,10-dihydronaphtho[2,3-b][1,4]dithian-2,3-dicarbonitrile (GB857 383);
唑酮菌，(RS)-3-苯胺基-5-甲基-5-(4-苯氧基苯基)-1，3-唑烷-2，4-二酮[CAS RN 131807-57-3]；oxazolidine-2,4-dione [CAS RN 131807- 57-3];
咪唑菌酮，(S)-1-苯胺基-4-甲基-2-甲硫基-4-苯基咪唑啉-5-酮[CAS RN161326-34-7]；imidazolidinone, (S)-1-anilino-4-methyl-2-methylthio-4-phenylimidazolidin-5-one [CAS RN161326-34-7];
异嘧菌醇，α-(2-氯苯基)-αt-(4-氯苯基)-5-嘧啶甲醇(GB 12 18 623)；麦穗宁，2-(2-呋喃基)-1H-苯并咪唑(DE-A 12 09 799)；Isomethystrobin, α-(2-chlorophenyl)-αt-(4-chlorophenyl)-5-pyrimidinemethanol (GB 12 18 623); Maisuining, 2-(2-furyl)-1H - benzimidazole (DE-A 12 09 799);
氟酰胺，α，α，α-三氟-3’-异丙氧基-邻甲苯甲酰苯胺(JP 1104514)；Fluoramide, α, α, α-trifluoro-3'-isopropoxy-o-toluanilide (JP 1104514);
呋吡唑灵，5-氯-N-(1，3-二氢-1，1，3-三甲基-4-异苯并呋喃基)-1，3-二甲基-1H-吡唑-4-甲酰胺[CAS RN 1 23572-88-3]；Furapazolin, 5-chloro-N-(1,3-dihydro-1,1,3-trimethyl-4-isobenzofuryl)-1,3-dimethyl-1H-pyrazole -4-Carboxamide [CAS RN 1 23572-88-3];
稻瘟灵，1，3-亚二硫戊环-2-基丙二酸二异丙基酯(Proc.Insectic.Fungic.Conf.8.第2卷，第715页(1975))；Insectic. Fungic. Conf. 8. Vol. 2, p. 715 (1975));
丙氧灭绣胺，3’-异丙氧基-邻甲苯甲酰苯胺(US 3 937 840)；氟苯嘧啶醇，α-(2-氯苯基)-αt-(4-氟苯基)-5-嘧啶甲醇(GB 12 18 623)；氟吡菌胺，2，6-二氯-N-(3-氯-5-三氟甲基吡啶-2-基甲基)苯甲酰胺(WO99/42447)；Propoxypyridine, 3'-isopropoxy-o-toluanilide (US 3 937 840); Fluoropyrimol, α-(2-chlorophenyl)-αt-(4-fluorophenyl) -5-pyrimidinemethanol (GB 12 18 623); fluopicolide, 2,6-dichloro-N-(3-chloro-5-trifluoromethylpyridin-2-ylmethyl)benzamide (WO99 /42447);
噻菌灵，3-烯丙氧基-1，2-苯并噻唑1，1-二氧化物(Agric.Biol.Chem.第37卷，第737页(1973))；Thiabendazole, 3-allyloxy-1,2-benzothiazole 1,1-dioxide (Agric. Biol. Chem. Vol. 37, p. 737 (1973));
丙氧喹啉，6-碘-2-丙氧基-3-丙基喹唑啉-4(3H)-酮(WO 97/48684)；Propoxyquinoline, 6-iodo-2-propoxy-3-propylquinazolin-4(3H)-one (WO 97/48684);
啶斑肟，2’，4’-二氯-2-(3-吡啶基)苯乙酮(EZ)-O-甲基肟(EP 49 854)；Pyridoxine, 2',4'-dichloro-2-(3-pyridyl)acetophenone (EZ)-O-methyloxime (EP 49 854);
咯喹酮，1，2，5，6-四氢吡咯并[3，2，1-ij]喹啉-4-酮(GB 139 43 373)；Proxoquinone, 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one (GB 139 43 373);
喹氧灵，5，7-二氯-4-(4-氟苯氧基)喹啉(US 5 240 940)；Quinoaline, 5,7-dichloro-4-(4-fluorophenoxy)quinoline (US 5 240 940);
硅噻菌胺，N-烯丙基-4，5-二甲基-2-(三甲基甲硅烷基)噻吩-3-甲酰胺[CAS RN175217-20-6]；Sithiopyram, N-allyl-4,5-dimethyl-2-(trimethylsilyl)thiophene-3-carboxamide [CAS RN175217-20-6];
涕必灵，2-(1，3-噻唑-4-基)苯并咪唑(US 3 017 415)；Albiline, 2-(1,3-thiazol-4-yl)benzimidazole (US 3 017 415);
溴氟唑菌，2’，6’-二溴-2-甲基-4’-三氟甲氧基-4-三氟甲基-1，3-噻唑-5-甲酰苯胺[CAS RN 130000-40-7]；Bromidazole, 2',6'-dibromo-2-methyl-4'-trifluoromethoxy-4-trifluoromethyl-1,3-thiazole-5-carboxanilide [CAS RN 130000 -40-7];
甲基托布津，1，2-亚苯基二(亚氨基硫代羰基)二(二甲基氨基甲酸酯)(DE-A 1930 540)；Thioprazine-methyl, 1,2-phenylene bis(iminothiocarbonyl) bis(dimethylcarbamate) (DE-A 1930 540);
噻酰菌胺，3’-氯-4，4’-二甲基-1，2，3-噻二唑-5-甲酰苯胺[CAS RN223580-51-6]；Thianodil, 3'-chloro-4,4'-dimethyl-1,2,3-thiadiazole-5-carboxanilide [CAS RN223580-51-6];
三环唑，5-甲基-1，2，4-三唑并[3，4-b][1，3]苯并噻唑[CAS RN 41814-78-2]；嗪氨灵，N，N’-{哌嗪-1，4-二基二[(三氯甲基)亚甲基]}二甲酰胺(DE-A 19 01421)；Tricyclazole, 5-methyl-1,2,4-triazolo[3,4-b][1,3]benzothiazole[CAS RN 41814-78-2]; '-{piperazine-1,4-diylbis[(trichloromethyl)methylene]}dicarboxamide (DE-A 19 01421);
5-氯-7-(4-甲基哌啶-1-基)-6-(2，4，6-三氟苯基)-[1，2，4]三唑并[1，5-a]嘧啶(WO98/46607)；5-Chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a ]pyrimidine (WO98/46607);
波尔多液，CuSO4×3Cu(OH)2×3CaSO4的混合物[CAS RN 8011-63-0]；Bordeaux mixture, mixture of CuSO 4 ×3Cu(OH) 2 ×3CaSO 4 [CAS RN 8011-63-0];
醋酸铜，Cu(OCOCH3)2[CAS RN 8011-63-0]；Copper acetate, Cu(OCOCH 3 ) 2 [CAS RN 8011-63-0];
王铜，Cu2Cl(OH)3[CAS RN 1332-40-7]；King Copper, Cu 2 Cl(OH) 3 [CAS RN 1332-40-7];
碱式硫酸铜，CuSO4[CAS RN 1344-73-6]；Basic copper sulfate, CuSO 4 [CAS RN 1344-73-6];
乐杀螨，3-甲基巴豆酸(RS)-2-仲丁基-4，6-二硝基苯基酯[CAS RN 485-31-4]；敌螨普，巴豆酸2，6-二硝基-4-辛基苯基酯和巴豆酸2，4-二硝基-6-辛基苯基酯的混合物，其中“辛基”为1-甲基庚基、1-乙基己基和1-丙基戊基的混合物(US 2 526 660)；Lexa, 3-methylcrotonate (RS)-2-sec-butyl-4,6-dinitrophenyl ester [CAS RN 485-31-4]; Mixture of dinitro-4-octylphenyl ester and 2,4-dinitro-6-octylphenyl crotonic acid ester, where "octyl" is 1-methylheptyl, 1-ethylhexyl Mixture with 1-propylpentyl (US 2 526 660);
敌螨通，碳酸(RS)-2-仲丁基-4，6-二硝基苯基·异丙基酯[CAS RN 973-21-7]；异丙消(nitrothal-isopropyl)，5-硝基间苯二甲酸二异丙基酯(Proc.Br.Insectic.Fungic.Conf.7.第2卷，第673页(1973))；拌种咯，4-(2，3-二氯苯基)-1H-吡咯-3-甲腈(Proc.1988 Br.Crop Prot.Conf.-Pests Dis.第1卷，第65页)；Didifen, carbonic acid (RS)-2-sec-butyl-4,6-dinitrophenyl·isopropyl ester [CAS RN 973-21-7]; nitrothal-isopropyl, 5- Diisopropyl nitroisophthalate (Proc.Br.Insectic.Fungic.Conf.7. Vol. 2, p. 673 (1973)); seed dressing, 4-(2,3-dichlorobenzene Base)-1H-pyrrole-3-carbonitrile (Proc.1988 Br.Crop Prot.Conf.-Pests Dis. Volume 1, page 65);
氟菌，4-(2，2-二氟苯并[1，3]二氧杂环戊烯-4-基)-1H-吡咯-3-甲腈(ThePesticide Manual，publ.The British Crop Protection Council，第10版，1995，第482页)；Fluoxetin, 4-(2,2-difluorobenzo[1,3]dioxol-4-yl)-1H-pyrrole-3-carbonitrile (The Pesticide Manual, publ. The British Crop Protection Council, 10th Edition, 1995, p. 482);
噻二唑素，1，2，3-苯并噻二唑-7-硫代羰酸甲基酯[CAS RN 135158-54-2]；苯噻菌胺(benthiavalicarb)，{(S)-1-[(1R)-1-(6-氟苯并噻唑-2-基)乙基氨基甲酰基]-2-甲基丙基}氨基甲酸异丙酯(JP-A 09/323 984)；Thiadiazoline, methyl 1,2,3-benzothiadiazole-7-thiocarboate [CAS RN 135158-54-2]; benthiavalicarb, {(S)-1 -[(1R)-1-(6-fluorobenzothiazol-2-yl)ethylcarbamoyl]-2-methylpropyl}carbamate isopropyl ester (JP-A 09/323 984);
氯环丙酰胺，2，2-二氯-N-[1-(4-氯苯基)乙基]-1-乙基-3-甲基环丙烷甲酰胺[CAS RN 104030-54-8]；Chlorocyclopropanamide, 2,2-Dichloro-N-[1-(4-chlorophenyl)ethyl]-1-ethyl-3-methylcyclopropanecarboxamide [CAS RN 104030-54-8] ;
百菌清，2，4，5，6-四氯间苯二甲腈(US 3 290 353)；Chlorothalonil, 2,4,5,6-tetrachloroisophthalonitrile (US 3 290 353);
环氟菌胺，(Z)-N-[α-(环丙基甲氧基亚氨基)-2，3-二氟-6-(三氟甲基)苄基]-2-苯基乙酰胺(WO 96/19442)；Cyflufenamide, (Z)-N-[α-(cyclopropylmethoxyimino)-2,3-difluoro-6-(trifluoromethyl)benzyl]-2-phenylacetamide (WO 96/19442);
清菌脲，1-(2-氰基-2-甲氧基亚氨基乙酰基)-3-乙基脲(US 3 957 847)；Chalprodione, 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea (US 3 957 847);
哒菌清，6-(3，5-二氯苯基对甲苯基)哒嗪-3(2H)-酮(US 4 052 395)；Pyridazinil, 6-(3,5-dichlorophenyl-p-tolyl)pyridazin-3(2H)-one (US 4 052 395);
双氯氰菌胺，(RS)-2-氰基-N-[(R)-1-(2，4-二氯苯基)乙基]-3，3-二甲基丁酰胺[CAS RN 139920-32-4]；Diclofenac, (RS)-2-cyano-N-[(R)-1-(2,4-dichlorophenyl)ethyl]-3,3-dimethylbutanamide [CAS RN 139920-32-4];
乙霉威，3，4-二乙氧基苯胺基甲酸异丙基酯(EP-A 78 663)；Dimethocarb, isopropyl 3,4-diethoxyaniscarbamate (EP-A 78 663);
克瘟散，二硫代磷酸O-乙基S，S-二苯基酯(DE-A 14 93 736)；Kewensan, O-ethyl S, S-diphenyl dithiophosphate (DE-A 14 93 736);
噻唑菌胺，N-(氰基-2-噻吩基甲基)-4-乙基-2-(乙氨基)-5-噻唑甲酰胺(EP-A639 574)；Ethaboxam, N-(cyano-2-thienylmethyl)-4-ethyl-2-(ethylamino)-5-thiazolecarboxamide (EP-A639 574);
环酰菌胺，N-(2，3-二氯-4-羟基苯基)-1-甲基环己烷甲酰胺(Proc.Br.CropProt.Conf.-Pests Dis.1998，第2卷，第327页)；Fenhexamid, N-(2,3-Dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide (Proc.Br.CropProt.Conf.-Pests Dis.1998, Vol. 2, page 327);
薯瘟锡，三苯基锡(US 3 499 086)；Potato tin, triphenyltin (US 3 499 086);
氰菌胺，N-(1-氰基-1，2-二甲基丙基)-2-(2，4-二氯苯氧基)丙酰胺(EP-A262 393)；Cyanoxil, N-(1-cyano-1,2-dimethylpropyl)-2-(2,4-dichlorophenoxy)propionamide (EP-A262 393);
嘧菌腙，(Z)-2’-甲基苯乙酮-4，6-二甲基嘧啶-2-基腙[CAS RN 89269-64-7]；Pyrimidin-2-ylhydrazone, (Z)-2'-methylacetophenone-4,6-dimethylpyrimidin-2-ylhydrazone [CAS RN 89269-64-7];
氟啶胺，3-氯-N-[3-氯-2，6-二硝基-4-(三氟甲基)苯基]-5-(三氟甲基)-2-吡啶胺(The Pesticide Manual，publ.The British Crop Protection Council，第10版(1995)，第474页)；Fluazinamine, 3-chloro-N-[3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2-pyridinamine (The Pesticide Manual, publ. The British Crop Protection Council, 10th Edition (1995), p. 474);
藻菌磷，乙磷铝，膦酸乙酯(FR 22 54 276)；Phytophos, phosphonate, ethyl phosphonate (FR 22 54 276);
异丙菌胺，[(1S)-2-甲基-1-(1-对甲苯基乙基氨基甲酰基)丙基]氨基甲酸异丙酯(EP-A 472 996)；Promethamid, isopropyl [(1S)-2-methyl-1-(1-p-tolylethylcarbamoyl)propyl]carbamate (EP-A 472 996);
六氯苯(C.R.Seances Acad.Agric.Fr.第31卷，第24页(1945))；Hexachlorobenzene (C.R. Seances Acad. Agric. Fr. Vol. 31, p. 24 (1945));
双炔酰菌胺，(RS)-2-(4-氯苯基)-N-[3-甲氧基-4-(丙-2-炔基氧基)苯乙基]-2-(丙-2-炔基氧基)乙酰胺(WO 03/042166)；Mandipropamid, (RS)-2-(4-chlorophenyl)-N-[3-methoxy-4-(prop-2-ynyloxy)phenethyl]-2-(prop -2-alkynyloxy)acetamide (WO 03/042166);
苯菌酮，3’-溴-2，3，4，6’-四甲氧基-2’，6-二甲基苯乙酮(US 5 945 567)；戊菌隆，1-(4-氯苄基)-1-环戊基-3-苯基脲(DE-A 27 32 257)；Metrafenone, 3'-bromo-2,3,4,6'-tetramethoxy-2',6-dimethylacetophenone (US 5 945 567); Penburone, 1-(4- Chlorobenzyl)-1-cyclopentyl-3-phenylurea (DE-A 27 32 257);
吡噻菌胺，(RS)-N-[2-(1，3-二甲基丁基)-3-噻吩基]-1-甲基-3-(三氟甲基)-1H-吡唑-4-甲酰胺(JP 10/130268)；Penthiopyrad, (RS)-N-[2-(1,3-Dimethylbutyl)-3-thienyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole -4-formamide (JP 10/130268);
百维灵，3-(二甲氨基)丙基氨基甲酸丙酯(DE-A 15 67 169)；Propylamine, Propyl 3-(Dimethylamino)propylcarbamate (DE-A 15 67 169);
四氯苯酞(DE-A 16 43 347)；Tetrachlorophthalide (DE-A 16 43 347);
甲基立枯磷，硫代磷酸O-2，6-二氯对甲苯基O，O-二甲基酯(GB 14 67 561)；Tolclofos-methyl, O-2,6-dichloro-p-tolyl O, O-dimethyl phosphorothioate (GB 14 67 561);
五氯硝基苯，五氯硝基苯(DE-A 682 048)；Pentachloronitrobenzene, Pentachloronitrobenzene (DE-A 682 048);
苯酰菌胺，(RS)-3，5-二氯-N-(3-氯-1-乙基-1-甲基-2-氧代丙基)-对甲苯甲酰胺[CAS RN 156052-68-5]；Benhexamid, (RS)-3,5-dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-p-toluamide [CAS RN 156052- 68-5];
敌菌丹，N-(1，1，2，2-四氯乙硫基)环己-4-烯-1，2-二甲酰亚胺(Phytopathology，第52卷，第754页(1962))；Captafol, N-(1,1,2,2-tetrachloroethylthio)cyclohex-4-ene-1,2-dicarboximide (Phytopathology, Vol. 52, p. 754 (1962) );
克菌丹，N-(三氯甲硫基)环己-4-烯-1，2-二甲酰亚胺(US 2 553 770)；抑菌灵，N-二氯一氟甲硫基-N’，N’-二甲基-N-苯基磺酰胺(DE-A 11 93 498)；Captan, N-(trichloromethylthio)cyclohex-4-ene-1,2-dicarboximide (US 2 553 770); N', N'-dimethyl-N-phenylsulfonamide (DE-A 11 93 498);
灭菌丹，N-(三氯甲硫基)邻苯二甲酰亚胺(US 2 553 770)；Folpet, N-(trichloromethylthio)phthalimide (US 2 553 770);
对甲抑菌灵，N-二氯一氟甲硫基-N’，N’-二甲基-N-对甲苯基磺酰胺(DE-A11 93 498)；Tolyzam, N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfonamide (DE-A11 93 498);
烯酰吗啉，3-(4-氯苯基)-3-(3，4-二甲氧基苯基)-1-吗啉-4-基丙烯酮(EP-A 120321)；Dimethomorph, 3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-morpholin-4-ylpropenone (EP-A 120321);
氟联苯菌，2-(3，4-二甲氧基苯基)-N-乙基-α，α，α-三氟-N-甲基对甲苯甲酰胺[AGROW no.243，22(1995)]；Fluorobiphenyl, 2-(3,4-dimethoxyphenyl)-N-ethyl-α,α,α-trifluoro-N-methyl-p-toluamide [AGROW no.243, 22( 1995)];
氟吗啉，3-(4-氟苯基)-3-(3，4-二甲氧基苯基)-1-吗啉-4-基丙烯酮(EP-A 860438)；Flumorpholine, 3-(4-fluorophenyl)-3-(3,4-dimethoxyphenyl)-1-morpholin-4-ylpropenone (EP-A 860438);
N-(4’-溴联苯-2-基)-4-二氟甲基-2-甲基噻唑-5-甲酰胺、N-(4’-三氟甲基联苯-2-基)-4-二氟甲基-2-甲基噻唑-5-甲酰胺、N-(4’-氯-3’-氟联苯-2-基)-4-二氟甲基-2-甲基噻唑-5-甲酰胺、N-(3’，4’-二氯-4-氟联苯-2-基)-3-二氟甲基-1-甲基吡唑-4-甲酰胺(WO 03/66610)，N-(4'-bromobiphenyl-2-yl)-4-difluoromethyl-2-methylthiazole-5-carboxamide, N-(4'-trifluoromethylbiphenyl-2-yl) -4-Difluoromethyl-2-methylthiazole-5-carboxamide, N-(4'-chloro-3'-fluorobiphenyl-2-yl)-4-difluoromethyl-2-methyl Thiazole-5-carboxamide, N-(3',4'-dichloro-4-fluorobiphenyl-2-yl)-3-difluoromethyl-1-methylpyrazole-4-carboxamide (WO 03/66610),
N-(2-氰基苯基)-3，4-二氯异噻唑-5-甲酰胺(WO 99/24413)；N-(2-cyanophenyl)-3,4-dichloroisothiazole-5-carboxamide (WO 99/24413);
N-(2-(4-[3-(4-氯苯基)丙-2-炔基氧基]-3-甲氧基苯基)乙基)-2-甲磺酰氨基-3-甲基丁酰胺、N-(2-(4-[3-(4-氯苯基)丙-2-炔基氧基]-3-甲氧基苯基)乙基)-2-乙磺酰氨基-3-甲基丁酰胺(WO 04/49804)；N-(2-(4-[3-(4-chlorophenyl)prop-2-ynyloxy]-3-methoxyphenyl)ethyl)-2-methanesulfonylamino-3-methyl N-(2-(4-[3-(4-chlorophenyl)prop-2-ynyloxy]-3-methoxyphenyl)ethyl)-2-ethanesulfonylamino - 3-methylbutanamide (WO 04/49804);
3-[5-(4-氯苯基)-2，3-二甲基异唑烷-3-基]吡啶(EP-A 10 35 122)；3-[5-(4-chlorophenyl)-2,3-dimethylisoxazolidin-3-yl]pyridine (EP-A 10 35 122);
2-丁氧基-6-碘-3-丙基苯并吡喃-4-酮(WO 03/14103)；2-butoxy-6-iodo-3-propylbenzopyran-4-one (WO 03/14103);
N，N-二甲基-3-(3-溴-6-氟-2-甲基吲哚-1-磺酰基)-[1，2，4]三唑-1-磺酰胺(EP-A10 31 571)；N,N-Dimethyl-3-(3-bromo-6-fluoro-2-methylindole-1-sulfonyl)-[1,2,4]triazole-1-sulfonamide (EP-A10 31 571);
(2-氯-5-[1-(3-甲基苄氧基亚氨基)乙基]苄基)氨基甲酸甲酯，(2-氯-5-[1-(6-甲基吡啶-2-基甲氧基亚氨基)乙基]苄基)氨基甲酸甲酯(EP-A 12 01 648)；Methyl (2-chloro-5-[1-(3-methylbenzyloxyimino)ethyl]benzyl)carbamate, (2-chloro-5-[1-(6-methylpyridine-2 -ylmethoxyimino)ethyl]benzyl)methyl carbamate (EP-A 12 01 648);
3-(4-氯苯基)-3-(2-异丙氧羰基氨基-3-甲基丁酰氨基)丙酸甲酯(EP-A 10 28125)；Methyl 3-(4-chlorophenyl)-3-(2-isopropoxycarbonylamino-3-methylbutyrylamino)propionate (EP-A 10 28125);
腈嘧菌酯，2-{2-[6-(2-氰基-1-乙烯基戊-1，3-二烯氧基)嘧啶-4-基氧基]苯基}-3-甲氧基丙烯酸甲酯(EP-A 382 375)，Azoxystrobin, 2-{2-[6-(2-cyano-1-vinylpenta-1,3-dienyloxy)pyrimidin-4-yloxy]phenyl}-3-methoxy Methyl acrylate (EP-A 382 375),
醚菌胺，(E)-2-(甲氧基亚氨基)-N-甲基-2-[α-(2，5-二甲苯氧基)-邻甲苯基]乙酰胺(EP-A 477 631)；Kresastrobin, (E)-2-(methoxyimino)-N-methyl-2-[α-(2,5-dimethylphenoxy)-o-tolyl]acetamide (EP-A 477 631);
氟嘧菌酯，(E)-{2-[6-(2-氯苯氧基)-5-氟嘧啶-4-基氧基]苯基}(5，6-二氢-1，4，2-二嗪-3-基)甲酮O-甲基肟(WO 97/27189)；Fluoxastrobin, (E)-{2-[6-(2-chlorophenoxy)-5-fluoropyrimidin-4-yloxy]phenyl}(5,6-dihydro-1,4, 2-dioxazin-3-yl)methanone O-methyloxime (WO 97/27189);
亚胺菌，(E)-甲氧基亚氨基[α-(邻甲苯氧基)-邻甲苯基]乙酸甲酯(EP-A 253213)；Iminobacterium, methyl (E)-methoxyimino[α-(o-tolyloxy)-o-tolyl]acetate (EP-A 253213);
叉氨苯酰胺，(E)-2-(甲氧基亚氨基)-N-甲基-2-(2-苯氧基苯基)乙酰胺(EP-A398 692)；Pyrenamide, (E)-2-(methoxyimino)-N-methyl-2-(2-phenoxyphenyl)acetamide (EP-A398 692);
肟醚菌胺，(2E)-2-(甲氧基亚氨基)-2-{2-[(3E，5E，6E)-5-(甲氧基亚氨基)-4，6-二甲基-2，8-二氧杂-3，7-二氮杂壬-3，6-二烯-1-基]苯基}-N-甲基乙酰胺(WO97/15552)；Orysastrobin, (2E)-2-(methoxyimino)-2-{2-[(3E,5E,6E)-5-(methoxyimino)-4,6-dimethyl -2,8-dioxa-3,7-diazanon-3,6-dien-1-yl]phenyl}-N-methylacetamide (WO97/15552);
啶氧菌酯，3-甲氧基-2-[2-(6-三氟甲基吡啶-2-基氧基甲基)苯基]丙烯酸甲酯(EP-A 278 595)；Picoxystrobin, methyl 3-methoxy-2-[2-(6-trifluoromethylpyridin-2-yloxymethyl)phenyl]acrylate (EP-A 278 595);
唑菌胺酯，N-{2-[1-(4-氯苯基)-1H-吡唑-3-基氧基甲基]苯基}(N-甲氧基)氨基甲酸甲酯(WO 96/01256)；Pyraclostrobin, methyl N-{2-[1-(4-chlorophenyl)-1H-pyrazol-3-yloxymethyl]phenyl}(N-methoxy)carbamate (WO 96/01256);
肟菌酯，(E)-甲氧基亚氨基-{(E)-α-[1-(α，α，α-三氟-间甲苯基)亚乙基氨基氧基]-邻甲苯基}乙酸甲酯(EP-A 460 575)；Trifloxystrobin, (E)-methoxyimino-{(E)-α-[1-(α,α,α-trifluoro-m-tolyl)ethylideneaminooxy]-o-tolyl} Methyl acetate (EP-A 460 575);
2-[邻-(2，5-二甲基苯氧基亚甲基)苯基]-3-甲氧基丙烯酸甲酯(EP-A 226917)；Methyl 2-[o-(2,5-dimethylphenoxymethylene)phenyl]-3-methoxyacrylate (EP-A 226917);
5-氯-7-(4-甲基哌啶-1-基)-6-(2，4，6-三氟苯基)-[1，2，4]三唑并[1，5-a]嘧啶(WO98/46608)；5-Chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a ]pyrimidine (WO98/46608);
3，4-二氯-N-(2-氰基苯基)异噻唑-5-甲酰胺(WO 99/24413)；3,4-Dichloro-N-(2-cyanophenyl)isothiazole-5-carboxamide (WO 99/24413);
式III化合物(WO 04/049804)；Compound of formula III (WO 04/049804);
N-(2-(4-[3-(4-氯苯基)丙-2-炔基氧基]-3-甲氧基苯基)乙基)-2-甲磺酰氨基-3-甲基丁酰胺和N-(2-(4-[3-(4-氯苯基)丙-2-炔基氧基]-3-甲氧基苯基)乙基)-2-乙磺酰氨基-3-甲基丁酰胺(WO 03/66609)；N-(2-(4-[3-(4-chlorophenyl)prop-2-ynyloxy]-3-methoxyphenyl)ethyl)-2-methanesulfonylamino-3-methyl ylbutanamide and N-(2-(4-[3-(4-chlorophenyl)prop-2-ynyloxy]-3-methoxyphenyl)ethyl)-2-ethanesulfonylamino - 3-methylbutanamide (WO 03/66609);
式IV的2-丁氧基-6-碘-3-丙基苯并吡喃-4-酮(WO 03/14103)；2-butoxy-6-iodo-3-propylbenzopyran-4-one of formula IV (WO 03/14103);
式V的N，N-二甲基-3-(3-溴-6-氟-2-甲基吲哚-1-磺酰基)-[1，2，4]三唑-1-磺酰胺(WO 03/053145)；N, N-dimethyl-3-(3-bromo-6-fluoro-2-methylindole-1-sulfonyl)-[1,2,4]triazole-1-sulfonamide ( WO 03/053145);
式VI的3-(4-氯苯基)-3-(2-异丙氧羰基氨基-3-甲基丁酰氨基)丙酸甲酯(EP-A 1028125)。Methyl 3-(4-chlorophenyl)-3-(2-isopropoxycarbonylamino-3-methylbutyrylamino)propionate of formula VI (EP-A 1028125).
为了降低活性化合物I和II的施用率并拓宽其活性谱，本发明的目的是提供在活性化合物的总施用量降低下对有害真菌，尤其是对于某些适应症具有改进活性的混合物。In order to reduce the application rate of active compounds I and II and to broaden their spectrum of activity, it was an object of the present invention to provide mixtures with improved activity against harmful fungi, especially for certain indications, at reduced total application rates of active compounds.
我们相应地发现了开头所定义的活性化合物I和II的混合物。此外，我们发现与单一化合物相比，同时，即一起或分开施用至少化合物I和至少一种活性化合物II或依次施用化合物I和至少一种活性化合物II可以更好地防治有害真菌(协同增效混合物)。We have accordingly found mixtures of the active compounds I and II defined at the outset. Furthermore, we found that simultaneous, i.e. together or separately, application of at least compound I and at least one active compound II or sequential application of compound I and at least one active compound II results in better control of harmful fungi compared to single compounds (synergistic mixture).
化合物I可以用作大量不同杀真菌活性化合物的协同增效剂。同时，即一起或分开施用化合物I和至少一种活性化合物II超和地提高了杀真菌活性。The compounds I can be used as synergists for a large number of different fungicidally active compounds. Simultaneous, ie together or separately, application of compound I and at least one active compound II super mildly increases the fungicidal activity.
化合物I可以各种晶型存在，其生物活性可能不同。Compound I can exist in various crystal forms, which may have different biological activities.
在式I中，卤素为氟、氯、溴或碘，优选氟或氯。In formula I, halogen is fluorine, chlorine, bromine or iodine, preferably fluorine or chlorine.
C1-C4烷基为甲基、乙基、正丙基、1-甲基乙基、正丁基、1-甲基丙基、2-甲基丙基或1，1-二甲基乙基，优选甲基或乙基。C 1 -C 4 Alkyl is methyl, ethyl, n-propyl, 1-methylethyl, n-butyl, 1-methylpropyl, 2-methylpropyl or 1,1-dimethyl Ethyl, preferably methyl or ethyl.
C1-C6烷基为上述C1-C4烷基，或者为正戊基、1-甲基丁基、2-甲基丁基、3-甲基丁基、2，2-二甲基丙基、1-乙基丙基、正己基、1，1-二甲基丙基、1，2-二甲基丙基、1-甲基戊基、2-甲基戊基、3-甲基戊基、4-甲基戊基、1，1-二甲基丁基、1，2-二甲基丁基、1，3-二甲基丁基、2，2-二甲基丁基、2，3-二甲基丁基、3，3-二甲基丁基、1-乙基丁基、2-乙基丁基、1，1，2-三甲基丙基、1，2，2-三甲基丙基、1-乙基-1-甲基丙基和1-乙基-2-甲基丙基；优选上述C1-C4烷基。C 1 -C 6 alkyl is the above C 1 -C 4 alkyl, or n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethyl propyl, 1-ethylpropyl, n-hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3- Methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl Base, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1, 2,2-Trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl; preferably the aforementioned C 1 -C 4 alkyl groups.
C1-C4卤代烷基是部分或完全卤代的C1-C4烷基，其中卤原子尤其为氟、氯和/或溴，即例如氯甲基、溴甲基、二氯甲基、三氯甲基、氟甲基、二氟甲基、三氟甲基、氯氟甲基、二氯一氟甲基、一氯二氟甲基、1-氯乙基、1-溴乙基、1-氟乙基、2-氟乙基、2，2-二氟乙基、2，2，2-三氟乙基、2-氯-2-氟乙基、2-氯-2，2-二氟乙基、2，2-二氯-2-氟乙基、2，2，2-三氯乙基、五氟乙基、七氟丙基或九氟丁基，尤其是卤代甲基，特别优选CH2-Cl、CH(Cl)2、CH2-F、CH(F)2、CF3、CHFCl、CF2Cl或CF(Cl)2，尤其是二氟甲基和三氟甲基。C 1 -C 4 haloalkyl is partially or fully halogenated C 1 -C 4 alkyl, wherein the halogen atoms are especially fluorine, chlorine and/or bromine, i.e. for example chloromethyl, bromomethyl, dichloromethyl, Trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2- Difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, heptafluoropropyl or nonafluorobutyl, especially halomethyl , particularly preferably CH2 -Cl, CH(Cl) 2 , CH2 -F, CH(F) 2 , CF3 , CHFCl, CF2Cl or CF(Cl) 2 , especially difluoromethyl and trifluoromethyl base.
C1-C6卤代烷基为部分或完全卤代的C1-C6烷基，其中卤原子尤其为氟、氯和/或溴，即例如上述C1-C4卤代烷基，或者为5-氟戊基、5-氯戊基、5-溴戊基、5-碘戊基、5，5，5-三氯戊基、十一氟戊基、6-氟己基、6-氯己基、6-溴己基、6-碘己基、6，6，6-三氯己基或十二氟己基；优选C1-C4卤代烷基。C 1 -C 6 haloalkyl is partially or fully halogenated C 1 -C 6 alkyl, wherein the halogen atoms are especially fluorine, chlorine and/or bromine, i.e. for example the above C 1 -C 4 haloalkyl, or 5- Fluoropentyl, 5-chloropentyl, 5-bromopentyl, 5-iodopentyl, 5,5,5-trichloropentyl, undecafluoropentyl, 6-fluorohexyl, 6-chlorohexyl, 6 - bromohexyl, 6-iodohexyl, 6,6,6-trichlorohexyl or dodecafluorohexyl; preferably C 1 -C 4 haloalkyl.
其中X为氧的式I的3，5-二取代的N-联苯基吡唑甲酰胺例如由WO2005/123689、WO 2005/123690和在先的德国申请第102005007160.0号已知，或者它们可以由其中所述方法制备。3,5-disubstituted N-biphenylpyrazole carboxamides of the formula I in which X is oxygen are known, for example, from WO 2005/123689, WO 2005/123690 and earlier German application No. 102005007160.0, or they can be obtained from Prepared by the method described therein.
其中X为硫的化合物I例如可以通过硫化其中X为氧的对应化合物I而制备(例如参见D.Petrova&K.Jakobcic，Croat.Chem.Acta 48，49(1976)以及WO 01/42223)。Compounds I in which X is sulfur can for example be prepared by sulfiding the corresponding compounds I in which X is oxygen (see eg D. Petrova & K. Jakobcic, Croat. Chem. Acta 48 , 49 (1976) and WO 01/42223).
在3，5-二取代的N-联苯基吡唑甲酰胺I中，首先优选其中X为氧的那些。Among the 3,5-disubstituted N-biphenylpyrazole carboxamides I, preference is given first to those in which X is oxygen.
其次，优选其中X为硫的那些化合物I。Second, preference is given to those compounds I in which X is sulfur.
对本发明混合物而言，优选其中R1和R2相互独立地为氰基、氟、氯、甲基、甲氧基或三氟甲基，R3为氟、氯、甲基或C1卤代烷基且R4为氢或卤素的式I化合物。Preference is given to mixtures according to the invention wherein R and R independently of each other are cyano, fluorine, chlorine, methyl, methoxy or trifluoromethyl and R is fluorine, chlorine, methyl or C haloalkyl and R 4 is a compound of formula I wherein hydrogen or halogen.
特别优选其中R1和R2相互独立地为氰基、氟、氯或甲氧基，R3为氟、氯、甲基、氟甲基、二氟甲基、氯氟甲基、一氯二氟甲基、二氯一氟甲基或三氟甲基且R4为氢、氟或氯的式I化合物。Particularly preferred are those wherein R and R independently of each other are cyano, fluorine, chlorine or methoxy, and R is fluorine, chlorine, methyl, fluoromethyl, difluoromethyl, chlorofluoromethyl, monochlorodi A compound of formula I in which fluoromethyl, dichlorofluoromethyl or trifluoromethyl and R 4 is hydrogen, fluoro or chloro.
非常特别优选其中R1和R2相互独立地为氟或氯，R3为甲基、氟甲基、二氟甲基、氯氟甲基、一氯二氟甲基、二氯一氟甲基或三氟甲基且R4为氢的式I化合物。Very particularly preferred wherein R and R independently of each other are fluorine or chlorine, R is methyl , fluoromethyl, difluoromethyl, chlorofluoromethyl, chlorodifluoromethyl, dichlorofluoromethyl or trifluoromethyl and R 4 is hydrogen compound of formula I.
特别优选下表所列化合物Ia：Particular preference is given to compounds Ia listed in the table below:
表ATable A
表1：Table 1:
化合物1.1-1.20Compound 1.1-1.20
其中R1为氟且R2和R3在每种情况下具有表A的一行所给含义的式I化合物。Compounds of the formula I in which R 1 is fluorine and R 2 and R 3 in each case have the meanings given in one row of Table A.
表2：Table 2:
化合物2.1-2.20Compound 2.1-2.20
其中R1为氯且R2和R3在每种情况下具有表A的一行所给含义的式I化合物。Compounds of the formula I in which R 1 is chlorine and R 2 and R 3 in each case have the meanings given in one row of Table A.
表3：table 3:
化合物3.1-3.20Compound 3.1-3.20
其中R1为溴且R2和R3在每种情况下具有表A的一行所给含义的式I化合物。Compounds of the formula I in which R 1 is bromo and R 2 and R 3 in each case have the meanings given in one row of Table A.
表4：Table 4:
化合物4.1-4.20Compound 4.1-4.20
其中R1为碘且R2和R3在每种情况下具有表A的一行所给含义的式I化合物。Compounds of the formula I in which R 1 is iodine and R 2 and R 3 in each case have the meanings given in one row of Table A.
表5：table 5:
化合物5.1-5.20Compound 5.1-5.20
其中R1为甲基且R2和R3在每种情况下具有表A的一行所给含义的式I化合物。Compounds of the formula I in which R 1 is methyl and R 2 and R 3 in each case have the meanings given in one row of Table A.
表6：Table 6:
化合物6.1-6.20Compound 6.1-6.20
其中R1为甲氧基且R2和R3在每种情况下具有表A的一行所给含义的式I化合物。Compounds of the formula I in which R 1 is methoxy and R 2 and R 3 in each case have the meanings given in one row of Table A.
表7：Table 7:
化合物7.1-7.20Compound 7.1-7.20
其中R1为三氟甲基且R2和R3在每种情况下具有表A的一行所给含义的式I化合物。Compounds of the formula I in which R 1 is trifluoromethyl and R 2 and R 3 in each case have the meanings given in one row of Table A.
表8：Table 8:
化合物8.1-8.20Compound 8.1-8.20
其中R1为三氟甲氧基且R2和R3在每种情况下具有表A的一行所给含义的式I化合物。Compounds of the formula I in which R 1 is trifluoromethoxy and R 2 and R 3 in each case have the meanings given in one row of Table A.
表9：Table 9:
化合物9.1-9.20Compound 9.1-9.20
其中R1为氰基且R2和R3在每种情况下具有表A的一行所给含义的式I化合物。Compounds of the formula I in which R 1 is cyano and R 2 and R 3 in each case have the meanings given in one row of Table A.
表10：Table 10:
化合物10.1-10.20Compound 10.1-10.20
其中R1为硝基且R2和R3在每种情况下具有表A的一行所给含义的式I化合物。Compounds of the formula I in which R 1 is nitro and R 2 and R 3 have in each case the meanings given in one row of Table A.
非常特别优选的式I化合物是N-(3’，5’-二氯联苯-2-基)-1-甲基-3-三氟甲基-1H-吡唑-4-甲酰胺、N-(3’，5’-二氟联苯-2-基)-1-甲基-3-三氟甲基-1H-吡唑-4-甲酰胺、N-(3’-氯-5’-氟联苯-2-基)-1-甲基-3-三氟甲基-1H-吡唑-4-甲酰胺、N-(3’，5’-二(三氟甲基)联苯-2-基)-1-甲基-3-三氟甲基-1H-吡唑-4-甲酰胺、N-(3’，5’-二氯联苯-2-基)-1-甲基-3-二氟甲基-1H-吡唑-4-甲酰胺、N-(3’，5’-二氟联苯-2-基)-1-甲基-3-二氟甲基-1H-吡唑-4-甲酰胺、N-(3’-氯-5’-氟联苯-2-基)-1-甲基-3-二氟甲基-1H-吡唑-4-甲酰胺、N-(3’，5’-二(三氟甲基)联苯-2-基)-1-甲基-3-二氟甲基-1H-吡唑-4-甲酰胺、N-(3′，5′-二氟联苯-2-基)-1-甲基-3-氟甲基-1H-吡唑-4-甲酰胺、N-(3′，5′-二氟联苯-2-基)-1-甲基-3-二氟甲基-1H-吡唑-4-甲酰胺、N-(3′，5′-二氟联苯-2-基)-1-甲基-3-三氟甲基-1H-吡唑-4-甲酰胺、N-(3′-氯-5′-氟联苯-2-基)-1-甲基-3-二氟甲基-1H-吡唑-4-甲酰胺、N-(3′-氯-5′-氟联苯-2-基)-1-甲基-3-三氟甲基-1H-吡唑-4-甲酰胺、N-(3′-氯-5′-氟联苯-2-基)-1-甲基-3-氟甲基-1H-吡唑-4-甲酰胺、N-(3′-氯-5′-氟联苯-2-基)-1，3-二甲基-5-氟-1H-吡唑-4-甲酰胺、N-(3′，5′-二(三氟甲基)联苯-2-基)-1，3-二甲基-5-氟-1H-吡唑-4-甲酰胺、N-(3′-氟-5′-甲基联苯-2-基)-1，3-二甲基-5-氟-1H-吡唑-4-甲酰胺、N-(3′-氰基-5′-氟联苯-2-基)-1，3-二甲基-5-氟-1H-吡唑-4-甲酰胺和N-(3′，5′-二甲基联苯-2-基)-1，3-二甲基-5-氟-1H-吡唑-4-甲酰胺。Very particularly preferred compounds of the formula I are N-(3',5'-dichlorobiphenyl-2-yl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N -(3',5'-difluorobiphenyl-2-yl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N-(3'-chloro-5' -Fluorobiphenyl-2-yl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N-(3',5'-bis(trifluoromethyl)biphenyl -2-yl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N-(3',5'-dichlorobiphenyl-2-yl)-1-methyl Base-3-difluoromethyl-1H-pyrazole-4-carboxamide, N-(3',5'-difluorobiphenyl-2-yl)-1-methyl-3-difluoromethyl- 1H-pyrazole-4-carboxamide, N-(3'-chloro-5'-fluorobiphenyl-2-yl)-1-methyl-3-difluoromethyl-1H-pyrazole-4-methanol Amide, N-(3',5'-bis(trifluoromethyl)biphenyl-2-yl)-1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxamide, N- (3′,5′-difluorobiphenyl-2-yl)-1-methyl-3-fluoromethyl-1H-pyrazole-4-carboxamide, N-(3′,5′-difluorobiphenyl Benzene-2-yl)-1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxamide, N-(3′,5′-difluorobiphenyl-2-yl)-1- Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N-(3'-chloro-5'-fluorobiphenyl-2-yl)-1-methyl-3-difluoromethane Base-1H-pyrazole-4-carboxamide, N-(3'-chloro-5'-fluorobiphenyl-2-yl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4 -formamide, N-(3'-chloro-5'-fluorobiphenyl-2-yl)-1-methyl-3-fluoromethyl-1H-pyrazole-4-carboxamide, N-(3' -Chloro-5'-fluorobiphenyl-2-yl)-1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxamide, N-(3',5'-bis(trifluoro Methyl)biphenyl-2-yl)-1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxamide, N-(3'-fluoro-5'-methylbiphenyl-2 -yl)-1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxamide, N-(3'-cyano-5'-fluorobiphenyl-2-yl)-1,3 -Dimethyl-5-fluoro-1H-pyrazole-4-carboxamide and N-(3′,5′-dimethylbiphenyl-2-yl)-1,3-dimethyl-5-fluoro -1H-pyrazole-4-carboxamide.
优选式I化合物与至少一种选自A)组唑类的活性化合物的混合物。Preference is given to mixtures of compounds of the formula I with at least one active compound selected from group A) azoles.
还优选式I化合物与至少一种选自B)组嗜球果伞素类的活性化合物的混合物。Preference is also given to mixtures of compounds of the formula I with at least one active compound from group B) of the strobilurins.
优选式I化合物与至少一种选自C)组羧酰胺的活性化合物的混合物。Preference is given to mixtures of compounds of the formula I with at least one active compound selected from the carboxamides of group C).
此外，还优选式I化合物与至少一种选自D)组杂环化合物的活性化合物的混合物。Furthermore, preference is also given to mixtures of compounds of the formula I with at least one active compound selected from the heterocyclic compounds of group D).
此外，还优选式I化合物与至少一种选自E)组氨基甲酸盐类活性化合物的混合物。Furthermore, preference is also given to mixtures of compounds of the formula I with at least one carbamate active compound from group E).
此外，还优选式I化合物与至少一种选自F)组其他杀真菌剂的活性化合物的混合物。Furthermore, preference is also given to mixtures of the compounds of the formula I with at least one active compound from the further fungicides of group F).
此外，还优选式I化合物与至少一种选自如下A)组唑类的活性化合物的混合物：环唑醇、醚唑、氧唑菌、喹唑菌酮、氟硅唑、粉唑醇、环戊唑菌、腈菌唑、戊菌唑、丙环唑、丙硫菌唑、三唑酮、唑菌醇、戊唑醇、氟醚唑、戊叉唑菌、丙氯灵、氰霜唑、苯菌灵、多菌灵和噻唑菌胺。In addition, mixtures of compounds of the formula I with at least one active compound selected from the group A) of the following azoles are preferred: cyconazole, femoconazole, oxaconazole, quinaconazole, flusilazole, triconazole, Meconazole, mycloconazole, penconazole, propiconazole, prothioconazole, triadimefon, pyracloxazole, tebuconazole, fluteconazole, tebuconazole, prochloraz, cyazofimazole , benomyl, carbendazim and ethaboxam.
还特别优选式I化合物与至少一种选自如下A)组唑类的活性化合物的混合物：环唑醇、醚唑、氧唑菌、喹唑菌酮、氟硅唑、粉唑醇、环戊唑菌、腈菌唑、丙环唑、丙硫菌唑、三唑酮、唑菌醇、戊唑醇、氟醚唑、戊叉唑菌、丙氯灵、氰霜唑、苯菌灵和多菌灵。Particular preference is also given to mixtures of compounds of the formula I with at least one active compound selected from the group A) of the following azoles: cyclaconazole, oxaconazole, oxaconazole, quinaconazole, flusilazole, triconazole, cyclazone Tebuconazole, mycloconazole, propiconazole, prothioconazole, triadimefon, pyracloconazole, tebuconazole, fluteconazole, tebuconazole, prochloraz, cyanazazole, benomyl and Carbendazim.
还非常特别优选式I化合物与至少一种选自如下A)组唑类的活性化合物的混合物：氧唑菌、喹唑菌酮、粉唑醇、环戊唑菌、戊唑醇、戊叉唑菌、丙氯灵和多菌灵。Very particular preference is also given to mixtures of compounds of the formula I with at least one active compound selected from the group A) of the following azoles: Oxaconazole, Feconazole, Triconazole, Meconazole, Tebuconazole, Triconazole bacteria, prochloraz and carbendazim.
还优选式I化合物与至少一种选自如下B)组嗜球果伞素类的活性化合物的混合物：腈嘧菌酯、醚菌胺、氟嘧菌酯、亚胺菌、肟醚菌胺、啶氧菌酯、唑菌胺酯和肟菌酯。Preference is also given to mixtures of compounds of the formula I with at least one active compound selected from the group B) of the following strobilurins: azoxystrobin, kysoxastrobin, fluoxastrobin, iminobacter, orysastrobin, Picoxystrobin, pyraclostrobin and trifloxystrobin.
还特别优选式I化合物与至少一种选自如下B)组嗜球果伞素类的活性化合物的混合物：亚胺菌、肟醚菌胺和唑菌胺酯。Particular preference is also given to mixtures of compounds of the formula I with at least one active compound selected from the group B) of the following strobilurins: iminobacter, orysastrobin and pyraclostrobin.
还非常特别优选式I化合物与唑菌胺酯的混合物。Very particular preference is also given to mixtures of compounds of the formula I with pyraclostrobin.
还优选式I化合物与至少一种选自如下C)组羧酰胺的活性化合物的混合物：环酰菌胺、甲霜灵、精甲霜灵、甲呋酰胺、烯酰吗啉、氟吗啉、氟吡菌胺、苯酰菌胺、氯环丙酰胺和双炔酰菌胺。Preference is also given to mixtures of compounds of the formula I with at least one active compound selected from the group C) of the following carboxamides: fenhexamid, metalaxyl, metalaxyl-p, tofuramide, dimethomorph, flumorph, Fluopyram, Benamid, Cyclopropamide, and Mandipropamid.
还特别优选式I化合物与至少一种选自如下C)组羧酰胺的活性化合物的混合物：环酰菌胺、甲霜灵、精甲霜灵、甲呋酰胺、烯酰吗啉、苯酰菌胺和氯环丙酰胺。Particular preference is also given to mixtures of compounds of formula I with at least one active compound selected from the group C) of carboxamides: fenhexamid, metalaxyl, metalaxyl-p, tofuramide, dimethomorph, benzoyl Amines and Cyclopropamide.
还优选式I化合物与至少一种选自如下D)组杂环化合物的活性化合物的混合物：氟啶胺、环丙嘧啶、异嘧菌醇、嘧菌胺、二甲嘧菌胺、嗪氨灵、氟菌、吗菌灵、丁苯吗啉、克啉菌、苯锈啶、异丙定、烯菌酮、唑酮菌、咪唑菌酮、噻菌灵、5-氯-7-(4-甲基哌啶-1-基)-6-(2，4，6-三氟苯基)-[1，2，4]三唑并[1，5-a]嘧啶、丙氧喹啉、噻二唑素、敌菌丹、灭菌丹、氰菌胺、喹氧灵，尤其是氟啶胺、环丙嘧啶、异嘧菌醇、嘧菌胺、二甲嘧菌胺、嗪氨灵、氟菌、吗菌灵、丁苯吗啉、克啉菌、苯锈啶、异丙定、烯菌酮、唑酮菌、咪唑菌酮、噻菌灵、丙氧喹啉、噻二唑素、敌菌丹、灭菌丹、氰菌胺和喹氧灵。Preference is also given to mixtures of compounds of the formula I with at least one active compound selected from the group D) of the following heterocyclic compounds: fluazinam, cyprodinil, isopyridol, azoxycarbin, pyrimethanil, pyrazinam , fluorine bacteria, mobendazim, fenpropimorph, clorizolin, fenpropidin, isopropidine, fenhexenone, oxaconazole, imidazole ketone, thiabendazole, 5-chloro-7-( 4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine, propoxyquinoline , thiadiazol, captafol, folpet, cyanamethanil, quinoxyfin, especially fluazinam, cyprodinil, isofamethanol, azoxycarb, pyrimethanil, and azinyl , Fluoxetin, Mobendazim, Fenpropimorph, Klebsiella, Fenpropidin, Isopropidine, Vinhexenone, Oxaconazole, Midazolone, Thiabendazole, Propoxyquinoline, Thiobendazole Azolazol, captafol, folpet, cyanoxanil and quinoxyfin.
还特别优选式I化合物与至少一种选自如下D)组杂环化合物的活性化合物的混合物：二甲嘧菌胺、吗菌灵、丁苯吗啉、克啉菌、异丙定、烯菌酮、5-氯-7-(4-甲基哌啶-1-基)-6-(2，4，6-三氟苯基)-[1，2，4]三唑并[1，5-a]嘧啶和喹氧灵，尤其是二甲嘧菌胺、吗菌灵、丁苯吗啉、克啉菌、异丙定、烯菌酮和喹氧灵。Particular preference is also given to mixtures of compounds of the formula I with at least one active compound selected from the group D) of the following heterocyclic compounds: pyrimethanil, mobendazim, fenpropimorph, clarizolin, iprodime, methazine Ketone, 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5 - a] pyrimidines and quinoxyfins, in particular pyrimethanil, mobendazim, fenpropimorph, clorizolin, iprodime, methadone and quinoxyfin.
还优选式I化合物与至少一种选自如下E)组氨基甲酸盐类的活性化合物的混合物：代森锰锌、代森联、甲基代森锌、福美双、异丙菌胺、苯噻菌胺和百维灵。Preference is also given to mixtures of compounds of the formula I with at least one active compound selected from the group E) carbamates: mancozeb, mancozeb, zinc-methyl, thiram, iprocarbam, phenthiazide Bacteramide and Proverbine.
还特别优选式I化合物与至少一种选自如下E)组氨基甲酸盐类的活性化合物的混合物：代森锰锌和代森联。Particular preference is also given to mixtures of compounds of the formula I with at least one active compound selected from the group E) carbamates: mancozeb and mancozeb.
还优选式I化合物与至少一种选自如下F)组其他杀真菌剂的活性化合物的混合物：二噻农、三苯锡基盐、如薯瘟锡、藻菌磷、乙磷铝、亚磷酸及其盐、百菌清、抑菌灵、甲基托布津、醋酸铜、氢氧化铜、王铜、碱式硫酸铜、硫、清菌脲、苯菌酮和螺茂胺。Preference is also given to mixtures of compounds of the formula I with at least one active compound selected from the group F) of the following other fungicides: dithianon, triphenyltin-based salts, such as dioscin, galenphos, phosphonium, phosphorous acid and its salts, chlorothalonil, fenzazolin, thiophanate-methyl, copper acetate, copper hydroxide, king copper, basic copper sulfate, sulfur, fenprodione, metrafenone and spiroxamin.
还特别优选式I化合物与至少一种选自如下F)组其他杀真菌剂的活性化合物的混合物：亚磷酸及其盐，百菌清和苯菌酮。Particular preference is also given to mixtures of a compound of the formula I with at least one active compound selected from the group F) of the following further fungicides: phosphorous acid and its salts, chlorothalonil and metrafenone.
还优选一种式I化合物与两种上述活性化合物II的三组分混合物。Preference is also given to three-component mixtures of one compound of the formula I with two of the abovementioned active compounds II.
活性化合物的优选组合列于下表11-17中：Preferred combinations of active compounds are listed in Tables 11-17 below:
表11：Table 11:
化合物I与A)组活性化合物II的活性化合物组合：Combination of active compounds of compound I with active compound II of group A):
表12Table 12
化合物I与B)组活性化合物II的活性化合物组合：Combination of active compounds of compound I with active compound II of group B):
表13：Table 13:
化合物I与C)组活性化合物II的活性化合物组合：Combination of active compounds of compound I with active compound II of group C):
表14：Table 14:
化合物I与D)组活性化合物II的活性化合物组合：Active compound combinations of compound I and active compound II of group D):
表15：Table 15:
化合物I与E)组活性化合物II的活性化合物组合：Active compound combinations of compound I and E) group active compound II:
表16Table 16
化合物I与F)组活性化合物II的活性化合物组合：Active compound combination of compound I and F) group active compound II:
表17Table 17
化合物I与两种活性化合物II的活性化合物组合：Active compound combination of compound I with two active compounds II:
化合物I和至少一种活性化合物II的混合物，或同时，即一起或分开施用的至少一种化合物I和至少一种活性化合物II对宽范围的植物病原性真菌，尤其是选自子囊菌纲(Ascomycetes)、担子菌纲(Basidiomycetes)、半知菌纲(Deuteromycetes)和Peronosporomycetes(同义词：卵菌纲(Oomycetes))的真菌具有优异的活性。它们中的一些内吸有效且可以作为叶面杀真菌剂、拌种用杀真菌剂和土壤杀真菌剂用于作物保护中。它们还可以用于处理种子。Mixtures of compound I and at least one active compound II, or at least one compound I and at least one active compound II applied simultaneously, i.e. together or separately, against a wide range of phytopathogenic fungi, especially selected from the class Ascomycetes ( Fungi of Ascomycetes), Basidiomycetes, Deuteromycetes and Peronosporomycetes (synonym: Oomycetes) have excellent activity. Some of them are systemically active and can be used in crop protection as foliar fungicides, seed-dressing fungicides and soil fungicides. They can also be used to treat seeds.
它们对在各种栽培植物如香蕉、棉花、蔬菜(例如黄瓜、豆类和葫芦科植物)、大麦、禾草、燕麦、咖啡、土豆、玉米、水果、稻、黑麦、大豆、西红柿、葡萄藤、小麦、观赏植物、甘蔗以及这些植物的种子中防治大量真菌尤其重要。They are effective on various cultivated plants such as bananas, cotton, vegetables (such as cucumbers, beans and cucurbits), barley, grasses, oats, coffee, potatoes, corn, fruits, rice, rye, soybeans, tomatoes, grapes It is especially important to control a large number of fungi in vines, wheat, ornamental plants, sugar cane and the seeds of these plants.
它们尤其适合防治下列植物病害：They are especially suitable for controlling the following plant diseases:
●蔬菜、油籽油菜、糖用甜菜、水果和稻上的链格孢属(Alternaria)，例如土豆和西红柿上的早疫链格孢(A.solani)或链格孢(A.alternata)；Alternaria on vegetables, oilseed rape, sugar beet, fruit and rice, such as A.solani or A.alternata on potatoes and tomatoes;
●糖用甜菜和蔬菜上的丝囊霉属(Aphanomyces)；Aphanomyces on sugar beets and vegetables;
●禾谷类和蔬菜上的壳二孢属(Ascochyta)；Ascochyta on cereals and vegetables;
●玉米、禾谷类、稻和草坪中的平脐蠕孢属(Bipolaris)和内脐蠕孢属(Drechslera)，例如玉米上的玉蜀黍平脐蠕孢(D.maydis)；Bipolaris and Drechslera in corn, cereals, rice and turf, such as D. maydis on maize;
●禾谷类上的禾白粉菌(Blumeria graminis)(白粉病)；Blumeria graminis (powdery mildew) on cereals;
●草莓、蔬菜、花卉和葡萄藤上的灰葡萄孢(Botrytis cinerea)(灰霉病)，Botrytis cinerea (botrytis cinerea) on strawberries, vegetables, flowers and grape vines,
●莴苣上的莴苣盘梗霉(Bremia lactucae)，Bremia lactucae on lettuce,
●玉米、大豆、稻和糖用甜菜上的尾孢属(Cercospora)；Cercospora on corn, soybean, rice and sugar beet;
●玉米、禾谷类、稻上的旋孢腔菌属(Cochliobolus)，例如禾谷类上的禾旋孢腔菌(Cochliobolus sativus)，稻上的宫部旋孢腔菌(Cochliobolusmiyabeanus)；Cochliobolus on corn, cereals, rice, such as Cochliobolus sativus on cereals, Cochliobolus miyabeanus on rice;
●大豆和棉花上的剌盘孢属(Colletotricum)；Colletotricum on soybean and cotton;
●玉米、禾谷类、稻和草坪上的内脐蠕孢属(Drechslera)、核腔菌属(Pyrenophora)，例如大麦上的大麦网斑内脐蠕孢(D.teres)或小麦上的D.tritci-repentis；Drechslera, Pyrenophora on corn, cereals, rice and turf, e.g. D. teres on barley or D. tritci-repentis;
●由Phaeoacremonium chlamydosporium、Ph.Aleophilum和Formitiporapunctata(同义词斑孔木层孔菌(Phellinus punctatus))引起的葡萄藤上的埃斯卡(Esca)；Esca on vines caused by Phaeoacremonium chlamydosporium, Ph.Aleophilum and Formitiorapunctata (synonym Phellinus punctatus);
●玉米上的突脐蠕孢属(Exserohilum)，●Exserohilum on maize,
●黄瓜上的二孢白粉菌(Erysiphe cichoracearum)和单丝壳(Sphaerothecafuliginea)，Erysiphe cichoracearum and Sphaerothecafuliginea on cucumbers,
●各种植物上的镰孢霉属(Fusarium)和轮枝孢属(Verticillium)，例如禾谷类上的禾本科镰孢(F.graminearum)或大刀镰孢(F.culmorum)或多种植物如西红柿上的尖镰孢(F.oxysporum)；Fusarium and Verticillium on various plants, such as F. graminearum or F. culmorum on cereals or various plants such as Fusarium oxysporum (F.oxysporum) on tomatoes;
●禾谷类上的禾顶囊壳(Gaeumanomyces graminis)；●Gaeumanomyces graminis on cereals;
●禾谷类和稻上的赤霉属(Gibberella)(例如稻上的藤仓赤霉(Gibberellafujikuroi))；Gibberella on cereals and rice (eg Gibberella fujikuroi on rice);
●稻上的Grainstaining complex；●Grainstaining complex on rice;
●玉米和稻上的长蠕孢属(Helminthosporium)；●Helminthosporium on corn and rice;
●禾谷类上的Michrodochium nivale；Michrodochium nivale on cereals;
●禾谷类、香蕉和花生上的球腔菌属(Mycosphaerella)，例如小麦上的禾生球腔菌(M.graminicola)或香蕉上的斐济球腔菌(M.fijiensis)；Mycosphaerella on cereals, bananas and peanuts, such as M. graminicola on wheat or M. fijiensis on bananas;
●卷心菜和球茎植物上的霜霉属(Peronospora)，例如卷心菜上的芸苔霜霉(P.brassicae)或洋葱上的葱霜霉(P.destructor)；Peronospora on cabbage and bulb plants, such as P. brassicae on cabbage or P. destructor on onions;
●大豆上的豆薯层锈菌(Phakopsora pachyrhizi)和山马蟥层锈菌(Phakopsara meibomiae)；Phakopsora pachyrhizi and Phakopsara meibomiae on soybeans;
●大豆和向日葵上的拟茎点霉属(Phomopsis)；Phomopsis on soybean and sunflower;
●土豆和西红柿上的致病疫霉(Phytophthora infestans)；Phytophthora infestans on potatoes and tomatoes;
●各种植物上的疫霉属(Phytophthora)，例如柿子椒上的辣椒疫霉(P.capsici)；Phytophthora on various plants, for example P. capsici on bell peppers;
●葡萄藤上的葡萄生单轴霉(Plasmopara viticola)，Plasmopara viticola on grapevines,
●苹果上的苹果白粉病菌(Podosphaera leucotricha)，Apple powdery mildew (Podosphaera leucotricha) on apples,
●禾谷类上的小麦基腐病菌(Pseudocercosporella herpotrichoides)，Pseudocercosporella herpotrichoides on cereals,
●各种植物上的假霜霉属(Pseudoperonospora)，例如黄瓜上的古巴假霜霉(P.Cubensis)或啤酒花上的葎草假霜霉(P.Humili)；Pseudoperonospora on various plants, such as P. Cubensis on cucumbers or P. Humili on hops;
●各种植物上的柄锈菌属(Puccinia)，例如禾谷类上的小麦柄锈菌(P.triticina)、条形柄锈病(P.striformis)、大麦柄锈病(P.hordei)或禾柄锈菌(P.graminis)，或芦笋上的天门冬属柄锈病(P.asparagi))；Puccinia on various plants, such as P. triticina on cereals, P. striformis, P. hordei or P. graminearum on cereals Rust fungus (P. graminis), or Puccinia spp. on asparagus (P. asparagi));
●稻上的稻瘟病菌(Pyricularia oryzae)、笹木伏革菌(Corticium sasakii)、帚梗柱孢属(Sarocladium oryzae)、稻叶鞘腐败病(S.attenuatum)、稻叶黑粉菌(Entyloma oryzae)，Pyricularia oryzae, Corticium sasakii, Sarocladium oryzae, S. attenuatum, Entyloma oryzae on rice ,
●草坪和禾谷类上的稻梨孢菌(Pyricularia grisea)，Pyricularia grisea on turf and cereals,
●草坪、稻、玉米、棉花、油籽油菜、向日葵、糖用甜菜、蔬菜和其他植物上的腐霉属(Pythium)，例如各种植物上的终极腐霉菌(P.ultiumum)，草坪上的瓜果腐霉(P.aphanidermatum)；Pythium on turf, rice, corn, cotton, oilseed rape, sunflower, sugar beet, vegetables and other plants such as P.ultiumum on various plants, P. ultimum on turf Pythium melon and fruit (P. aphanidermatum);
●棉花、稻、土豆、草坪、玉米、油籽油菜、糖用甜菜、蔬菜和各种植物上的丝核菌属(Rhizoctonia)，例如甜菜和各种植物上的立枯丝核病菌(R.solani)；Rhizoctonia on cotton, rice, potatoes, turf, corn, oilseed rape, sugar beet, vegetables and various plants, such as Rhizoctonia solani (R. solani);
●大麦、黑麦和黑小麦上的黑麦喙孢(Rhynchosporium secalis)；Rhynchosporium secalis on barley, rye and triticale;
●油籽油菜和向日葵上的核盘菌属(Sclerotinia)；Sclerotinia on oilseed rape and sunflower;
●小麦上的小麦壳针孢(Septoria tritici)和颖枯壳多孢(Stagonosporanodorum)，Septoria tritici and Stagonosporanodorum on wheat,
●葡萄藤上的葡萄钩丝壳(Erysiphe(同义词Uncinula)necator)，Erysiphe (synonym Uncinula) necator on the vine,
●玉米和草坪上的Setospaeria属，The genus Setospaeria on maize and turf,
●玉米上的丝轴黑粉菌(Sphacelotheca reilinia)，Sphacelotheca reilinia on corn,
●大豆和棉花上的根串珠霉属(Thievaliopsis)，Thievaliopsis on soybean and cotton,
●禾谷类上的腥黑粉菌属(Tilletia)，Tilletia on cereals,
●禾谷类、玉米和甘蔗上的黑粉菌属(Ustilago)，例如玉米上的玉蜀黍黑粉菌(U.maydis)；Ustilago on cereals, corn and sugarcane, such as U. maydis on corn;
●苹果和梨上的黑星菌属(Venturia)(黑星病)，例如苹果上的苹果黑星病(V.inaequalis)。• Venturia (scat) on apples and pears, eg Apple scab (V. inaequalis) on apples.
本发明混合物还适于防治有害真菌以保护材料(如木材、纸张、漆分散体、纤维或织物)和保护储藏的产品。在木材保护中，特别应注意下列有害真菌：子囊菌纲真菌，如线嘴壳属(Ophiostoma spp.)，长喙壳属(Ceratocystisspp.)，出芽短梗霉(Aureobasidium pullulans)，Sclerophoma spp.毛壳属(Chaetomium spp.)，腐质霉属(Humicola spp.)，彼得壳属(Petriella spp.)，毛束霉属(Trichurus spp.)；担子菌纲真菌，如粉孢革菌属(Coniophoraspp.)，革盖菌属(Coriolus spp.)，粘褶菌属(Gloeophyllum spp.)，香菇属(Lentinus spp.)，侧耳属(Pleurotus spp.)，卧孔属(Poria spp.)，干朽菌属(Serpula spp.)和干酪菌属(Tyromyces spp.)，半知菌纲真菌，如曲霉属(Aspergillus spp.)，枝孢属(Cladosporium spp.)，青霉属(Penicillium spp.)，木霉属(Trichoderma spp.)，链格孢属(Alternaria spp.)，拟青霉属(Paecilomyces spp.)和接合菌纲(Zygomycetes)真菌，如毛霉属(Mucor spp.)，此外在材料保护中应注意下列酵母：假丝酵母属(Candida spp.)和酿酒酵母(Saccharomyces cerevisae)。The mixtures according to the invention are also suitable for controlling harmful fungi for the protection of materials (eg wood, paper, paint dispersions, fibers or textiles) and for the protection of stored products. In wood protection, special attention should be paid to the following harmful fungi: Ascomycetes, such as Ophiostoma spp., Ceratocystisspp., Aureobasidium pullulans, Sclerophoma spp. Chaetomium spp., Humicola spp., Petriella spp., Trichurus spp.; Basidiomycetes, such as Coniophoraspp .), Coriolus spp., Gloeophyllum spp., Lentinus spp., Pleurotus spp., Poria spp., dry rot Serpula spp. and Tyromyces spp., Deuteromycetes fungi, such as Aspergillus spp., Cladosporium spp., Penicillium spp., Trichoderma spp., Alternaria spp., Paecilomyces spp. and Zygomycetes fungi, such as Mucor spp. Attention should be paid to the following yeasts in conservation: Candida spp. and Saccharomyces cerevisae.
混合物通过用杀真菌有效量的活性化合物处理真菌或要防止真菌侵袭的植物、种子、材料或土壤而施用。施用可以在材料、植物或种子被真菌侵染之前和之后进行。The mixtures are applied by treating the fungus or the plant, seed, material or soil to be protected against fungal attack with a fungicidally effective amount of the active compounds. Application can be carried out before and after the material, plants or seeds have been infected by the fungus.
化合物I和至少一种活性化合物II可以同时，即一起或分开施用，或依次施用，在分开施用的情况下施用顺序通常对防治结果没有任何影响。The compound I and the at least one active compound II can be applied simultaneously, ie together or separately, or in succession, the order of application generally not having any influence on the control result in the case of separate application.
当提供混合物时，优选使用纯活性化合物I至II，可以向其中加入其他对抗有害真菌或其他害虫如昆虫、蜘蛛或线虫的活性化合物或除草活性或生长调节活性化合物或肥料。When mixtures are provided, preference is given to using the pure active compounds I to II, to which other active compounds against harmful fungi or other pests such as insects, arachnids or nematodes or herbicidally active or growth-regulating active compounds or fertilizers can be added.
该类三种活性化合物的混合物例如由式I化合物，尤其是N-(3′，5′-二氟联苯-2-基)-1-甲基-3-三氟甲基-1H-吡唑-4-甲酰胺、N-(3′，5′-二氯联苯-2-基)-1-甲基-3-三氟甲基-1H-吡唑-4-甲酰胺、N-(3′，5′-二氟联苯-2-基)-1-甲基-3-二氟甲基-1H-吡唑-4-甲酰胺或N-(3′，5′-二氯联苯-2-基)-1-甲基-3-二氟甲基-1H-吡唑-4-甲酰胺，A)组的唑类，尤其是氧唑菌、环戊唑菌、戊叉唑菌或喹唑菌酮，以及杀虫剂组成，合适的杀虫剂尤其是锐劲特(fipronil)以及新烟碱类，如吡虫清(acetamiprid)、噻虫胺(clothianidin)、呋虫胺(dinotefuran)、吡虫啉(imidacloprid)、硝胺烯啶(nitenpyram)、噻虫啉(thiacloprid)和噻虫嗪(thiamethoxam)。The mixture of these three active compounds is, for example, composed of a compound of formula I, especially N-(3',5'-difluorobiphenyl-2-yl)-1-methyl-3-trifluoromethyl-1H-pyridine Azole-4-carboxamide, N-(3′,5′-dichlorobiphenyl-2-yl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N- (3′,5′-difluorobiphenyl-2-yl)-1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxamide or N-(3′,5′-dichloro Biphenyl-2-yl)-1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxamide, azoles of group A), especially oxyconazole, metconazole, pentylidene Composition of pyraclofen or quinazole, and insecticides, suitable insecticides are especially fipronil and neonicotinoids, such as acetamiprid, clothianidin, difuran dinotefuran, imidacloprid, nitenpyram, thiacloprid and thiamethoxam.
通常，使用至少一种化合物I和至少一种活性化合物II的混合物。这里至少一种化合物I与两种或需要的话更多种活性组分的混合物可能提供特殊优点。In general, a mixture of at least one compound I and at least one active compound II is used. Mixtures of at least one compound I with two or, if desired, more active ingredients may offer particular advantages here.
在上述意义上合适的其他活性组分尤其是开头所提到的活性化合物II，特别是上述优选的活性化合物II。Suitable further active ingredients in the above sense are in particular the active compounds II mentioned at the outset, in particular the abovementioned preferred active compounds II.
化合物I和活性化合物II通常以100∶1-1∶100，优选20∶1-1∶20，尤其是10∶1-1∶10的重量比使用。Compound I and active compound II are generally used in a weight ratio of 100:1 to 1:100, preferably 20:1 to 1:20, especially 10:1 to 1:10.
需要的话，其他活性组分以20∶1-1∶20的比例加入化合物I中。If desired, other active ingredients are added to compound I in a ratio of 20:1 to 1:20.
取决于化合物I和II的类型以及所需效果，本发明混合物尤其在农业作物区域情况下的施用率为5-2000g/ha，优选20-1500g/ha，尤其是50-1000g/ha。Depending on the type of compounds I and II and the desired effect, the application rates of the mixtures according to the invention are 5-2000 g/ha, preferably 20-1500 g/ha, especially 50-1000 g/ha, especially in the case of agricultural crop areas.
相应地，化合物I的施用率通常为1-1000g/ha，优选10-900g/ha，尤其是20-750g/ha。Correspondingly, the application rates of the compounds I are generally 1-1000 g/ha, preferably 10-900 g/ha, especially 20-750 g/ha.
相应地，活性化合物II的施用率通常为1-2000g/ha，优选1-1500g/ha，尤其是40-1000g/ha。Correspondingly, the application rates of active compound II are generally from 1 to 2000 g/ha, preferably from 1 to 1500 g/ha, especially from 40 to 1000 g/ha.
在种子处理中，混合物的施用率通常为1-1000g/100kg种子，优选1-750g/100kg，尤其是5-500g/100kg种子。In seed treatment, the application rate of the mixture is generally 1-1000 g/100 kg seed, preferably 1-750 g/100 kg, especially 5-500 g/100 kg seed.
防治有害真菌的方法通过在植物播种之前或之后或植物出苗之前或之后通过对种子、植物或土壤喷雾或撒粉而分开或一起施用化合物I和至少一种活性化合物II或化合物I与至少一种活性化合物II的混合物进行。Method for controlling harmful fungi by applying compound I and at least one active compound II or compound I and at least one Mixtures of active compounds II are carried out.
可以将本发明的协同增效杀真菌混合物或化合物I和至少一种活性化合物II转化成常规配制剂，例如溶液、乳液、悬浮液、粉剂、粉末、糊或颗粒。使用形式取决于特定的意欲目的；在每种情况下应确保本发明混合物尽可能精细和均匀地分布。The synergistic fungicidal mixtures or compounds I and at least one active compound II according to the invention can be converted into customary formulations such as solutions, emulsions, suspensions, dusts, powders, pastes or granules. The use forms depend on the particular intended purpose; in each case it should ensure that the mixture according to the invention is distributed as finely and homogeneously as possible.
配制剂以本身已知的方式制备，例如通过将活性化合物与溶剂和/或载体混合而制备，需要的话使用乳化剂和分散剂。对该目的合适的溶剂/助剂主要为：The formulations are prepared in a manner known per se, for example by mixing the active compounds with solvents and/or carriers, using emulsifiers and dispersants if desired. Suitable solvents/auxiliaries for this purpose are primarily:
-水、芳族溶剂(如Solvesso产品、二甲苯)、石蜡(如矿物油馏分)、醇类(如甲醇、丁醇、戊醇、苄醇)、酮类(如环己酮、γ-丁内酯)、吡咯烷酮(N-甲基吡咯烷酮、N-辛基吡咯烷酮)、乙酸酯(乙二醇二乙酸酯)、二元醇、脂肪酸二甲基酰胺、脂肪酸及脂肪酸酯。原则上还可以使用溶剂混合物。- water, aromatic solvents (such as Solvesso® products, xylene), paraffins (such as mineral oil fractions), alcohols (such as methanol, butanol, pentanol, benzyl alcohol), ketones (such as cyclohexanone, γ- butyrolactone), pyrrolidone (N-methylpyrrolidone, N-octylpyrrolidone), acetate (ethylene glycol diacetate), glycol, fatty acid dimethylamide, fatty acid and fatty acid ester. In principle it is also possible to use solvent mixtures.
-载体如磨碎的天然矿物(如高岭土、粘土、滑石、白垩)和磨碎的合成矿物(如高度分散的硅石、硅酸盐)；乳化剂如非离子和阴离子乳化剂(如聚氧乙烯脂肪醇醚、烷基磺酸盐和芳基磺酸盐)以及分散剂如木素亚硫酸盐废液和甲基纤维素。- Carriers such as ground natural minerals (such as kaolin, clay, talc, chalk) and ground synthetic minerals (such as highly dispersed silica, silicates); emulsifiers such as nonionic and anionic emulsifiers (such as polyoxyethylene fatty alcohol ethers, alkyl sulfonates and aryl sulfonates) and dispersants such as lignosulfite waste liquor and methyl cellulose.
合适的表面活性剂是木素磺酸、萘磺酸、苯酚磺酸、二丁基萘磺酸的碱金属盐、碱土金属盐和铵盐，烷基芳基磺酸盐，烷基硫酸盐，烷基磺酸盐，脂肪醇硫酸盐，脂肪酸和硫酸化脂肪醇乙二醇醚，还有磺化萘和萘衍生物与甲醛的缩合物，萘或萘磺酸与苯酚和甲醛的缩合物，聚氧乙烯辛基酚醚，乙氧基化异辛基酚、辛基酚、壬基酚，烷基酚聚乙二醇醚，三丁基苯基聚乙二醇醚，三硬脂基苯基聚乙二醇醚，烷基芳基聚醚醇，醇和脂肪醇/氧化乙烯缩合物，乙氧基化蓖麻油，聚氧乙烯烷基醚，乙氧基化聚氧丙烯，月桂醇聚乙二醇醚缩醛，山梨醇酯，木素亚硫酸盐废液和甲基纤维素。Suitable surfactants are the alkali metal, alkaline earth metal and ammonium salts of lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, dibutylnaphthalenesulfonic acid, alkylarylsulfonates, alkyl sulfates, Alkylsulfonates, fatty alcohol sulfates, glycol ethers of fatty acids and sulfated fatty alcohols, also condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensates of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, Polyoxyethylene octylphenol ether, ethoxylated isooctylphenol, octylphenol, nonylphenol, alkylphenol polyglycol ether, tributylphenyl polyglycol ether, tristearylbenzene Polyethylene glycol ethers, alkylaryl polyether alcohols, alcohol and fatty alcohol/ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers, ethoxylated polyoxypropylene, polyethylene lauryl alcohol Glycol ether acetals, sorbitol esters, lignosulfite waste liquor and methylcellulose.
适于制备可直接喷雾溶液、乳液、糊或油分散体的物质是中沸点到高沸点的矿物油馏分，如煤油或柴油，此外还有煤焦油和植物或动物来源的油，脂族、环状和芳族烃，例如甲苯、二甲苯、石蜡、四氢化萘、烷基化萘或其衍生物、甲醇、乙醇、丙醇、丁醇、环己醇、环己酮、异佛尔酮，强极性溶剂，例如二甲亚砜、N-甲基吡咯烷酮和水。Substances suitable for the preparation of sprayable solutions, emulsions, pastes or oil dispersions are medium to high boiling mineral oil fractions such as kerosene or diesel oil, also coal tar and oils of vegetable or animal origin, aliphatic, cyclo and aromatic hydrocarbons, such as toluene, xylene, paraffin, tetralin, alkylated naphthalene or its derivatives, methanol, ethanol, propanol, butanol, cyclohexanol, cyclohexanone, isophorone, Strongly polar solvents such as dimethylsulfoxide, N-methylpyrrolidone, and water.
粉末、撒播用材料和可撒粉产品可以通过将活性物质与至少一种固体载体混合或同时研磨而制备。Powders, materials for spreading and dustable products can be prepared by mixing or simultaneously grinding the active substance with at least one solid carrier.
颗粒如涂覆颗粒、浸渍颗粒和均质颗粒可以通过将活性化合物与至少一种固体载体粘附而制备。固体载体的实例是矿土如硅胶、硅酸盐、滑石、高岭土、活性粘土(attaclay)、石灰石、石灰、白垩、红玄武土、黄土、粘土、白云石、硅藻土、硫酸钙、硫酸镁、氧化镁；磨碎的合成材料；肥料如硫酸铵、磷酸铵、硝酸铵、尿素；植物来源的产品如谷粉、树皮粉、木粉和坚果壳粉，纤维素粉和其它固体载体。Granules such as coated granules, impregnated granules and homogeneous granules can be prepared by binding the active compounds to at least one solid carrier. Examples of solid carriers are mineral earths such as silica gel, silicates, talc, kaolin, attaclay, limestone, lime, chalk, basalt, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate , magnesium oxide; ground synthetic materials; fertilizers such as ammonium sulphate, ammonium phosphate, ammonium nitrate, urea; products of plant origin such as grain flour, bark flour, wood flour and nut shell flour, cellulose flour and other solid carriers.
通常，配制剂包含0.01-95重量％，优选0.1-90重量％的化合物I和至少一种活性化合物II或化合物I与至少一种活性化合物II的混合物。活性化合物以90-100％，优选95-100％的纯度(根据NMR或HPLC谱)使用。In general, the formulations comprise 0.01-95% by weight, preferably 0.1-90% by weight, of compound I and at least one active compound II or a mixture of compound I and at least one active compound II. The active compounds are used in a purity of 90-100%, preferably 95-100% (according to NMR or HPLC spectrum).
下列为配制剂实例：The following are examples of formulations:
1.用水稀释的产品1. Products diluted with water
A)水溶性浓缩物(SL)A) Water Soluble Concentrate (SL)
将10重量份本发明混合物溶于90重量份水或水溶性溶剂中。或者，加入湿润剂或其它助剂。活性化合物经水稀释溶解。得到活性化合物含量为10重量％的配制剂。10 parts by weight of the mixture of the present invention are dissolved in 90 parts by weight of water or a water-soluble solvent. Alternatively, wetting agents or other auxiliaries are added. The active compound dissolves upon dilution with water. This gives a formulation with an active compound content of 10% by weight.
B)分散性浓缩物(DC)B) Dispersible Concentrate (DC)
将20重量份本发明混合物溶于70重量份环己酮中并加入10重量份分散剂如聚乙烯基吡咯烷酮。用水稀释得到分散体。活性化合物含量为20重量％。20 parts by weight of the mixture according to the invention are dissolved in 70 parts by weight of cyclohexanone and 10 parts by weight of a dispersant such as polyvinylpyrrolidone are added. Dilution with water gives a dispersion. The active compound content is 20% by weight.
C)可乳化的浓缩物(EC)C) Emulsifiable Concentrate (EC)
将15重量份本发明混合物溶于75重量份二甲苯中并加入十二烷基苯磺酸钙和蓖麻油乙氧基化物(在每种情况下为5重量份)。用水稀释得到乳液。该配制剂的活性化合物含量为15重量％。15 parts by weight of the mixture according to the invention are dissolved in 75 parts by weight of xylene and calcium dodecylbenzenesulfonate and castor oil ethoxylate (in each case 5 parts by weight) are added. Dilute with water to give an emulsion. The active compound content of this formulation is 15% by weight.
D)乳液(EW、EO)D) Emulsion (EW, EO)
将25重量份本发明混合物溶于35重量份二甲苯中并加入十二烷基苯磺酸钙和蓖麻油乙氧基化物(在每种情况下为5重量份)。借助乳化机(如Ultraturrax)将该混合物引入30重量份水中并制成均相乳液。用水稀释得到乳液。该配制剂的活性化合物含量为25重量％。25 parts by weight of the mixture according to the invention are dissolved in 35 parts by weight of xylene and calcium dodecylbenzenesulfonate and castor oil ethoxylate (in each case 5 parts by weight) are added. The mixture is introduced into 30 parts by weight of water by means of an emulsifying machine (eg Ultraturrax) and a homogeneous emulsion is produced. Dilute with water to give an emulsion. The active compound content of this formulation is 25% by weight.
E)悬浮液(SC、OD)E) Suspension (SC, OD)
在搅拌的球磨机中，将20重量份本发明混合物粉碎并加入10重量份分散剂和湿润剂以及70重量份水或有机溶剂，得到微细活性化合物悬浮液。用水稀释得到稳定的活性化合物悬浮液。该配制剂中的活性化合物含量为20重量％。In a stirred ball mill, 20 parts by weight of the mixture according to the invention are comminuted and 10 parts by weight of dispersants and wetting agents and 70 parts by weight of water or organic solvents are added to give a finely divided active compound suspension. Dilution with water gives a stable active compound suspension. The active compound content of this formulation is 20% by weight.
F)水分散性颗粒和水溶性颗粒(WG、SG)F) Water Dispersible Granules and Water Soluble Granules (WG, SG)
将50重量份本发明混合物细碎研磨并加入50重量份分散剂和湿润剂，借助工业装置(如挤出机、喷雾塔、流化床)将其制成水分散性或水溶性颗粒。用水稀释得到稳定的活性化合物分散体或溶液。该配制剂的活性化合物含量为50重量％。50 parts by weight of the mixture according to the invention are finely ground and added with 50 parts by weight of dispersant and wetting agent, which are produced into water-dispersible or water-soluble granules by means of industrial equipment (eg extruder, spray tower, fluidized bed). Dilution with water gives a stable dispersion or solution of the active compound. The active compound content of this formulation is 50% by weight.
G)水分散性粉末和水溶性粉末(WP、SP)G) Water dispersible powder and water soluble powder (WP, SP)
将75重量份本发明混合物在转子-定子磨机中研磨并加入25重量份分散剂、湿润剂和硅胶。用水稀释得到稳定的活性化合物分散体或溶液。该配制剂的活性化合物含量为75重量％。75 parts by weight of the mixture according to the invention are ground in a rotor-stator mill and 25 parts by weight of dispersant, wetting agent and silica gel are added. Dilution with water gives a stable dispersion or solution of the active compound. The active compound content of this formulation is 75% by weight.
2.不经稀释而施用的产品2. Products to be applied undiluted
H)可撒粉粉末(DP)H) Dustable Powder (DP)
将5重量份本发明混合物细碎研磨并与95重量份细碎高岭土充分混合。这得到活性化合物含量为5重量％的可撒粉产品。5 parts by weight of the mixture according to the invention are ground finely and mixed thoroughly with 95 parts by weight of finely divided kaolin. This gives a dustable product with an active compound content of 5% by weight.
J)颗粒(GR、FG、GG、MG)J) Particles (GR, FG, GG, MG)
将0.5重量份本发明混合物细碎研磨并结合99.5重量份载体。现行方法是挤出、喷雾干燥或流化床方法。这得到活性化合物含量为0.5重量％的不经稀释而施用的颗粒。0.5 part by weight of the inventive mixture is ground finely and combined with 99.5 parts by weight of carrier. Current methods are extrusion, spray drying or fluidized bed methods. This gives granules to be applied neat with an active compound content of 0.5% by weight.
K)ULV溶液(UL)K) ULV solution (UL)
将10重量份本发明混合物溶于90重量份有机溶剂如二甲苯中。这得到活性化合物含量为10重量％的不经稀释而施用的产品。10 parts by weight of the inventive mixture are dissolved in 90 parts by weight of an organic solvent such as xylene. This gives a product to be applied undiluted with an active compound content of 10% by weight.
活性化合物可以直接、以其配制剂形式或由其制备的使用形式(如可直接喷雾溶液、粉末、悬浮液或分散体、乳液、油分散体、糊、可撒粉产品、撒播用材料或颗粒)，借助喷雾、雾化、撒粉、撒播或浇灌来使用。使用形式完全取决于意欲的目的；意欲在每种情况下确保活性化合物的最佳可能分布。The active compounds can be used directly, in the form of their formulations or in the use forms prepared therefrom (e.g. directly sprayable solutions, powders, suspensions or dispersions, emulsions, oil dispersions, pastes, dustable products, spreading materials or granules ), applied by spraying, misting, dusting, spreading or watering. The use forms depend entirely on the intended purpose; it is intended in each case to ensure the best possible distribution of the active compound.
含水使用形式可通过加入水由乳液浓缩物、糊或可湿性粉末(可喷雾粉末、油分散体)制备。为制备乳液、糊或油分散体，可借助湿润剂、增粘剂、分散剂或乳化剂将该物质直接或溶于油或溶剂中后在水中均化。然而，还可以制备由活性物质、湿润剂、增粘剂、分散剂或乳化剂以及合适的话溶剂或油组成的浓缩物且该浓缩物适于用水稀释。Aqueous use forms can be prepared from emulsion concentrates, pastes or wettable powders (sprayable powders, oil dispersions) by adding water. To prepare emulsions, pastes or oil dispersions, the substances are homogenized in water as such or dissolved in an oil or solvent with the aid of wetting agents, tackifiers, dispersants or emulsifiers. However, it is also possible to prepare concentrates consisting of active substance, wetter, tackifier, dispersant or emulsifier and, if appropriate, solvent or oil and which are suitable for dilution with water.
即用制剂中的活性化合物浓度可在较宽范围内变化。它们通常为0.0001-10％，优选0.01-1％。The active compound concentrations in the ready-to-use preparations can be varied within relatively wide ranges. They are usually 0.0001-10%, preferably 0.01-1%.
活性化合物也可成功用于超低容量法(ULV)，通过这种方法可以施用包含超过95重量％活性化合物的配制剂，或甚至施用不含添加剂的活性化合物。The active compounds can also be used successfully in the ultra-low volume method (ULV), by means of which it is possible to apply formulations comprising more than 95% by weight of active compound, or even to apply the active compound without additives.
可以向活性化合物中加入各种类型的油、润湿剂、辅助剂、除草剂、其他农药或杀菌剂，需要的话仅在紧临使用前加入(桶混合)。这些试剂通常与本发明混合物以1∶100-100∶1，优选1∶10-10∶1的重量比混合。Oils of various types, wetting agents, adjuvants, herbicides, other pesticides or fungicides can be added to the active compounds, if desired only immediately before use (tank mix). These agents are generally mixed with the mixtures according to the invention in a weight ratio of 1:100 to 100:1, preferably 1:10 to 10:1.
就此而言合适的辅助剂尤其是：有机改性的聚硅氧烷，例如BreakThru S 240；醇烷氧基化物，例如Atplus 245、Atplus MBA 1303、Plurafac LF 300和LutensolON 30；EO/PO嵌段聚合物，例如PluronicRPE 2035和GenapolB；醇乙氧基化物，例如LutensolXP 80；以及磺基琥珀酸二辛基酯钠，例如LeophenRA。Suitable auxiliaries in this regard are, inter alia: organomodified polysiloxanes, such as BreakThru S 240(R); alcohol alkoxylates, such as Atplus 245 ( R) , Atplus MBA 1303(R ), Plurafac LF 300 (R) and Lutensol (R) ON 30 EO/PO block polymers such as Pluronic ( R) RPE 2035 and Genapol (R) B; alcohol ethoxylates such as Lutensol ( R) XP 80; and sodium dioctyl sulfosuccinate such as Leophen (R) RA.
化合物I和II或混合物或对应配制剂通过用杀真菌有效量的混合物或在分开施用情况下的化合物I和II处理有害真菌、其栖息地或需要防止它们的植物、种子、土壤、区域、材料或空间而施用。施用可以在有害真菌侵染之前或之后进行。Compounds I and II or mixtures or corresponding formulations by treating harmful fungi, their habitat or plants, seeds, soil, areas, materials to be protected against them with a fungicidally effective amount of the mixture or compounds I and II in the case of separate application or space for application. Application can take place before or after infestation by the harmful fungi.
制备实施例Preparation Example
1.)邻-(3，5-二氯苯基)苯胺的合成1.) Synthesis of o-(3,5-dichlorophenyl)aniline
将1.4g四(三苯基膦)钯(0)加入20.47g 2-溴苯胺、24.98g 3，5-二氯苯基硼酸和25.23g碳酸钠在150ml水和450ml乙二醇二甲醚的混合物中的溶液中。将该混合物在回流下搅拌23小时。减压浓缩反应物。将残留物溶于甲基叔丁基醚中并用水洗涤3次，在硫酸钠上干燥并减压浓缩。使用甲苯和环己烷(1∶4)的混合物层析提纯得到13.3g白色粉状产物。Add 1.4g tetrakis(triphenylphosphine) palladium (0) to 20.47g 2-bromoaniline, 24.98g 3,5-dichlorophenylboronic acid and 25.23g sodium carbonate in 150ml water and 450ml ethylene glycol dimethyl ether solution in the mixture. The mixture was stirred at reflux for 23 hours. The reaction was concentrated under reduced pressure. The residue was dissolved in methyl tert-butyl ether and washed 3 times with water, dried over sodium sulfate and concentrated under reduced pressure. Purification by chromatography using a mixture of toluene and cyclohexane (1:4) gave 13.3 g of the product as a white powder.
2.)1-甲基-3-三氟甲基-N-(邻-(3，5-二氯苯基)苯基)-吡唑-4-甲酰胺的合成2.) Synthesis of 1-methyl-3-trifluoromethyl-N-(o-(3,5-dichlorophenyl)phenyl)-pyrazole-4-carboxamide
将9.88g 1-甲基-3-三氟甲基吡唑-4-碳酰氯、11.07g邻-(3，5-二氯苯基)苯胺和5.52g吡啶溶于350ml甲苯中。在室温下搅拌48小时之后，加入400ml甲基叔丁基醚。然后将反应混合物用浓度为5％的盐酸洗涤2次，用浓度为5％的氢氧化钠水溶液洗涤1次并用水洗涤2次。将有机相在硫酸钠上干燥并减压浓缩。由二异丙基醚重结晶粗产物并用正戊烷洗涤。得到16.94g无色粉状产物；熔点为101-105℃。9.88 g of 1-methyl-3-trifluoromethylpyrazole-4-carbonyl chloride, 11.07 g of o-(3,5-dichlorophenyl)aniline and 5.52 g of pyridine were dissolved in 350 ml of toluene. After stirring at room temperature for 48 hours, 400 ml of methyl tert-butyl ether were added. The reaction mixture was then washed twice with 5% strength hydrochloric acid, once with 5% strength aqueous sodium hydroxide solution and twice with water. The organic phase was dried over sodium sulfate and concentrated under reduced pressure. The crude product was recrystallized from diisopropyl ether and washed with n-pentane. 16.94 g of the product are obtained as a colorless powder; melting point 101-105°C.
除了上述化合物，下表18以示例方式列出了其他其中X为氧的式I的3，5-二取代的N-联苯基吡唑甲酰胺，这些化合物以相同方式制备或可以相同方式制备。In addition to the above-mentioned compounds, the following table 18 lists by way of example other 3,5-disubstituted N-biphenylpyrazole carboxamides of the formula I in which X is oxygen, which are prepared or can be prepared in the same way .
表18Table 18
应用实施例Application example
本发明混合物的协同增效作用由下列试验证实：The synergistic effect of the mixture of the present invention is confirmed by the following tests:
使用溶剂/乳化剂体积比为99∶1的丙酮和/或二甲亚砜与乳化剂UniperolEL(具有乳化和分散作用的基于乙氧基化烷基酚的润湿剂)的混合物将活性化合物单独或一起制成包含25mg活性化合物并配成10ml的储备溶液。然后将该混合物用水配成100ml。用所述溶剂/乳化剂/水混合物稀释该储备溶液至下述活性化合物浓度。Use a mixture of acetone and/or dimethyl sulfoxide in a solvent/emulsifier volume ratio of 99:1 and the emulsifier Uniperol ® EL (wetting agent based on ethoxylated alkylphenols with emulsifying and dispersing action). Compounds were prepared individually or together as a stock solution containing 25 mg of active compound in 10 ml. The mixture was then made up to 100ml with water. This stock solution was diluted with the solvent/emulsifier/water mixture to the concentration of active compound described below.
或者以市售配制剂使用活性化合物氧唑菌和唑菌胺酯并将它们用水稀释到所述活性化合物浓度。Alternatively the active compounds econazole and pyraclostrobin were used in the commercially available formulations and diluted with water to the stated active compound concentration.
将目测测定的侵染叶面积百分数转化成以相对于未处理对照的％表示的效力。The percent infected leaf area determined visually was converted into efficacy expressed as % relative to the untreated control.
使用Abbot公式按如下计算效力(E)：Efficacy (E) was calculated using Abbot's formula as follows:
E＝(1-α/β)·100E＝(1-α/β)·100
α对应于处理植物的真菌侵染百分数，和α corresponds to the percent fungal infection of the treated plants, and
β对应于未处理(对照)植物的真菌侵染百分数。β corresponds to the percent fungal infection of untreated (control) plants.
效力为0表示处理植物的侵染水平相当于未处理的对照植物；效力为100表示处理植物未受侵染。An efficacy of 0 indicates that the treated plants have an infection level equivalent to that of the untreated control plants; an efficacy of 100 indicates that the treated plants are not infected.
活性化合物混合物的预期效力使用Colby公式[R.S.Colby，“计算除草剂组合的协同增效和拮抗响应”，Weeds(杂草)15，20-22(1967)]确定并与观察的效力比较。The expected efficacy of active compound mixtures is determined using Colby's formula [RS Colby, "Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 15 , 20-22 (1967)] and compared to observed efficacy.
Colby公式：E＝x+y-x·y/100Colby's formula: E=x+y-x y/100
E使用浓度为a和b的活性化合物A和B的混合物时的预期效力，以相对于未处理对照的％表示，E Expected potency in % relative to untreated control using a mixture of active compounds A and B at concentrations a and b,
x使用浓度为a的活性化合物A时的效力，以相对于未处理对照的％表示，y使用浓度为b的活性化合物B时的效力，以相对于未处理对照的％表示。应用实施例1-对由早疫链格孢引起的西红柿上的早疫病的活性x Potency with active compound A at concentration a in % relative to untreated control, y potency with active compound B at concentration b in % relative to untreated control. Application example 1 - Activity against early blight on tomatoes caused by Alternaria infestans
将盆栽西红柿植物的叶子用活性化合物浓度如下所述的含水悬浮液喷雾至滴流点。第二天将叶子用早疫链格孢在2％生物麦芽溶液中的含水孢子悬浮液侵染，该悬浮液具有0.17×106个孢子/ml的密度。然后将植物置于温度为20-22℃的水蒸气饱和室中。5天之后，在未处理但侵染的对照植物上的病害已经发展到可以百分数目测测定侵染的程度。The leaves of potted tomato plants are sprayed to the point of dripping with the aqueous suspension at the concentration of active compound indicated below. The next day the leaves were infested with an aqueous spore suspension of Alternaria infestans in a 2% biomalt solution having a density of 0.17×10 6 spores/ml. The plants were then placed in a steam-saturated chamber at a temperature of 20-22°C. After 5 days, the disease on the untreated but infected control plants had developed to such an extent that the infection could be measured as a percentage.
应用实施例2-对由灰葡萄孢引起的柿子椒叶子上的灰霉病的活性，1天保护性施用Use Example 2 - Activity against botrytis cinerea on bell pepper leaves caused by Botrytis cinerea, 1-day protective application
将栽培品种为“Neusiedler Ideal Elite”的柿子椒秧苗在充分发育出2-3片叶后用活性化合物浓度如下所述的含水悬浮液喷雾至滴流点。第二天将已处理植物用在浓度为2％的生物麦芽水溶液中含有1.7×106个孢子/ml的灰葡萄孢的孢子悬浮液接种。然后将试验植物置于22-24℃和高大气湿度的黑暗气候调节室中。5天后可以百分数目测测定叶子上的真菌侵染程度。Bell pepper seedlings of the cultivar "Neusiedler Ideal Elite" are sprayed to the point of dripping after they have fully developed 2-3 leaves with an aqueous suspension at the concentration of active compound indicated below. The next day the treated plants were inoculated with a spore suspension of Botrytis cinerea containing 1.7 x 106 spores/ml in a 2% aqueous biomalt solution. The test plants are then placed in a dark climate-conditioned room at 22-24° C. and high atmospheric humidity. After 5 days the degree of fungal infection on the leaves can be determined quantitatively.
应用实施例3-对由禾白粉菌(Erysiphe[同义词Blumeria]graminis formaspecialis.tritici)引起的小麦霉病的活性Use Example 3 - Activity against wheat mildew caused by Erysiphe [synonym Blumeria] graminis formaspecialis.tritici
将盆栽小麦秧苗的叶子用活性化合物浓度如下所述的含水悬浮液喷雾至滴流点。该悬浮液或乳液如上所述制备。喷雾涂层干燥24小时之后，将植物用小麦霉病(禾白粉菌)的孢子撒粉。然后将试验植物置于温度为20-24℃且相对大气湿度为60-90％的温室中。7天后以整个叶面积的侵染％目测测定霉病发展程度。The leaves of potted wheat seedlings are sprayed to the point of dripping with the aqueous suspension at the concentration of active compound indicated below. This suspension or emulsion is prepared as described above. 24 hours after the spray coating had dried, the plants were dusted with spores of wheat mildew (Erysipha graminis). The test plants are then placed in a greenhouse at a temperature of 20-24° C. and a relative atmospheric humidity of 60-90%. The degree of mildew development was determined visually after 7 days as % infection of the entire leaf area.
应用实施例4-在小麦上对隐匿柄锈菌(Puccinia recondita)(小麦褐锈病)的保护活性Use Example 4 - Protective activity against Puccinia recondita (wheat brown rust) on wheat
将栽培品种为“Kanzler”的盆栽小麦秧苗的叶子用活性化合物浓度如下所述的含水悬浮液喷雾至滴流点。第二天将已处理植物用小麦褐锈病菌(隐匿柄锈菌)的孢子悬浮液接种。然后将植物放置在20-22℃，高大气湿度(90-95％)的室中24小时。在此期间孢子萌发并且芽管穿透到叶组织中。第二天将试验植物送回温室中并在温度为20-22℃和相对大气湿度为65-70％下再栽培7天。然后目测测定锈病真菌在叶子上的发展程度。Leaves of potted wheat seedlings of the cultivar "Kanzler" are sprayed to the point of dripping with an aqueous suspension having the concentration of active compound indicated below. The treated plants were inoculated the next day with a spore suspension of the wheat brown rust fungus (Puccinia recondita). The plants are then placed in a room at 20-22° C. with high atmospheric humidity (90-95%) for 24 hours. During this time the spores germinate and the germ tube penetrates into the leaf tissue. The next day the test plants were returned to the greenhouse and cultivated for a further 7 days at a temperature of 20-22° C. and a relative atmospheric humidity of 65-70%. The extent of rust fungus development on the leaves was then determined visually.
应用实施例5-对由豆薯层锈菌引起的大豆锈病的治疗活性Application Example 5 - Therapeutic activity against soybean rust caused by Phakopsora pachyrhizi
将栽培品种为“Oxford”的盆栽大豆秧苗的叶子用大豆锈病(豆薯层锈菌)的孢子悬浮液接种。将盆置于高大气湿度(90-95％)和23-27℃的室中24小时。在此期间孢子萌发并且芽管穿透到叶组织中。2天后将侵染的植物用活性化合物浓度如下所述的上述活性化合物溶液喷雾至滴流点。在喷雾涂层干燥后，将测试植物在温度为23-27℃且相对大气湿度为60-80％的温室中栽培14天。然后测定叶子上的锈病真菌发展程度。Leaves of potted soybean seedlings of the cultivar "Oxford" were inoculated with a spore suspension of soybean rust (Phaakopsora pachyrhiza). The pots were placed in a room with high atmospheric humidity (90-95%) and 23-27°C for 24 hours. During this time the spores germinate and the germ tube penetrates into the leaf tissue. After 2 days the infested plants are sprayed to the point of dripping with the abovementioned active compound solution at the concentration of active compound indicated below. After the spray coating had dried on, the test plants were grown for 14 days in a greenhouse at a temperature of 23-27° C. and a relative atmospheric humidity of 60-80%. The extent of rust fungus development on the leaves was then determined.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101816308A (en) * | 2010-03-19 | 2010-09-01 | 深圳诺普信农化股份有限公司 | Bactericidal composition |
| CN103734149A (en) * | 2013-12-28 | 2014-04-23 | 上海艳紫化工科技有限公司 | Activated ester and quinoxyfen compound insecticidal suspending agent |
| CN104705305A (en) * | 2013-12-12 | 2015-06-17 | 南京华洲药业有限公司 | Sterilization composition containing penconazole and cyazofamid and use thereof |
| CN104705312A (en) * | 2013-12-12 | 2015-06-17 | 南京华洲药业有限公司 | Sterilization composition containing penconazole and triadimenol, and applications thereof |
| WO2020078426A1 (en) * | 2018-10-20 | 2020-04-23 | 南通江山农药化工股份有限公司 | Germicidal composition and use thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101816308A (en) * | 2010-03-19 | 2010-09-01 | 深圳诺普信农化股份有限公司 | Bactericidal composition |
| CN104705305A (en) * | 2013-12-12 | 2015-06-17 | 南京华洲药业有限公司 | Sterilization composition containing penconazole and cyazofamid and use thereof |
| CN104705312A (en) * | 2013-12-12 | 2015-06-17 | 南京华洲药业有限公司 | Sterilization composition containing penconazole and triadimenol, and applications thereof |
| CN103734149A (en) * | 2013-12-28 | 2014-04-23 | 上海艳紫化工科技有限公司 | Activated ester and quinoxyfen compound insecticidal suspending agent |
| CN103734149B (en) * | 2013-12-28 | 2016-04-20 | 上海艳紫化工科技有限公司 | Acibenzolar and benzene oxygen quinoline compound insecticidal suspending agent |
| WO2020078426A1 (en) * | 2018-10-20 | 2020-04-23 | 南通江山农药化工股份有限公司 | Germicidal composition and use thereof |
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