CN101557706B - 雷沙吉兰碱结晶固体 - Google Patents

雷沙吉兰碱结晶固体 Download PDF

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Publication number
CN101557706B
CN101557706B CN2007800458662A CN200780045866A CN101557706B CN 101557706 B CN101557706 B CN 101557706B CN 2007800458662 A CN2007800458662 A CN 2007800458662A CN 200780045866 A CN200780045866 A CN 200780045866A CN 101557706 B CN101557706 B CN 101557706B
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CN
China
Prior art keywords
propargyl
aminoidan
crystallization
solution
rasagiline
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Expired - Fee Related
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CN2007800458662A
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English (en)
Chinese (zh)
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CN101557706A (zh
Inventor
安东·弗兰克尔
托马斯·科尓泰
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Teva Pharmaceutical Industries Ltd
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Teva Pharmaceutical Industries Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
CN2007800458662A 2006-12-14 2007-12-13 雷沙吉兰碱结晶固体 Expired - Fee Related CN101557706B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87501106P 2006-12-14 2006-12-14
US60/875,011 2006-12-14
PCT/US2007/025583 WO2008076348A1 (en) 2006-12-14 2007-12-13 Crystalline solid rasagiline base

Publications (2)

Publication Number Publication Date
CN101557706A CN101557706A (zh) 2009-10-14
CN101557706B true CN101557706B (zh) 2013-08-07

Family

ID=39536623

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800458662A Expired - Fee Related CN101557706B (zh) 2006-12-14 2007-12-13 雷沙吉兰碱结晶固体

Country Status (24)

Country Link
US (4) US7750051B2 (de)
EP (1) EP2101569B1 (de)
JP (1) JP5623081B2 (de)
KR (1) KR101459744B1 (de)
CN (1) CN101557706B (de)
AT (1) ATE528989T1 (de)
AU (1) AU2007334428B2 (de)
CA (1) CA2672414A1 (de)
CY (1) CY1112511T1 (de)
DK (1) DK2101569T3 (de)
EA (1) EA016820B1 (de)
ES (1) ES2375761T3 (de)
HR (1) HRP20110980T1 (de)
IL (1) IL198985A0 (de)
MX (1) MX2009006251A (de)
NO (1) NO20092611L (de)
NZ (1) NZ577460A (de)
PL (1) PL2101569T3 (de)
PT (1) PT2101569E (de)
RS (1) RS52183B (de)
SI (1) SI2101569T1 (de)
UA (1) UA97502C2 (de)
WO (1) WO2008076348A1 (de)
ZA (1) ZA200903903B (de)

Families Citing this family (42)

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PL1848415T3 (pl) * 2005-02-17 2013-10-31 Teva Pharma Terapia kombinowana obejmująca octan glatirameru oraz rasagilinę do leczenia stwardnienia rozsianego
WO2006091657A1 (en) 2005-02-23 2006-08-31 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations of improved content uniformity
CA2630037C (en) * 2005-11-17 2015-03-31 Teva Pharmaceutical Industries Ltd. Methods for isolating propargylated aminoindans
US7572834B1 (en) 2005-12-06 2009-08-11 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations and processes for their preparation
ES2551481T3 (es) 2006-02-21 2015-11-19 Teva Pharmaceutical Industries, Ltd. Uso de rasagilina para el tratamiento de atrofia multisistémica
JP5769923B2 (ja) * 2006-04-03 2015-08-26 テバ ファーマシューティカル インダストリーズ リミティド レストレスレッグス症候群の治療のためのラサギリンの使用
EP1892233A1 (de) 2006-08-18 2008-02-27 Ratiopharm GmbH Neue Salze des Wirkstoffs Rasagilin
CN101557706B (zh) 2006-12-14 2013-08-07 泰华制药工业有限公司 雷沙吉兰碱结晶固体
EP1987816A1 (de) * 2007-04-30 2008-11-05 Ratiopharm GmbH Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff
CA2698695A1 (en) * 2007-09-05 2009-03-12 Teva Pharmaceutical Industries Ltd. Method of treating glaucoma using rasagiline
US8188149B2 (en) * 2007-09-17 2012-05-29 Teva Pharmaceutical Industries, Ltd. Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss
EP2234478A4 (de) * 2008-01-11 2013-01-23 Teva Pharma Rasagilinformulierungen, ihre herstellung und verwendung
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CN101606923B (zh) * 2008-06-20 2013-01-09 重庆医药工业研究院有限责任公司 一种稳定的控释释放的雷沙吉兰透皮贴片及其制备方法
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US20100189791A1 (en) 2009-01-23 2010-07-29 Teva Pharmaceutical Industries, Ltd. Delayed release rasagiline malate formulation
SI2451771T1 (sl) 2009-07-09 2014-10-30 Ratiopharm Gmbh Soli rasagilina in njihovi farmacevtski pripravki
EP2298277A1 (de) * 2009-09-09 2011-03-23 Labtec GmbH Transdermale Pflasterformulierung
CN102048717B (zh) 2009-10-29 2014-02-19 重庆医药工业研究院有限责任公司 一种稳定的雷沙吉兰组合物
EP2325159A1 (de) 2009-11-24 2011-05-25 LEK Pharmaceuticals d.d. Neuartige Salze von Rasagilin
EP2515891A4 (de) * 2009-12-22 2013-06-05 Teva Pharma 3-keto-n-propargyl-1-aminoindan
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AU2011282720B2 (en) 2010-07-27 2016-12-22 Teva Pharmaceutical Industries Ltd. Use of rasagiline for the treatment of olfactory dysfunction
JP2013537530A (ja) 2010-07-27 2013-10-03 テバ ファーマシューティカル インダストリーズ リミティド ラサギリンシトレートの分散物
KR101853082B1 (ko) 2011-03-24 2018-04-27 테이코쿠 팔마 유에스에이, 인코포레이티드 활성제층 및 활성제 변환층을 포함하는 경피 조성물
EP2705021A2 (de) 2011-05-04 2014-03-12 Cadila Healthcare Limited Rasagilin und pharmazeutisch zulässige salze davon
HK1200315A1 (en) 2011-10-10 2015-08-07 Teva Pharmaceutical Industries Ltd. R(+)-n-formyl-propargyl-aminoindan
JP2014534197A (ja) 2011-10-10 2014-12-18 テバ ファーマシューティカル インダストリーズ リミティド Ｒ（＋）−ｎ−メチル−プロパルギルアミノインダン
JP5913614B2 (ja) 2011-11-09 2016-04-27 テイコク ファーマ ユーエスエー インコーポレーテッド 皮膚新生物の処置方法
EP2610239A1 (de) 2012-01-02 2013-07-03 Dr. Reddy's Laboratories Ltd. Herstellung von Rasagilin-Hemitartrat
EA201491734A1 (ru) 2012-03-21 2015-01-30 Синтон Бв Стабилизированные фармацевтические композиции, содержащие соли разагилина
JP2015529196A (ja) 2012-08-17 2015-10-05 テバ ファーマシューティカル インダストリーズ リミティド ラサギリンの非経口製剤
JP6050896B2 (ja) 2012-11-02 2016-12-21 テイコク ファーマ ユーエスエー インコーポレーテッド プロピニルアミノインダン経皮組成物

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US20080161408A1 (en) 2008-07-03
NZ577460A (en) 2012-01-12
EP2101569A4 (de) 2009-12-02
CY1112511T1 (el) 2015-12-09
EP2101569B1 (de) 2011-10-19
JP5623081B2 (ja) 2014-11-12
WO2008076348A1 (en) 2008-06-26
ES2375761T3 (es) 2012-03-06
AU2007334428B2 (en) 2014-05-29
US8614252B2 (en) 2013-12-24
EA016820B1 (ru) 2012-07-30
ZA200903903B (en) 2010-08-25
EA200970581A1 (ru) 2009-12-30
HRP20110980T1 (hr) 2012-02-29
US20150038744A1 (en) 2015-02-05
PT2101569E (pt) 2012-01-13
HK1129276A1 (en) 2009-11-27
US20100145101A1 (en) 2010-06-10
IL198985A0 (en) 2010-02-17
CN101557706A (zh) 2009-10-14
US7750051B2 (en) 2010-07-06
US20100144887A1 (en) 2010-06-10
WO2008076348A8 (en) 2008-08-21
PL2101569T3 (pl) 2012-03-30
DK2101569T3 (da) 2012-01-30
SI2101569T1 (sl) 2012-02-29
MX2009006251A (es) 2009-10-12
AU2007334428A1 (en) 2008-06-26
NO20092611L (no) 2009-09-11
JP2010513282A (ja) 2010-04-30
UA97502C2 (ru) 2012-02-27
EP2101569A1 (de) 2009-09-23
ATE528989T1 (de) 2011-11-15
RS52183B (sr) 2012-10-31
CA2672414A1 (en) 2008-06-26
KR101459744B1 (ko) 2014-11-20
KR20090089894A (ko) 2009-08-24

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