CN101810198B - Salicylic acid-iodine disinfector and preparation method thereof - Google Patents
Salicylic acid-iodine disinfector and preparation method thereof Download PDFInfo
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- CN101810198B CN101810198B CN201010163672.6A CN201010163672A CN101810198B CN 101810198 B CN101810198 B CN 101810198B CN 201010163672 A CN201010163672 A CN 201010163672A CN 101810198 B CN101810198 B CN 101810198B
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- ZVVHPYOYQRQSJH-UHFFFAOYSA-N [I].OC(=O)C1=CC=CC=C1O Chemical compound [I].OC(=O)C1=CC=CC=C1O ZVVHPYOYQRQSJH-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000007788 liquid Substances 0.000 claims abstract description 14
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 14
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000011630 iodine Substances 0.000 claims abstract description 13
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims abstract description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 11
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 6
- 241001465754 Metazoa Species 0.000 abstract description 3
- 238000003912 environmental pollution Methods 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 3
- 241000282414 Homo sapiens Species 0.000 abstract description 2
- 238000003756 stirring Methods 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 13
- 239000000725 suspension Substances 0.000 description 13
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 6
- 229940033663 thimerosal Drugs 0.000 description 6
- 239000000645 desinfectant Substances 0.000 description 5
- 244000144972 livestock Species 0.000 description 5
- 244000144977 poultry Species 0.000 description 5
- 244000063299 Bacillus subtilis Species 0.000 description 4
- 235000014469 Bacillus subtilis Nutrition 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 241000565675 Oncomelania Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 238000009360 aquaculture Methods 0.000 description 2
- 244000144974 aquaculture Species 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000012422 test repetition Methods 0.000 description 2
- RQTVIKMRXYJTDX-UHFFFAOYSA-N 1-(4-methylphenyl)sulfonyl-4-phenylpiperidine-4-carbonitrile Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1CCC(C=2C=CC=CC=2)(C#N)CC1 RQTVIKMRXYJTDX-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- OWBBAPRUYLEWRR-UHFFFAOYSA-N 4-hydroxycoumarin Chemical compound C1=CC=C2OC(O)=CC(=O)C2=C1 OWBBAPRUYLEWRR-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- ULSLJYXHZDTLQK-UHFFFAOYSA-N Coumatetralyl Chemical group C1=CC=CC2=C1OC(=O)C(C1C3=CC=CC=C3CCC1)=C2O ULSLJYXHZDTLQK-UHFFFAOYSA-N 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 238000004500 asepsis Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- VXIXUWQIVKSKSA-UHFFFAOYSA-N benzotetronic acid Natural products C1=CC=CC2=C1OC(=O)C=C2O VXIXUWQIVKSKSA-UHFFFAOYSA-N 0.000 description 1
- 244000144987 brood Species 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- YFVOXLJXJBQDEF-UHFFFAOYSA-N isocarbophos Chemical compound COP(N)(=S)OC1=CC=CC=C1C(=O)OC(C)C YFVOXLJXJBQDEF-UHFFFAOYSA-N 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000003986 organophosphate insecticide Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- IXTOWLKEARFCCP-UHFFFAOYSA-N propan-2-yl 2-[methoxy-(propan-2-ylamino)phosphinothioyl]oxybenzoate Chemical group CC(C)NP(=S)(OC)OC1=CC=CC=C1C(=O)OC(C)C IXTOWLKEARFCCP-UHFFFAOYSA-N 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000003128 rodenticide Substances 0.000 description 1
- 238000011012 sanitization Methods 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- 206010048282 zoonosis Diseases 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a salicylic acid-iodine disinfector. The invention is characterized by comprising the following components in percentage by weight: 10-50% of salicylic acid, 0.5-2.5% of iodine, 10-50% of ethanol and 1-65% of water. The preparation method comprises the following steps: firstly dissolving the salicylic acid and the iodine in the components by the ethanol, adding the formed uniform liquid to a reaction kettle, adding water, stirring, and mixing for 2-5 hours to generate a homogeneous-phase clear liquid. The salicylic acid-iodine disinfector has the advantages of wide sterilization spectrum, strong sterilization capability, high action speed, good stability, safe application to human beings and animals and low environmental pollution degree, thereby being an environment-friendly salicylic acid-iodine disinfector.
Description
Technical field
The invention belongs to disinfectant field, particularly a kind of compound salicylic acid-iodine disinfector and preparation method thereof for livestock and poultry, aquaculture and public place sterilization.
Background technology
In recent years; because of the factor such as environment and drug abuse; the various infectious disease of livestock and poultry breeding industry is caused to take place frequently; to such an extent as to the relevant industries such as livestock and poultry breeding industry, veterinary drug production and operation are subject to great impact; along with the layer of food safety affair go out, the propagation of zoonosis, the development of large-scale cultivation; and people " prevent overweighting controlling " continually strengthening of medication idea; in the urgent need to for improving feeding environment, prophylactic green safety disinfectant; effectively should kill virus, again to livestock and poultry, aquatic products without stress.
Iodine is used for the history that body sterilizing has 150 years, and since latter half in 19th century, many people have spoken highly of the usefulness of iodine as antibacterial agent, and this is mainly because it has the unexistent and inaccessiable bactericidal effect of many bactericide.Its has a broad antifungal spectrum, little to tissue toxicity, be widely used, its sterilizing scope relates to clinical, health, daily life, livestock and poultry cultivation, aquaculture, public place and drinking water etc., different classes of, different dosage form, different efficacies iodine sterilizing medicine is just being widely used in practice, as for the sterilization of human body skin, wound surface, mucomembranous surface, surgical instruments, Chi Shui, drinking water and the sanitized of tableware, be used for treating the various diseases of the various mankind etc.
Salicylic acid that is septichen (o-hydroxybenzoic acid) are a kind of important organic synthesis raw materials.In pesticide producing, for the synthesis of the intermediate 4 hydroxy coumarin of the intermediate isopropyl salicylate of organophosphorus insecticide isocarbophos, Isofenphos methyl and rodenticide warfarin, coumatetralyl; In medical industry, salicylic acid is used as except Cidex-7, also as the intermediate of the multi-medicaments such as acetylsalicylic acid (aspirin) except own; It is also the important source material of the industry such as dyestuff, spices, rubber.How salicylic acid and iodine combination to be utilized, be a problem being worth inquiring into.
Summary of the invention
The object of this invention is to provide a kind of new disinfectant, have that fungicidal spectrum is wide, sterilizing ability is strong, speed of action is fast, good stability, to humans and animals safety, environmental pollution degree is low, salicylic acid-iodine disinfector of the advantages such as environmentally friendly type and preparation method thereof.
The present invention adopts following technical scheme to realize above-mentioned purpose:
Salicylic acid-iodine disinfector of the present invention, is characterized in that: it contains following component, and the percentage by weight of each component is as follows:
Salicylic acid 10-50%,
Iodine 0.5-2.5%,
Ethanol 10-50%,
Water 1-65%.
Salicylic acid-iodine disinfector preparation method of the present invention is, first flow into reactor with the uniform liquid that ethanol dissolves after each component, then adds appropriate water, be uniformly mixed 2-5 hours, become the liquid that homogeneous phase is clear and bright.
The beneficial effect that the present invention adopts above technical scheme to reach is:
Salicylic acid-iodine disinfector of the present invention is a kind of liquid sterilization disinfectant formulated by salicylic acid, iodine, ethanol, water, and it has the double sterilization effect of salicylic acid and Operand; Sterilizing ability is strong, speed of action is fast, good stability, and to humans and animals safety, environmental pollution degree is low; Its preparation method is simple, and production cost is low, and product has use value widely.
Embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1:
Salicylic acid-iodine disinfector of the present invention, it contains following component, salicylic acid 10%, iodine 1%, ethanol 29%, water 60%; First use the salicylic acid in ethanol dissolved constituent and iodine, the uniform liquid of formation is flow into reactor, then add water and be uniformly mixed 2 hours, become the liquid that homogeneous phase is clear and bright.
Embodiment 2:
Salicylic acid-iodine disinfector of the present invention, it contains following component, salicylic acid 20%, iodine 0.5%, ethanol 29.5%, water 50%, flow into reactor with the uniform liquid that ethanol dissolves after each component, add appropriate water, be then uniformly mixed 3 hours, become the liquid that homogeneous phase is clear and bright.
Embodiment 3:
Salicylic acid-iodine disinfector of the present invention, it contains following component, salicylic acid 40%, iodine 1.5%, ethanol 10%, water 48.5%, flow into reactor with the uniform liquid that ethanol dissolves after each component, add appropriate water, be then uniformly mixed 4 hours, become the liquid that homogeneous phase is clear and bright.
Salicylic acid-iodine disinfector of the present invention can be embodied from following bactericidal assay from bactericidal effect:
1 materials and methods
1.1 test equipment
1.1.1 salicylic acid-iodine disinfector is provided by Zhengdian Biological Tech. Co., Ltd., Foshan City.
1.1.2 test strain Escherichia coli (8099) and staphylococcus aureus (ATCC6538), cultivated for 6th ~ 8 generations; Bacillus subtilis var (ATCC9372), cultivated for the 4th generation, preparation brood cell.
1.2 method
1.2.1 staphylococcus aureus (ATCC6538) and Escherichia coli (8099) are got in the preparation of bacteria suspension
24h fresh cultured thing and bacillus subtilis var (ATCC9372) spore suspension, for subsequent use with the bacteria suspension being mixed with experimental concentration containing the dilution of 10g/L peptone phosphate buffer.
1.2.2 neutralizer Selection experiment take Escherichia coli as representative.Under 20 DEG C of conditions, if parallel 6 groups of tests, undertaken by Suspension quantitative bactericidal test program.1. thimerosal+bacteria suspension; 2. (thimerosal+bacteria suspension)+neutralizer; 3. neutralizer+bacteria suspension; 4. (thimerosal+neutralizer)+bacteria suspension; 5. dilution+bacteria suspension (normal bacteria contrast); 6. dilution+neutralizer+medium is as negative control.Result of the test, with the 1st group of not long bacterium or only there is only a few colony growth; 2nd group has colony growth, and comparatively the 1st group is many, but is few compared with the 3rd, 4,5 group; 3rd, 4,5 groups of bacterium numbers are similar, error rate≤10%; 6th group of asepsis growth, for selected neutralizer and concentration thereof are suitable for.Test repetition 3 times.
1.2.3 Suspension quantitative bactericidal test is under 20 DEG C of conditions, organic interfering substance and bacteria suspension 1: 1 mix for subsequent use, mix with the ratio (positive control is hard water) of 4ml disinfectant in every test tube 1ml bacteria suspension, effect, to the scheduled time, is drawn 0.5ml bacterium medicine and is added in 4.5ml neutralizer and mix.Neutralization 10min, gets this liquid 1ml and inoculates plate, pour into corresponding agar medium, cultivates 48h (bacillus subtilis black variety bud cell is 72h) for 37 DEG C, calculates clump count, calculate kill oncomelania.Test repetition 3 times.
2 results
2.1 neutralizer Selection experiment result of the tests show, under 20 DEG C of conditions, the aseptic PBS solution of 1% lecithin+1% Tween 80+0.5% sodium thiosulfate, effectively can neutralize residual thimerosal residual action, and neutralizer and neutralized reaction product have no significant effect test bacterial growth and medium.
2.2 Suspension quantitative bactericidal test result of the tests show, under 20 DEG C of conditions, available iodine is that 100mg/L thimerosal dilution acts on 3min respectively to Escherichia coli, staphylococcus aureus, kill oncomelania >=5.0; Available iodine be 500mg/L thimerosal dilution to bacillus subtilis black variety bud cell effect 5min, kill oncomelania >=5.0, in table 1.
Table 1 salicylic acid-iodine disinfector bactericidal effect
Note: test temperature is 20 DEG C, Negative control Sterile grows, and result is 3 test mean values.
3 discuss
This experimental study salicylic acid-iodine disinfector available iodine is that the dilution of 500mg/L has good killing effect to microorganism.
Above embodiment is only in order to illustrate that technical scheme of the present invention is not intended to limit; Although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the field are to be understood that.Still can modify to the embodiment of invention or portion of techniques feature be carried out to equivalent replacement; And not departing from the spirit of technical solution of the present invention, it all should be encompassed in the middle of the technical scheme scope of request of the present invention protection.
Claims (1)
1. a salicylic acid-iodine disinfector, is characterized in that, it contains following component, and the percentage by weight of each component is as follows:
Salicylic acid 20%, iodine 0.5%, ethanol 29.5%, water 50%.
2
.a preparation method for salicylic acid-iodine disinfector described in claim 1, is characterized in that, first uses the salicylic acid in ethanol dissolved constituent and iodine, and the uniform liquid of formation is flow into reactor, then adds water and is uniformly mixed 3 hours, becomes the liquid that homogeneous phase is clear and bright.
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| CN201010163672.6A CN101810198B (en) | 2010-05-06 | 2010-05-06 | Salicylic acid-iodine disinfector and preparation method thereof |
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| CN201010163672.6A CN101810198B (en) | 2010-05-06 | 2010-05-06 | Salicylic acid-iodine disinfector and preparation method thereof |
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| CN101810198A CN101810198A (en) | 2010-08-25 |
| CN101810198B true CN101810198B (en) | 2015-01-28 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105557752A (en) * | 2016-03-03 | 2016-05-11 | 佛山市正典生物技术有限公司 | Iodine salicylate foam-type disinfectant and preparation method thereof |
| CN107513014A (en) * | 2016-06-17 | 2017-12-26 | 佛山市正典生物技术有限公司 | A kind of salicylic acid-iodine complex compound, preparation method and application |
| CN107306992A (en) * | 2017-09-01 | 2017-11-03 | 四川创美克科技有限公司 | A kind of salicylic acid-iodine powder disinfectant and preparation method thereof |
| CN107518001A (en) * | 2017-09-01 | 2017-12-29 | 四川创美克科技有限公司 | A kind of new disinfectant of alcohol containing iodo-salicylic acid and preparation method thereof |
| CN112704080B (en) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with stable component content and preparation method thereof |
| CN112640913B (en) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with long-term component stability and preparation method thereof |
| CN112806387B (en) * | 2020-12-31 | 2022-02-25 | 佛山市正典生物技术有限公司 | Preparation method of iodine-containing disinfectant with stable component content |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3764669A (en) * | 1970-11-02 | 1973-10-09 | S Santorelli | Method of making microbiocidal complexes |
| CN1301537A (en) * | 1999-12-29 | 2001-07-04 | 范家忠 | Liniment for skin disease and use |
| CN1183934C (en) * | 2002-02-03 | 2005-01-12 | 沈志强 | Disinfectant |
-
2010
- 2010-05-06 CN CN201010163672.6A patent/CN101810198B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3764669A (en) * | 1970-11-02 | 1973-10-09 | S Santorelli | Method of making microbiocidal complexes |
| CN1301537A (en) * | 1999-12-29 | 2001-07-04 | 范家忠 | Liniment for skin disease and use |
| CN1183934C (en) * | 2002-02-03 | 2005-01-12 | 沈志强 | Disinfectant |
Non-Patent Citations (2)
| Title |
|---|
| 水杨酸碘搽剂含量测定的实验;邝煜宏;《现代食品与药品杂志》;20060831;第16卷(第4期);13-14 * |
| 碘附与水杨酸治疗真菌性外耳道炎的比较;王木庆 等;《中国新药与临床杂志》;20000430;第9卷(第2期);158 * |
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