CN101932340A - 生产超极化的氨基酸和氨基磺酸的方法 - Google Patents

生产超极化的氨基酸和氨基磺酸的方法 Download PDF

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Publication number
CN101932340A
CN101932340A CN2009801037778A CN200980103777A CN101932340A CN 101932340 A CN101932340 A CN 101932340A CN 2009801037778 A CN2009801037778 A CN 2009801037778A CN 200980103777 A CN200980103777 A CN 200980103777A CN 101932340 A CN101932340 A CN 101932340A
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CN
China
Prior art keywords
acid
hyperpolarized
amino acid
sample
sulfamic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801037778A
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English (en)
Chinese (zh)
Inventor
M·H·莱彻
M·卡尔森
P·R·詹森
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN101932340A publication Critical patent/CN101932340A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2009801037778A 2008-02-04 2009-02-03 生产超极化的氨基酸和氨基磺酸的方法 Pending CN101932340A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08002001 2008-02-04
EP08002001.9 2008-02-04
PCT/EP2009/051172 WO2009098191A2 (fr) 2008-02-04 2009-02-03 Procédé permettant de produire des acides aminés et des acides aminosulphoniques hyperpolarisés

Publications (1)

Publication Number Publication Date
CN101932340A true CN101932340A (zh) 2010-12-29

Family

ID=40436248

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801037778A Pending CN101932340A (zh) 2008-02-04 2009-02-03 生产超极化的氨基酸和氨基磺酸的方法

Country Status (5)

Country Link
US (1) US20110008261A1 (fr)
EP (1) EP2237802A2 (fr)
JP (1) JP2011514313A (fr)
CN (1) CN101932340A (fr)
WO (1) WO2009098191A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2348327B1 (fr) * 2010-01-18 2013-11-27 Bruker BioSpin AG Procédé de mesure par RMN utilisant la polarisation nucléaire dynamique de dissolution avec élimination des radicaux libres
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
US10408895B2 (en) * 2013-03-15 2019-09-10 Bruker Biospin Corporation Polarization sample geometry
US9606200B2 (en) * 2013-08-27 2017-03-28 Bruker Biospin Corporation Sample-preparation method to manipulate nuclear spin-relaxation times, including to facilitate ultralow temperature hyperpolarization
WO2015040877A1 (fr) * 2013-09-20 2015-03-26 国立大学法人九州大学 Capteur moléculaire de résonance magnétique nucléaire
US10088536B2 (en) * 2015-03-27 2018-10-02 Bruker Biospin Corporation Sample introduction system and method for polarization
EP3101012A1 (fr) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Nouveaux composés de chélate de gadolinium pour une utilisation dans l'imagerie par résonance magnétique
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法
CN112735799B (zh) * 2020-12-10 2022-12-20 华东理工大学 一种新型磁性材料及其制备方法
US20230400538A1 (en) * 2022-06-10 2023-12-14 GE Precision Healthcare LLC Use of lactic acid in hyperpolarization for magnetic resonance applications

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0122049D0 (en) * 2001-09-12 2001-10-31 Nycomed Imaging As Method
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
EP1948248A2 (fr) * 2005-11-06 2008-07-30 Katz-Brull, Rachel Imagerie par resonance magnetique et moyen de spectroscopie et procedes associes
JP5475995B2 (ja) * 2005-12-01 2014-04-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）法
PL1962912T3 (pl) * 2005-12-16 2013-03-29 Ge Healthcare As Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych
JP2009531422A (ja) * 2006-03-29 2009-09-03 ジーイー・ヘルスケア・アクスイェ・セルスカプ 過分極カルボン酸塩及びスルホン酸塩の製造方法
JP5269791B2 (ja) * 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物
EP2117607A4 (fr) * 2007-01-11 2012-08-08 Huntington Medical Res Inst Agents d'imagerie et leurs procédés d'utilisation

Also Published As

Publication number Publication date
EP2237802A2 (fr) 2010-10-13
US20110008261A1 (en) 2011-01-13
WO2009098191A2 (fr) 2009-08-13
WO2009098191A3 (fr) 2009-12-30
JP2011514313A (ja) 2011-05-06

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20101229