CN102471287A - 2-氨基-5-三氟甲基嘧啶衍生物的区域选择性制备方法 - Google Patents

2-氨基-5-三氟甲基嘧啶衍生物的区域选择性制备方法 Download PDF

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Publication number
CN102471287A
CN102471287A CN2010800346368A CN201080034636A CN102471287A CN 102471287 A CN102471287 A CN 102471287A CN 2010800346368 A CN2010800346368 A CN 2010800346368A CN 201080034636 A CN201080034636 A CN 201080034636A CN 102471287 A CN102471287 A CN 102471287A
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formula
reaction
compound
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groups
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English (en)
Chinese (zh)
Inventor
G.林茨
G.克雷默
S.库斯罗
J.施诺贝尔特
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CN102471287A publication Critical patent/CN102471287A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2010800346368A 2009-08-14 2010-08-13 2-氨基-5-三氟甲基嘧啶衍生物的区域选择性制备方法 Pending CN102471287A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09167934 2009-08-14
EP09167934.0 2009-08-14
PCT/EP2010/061840 WO2011018518A1 (en) 2009-08-14 2010-08-13 Regioselective preparation of 2 -amino-5-trifluoromethylpyrimidine derivatives

Publications (1)

Publication Number Publication Date
CN102471287A true CN102471287A (zh) 2012-05-23

Family

ID=42712695

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800346368A Pending CN102471287A (zh) 2009-08-14 2010-08-13 2-氨基-5-三氟甲基嘧啶衍生物的区域选择性制备方法

Country Status (17)

Country Link
US (1) US8933227B2 (2)
EP (1) EP2464634B1 (2)
JP (1) JP5539519B2 (2)
KR (1) KR20120046248A (2)
CN (1) CN102471287A (2)
AR (1) AR077925A1 (2)
AU (1) AU2010283713A1 (2)
BR (1) BR112012002971A2 (2)
CA (1) CA2767965A1 (2)
CL (1) CL2012000278A1 (2)
EA (1) EA201200282A1 (2)
IL (1) IL217112A0 (2)
IN (1) IN2012DN01342A (2)
MX (1) MX2012001469A (2)
NZ (1) NZ597538A (2)
TW (1) TW201124385A (2)
WO (1) WO2011018518A1 (2)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102887860A (zh) * 2012-09-29 2013-01-23 上海泰坦科技有限公司 4-氯-6-三氟甲基嘧啶类化合物的制备方法

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
UY31714A (es) * 2008-03-20 2009-11-10 Boehringer Ingelheim Int Preparación selectiva de pirimidinas sustituidas
WO2009115583A1 (en) * 2008-03-20 2009-09-24 Boehringer Ingelheim International Gmbh Regioselective preparation of substituted pyrimidines
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
EP2464633A1 (en) 2009-08-14 2012-06-20 Boehringer Ingelheim International GmbH Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
JP6391985B2 (ja) * 2014-05-16 2018-09-19 東ソー・ファインケム株式会社 ２−置換−４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法
JP6391988B2 (ja) * 2014-05-21 2018-09-19 東ソー・ファインケム株式会社 ５−（トリフルオロメチル）ピリミジン誘導体の製造方法及び新規５−（トリフルオロメチル）ピリミジン誘導体
JP6262079B2 (ja) * 2014-06-02 2018-01-17 東ソー・ファインケム株式会社 ４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法
JP6431294B2 (ja) * 2014-06-16 2018-11-28 東ソー・ファインケム株式会社 ５−（トリフルオロメチル）ピリミジン誘導体及びその製造法
JP6479486B2 (ja) * 2015-01-16 2019-03-06 東ソー・ファインケム株式会社 ４−アルコキシ−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102887860A (zh) * 2012-09-29 2013-01-23 上海泰坦科技有限公司 4-氯-6-三氟甲基嘧啶类化合物的制备方法
CN102887860B (zh) * 2012-09-29 2015-07-01 上海泰坦科技有限公司 4-氯-6-三氟甲基嘧啶类化合物的制备方法

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AR077925A1 (es) 2011-10-05
CA2767965A1 (en) 2011-02-17
US20110190499A1 (en) 2011-08-04
BR112012002971A2 (pt) 2015-10-13
TW201124385A (en) 2011-07-16
JP5539519B2 (ja) 2014-07-02
CL2012000278A1 (es) 2012-10-12
MX2012001469A (es) 2012-02-22
EP2464634A1 (en) 2012-06-20
NZ597538A (en) 2014-05-30
IN2012DN01342A (2) 2015-06-05
KR20120046248A (ko) 2012-05-09
US8933227B2 (en) 2015-01-13
EA201200282A1 (ru) 2012-09-28
AU2010283713A1 (en) 2012-02-02
EP2464634B1 (en) 2016-11-30
WO2011018518A1 (en) 2011-02-17
JP2013501759A (ja) 2013-01-17
IL217112A0 (en) 2012-02-29

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Application publication date: 20120523