CN102648002A - Il-17家族细胞因子组合物及用途 - Google Patents

Il-17家族细胞因子组合物及用途 Download PDF

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Publication number
CN102648002A
CN102648002A CN2010800536540A CN201080053654A CN102648002A CN 102648002 A CN102648002 A CN 102648002A CN 2010800536540 A CN2010800536540 A CN 2010800536540A CN 201080053654 A CN201080053654 A CN 201080053654A CN 102648002 A CN102648002 A CN 102648002A
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China
Prior art keywords
seq
albumen
subunit
numbering
polypeptide
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Pending
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CN2010800536540A
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English (en)
Chinese (zh)
Inventor
T·M·巴尼斯
M·M·施密特
B·M·金
C·K·加西亚
S·雷迪
G·J·斯茨克维奇
L·K·埃里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Carisma Therapeutics Inc
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Leland Stanford Junior University
Eleven Biotherapeutics Inc
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Application filed by Leland Stanford Junior University, Eleven Biotherapeutics Inc filed Critical Leland Stanford Junior University
Publication of CN102648002A publication Critical patent/CN102648002A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2010800536540A 2009-10-10 2010-10-11 Il-17家族细胞因子组合物及用途 Pending CN102648002A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27877909P 2009-10-10 2009-10-10
US61/278,779 2009-10-10
PCT/US2010/052194 WO2011044563A2 (en) 2009-10-10 2010-10-11 Il-17 family cytokine compositions and uses

Publications (1)

Publication Number Publication Date
CN102648002A true CN102648002A (zh) 2012-08-22

Family

ID=43857433

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800536540A Pending CN102648002A (zh) 2009-10-10 2010-10-11 Il-17家族细胞因子组合物及用途

Country Status (11)

Country Link
US (1) US20130064788A1 (2)
EP (1) EP2485763A4 (2)
JP (1) JP2013507132A (2)
KR (1) KR20120093932A (2)
CN (1) CN102648002A (2)
AU (1) AU2010303166A1 (2)
BR (1) BR112012008444A2 (2)
CA (1) CA2777222A1 (2)
EA (1) EA201270528A1 (2)
IL (1) IL219209A0 (2)
WO (1) WO2011044563A2 (2)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111093678A (zh) * 2017-07-21 2020-05-01 克利夫兰诊所基金会 用于治疗IL-17a相关疾病和病状的SBE适体
CN113403259A (zh) * 2021-06-04 2021-09-17 华南农业大学 一种提高克隆胚胎发育质量的添加剂及其应用
CN113563453A (zh) * 2021-07-23 2021-10-29 四川大学 鸡白细胞介素17b重组乳酸菌免疫制剂的制备和应用

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767206B2 (en) 2006-10-02 2010-08-03 Amgen Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
KR101722961B1 (ko) 2009-02-11 2017-04-04 알부메딕스 에이/에스 알부민 변이체 및 접합체
EP2493921B1 (en) 2009-10-30 2018-09-26 Albumedix Ltd Albumin variants
EP2556087A1 (en) 2010-04-09 2013-02-13 Novozymes Biopharma DK A/S Albumin derivatives and variants
ES2952394T3 (es) 2010-07-29 2023-10-31 Buzzard Pharmaceuticals AB Antagonistas quiméricos del receptor IL-1 de tipo I
US20140105855A1 (en) * 2011-04-06 2014-04-17 Kenan Christopher Garcia Structural based design of il-17 dominant negative mutants
WO2013016220A1 (en) * 2011-07-22 2013-01-31 Amgen Inc. Il-17 receptor a is required for il-17c biology
ME03073B (me) 2011-10-19 2019-01-20 Galapagos Nv Ant agonisti il17с za lečenje zapaljenskih poremećaja
EP2768946A1 (en) * 2011-10-21 2014-08-27 Baylor College Of Medicine Method to measure inflammation in the conjunctiva of patients with tear dysfunction
EP2780364A2 (en) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Proteins with improved half-life and other properties
DK2825556T3 (en) 2012-03-16 2018-04-16 Albumedix As albumin Variants
JP2013253842A (ja) 2012-06-06 2013-12-19 Univ Of Tokyo ｐＨ依存的に標的分子に結合するペプチドのスクリーニング方法
JP2015521591A (ja) 2012-06-12 2015-07-30 オレガ・バイオテック Ｉｌ−１７アイソフォームのアンタゴニストおよびその使用
EP3417878A1 (en) * 2012-06-12 2018-12-26 Orega Biotech Antagonists of il-17 isoforms and their uses
MX2015005363A (es) 2012-11-08 2015-11-06 Novozymes Biopharma Dk As Variantes de albumina.
EP2968468B1 (en) 2013-03-13 2021-07-14 Buzzard Pharmaceuticals AB Chimeric cytokine formulations for ocular delivery
CA2909706C (en) * 2013-04-17 2023-02-14 Genzyme Corporation Use of an il17 inhibitor for treating and preventing macular degeneration
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
JP7007261B2 (ja) 2015-08-20 2022-01-24 アルブミディクス リミティド アルブミン変異体及びコンジュゲート
ES3044918T3 (en) * 2016-03-25 2025-11-27 The Univ Of Osaka Conjugate vaccine targeting disorder-causing in vivo protein
JP2019513775A (ja) * 2016-04-19 2019-05-30 アズーラ オフサルミックス エルティーディー． 角化症の処置のための組成物
WO2019222296A1 (en) 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Activatable interleukin 12 polypeptides and methods of use thereof
AU2019271148B9 (en) 2018-05-14 2025-05-29 Werewolf Therapeutics, Inc. Activatable interleukin-2 polypeptides and methods of use thereof
PT3946377T (pt) 2019-04-03 2026-03-09 Univ Montpellier Terapias de combinação baseadas em inibidores da pd1 e il-17b
EP3969035A4 (en) 2019-05-14 2023-06-21 Werewolf Therapeutics, Inc. SEPARATION UNITS AND METHODS AND THEIR USE
WO2021023624A1 (en) * 2019-08-02 2021-02-11 Orega Biotech Novel il-17b antibodies
KR102265435B1 (ko) * 2019-08-20 2021-06-15 주식회사 케어젠 피부 미백 활성을 갖는 펩타이드 및 이의 용도
MX2022005666A (es) 2019-11-14 2022-10-07 Werewolf Therapeutics Inc Polipeptidos de citocina activables y metodos de uso de los mismos.
EP4087655A4 (en) 2020-01-10 2024-02-21 Azura Ophthalmics Ltd INSTRUCTIONS FOR COMPOSITION AND SENSITIVITY
WO2021170750A1 (en) 2020-02-28 2021-09-02 Orega Biotech Combination therapies based on ctla4 and il-17b inhibitors
WO2022032592A1 (en) * 2020-08-13 2022-02-17 Tsinghua University Interleukin-17d and cd93 as a new cytokine-receptor pair in the immune system

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6072033A (en) * 1995-03-23 2000-06-06 Immunex Corporation Receptor that binds IL-17
US20020039568A1 (en) * 2000-02-29 2002-04-04 Moore Emma E. Methods for promoting production of myelin by schwann cells
US20040115191A1 (en) * 2002-01-24 2004-06-17 Moore Emma E Method for treating psoriasis
US20060083713A1 (en) * 2000-10-13 2006-04-20 Eli Lilly And Company Methods of using a human il-17 related polypeptide to treat disease
US20060270003A1 (en) * 2003-07-08 2006-11-30 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
US20070083334A1 (en) * 2001-09-14 2007-04-12 Compugen Ltd. Methods and systems for annotating biomolecular sequences
US20070218065A1 (en) * 2006-03-10 2007-09-20 Jaspers Stephen R Antibodies that bind both il-17a and il-17f and methods of using the same
US20080221307A1 (en) * 2006-10-02 2008-09-11 Amgen, Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
WO2008131315A2 (en) * 2007-04-20 2008-10-30 Amgen Inc. Jacquelinidentification and method for using the pre-ligand assembly domain of the il-17 receptor
WO2009015063A2 (en) * 2007-07-23 2009-01-29 Centocor Methods and compositions for treating fibrosis related disorders using il-17 antagonists
CN101501072A (zh) * 2006-06-29 2009-08-05 Ucb医药有限公司 与人il-17结合的抗体分子

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US20030203451A1 (en) * 2000-08-24 2003-10-30 Genentech, Inc. IL-17 homologous polypeptides and therapeutic uses thereof
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
AU2440802A (en) 2000-10-18 2002-04-29 Massachusetts Inst Technology Methods and products related to pulmonary delivery of polysaccharides
CA2425506A1 (en) * 2000-10-18 2002-08-01 Immunex Corporation Methods for treating rheumatoid arthritis using il-17 antagonists
CA2452233A1 (en) * 2001-03-26 2002-10-03 Zymogenetics, Inc. Method of inducing proliferation of retinal stem cells
US20070160576A1 (en) * 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
GB0417487D0 (en) * 2004-08-05 2004-09-08 Novartis Ag Organic compound
US20070197441A1 (en) * 2006-02-10 2007-08-23 Rixon Mark W Truncated il-17ra soluble receptor and methods of using in inflammation
EP2046835B1 (en) * 2006-08-11 2011-10-26 Schering Corporation Antibodies to il-17a
US7790676B2 (en) 2007-03-28 2010-09-07 Zymogenetics, Inc. Soluble IL-17RA/RC fusion proteins
JP5116842B2 (ja) * 2007-04-27 2013-01-09 ザイモジェネティクス， インコーポレイテッド ＩＬ−１７ＡおよびＩｌ−１７Ｆの両方に結合する抗体ならびにそれを使用する方法

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6072033A (en) * 1995-03-23 2000-06-06 Immunex Corporation Receptor that binds IL-17
US20020039568A1 (en) * 2000-02-29 2002-04-04 Moore Emma E. Methods for promoting production of myelin by schwann cells
US20060083713A1 (en) * 2000-10-13 2006-04-20 Eli Lilly And Company Methods of using a human il-17 related polypeptide to treat disease
US20070083334A1 (en) * 2001-09-14 2007-04-12 Compugen Ltd. Methods and systems for annotating biomolecular sequences
US20040115191A1 (en) * 2002-01-24 2004-06-17 Moore Emma E Method for treating psoriasis
US20060270003A1 (en) * 2003-07-08 2006-11-30 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
US20070218065A1 (en) * 2006-03-10 2007-09-20 Jaspers Stephen R Antibodies that bind both il-17a and il-17f and methods of using the same
CN101501072A (zh) * 2006-06-29 2009-08-05 Ucb医药有限公司 与人il-17结合的抗体分子
US20080221307A1 (en) * 2006-10-02 2008-09-11 Amgen, Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
WO2008131315A2 (en) * 2007-04-20 2008-10-30 Amgen Inc. Jacquelinidentification and method for using the pre-ligand assembly domain of the il-17 receptor
WO2009015063A2 (en) * 2007-07-23 2009-01-29 Centocor Methods and compositions for treating fibrosis related disorders using il-17 antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SARAH G.HYMOWITZ ET.AL.: "IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine，IL-17F，and implications for receptor binding", 《THE EMBO JOURNAL》, vol. 20, no. 19, 31 December 2001 (2001-12-31), pages 5338 - 3 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111093678A (zh) * 2017-07-21 2020-05-01 克利夫兰诊所基金会 用于治疗IL-17a相关疾病和病状的SBE适体
CN113403259A (zh) * 2021-06-04 2021-09-17 华南农业大学 一种提高克隆胚胎发育质量的添加剂及其应用
CN113563453A (zh) * 2021-07-23 2021-10-29 四川大学 鸡白细胞介素17b重组乳酸菌免疫制剂的制备和应用

Also Published As

Publication number Publication date
EA201270528A1 (ru) 2012-12-28
US20130064788A1 (en) 2013-03-14
IL219209A0 (en) 2012-06-28
CA2777222A1 (en) 2011-04-14
WO2011044563A3 (en) 2011-06-03
JP2013507132A (ja) 2013-03-04
EP2485763A4 (en) 2013-10-30
AU2010303166A1 (en) 2012-05-24
EP2485763A2 (en) 2012-08-15
WO2011044563A2 (en) 2011-04-14
BR112012008444A2 (pt) 2019-09-24
KR20120093932A (ko) 2012-08-23

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Application publication date: 20120822