CN102686579A - 作为gpr119活性调节剂的化合物和组合物 - Google Patents

作为gpr119活性调节剂的化合物和组合物 Download PDF

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Publication number
CN102686579A
CN102686579A CN2010800453177A CN201080045317A CN102686579A CN 102686579 A CN102686579 A CN 102686579A CN 2010800453177 A CN2010800453177 A CN 2010800453177A CN 201080045317 A CN201080045317 A CN 201080045317A CN 102686579 A CN102686579 A CN 102686579A
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bases
methyl
fluoro
phenyl
trifluoromethyl
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Chinese (zh)
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M·阿奇米奥拉
C·考
R·艾普勒
G·勒莱斯
J·麦克姆
V·尼库林
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IRM LLC
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IRM LLC
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CN2010800453177A 2009-10-09 2010-10-01 作为gpr119活性调节剂的化合物和组合物 Pending CN102686579A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25042409P 2009-10-09 2009-10-09
US61/250,424 2009-10-09
US36511210P 2010-07-16 2010-07-16
US61/365,112 2010-07-16
PCT/US2010/051186 WO2011044001A1 (en) 2009-10-09 2010-10-01 Compounds and compositions as modulators of gpr119 activity

Publications (1)

Publication Number Publication Date
CN102686579A true CN102686579A (zh) 2012-09-19

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CN2010800453177A Pending CN102686579A (zh) 2009-10-09 2010-10-01 作为gpr119活性调节剂的化合物和组合物

Country Status (15)

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US (1) US8575168B2 (2)
EP (1) EP2486033A1 (2)
JP (1) JP2013507366A (2)
KR (1) KR20120092629A (2)
CN (1) CN102686579A (2)
AR (1) AR078550A1 (2)
AU (1) AU2010303780B2 (2)
BR (1) BR112012008004A2 (2)
CA (1) CA2774573A1 (2)
EA (1) EA201200570A1 (2)
IN (1) IN2012DN02471A (2)
MX (1) MX2012004078A (2)
TW (1) TW201124400A (2)
UY (1) UY32937A (2)
WO (1) WO2011044001A1 (2)

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KR20200125758A (ko) 2017-10-27 2020-11-04 베링거 인겔하임 인터내셔날 게엠베하 피리딘 카보닐 유도체 및 trpc6 억제제로서 이의 치료학적 용도
CN112839935A (zh) 2018-09-26 2021-05-25 北京加科思新药研发有限公司 可用作shp2抑制剂的新型杂环衍生物
MX2022010548A (es) 2020-02-28 2022-09-23 Kallyope Inc Agonistas de gpr40.
MX2022014505A (es) 2020-05-19 2022-12-13 Kallyope Inc Activadores de la ampk.
CA3183575A1 (en) 2020-06-26 2021-12-30 Iyassu Sebhat Ampk activators

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AU2010303780A1 (en) 2012-04-12
BR112012008004A2 (pt) 2016-03-29
AU2010303780B2 (en) 2014-02-20
EA201200570A1 (ru) 2012-11-30
US8575168B2 (en) 2013-11-05
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