CN102755664B - First-aid dressing used for traumatic wounds in cold area and preparation method of dressing - Google Patents
First-aid dressing used for traumatic wounds in cold area and preparation method of dressing Download PDFInfo
- Publication number
- CN102755664B CN102755664B CN201210252565.XA CN201210252565A CN102755664B CN 102755664 B CN102755664 B CN 102755664B CN 201210252565 A CN201210252565 A CN 201210252565A CN 102755664 B CN102755664 B CN 102755664B
- Authority
- CN
- China
- Prior art keywords
- parts
- layer
- heating
- medicine film
- overcoat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- 230000000472 traumatic effect Effects 0.000 title claims abstract description 20
- 206010052428 Wound Diseases 0.000 title abstract description 48
- 208000027418 Wounds and injury Diseases 0.000 title abstract description 47
- 239000003814 drug Substances 0.000 claims abstract description 196
- 238000010438 heat treatment Methods 0.000 claims abstract description 145
- 239000000463 material Substances 0.000 claims abstract description 39
- 239000000284 extract Substances 0.000 claims abstract description 33
- 239000000203 mixture Substances 0.000 claims abstract description 25
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 22
- 230000001954 sterilising effect Effects 0.000 claims abstract description 21
- 229940079593 drug Drugs 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 60
- 239000006071 cream Substances 0.000 claims description 56
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 48
- 238000003756 stirring Methods 0.000 claims description 42
- 239000000243 solution Substances 0.000 claims description 41
- 239000000758 substrate Substances 0.000 claims description 39
- 239000004745 nonwoven fabric Substances 0.000 claims description 37
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 36
- 239000000853 adhesive Substances 0.000 claims description 35
- 230000001070 adhesive effect Effects 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 32
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 29
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 29
- 239000004744 fabric Substances 0.000 claims description 24
- 239000002131 composite material Substances 0.000 claims description 23
- 239000008213 purified water Substances 0.000 claims description 22
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 20
- 239000012567 medical material Substances 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 20
- 229920001661 Chitosan Polymers 0.000 claims description 19
- 238000010792 warming Methods 0.000 claims description 19
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 18
- 230000008961 swelling Effects 0.000 claims description 18
- 241000717739 Boswellia sacra Species 0.000 claims description 17
- 241000221079 Euphorbia <genus> Species 0.000 claims description 17
- 239000004863 Frankincense Substances 0.000 claims description 17
- 241001057584 Myrrha Species 0.000 claims description 17
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 17
- 241000180649 Panax notoginseng Species 0.000 claims description 17
- 239000000052 vinegar Substances 0.000 claims description 17
- 235000021419 vinegar Nutrition 0.000 claims description 17
- 241001091433 Itea Species 0.000 claims description 16
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 16
- 229960000583 acetic acid Drugs 0.000 claims description 16
- 239000012362 glacial acetic acid Substances 0.000 claims description 16
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 16
- 239000003921 oil Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000000571 coke Substances 0.000 claims description 10
- 239000011888 foil Substances 0.000 claims description 10
- 239000000499 gel Substances 0.000 claims description 10
- 239000011780 sodium chloride Substances 0.000 claims description 10
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 9
- 239000000377 silicon dioxide Substances 0.000 claims description 9
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 8
- -1 2 parts Chemical compound 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 241000581682 Sanguisorba Species 0.000 claims description 8
- 235000008282 Sanguisorba officinalis Nutrition 0.000 claims description 8
- 229910052742 iron Inorganic materials 0.000 claims description 8
- 229920003023 plastic Polymers 0.000 claims description 8
- 239000004033 plastic Substances 0.000 claims description 8
- 239000000741 silica gel Substances 0.000 claims description 8
- 229910002027 silica gel Inorganic materials 0.000 claims description 8
- 229920002545 silicone oil Polymers 0.000 claims description 8
- 230000007480 spreading Effects 0.000 claims description 8
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 238000001739 density measurement Methods 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- 238000005325 percolation Methods 0.000 claims description 6
- 238000010298 pulverizing process Methods 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 229910052710 silicon Inorganic materials 0.000 claims description 4
- 239000010703 silicon Substances 0.000 claims description 4
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 2
- 238000007654 immersion Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 230000003068 static effect Effects 0.000 claims description 2
- 239000010410 layer Substances 0.000 abstract description 151
- 230000000694 effects Effects 0.000 abstract description 11
- 208000015181 infectious disease Diseases 0.000 abstract description 5
- 230000036407 pain Effects 0.000 abstract description 5
- 239000011241 protective layer Substances 0.000 abstract description 5
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 208000009084 Cold Injury Diseases 0.000 description 14
- 206010063560 Excessive granulation tissue Diseases 0.000 description 14
- 230000002595 cold damage Effects 0.000 description 14
- 210000001126 granulation tissue Anatomy 0.000 description 14
- 239000002671 adjuvant Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000007789 sealing Methods 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000002950 fibroblast Anatomy 0.000 description 5
- 230000002980 postoperative effect Effects 0.000 description 5
- 230000035755 proliferation Effects 0.000 description 5
- 230000005855 radiation Effects 0.000 description 5
- 206010020880 Hypertrophy Diseases 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000001186 cumulative effect Effects 0.000 description 4
- 238000007710 freezing Methods 0.000 description 4
- 230000008014 freezing Effects 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 206010020718 hyperplasia Diseases 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 208000008277 Immersion Foot Diseases 0.000 description 2
- 206010044584 Trench foot Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 210000000589 cicatrix Anatomy 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000020169 heat generation Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000010445 Chilblains Diseases 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 244000257039 Duranta repens Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 1
- 208000001034 Frostbite Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000010513 Stupor Diseases 0.000 description 1
- 206010042566 Superinfection Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 241000425571 Trepanes Species 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 230000002364 anti-haemorrhagic effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 229940058573 b-d glucose Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 238000003490 calendering Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000035617 depilation Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000036566 epidermal hyperplasia Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- UFRKOOWSQGXVKV-UHFFFAOYSA-N ethene;ethenol Chemical compound C=C.OC=C UFRKOOWSQGXVKV-UHFFFAOYSA-N 0.000 description 1
- 239000004715 ethylene vinyl alcohol Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 210000000630 fibrocyte Anatomy 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002061 histotrophic effect Effects 0.000 description 1
- 230000002390 hyperplastic effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000010309 melting process Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 210000004493 neutrocyte Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000004987 nonapoptotic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 210000002640 perineum Anatomy 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000003904 radioactive pollution Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000010388 wound contraction Effects 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Images
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种用于寒区外伤创面的急救敷料及其制备方法，急救敷料由依次设置的药膜防护层、药膜层、发热层、背衬层和发热防护层组成，急救辅料可在1～2小时内达到28～38℃的发热温度，且能持续发热4～6个小时；通过以下步骤制得：1、制备中药提取物和基质，混合后制得药膜膏；2、制备发热料，装袋后制得发热层；3、制备发热防护层和背衬层；4、制备急救敷料，并封装消毒。本发明的急救敷料可用于伤员的院前急救，能覆盖和保护伤口、免受进一步感染，并通过内置发热料，即使在温度较低的寒区，也能使药物层达到较高的温度，并且疗效时间长，大大减少换药次数、缩短治疗周期，更利于消毒除菌，减轻伤员的痛楚。
The invention relates to a first-aid dressing for traumatic wounds in cold regions and a preparation method thereof. The first-aid dressing is composed of a medicinal film protective layer, a medicinal film layer, a heating layer, a backing layer and a heating protective layer arranged in sequence. The first-aid auxiliary materials can be It reaches a heating temperature of 28-38°C within 1-2 hours, and can continue to generate heat for 4-6 hours; it is prepared by the following steps: 1. Prepare the Chinese medicine extract and matrix, and mix them to obtain a medical film ointment; 2. Prepare The heat-generating material is bagged to produce a heat-generating layer; 3. The heat-generating protective layer and the backing layer are prepared; 4. The first-aid dressing is prepared and packaged and sterilized. The first aid dressing of the present invention can be used for the pre-hospital first aid of the wounded, can cover and protect the wound from further infection, and through the built-in heating material, the drug layer can reach a higher temperature even in a cold area with a lower temperature, And the curative effect is long, which greatly reduces the number of dressing changes, shortens the treatment cycle, is more conducive to disinfection and sterilization, and reduces the pain of the wounded.
Description
Technical field
The present invention relates to a kind of first aid dressing for traumatic surface, be specifically related to a kind of first aid dressing for cold district traumatic surface and preparation method thereof.
Background technology
People are out of doors during operation, injured always unavoidable, and show as wound more.Wound generally refers to because of tumbling down, external force collision, weapons damage, and insect and animal biting, scalds, the paathogenic factor such as burning, cold injury and the skin and flesh muscles and bones and the internal organs that cause are injured.The traumatic condition of wound shows as that multiple location multimachine reason is complicated and changeable, and traumatic surface, as do not processed in time, traumatic infection very easily occurs, or Massive Bleeding, can cause the serious pathological changes such as stupor, tic, YANG-depletion collapse.
Especially in the wild, and lower Huo Han in the winter district of some temperature be also often attended by the generation of cold injury.Because China is located in northern warm area, three northern areas of China are colder winter, and some areas minimum temperature reaches-30～-40 ℃, in the wild or at durante bello, because worsening condition is also very easy to occur cold injury.The reason of cold injury mostly is ambient temperature and reduces, keep warm measure is unfavorable, next is that wind speed accelerates to increase limbs thermal loss, cold adds strong wind, the effect of cold injury will obviously be accelerated, and is originally unlikely to cause the low temperature of cold injury, because wind speed is large, just can cause cold injury, in addition tired, hungry, to have a delicate constitution etc. be all the important inducement of cold injury.Cold injury, according to there being inorganization freezing process, is divided into the property freezed cold injury and the non-property freezed cold injury.Be exposed to for a long time or repeatedly under cold and moist condition, due to local organization poor circulation, histotrophic nutrition obstacle and what occur is the non-cold injury of freezing without the cold injury in the melting process of freezing.Sometimes temperature is 10～0 ℃ of left and right, and heat-retaining condition is poor, when particularly humidity is larger, the non-cold injury of freezing also can occur, and comprises chilblain, immersion foot and trench foot, and severe frostbite is due to thrombosis, disturbance of blood circulation, finally causing endures cold organize destroyed.
If nearer apart from medical institutions when the injured residing region of the wounded, can wait for the relief of hospital.But if injured residing region is far away apart from medical institutions, just can only rely on Field Force's self and mutual medical aid, if necessary medical rescue cannot must be implemented in time, the harm meeting that health is caused is larger.
Summary of the invention
The object of the invention is the deficiency for solving the problems of the technologies described above, provide a kind of for Han Qu
First aid dressing of traumatic surface and preparation method thereof, first aid dressing, for the wounded's pre hospital care, can cover and protect wound, avoid further infection, and can carry out active, effective disinfection to wound and skin around, reduces the wounded's misery.
The present invention is the deficiency solving the problems of the technologies described above, the technical scheme adopting is: a kind of first aid dressing for cold district traumatic surface, the medicine film overcoat, medicine film layer, heating layer, backing layer and the heating overcoat that successively arrange, consist of, medicine film layer, heating layer and backing layer are fixedly connected with; The area of described medicine film overcoat, backing layer and heating overcoat is equal, and the area of heating layer and the area of medicine film layer are equal, and the area of backing layer is greater than the area of heating layer; Described medicine film layer, is comprised of non-woven fabrics and the medicine film cream spreading upon on non-woven fabrics, and the smearing thickness of its Chinese medicinal film cream is 0.5～5mm; Described medicine film overcoat is single silicon release paper, and single silicon release paper is covered with silicone oil with the one side that the medicine film cream of medicine film layer contacts; Described backing layer is non-woven fabrics, at backing layer, towards the periphery of the one side of heating layer, is provided with a circle adhesive sticker, and the width of adhesive sticker is 2～5 ㎝; Described heating overcoat is plastic foil, and the pressure sensitive adhesive that heating overcoat simultaneously arranges by it is on backing layer;
Described medicine film cream is comprised of Chinese medicine extract and substrate, and the percentage by weight of Chinese medicine extract and substrate is: Chinese medicine extract 30～50%, substrate 50～70%;
The crude drug of described Chinese medicine extract is comprised of Radix Et Rhizoma Rhei, Rhizoma Coptidis, Halloysitum Rubrum, Calamina, Radix Sanguisorbae, Olibanum (processed with vinegar), Myrrha, Euphorbia kozlowii Prok, Radix Notoginseng, Ramulus Sambuci Williamsii and itea orientalis Hemsl., and the ratio of weight and number that each medical material adds is respectively: 45～60 parts of 40～50 parts of Radix Et Rhizoma Rhei, 45～55 parts of Rhizoma Coptidis, 45～60 parts of Halloysitum Rubrums, 35～55 parts of Calaminas, 40～60 parts of Radix Sanguisorbaes, 15～30 parts of Olibanum (processed with vinegar), 15～30 parts of Myrrhas, 40～60 parts of Euphorbia kozlowii Prok, 10～30 parts of Radix Notoginseng, 40～60 parts of Ramulus Sambuci Williamsii and itea orientalis Hemsl.;
The glacial acetic acid solution that described substrate is 1～2% by polyvidone, glycerol, micropowder silica gel, purified water, Borneolum Syntheticum, chitosan, polyvinyl alcohol and concentration forms, and the ratio of weight and number that each raw material adds is respectively: 10～70 parts of 5～10 parts of the glacial acetic acid solutions that 5～10 parts of polyvidones, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 2～10 parts of Borneolum Syntheticums, 8～15 parts of chitosans, 1～5 part of polyvinyl alcohol, concentration are 1～2% and purified water;
Described heating layer is comprised of two-layer nonwoven and the heating material that is arranged between two-layer nonwoven, and the thickness of described heating material is 0.1～0.5 ㎝;
Described heating material is comprised of iron powder, coke blacking, kieselguhr, sodium chloride and water, and the ratio of weight and number that each raw material adds is respectively: 35～50 parts of iron powders, 10～20 parts of coke blackings, 5～15 parts, kieselguhr, 22 parts, 2 parts, sodium chloride and water;
The preparation method of the described first aid dressing for cold district traumatic surface, preparation method is as follows:
One, prepare medicine film cream
(one), prepare Chinese medicine extract
(1), by weight, get 45～60 parts of 45～60 parts of Halloysitum Rubrums, 35～55 parts of Calaminas, 15～30 parts of Olibanum (processed with vinegar), 15～30 parts of Myrrhas, 40～50 parts of Radix Et Rhizoma Rhei, 45～55 parts of Rhizoma Coptidis, 40～60 parts of Radix Sanguisorbaes, 40～60 parts of Euphorbia kozlowii Prok, 10～30 parts of Radix Notoginseng, 40～60 parts of Ramulus Sambuci Williamsii and itea orientalis Hemsl., standby;
(2), by the Halloysitum Rubrum, Calamina, Olibanum (processed with vinegar) and the Myrrha that take out in step (1)
Mix, be crushed to 200～400 orders, standby;
(3), by the Radix Et Rhizoma Rhei, Rhizoma Coptidis, Radix Sanguisorbae, Euphorbia kozlowii Prok, Radix Notoginseng, Ramulus Sambuci Williamsii and the itea orientalis Hemsl. mix homogeneously that take out in step (1), after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 10～100% ethanol soaks, the addition of ethanol, for soaking 1.2～1.5 times of medical material volume, is soaked after 12～48 hours, then adds the ethanol that the concentration of 3～10 times of immersion medical material original volumes is 10～100%, carry out percolation, collect percolate standby;
(4), percolate that above-mentioned steps (3) is collected sends in vacuum decompressioning and concentrating tank, carries out concentrating under reduced pressure, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims ethanol simultaneously, the thick paste making is standby;
(5), the medicated powder prepared with step (2) of thick paste that above-mentioned steps (4) is made mixs homogeneously, and dries, then is ground into 200～400 object fine powders, makes Chinese medicine extract;
(two), preparation substrate
(1), by weight, 5～10 parts of the glacial acetic acid solutions that to get 5～10 parts of polyvidones, 40～70 parts of purified water, 1～5 part of polyvinyl alcohol, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 2～10 parts of Borneolum Syntheticums, 8～15 parts of chitosans, concentration be 1～2%, standby;
(2), polyvidone and 10～20 parts of purified water of taking out in step (1) are added in reactor, be warming up to 60～70 ℃, stir 30～60 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), the polyvinyl alcohol and the glycerol that take out in step (1) are added in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4) glacial acetic acid solution and 30～50 parts of purified water that by micropowder silica gel, Borneolum Syntheticum, chitosan, the concentration of taking out in step (1), are, 1～2%, add in reactor, stir 1～2 minute, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 40～70 ℃, stir 2～10 minutes, stop stirring and static 2～5 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 2～10 minutes, makes substrate;
(three), prepare medicine film cream
Get by weight percentage substrate prepared by the above-mentioned steps (two) of Chinese medicine extract prepared by 30～50% above-mentioned steps () and 50～70%; First substrate is added in reactor, make the substrate in reactor be warming up to 45～55 ℃, then Chinese medicine extract is added in reactor, stir 20～40 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer, and wherein, the smearing thickness of medicine film cream is 0.5～5mm; The film overcoat of getting it filled afterwards, makes the silicone oil of medicine film overcoat facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat, makes the medicine film layer with medicine film overcoat;
Three, prepare heating layer
(one), preparation heating material
By ratio of weight and the number of copies, get 22 parts, 35～50 parts of iron powders, 10～20 parts of coke blackings, 5～15 parts, kieselguhr, 2 parts, sodium chloride and water, insert in container, mix homogeneously, making heating material, and mixing process carries out under nitrogen protection;
(two), prepare heating layer
Get the heating material making in step (), uniform spreading is located in the cloth bag that non-woven fabrics makes, cloth bag is sealed, and cloth bag is sewn with line into the cage of 4 * 4cm, make heating layer, prepare the process of heating layer and carry out under nitrogen protection, wherein in non-woven bag, the laying depth of heating material is 0.1～0.5 ㎝;
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 2～5 ㎝ is set, make backing layer;
Five, preparation heating overcoat
Get the plastic foil that one side is provided with adhesive sticker, according to the shape and size of reserving in advance, cut out in flakes, make heating overcoat;
Six, prepare first aid dressing
(one), get that above-mentioned steps two makes with one of the medicine film layer of medicine film overcoat, on work platform for placing, wherein, medicine film overcoat under, medicine film layer is upper;
(two), get one of the heating layer that above-mentioned steps three prepares, heating layer is pasted on the nonwoven cloth cover of medicine film layer;
(three), get one of the backing layer that above-mentioned steps four prepares, backing layer surrounding is pasted on heating layer with the one side of adhesive sticker, the adhesive sticker of backing layer surrounding sticks on medicine film overcoat;
(four), get one of the heating overcoat that above-mentioned steps five prepares, the one side by heating overcoat with adhesive sticker abuts on backing layer;
(five), pack dressing into composite film packaging bag, evacuation, sealed composite film package bag;
(six), the sealed composite film package bag that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the first aid dressing for cold district traumatic surface.
beneficial effect
1, to be easy to carry, to treat wound method simple for first aid adjuvant of the present invention, and easy to use, need not smear any medicine, after debridement, directly cover wound, do not need special condition and operant skill, there is antibacterial anti hemorrhagic, antiinflammatory, erosion prevention and muscle growing, antifreeze, warming, promote the effect of healing and have no side effect.Secondly, because this first aid dressing has autohension, thus be specially adapted to be difficult to wrapping, fixing position, as upper arm, the shoulder back of the body, head, perineum, lower limb energy position.First aid dressing can form the healing space sealing after being bonded at wound position, can effectively prevent superinfection.
2, the bactericidal effect of first aid adjuvant of the present invention is good, can kill multiple common pathogen, and of many uses, and the getting up early treatment that is particularly useful for the open wound in batch that war, natural disaster etc. cause is processed, and prevents the personnel reduction and the deformity that because infecting, cause.
3, first aid dressing of the present invention easily stores, by built-in heating material, even in temperature compare Di Han district, also can reach 28-38 ℃ a 1-2 hour internal heat generation temperature, and the persistent period can reach 4-6 hour, can greatly reduce dressing change frequency, shorten treatment cycle, be more conducive to the degerming of sterilizing, alleviate the wounded's pain.
4, heating layer of the present invention is separated into a plurality of junior unit lattice, and moving, in walking process, the heating material in heating layer can not drop the wounded, causing inhomogeneous that heating material distributes, thereby affects the uniformity of heating temp.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Fig. 2 is hierarchy schematic diagram of the present invention.
Fig. 3 is the structural representation of backing layer of the present invention.
Fig. 4 is the structural representation of heating layer of the present invention.
Labelling in figure: 1, medicine film overcoat, 2, medicine film layer, 3, heating layer, 4, backing layer, 5, heating overcoat, 6, composite film packaging bag.
The specific embodiment
The invention provides a kind of first aid dressing for cold district traumatic surface, by the medicine film overcoat 1 setting gradually, medicine film layer 2, heating layer 3, backing layer 4 and heating overcoat 5, formed, first aid adjuvant can in 1-2 hour, reach the heating temp of 28～38 ℃, and can persistent fever 4-6 hour; Wherein, medicine film overcoat 1 equates with the area of backing layer 4, and the area of heating layer 3 equates with the area of medicine film layer 2, and the area of backing layer 4 is greater than the area of heating layer 3, and heating overcoat 5 equates with the area of backing layer 4; This first aid dressing, for the wounded's pre hospital care, can cover and protect wound, avoid further infection, and can carry out active, effective disinfection to wound and skin around, reduces the wounded's misery.
Below by a plurality of embodiment, the preparation method of first aid dressing of the present invention is described further, but the present embodiment does not mean that any limitation of the invention.
embodiment 1
One, prepare medicine film cream
(1), prepare Chinese medicine extract
(1) by weight, get 45 parts of 45 parts of Halloysitum Rubrums, 35 parts of Calaminas, 15 parts of Olibanum (processed with vinegar), 15 parts of Myrrhas, 40 parts of Radix Et Rhizoma Rhei, 45 parts of Rhizoma Coptidis, 40 parts of Radix Sanguisorbaes, 40 parts of Euphorbia kozlowii Prok, 10 parts of Radix Notoginseng, 40 parts of Ramulus Sambuci Williamsii and itea orientalis Hemsl., standby.
Halloysitum Rubrum, Calamina and Ramulus Sambuci Williamsii heat-clearing and toxic substances removing, pain relieving, anticorrosion antipruritic, restrain, can absorb the secretions of wound surface, keep the dry of wound surface, there is again prevention infection, promote the effect of wound healing.Radix Et Rhizoma Rhei, Radix Sanguisorbae, Fructus Gardeniae, Radix Notoginseng have the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, convergence, granulation promoting pain relieving, tool moisture absorption exudation, ease the pain, prevent the effect of wound infection.
(2), Halloysitum Rubrum that step (1) is got, Calamina, Olibanum (processed with vinegar) and Myrrha mix, and is crushed to 400 orders, standby;
(3) Radix Et Rhizoma Rhei, Rhizoma Coptidis, Radix Sanguisorbae, Euphorbia kozlowii Prok, Radix Notoginseng, Ramulus Sambuci Williamsii and the itea orientalis Hemsl., step (1) got, mix homogeneously, after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 10% ethanol soaks, and the addition of ethanol is for soaking 1.5 times of medical material volume, soak after 12 hours, the ethanol that the concentration that adds again 5 times of soaked medical material cumulative volumes is 100%, carries out percolation, collects percolate standby;
Euphorbia kozlowii Prok, Olibanum (processed with vinegar), Myrrha have invigorates blood circulation, the effect of blood-activating analgetic.Rhizoma Coptidis has the effect of heat clearing away, removing toxic substances, dampness, has stronger antibacterial action, can suppress comparatively significantly bacillus pyocyaneus and staphylococcic growth, strengthens anti-infectious function.
(4), percolate that above-mentioned steps (3) is collected sends in vacuum decompressioning and concentrating tank, carries out concentrating under reduced pressure, is evaporated to the thick paste that density is 1.2g/cm3, density measurement is carried out in the time of 50 ℃, reclaims ethanol simultaneously, the thick paste making is standby;
(5), the medicated powder prepared with step (2) of thick paste that above-mentioned steps (4) is made mixs homogeneously, and dries, then is ground into 200 object fine powders, makes Chinese medicine extract;
(two), preparation substrate
(1) get, by weight 5 parts of the glacial acetic acid solutions that 5 parts of polyvidones, 40 parts of purified water, 1 part of polyvinyl alcohol, 30 parts of glycerol, 15 parts of micropowder silica gels, 2 parts of Borneolum Syntheticums, 8 parts of chitosans and concentration are 1～2%, standby.
(2), polyvidone and 10 parts of purified water that step (1) is got, add in reactor, be warming up to 60 ℃, stir 30 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), polyvinyl alcohol and glycerol that step (1) is got, add in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4) glacial acetic acid solution that the micropowder silica gel of, step (1) being got, Borneolum Syntheticum, chitosan, concentration are 1～2% and 30 parts of purified water, add in reactor, stir 1～2 minute, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 40 ℃, stir 8 minutes, stop stirring and standing 5 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 2 minutes, makes substrate;
Chitosan is that the chitin extensively being existed by nature obtains through deacetylation, chemical name is Chitosan (1-4)-2-amino-B-D glucose, its chemical constitution is similar to cellulose, within the scope of lower PH, can dissolve the macromolecule cation gel solution that forms thickness, there is good film property, the technical program be take chitosan as major ingredient, be equipped with the adjuvants such as micropowder silica gel, polyvidone and Borneolum Syntheticum, the substrate resilient flexibility preparing is good, coordinate Chinese medicine rete, for clinical various skin, the burn of mucosa, trauma care, effect is very good.
(three), prepare medicine film cream
Get by weight percentage substrate prepared by the above-mentioned steps (two) of Chinese medicine extract prepared by 30% above-mentioned steps () and 70%; First substrate is added in reactor, make the substrate in reactor be warming up to 50 ℃, then Chinese medicine extract is added in reactor, stir 20 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer 2, and wherein, the smearing thickness of medicine film cream is 0.5～5mm; The film overcoat 1 of getting it filled afterwards, makes the silicone oil of medicine film overcoat 1 facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat 1, makes the medicine film layer 2 with medicine film overcoat 1;
Three, prepare heating layer
(one), preparation heating material
By ratio of weight and the number of copies, get 35 parts of iron powders, 10 parts of coke blackings, 5 parts, kieselguhr, 22 parts, 2 parts, sodium chloride and water, insert in container, and mix homogeneously makes heating material;
(two), prepare heating layer
Get the heating material making in step (), uniform spreading is located in the cloth bag that non-woven fabrics makes, and by cloth bag sealing, and cloth bag is sewn with line into the cage of 4 * 4cm, makes heating layer 3, and wherein in non-woven bag, the laying depth of heating material is 0.5 ㎝; Heating layer 3 is separated into a plurality of junior unit lattice, and moving, in walking process, the heating material in heating layer can not drop the wounded, causing inhomogeneous that heating material distributes, thereby affects the uniformity of heating temp.
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 2 ㎝ is set, make backing layer 4;
Five, preparation heating overcoat
Get the plastic foil that one side is provided with adhesive sticker, according to the shape and size of reserving in advance, cut out in flakes, make heating overcoat 5;
Six, prepare first aid dressing
(one), get that above-mentioned steps two makes with 2 one of the medicine film layers of medicine film overcoat 1, on work platform for placing, wherein, medicine film overcoat 1 under, medicine film layer 2 is upper;
(two), get 3 one of the heating layers that above-mentioned steps three prepares, heating layer 3 is pasted on the nonwoven cloth cover of medicine film layer 2;
(three), get 4 one of the backing layer that above-mentioned steps four prepares, backing layer 4 surroundings are pasted on heating layer 3 with the one side of adhesive sticker, the adhesive sticker of backing layer 4 surroundings sticks on medicine film overcoat 1;
(four), get 5 one of the heating overcoats that above-mentioned steps five prepares, the one side by heating overcoat 5 with adhesive sticker abuts on backing layer 4;
(five), pack dressing into composite film packaging bag 6, evacuation, sealed composite film package bag 6; Wherein, it is disclosed composite package film in 201020573784.4 that composite membrane can be used the patent No.; described composite package film is comprised of according to level protective layer, intermediate layer and barrier layer; wherein protective layer is polyester rete; intermediate layer is pure aluminum foil layer; barrier layer is evoh layer, and EVOH is the copolymer of ethylene and vinyl alcohol.Wherein, to be 99.5% electrolytic aluminium obtain through calendering repeatedly pure aluminum foil layer, and optical density is between 0.15-0.50.This composite membrane can adapt to the humiture situation of external complex, and have comprehensive block water, gas barrier properties, air transmission coefficient is minimum.Be highly suitable for packing of this first aid dressing.
(six), the sealed composite film package bag 6 that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the first aid dressing for cold district traumatic surface.
60co radiation sterilization, as a kind of new method for disinfection and sterilization, has been incorporated into American Pharmacopeia.
60the mechanism of Co radiation sterilization is mainly to utilize
60co-energy of γ ray transmittance process, destroys the DNA in bacterial cell, makes it lose synthetic protein and Genetic Function, and bacterial cell propagation is stopped and death.Also someone thinks, due to the hydrone of ray indirect action in bacterial cell, to have produced activated free radical, thereby destroyed cyton, reaches the object of sterilizing.
During sterilizing, sealed and packed first aid dressing is put in special-purpose sterile chamber, first aid dressing in 60cm left and right, is selected irradiation dose apart from radiation source, and solid preparation is generally 8-10kGy, and exposure time is generally 4-5h.
60co radiation sterilization has following outstanding feature:
1, penetration power is strong, generally can reach 40-60cm;
2, under normal temperature and pressure, can carry out, also can not cause that temperature significantly rises;
3, sterilization process simple, be applicable to large-scale industrialization application, and can not there is radioactive pollution or residual, free from environmental pollution, generally also can not cause the significant change of pharmacology and toxicity, safe and effective.
The wounded are when using first aid dressing, first aid dressing is taken out from sealing bags, take medicine film overcoat 1 off, medicine film layer 2 is exposed, medicine film layer 2 is aimed on bandage, the adhesive sticker of backing layer 4 surroundings and the skin attachement of wound surrounding, now take heating overcoat 5 off, make in backing layer 4 exposures and air, backing layer 4 is ventilative non-woven fabrics, can not affect heating layer 3 and contact with air, and the heating material in heating layer 3 starts heating after running into air, finally reach certain heating temp, and the lasting long period.
One, prepare medicine film cream
(1), prepare Chinese medicine extract
(1), by weight, get 50 parts of 50 parts of Halloysitum Rubrums, 50 parts of Calaminas, 20 parts of Olibanum (processed with vinegar), 25 parts of Myrrhas, 44 parts of Radix Et Rhizoma Rhei, 51 parts of Rhizoma Coptidis, 48 parts of Radix Sanguisorbaes, 55 parts of Euphorbia kozlowii Prok, 18 parts of Radix Notoginseng, 53 parts of Ramulus Sambuci Williamsii and itea orientalis Hemsl., standby.
(2), Halloysitum Rubrum that step (1) is got, Calamina, Olibanum (processed with vinegar) and Myrrha mix, and is crushed to 300 orders, standby;
(3) Radix Et Rhizoma Rhei, Rhizoma Coptidis, Radix Sanguisorbae, Euphorbia kozlowii Prok, Radix Notoginseng, Ramulus Sambuci Williamsii and the itea orientalis Hemsl., step (1) got, mix homogeneously, after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 30% ethanol soaks, and the addition of ethanol is for soaking 1.2 times of medical material volume, soak after 24 hours, the ethanol that the concentration that adds again 8 times of soaked medical material cumulative volumes is 30%, carries out percolation, collects percolate standby;
(4), percolate that above-mentioned steps (3) is collected sends in vacuum decompressioning and concentrating tank, carries out concentrating under reduced pressure, is evaporated to the thick paste that density is 1.1g/cm3, density measurement is carried out in the time of 50 ℃, reclaims ethanol simultaneously, the thick paste making is standby;
(5), the medicated powder prepared with step (2) of thick paste that above-mentioned steps (4) is made mixs homogeneously, and dries, then is ground into 200 object fine powders, makes Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 7 parts of the glacial acetic acid solutions that 8 parts of polyvidones, 53 parts of purified water, 2 parts of polyvinyl alcohol, 30 parts of glycerol, 25 parts of micropowder silica gels, 4 parts of Borneolum Syntheticums, 12 parts of chitosans and concentration are 1～2%, standby.
(2), polyvidone and 13 parts of purified water that step (1) is got, add in reactor, be warming up to 65 ℃, stir 40 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), polyvinyl alcohol and glycerol that step (1) is got, add in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4) glacial acetic acid solution that the micropowder silica gel of, step (1) being got, Borneolum Syntheticum, chitosan, concentration are 1～2% and 40 parts of purified water, add in reactor, stir 1～2 minute, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 50 ℃, stir 2 minutes, stop stirring and standing 4 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 8 minutes, makes substrate;
(three), prepare medicine film cream
Get by weight percentage substrate prepared by the above-mentioned steps (two) of Chinese medicine extract prepared by 50% above-mentioned steps () and 50%; First substrate is added in reactor, make the substrate in reactor be warming up to 55 ℃, then Chinese medicine extract is added in reactor, stir 30 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer 2, and wherein, the smearing thickness of medicine film cream is 0.5～5mm; The film overcoat 1 of getting it filled afterwards, makes the silicone oil of medicine film overcoat 1 facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat 1, makes the medicine film layer 2 with medicine film overcoat 1;
Three, prepare heating layer
(one), preparation heating material
By ratio of weight and the number of copies, get 40 parts of iron powders, 17 parts of coke blackings, 8 parts, kieselguhr, 22 parts, 2 parts, sodium chloride and water, insert in container, and mix homogeneously makes heating material;
(two), prepare heating layer
Get the heating material making in step (), uniform spreading is located in the cloth bag that non-woven fabrics makes, and by cloth bag sealing, and cloth bag is sewn with line into the cage of 4 * 4cm, makes heating layer 3, and wherein in non-woven bag, the laying depth of heating material is 0.4 ㎝;
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 3 ㎝ is set, make backing layer 4;
Five, preparation heating overcoat
Get the plastic foil that one side is provided with adhesive sticker, according to the shape and size of reserving in advance, cut out in flakes, make heating overcoat 5;
Six, prepare first aid dressing
(one), get that above-mentioned steps two makes with 2 one of the medicine film layers of medicine film overcoat 1, on work platform for placing, wherein, medicine film overcoat 1 under, medicine film layer 2 is upper;
(two), get 3 one of the heating layers that above-mentioned steps three prepares, heating layer 3 is pasted on the nonwoven cloth cover of medicine film layer 2;
(three), get 4 one of the backing layer that above-mentioned steps four prepares, backing layer 4 surroundings are pasted on heating layer 3 with the one side of adhesive sticker, the adhesive sticker of backing layer 4 surroundings sticks on medicine film overcoat 1;
(four), get 5 one of the heating overcoats that above-mentioned steps five prepares, the one side by heating overcoat 5 with adhesive sticker abuts on backing layer 4;
(five), pack dressing into composite film packaging bag 6, evacuation, sealed composite film package bag 6;
(six), the sealed composite film package bag 6 that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the first aid dressing for cold district traumatic surface.
One, prepare medicine film cream
(1), prepare Chinese medicine extract
(1) get, by weight 55 parts of 55 parts of Halloysitum Rubrums, 40 parts of Calaminas, 25 parts of Olibanum (processed with vinegar), 20 parts of Myrrhas, 47 parts of Radix Et Rhizoma Rhei, 78 parts of Rhizoma Coptidis, 54 parts of Radix Sanguisorbaes, 48 parts of Euphorbia kozlowii Prok, 22 parts of Radix Notoginseng, 48 parts of Ramulus Sambuci Williamsii and itea orientalis Hemsl., standby.
(2), Halloysitum Rubrum that step (1) is got, Calamina, Olibanum (processed with vinegar) and Myrrha mix, and is crushed to 300 orders, standby;
(3) Radix Et Rhizoma Rhei, Rhizoma Coptidis, Radix Sanguisorbae, Euphorbia kozlowii Prok, Radix Notoginseng, Ramulus Sambuci Williamsii and the itea orientalis Hemsl., step (1) got, mix homogeneously, after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 50% ethanol soaks, and the addition of ethanol is for soaking 1.4 times of medical material volume, soak after 36 hours, the ethanol that the concentration that adds again 3 times of soaked medical material cumulative volumes is 50%, carries out percolation, collects percolate standby;
(4), percolate that above-mentioned steps (3) is collected sends in vacuum decompressioning and concentrating tank, carries out concentrating under reduced pressure, is evaporated to the thick paste that density is 1.3g/cm3, density measurement is carried out in the time of 50 ℃, reclaims ethanol simultaneously, the thick paste making is standby;
(5), the medicated powder prepared with step (2) of thick paste that above-mentioned steps (4) is made mixs homogeneously, and dries, then is ground into 300 object fine powders, makes Chinese medicine extract;
(two), preparation substrate
(1), get by weight 8 parts of the glacial acetic acid solutions that 7 parts of polyvidones, 64 parts of purified water, 3 parts of polyvinyl alcohol, 40 parts of glycerol, 32 parts of micropowder silica gels, 7 parts of Borneolum Syntheticums, 10 parts of chitosans and concentration are 1～2%
(2), 16 parts of 7 parts of polyvidones that step (1) is got and purified water, add in reactor, be warming up to 65 ℃, stir 50 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), 40 parts of 3 parts of polyvinyl alcohol that step (1) is got and glycerol, add in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4) 48 parts of 10 parts of 7 parts of 32 parts of micropowder silica gels, Borneolum Syntheticums, the chitosans of, step (1) being got, 8 parts of the glacial acetic acid solutions that concentration is 1～2% and purified water, add in reactor, stir 1～2 minute, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 60 ℃, stir 10 minutes, stop stirring and standing 3 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 10 minutes, makes substrate;
(three), prepare medicine film cream
Get by weight percentage substrate prepared by the above-mentioned steps (two) of Chinese medicine extract prepared by 40% above-mentioned steps () and 60%; First substrate is added in reactor, make the substrate in reactor be warming up to 45 ℃, then Chinese medicine extract is added in reactor, stir 35 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer 2, and wherein, the smearing thickness of medicine film cream is 0.5～5mm; The film overcoat 1 of getting it filled afterwards, makes the silicone oil of medicine film overcoat 1 facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat 1, makes the medicine film layer 2 with medicine film overcoat 1;
Three, prepare heating layer 3
(one), preparation heating material
By ratio of weight and the number of copies, get 45 parts of iron powders, 14 parts of coke blackings, 12 parts, kieselguhr, 22 parts, 2 parts, sodium chloride and water, insert in container, and mix homogeneously makes heating material;
(two), prepare heating layer
Get the heating material making in step (), uniform spreading is located in the cloth bag that non-woven fabrics makes, and by cloth bag sealing, and cloth bag is sewn with line into the cage of 4 * 4cm, makes heating layer 3, and wherein in non-woven bag, the laying depth of heating material is 0.2 ㎝;
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 4 ㎝ is set, make backing layer 4;
Five, preparation heating overcoat
Get the plastic foil that one side is provided with adhesive sticker, according to the shape and size of reserving in advance, cut out in flakes, make heating overcoat 5;
Six, prepare first aid dressing
(one), get that above-mentioned steps two makes with 2 one of the medicine film layers of medicine film overcoat 1, on work platform for placing, wherein, medicine film overcoat 1 under, medicine film layer 2 is upper;
(two), get 3 one of the heating layers that above-mentioned steps three prepares, heating layer 3 is pasted on the nonwoven cloth cover of medicine film layer 2;
(three), get 4 one of the backing layer that above-mentioned steps four prepares, backing layer 4 surroundings are pasted on heating layer 3 with the one side of adhesive sticker, the adhesive sticker of backing layer 4 surroundings sticks on medicine film overcoat 1;
(four), get 5 one of the heating overcoats that above-mentioned steps five prepares, the one side by heating overcoat 5 with adhesive sticker abuts on backing layer 4;
(five), pack dressing into composite film packaging bag 6, evacuation, sealed composite film package bag 6;
(six), the sealed composite film package bag 6 that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the first aid dressing for cold district traumatic surface.
embodiment 4
One, prepare medicine film cream
(1), prepare Chinese medicine extract
(1) get, by weight 60 parts of 60 parts of Halloysitum Rubrums, 55 parts of Calaminas, 30 parts of Olibanum (processed with vinegar), 30 parts of Myrrhas, 50 parts of Radix Et Rhizoma Rhei, 55 parts of Rhizoma Coptidis, 60 parts of Radix Sanguisorbaes, 60 parts of Euphorbia kozlowii Prok, 30 parts of Radix Notoginseng, 60 parts of Ramulus Sambuci Williamsii and itea orientalis Hemsl., standby.
(2), Halloysitum Rubrum, Calamina, Olibanum (processed with vinegar) and Myrrha that step (1) is got, mix, be crushed to 200 orders, standby;
(3) Radix Et Rhizoma Rhei, Rhizoma Coptidis, Radix Sanguisorbae, Euphorbia kozlowii Prok, Radix Notoginseng, Ramulus Sambuci Williamsii and the itea orientalis Hemsl., step (1) got, mix homogeneously, after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 100% ethanol soaks, and the addition of ethanol is for soaking 1.2 times of medical material volume, soak after 48 hours, the ethanol that the concentration that adds again 10 times of soaked medical material cumulative volumes is 10%, carries out percolation, collects percolate standby;
(4), percolate that above-mentioned steps (3) is collected sends in vacuum decompressioning and concentrating tank, carries out concentrating under reduced pressure, is evaporated to the thick paste that density is 1.2g/cm3, density measurement is carried out in the time of 50 ℃, reclaims ethanol simultaneously, the thick paste making is standby;
(5), the medicated powder prepared with step (2) of thick paste that above-mentioned steps (4) is made mixs homogeneously, and dries, then is ground into 400 object fine powders, makes Chinese medicine extract;
(two), preparation substrate
(1) get, by weight 10 parts of the glacial acetic acid solutions that 10 parts of polyvidones, 70 parts of purified water, 5 parts of polyvinyl alcohol, 50 parts of glycerol, 40 parts of micropowder silica gels, 10 parts of Borneolum Syntheticums, 15 parts of chitosans and concentration are 1～2%, standby.
(2), 20 parts of polyvidone that step (1) is got and purified water, add in reactor, be warming up to 70 ℃, stir 60 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), 50 parts of 5 parts of polyvinyl alcohol that step (1) is got and glycerol, add in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4) 50 parts of the glacial acetic acid solution that the micropowder silica gel of, step (1) being got, Borneolum Syntheticum, chitosan, concentration are 1～2% and purified water, add in reactor, stir 1～2 minute, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 70 ℃, stir 6 minutes, stop stirring and standing 2 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 6 minutes, makes substrate;
(three), prepare medicine film cream
Get by weight percentage substrate prepared by the above-mentioned steps (two) of Chinese medicine extract prepared by 45% above-mentioned steps () and 55%; First substrate is added in reactor, make the substrate in reactor be warming up to 45 ℃, then Chinese medicine extract is added in reactor, stir 40 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer 2, and wherein, the smearing thickness of medicine film cream is 0.5～5mm; The film overcoat 1 of getting it filled afterwards, makes the silicone oil of medicine film overcoat 1 facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat 1, makes the medicine film layer 2 with medicine film overcoat 1.
Three, prepare heating layer
(one), preparation heating material
By ratio of weight and the number of copies, get 50 parts of iron powders, 20 parts of coke blackings, 15 parts, kieselguhr, 22 parts, 2 parts, sodium chloride and water, insert in container, and mix homogeneously makes heating material;
(two), prepare heating layer
Get the heating material making in step (), uniform spreading is located in the cloth bag that non-woven fabrics makes, and by cloth bag sealing, and cloth bag is sewn with line into the cage of 4 * 4cm, makes heating layer 3, and wherein in non-woven bag, the laying depth of heating material is 0.1 ㎝;
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 5 ㎝ is set, make backing layer 4;
Five, preparation heating overcoat
Get the plastic foil that one side is provided with adhesive sticker, according to the shape and size of reserving in advance, cut out in flakes, make heating overcoat 5;
Six, prepare first aid dressing
(one), get that above-mentioned steps two makes with 2 one of the medicine film layers of medicine film overcoat 1, on work platform for placing, wherein, medicine film overcoat 1 under, medicine film layer 2 is upper;
(two), get 3 one of the heating layers that above-mentioned steps three prepares, heating layer 3 is pasted on the nonwoven cloth cover of medicine film layer 2;
(three), get 4 one of the backing layer that above-mentioned steps four prepares, backing layer 4 surroundings are pasted on heating layer 3 with the one side of adhesive sticker, the adhesive sticker of backing layer 4 surroundings sticks on medicine film overcoat 1;
(four), get 5 one of the heating overcoats that above-mentioned steps five prepares, the one side by heating overcoat 5 with adhesive sticker abuts on backing layer 4;
(five), pack dressing into composite film packaging bag 6, evacuation, sealed composite film package bag 6;
(six), the sealed composite film package bag 6 that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the first aid dressing for cold district traumatic surface.
zoopery
By following experimental technique, further illustrate the therapeutic effect of first aid adjuvant of the present invention, concrete test method is: get 5 of commercially available piglets, every heavy 10-15kg, respectively at spinal column both sides, back, cervical region and four position depilations of buttocks, and under anesthesia, with U.S. ZMP motor dermatome, carry out bark fetching processing, form altogether 6 wound surface, symmetrical with spinal column, each wound surface size 5cm * 5cm, degree of depth 0.25mm.By above-mentioned 5 porklings that form wound surface, be suspended on outdoor (0 ℃-subzero 4 ℃ of outdoor temperatures), 3 wound surface of every piglet left of spine are attached to the dressing of preparation, as experimental group, the symmetrical wound surface in spinal column right side sticks the adjuvant of not being with heating layer, is matched group.Size flap coverage is advisable.Change once every day, amounts to 10 days.With the infrared non-contact temperature sensor of MLX90614, measure during this time the temperature on dressing surface.Simultaneously, from wound surface formation and with 3,5,7,10 days dressing treatment, observe wound healing situation, and get wound subcutaneous tissue and skin with the trepan of 0.2mm, micro-Microscopic observation wound granulation tissue increases situation, this place's capillary vessel number and fibroblast number (high power field C * 400).
experimental result
1. monitor dressing surface temperature situation of change
Change after the dressing with zone of heating at every turn, use infrared radiation thermometer to monitor the heating temp of dressing, monitoring result shows that dressing all can reach 28-38 ℃ 1-2 hour internal heat generation temperature, and can continue 4-6 hour.
2. perusal
Experimental group is 1d after treatment, wound surface starts to occur a little blush, there is a small amount of fresh granulation tissue, wound surface size is shown in and dwindles, 2d is similar to 1d result, and special change does not occur on same wound surface surface, and the fresh granulation tissue along surface imperfection hypertrophy appears in 3d in region, wound surface marginal portion, be island growth, along wound surface notching edge, arrange; The obvious centration of 5d granulation tissue, lumps, neoplastic hyperplasia, wound surface is owing to becoming large for the granulation tissue volume of growing from different directions, wound surface is sealed completely, 8d granulation tissue volume-diminished, 9d hypertrophy goes out organizes and further flattens wholely, and 10d granulation tissue and epithelium are dissolved in together completely, and the smooth wound of hyperplastic tissue place is repaired, and the rarely seen thin layer granulation tissue of matched group wound wound contraction is not obvious, wound repair out-of-flatness.
3. quantitative observation
A, with rear 1d, observe dressing of the present invention and have and promote the effect of wound blood capillary proliferation.
Table 1 wound healing place blood capillary proliferation is counted statistics of variables n=20
| Group | 1d | 3d | 5d | 7d | 10d |
| Matched group | 5.1±1.8 | 15.3±2.1 | 19.5±2.5 | 31.6±3.5 | 15.2±2.0 |
| Experimental group | 7.2±2.2 | 24.1±5.1 | 36.3±3.8 | 20.3±2.1 | 10.6±3.2 |
B, with rear 3d, demonstrate dressing of the present invention and there is the effect that promotes wound fibroblast proliferation.
Table 2 wound healing place fibroblast proliferation quantity n=20
| Group | 1d | 3d | 5d | 7d | 10d |
| Matched group | 30.2±5.8 | 61.4±4.2 | 91.2±6.3 | 141.4±9.1 | 279.2±8.6 |
| Experimental group | 40.1±5.4 | 89.2±7.8 | 179.2±15.4 | 342.3±10.5 | 185.4±12.5 |
4. qualitative observation
1d after medication, under mirror, 2 groups of wounds all have a large amount of inflammatory exudates, inside have serosity, neutrophilic leukocyte, mononuclear cell, macrophage, cellulose and non-viable non-apoptotic cell chip; Postoperative 1d, the visible a small amount of blood capillary of experimental group wound and fibroblast, periphery subcutaneous tissue is congested, edema, inflammatory cell infiltration; Postoperative 3d, matched group has granulation tissue to grow into, but is not full of wound, and experimental group granulation tissue hyperplasia is obvious, and has been full of wound, and epidermal hyperplasia has covered wound, the major part on surface, visible a lot of new vesselses and fibroblast proliferation; Postoperative 5d, matched group granulation tissue is full of wound substantially, and epidermis starts the major part that hypertrophy covers wound surface, but wound do not heal, and experimental group granulation tissue is more obvious, finer and close, and surface is covered completely by the epidermis of hypertrophy, and wound heals.Postoperative 7d, experimental group granulation tissue is ripe gradually, and blood capillary reduces, and fibrocyte and collagen fiber increase, and start to cicatrix transition; Matched group granulation tissue is full of wound completely, and epidermis covers completely, and wound heals; Postoperative 10d, 2 groups of granulation tissuies are all gradually ripe, but experimental group collagen fiber further increase, and more tend to cicatrix transition, and experimental group claims the 2～3d healing in advance of matched group wound.
Claims (2)
1. for the first aid dressing of cold district traumatic surface, it is characterized in that: the medicine film overcoat (1) successively arranging, medicine film layer (2), heating layer (3), backing layer (4) and heating overcoat (5), consist of, medicine film layer (2), heating layer (3) and backing layer (4) are fixedly connected with; The area of described medicine film overcoat (1), backing layer (4) and heating overcoat (5) is equal, and the area of the area of heating layer (3) and medicine film layer (2) is equal, and the area of backing layer (4) is greater than the area of heating layer (3); Described medicine film layer (2), is comprised of non-woven fabrics and the medicine film cream spreading upon on non-woven fabrics, and the smearing thickness of its Chinese medicinal film cream is 0.5～5mm; Described medicine film overcoat (1) is single silicon release paper, and single silicon release paper is covered with silicone oil with the one side that the medicine film cream of medicine film layer (2) contacts; Described backing layer (4) is non-woven fabrics, at backing layer (4), towards the periphery of the one side of heating layer (3), is provided with a circle adhesive sticker, and the width of adhesive sticker is 2～5 ㎝; Described heating overcoat (5) is plastic foil, and the pressure sensitive adhesive that heating overcoat (5) simultaneously arranges by it is on backing layer (4);
Described medicine film cream is comprised of Chinese medicine extract and substrate, and the percentage by weight of Chinese medicine extract and substrate is:
Chinese medicine extract 30～50%, substrate 50～70%;
The crude drug of described Chinese medicine extract is comprised of Radix Et Rhizoma Rhei, Rhizoma Coptidis, Halloysitum Rubrum, Calamina, Radix Sanguisorbae, Olibanum (processed with vinegar), Myrrha, Euphorbia kozlowii Prok, Radix Notoginseng, Ramulus Sambuci Williamsii and itea orientalis Hemsl., and the ratio of weight and number that each medical material adds is respectively: 45～60 parts of 40～50 parts of Radix Et Rhizoma Rhei, 45～55 parts of Rhizoma Coptidis, 45～60 parts of Halloysitum Rubrums, 35～55 parts of Calaminas, 40～60 parts of Radix Sanguisorbaes, 15～30 parts of Olibanum (processed with vinegar), 15～30 parts of Myrrhas, 40～60 parts of Euphorbia kozlowii Prok, 10～30 parts of Radix Notoginseng, 40～60 parts of Ramulus Sambuci Williamsii and itea orientalis Hemsl.;
The glacial acetic acid solution that described substrate is 1～2% by polyvidone, glycerol, micropowder silica gel, purified water, Borneolum Syntheticum, chitosan, polyvinyl alcohol and concentration forms, and the ratio of weight and number that each raw material adds is respectively: 10～70 parts of 5～10 parts of the glacial acetic acid solutions that 5～10 parts of polyvidones, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 2～10 parts of Borneolum Syntheticums, 8～15 parts of chitosans, 1～5 part of polyvinyl alcohol, concentration are 1～2% and purified water;
Described heating layer is comprised of two-layer nonwoven and the heating material that is arranged between two-layer nonwoven, and the thickness of described heating material is 0.1～0.5 ㎝;
Described heating material is comprised of iron powder, coke blacking, kieselguhr, sodium chloride and water, and the ratio of weight and number that each raw material adds is respectively: 35～50 parts of iron powders, 10～20 parts of coke blackings, 5～15 parts, kieselguhr, 22 parts, 2 parts, sodium chloride and water.
2. the preparation method of the first aid dressing for cold district traumatic surface according to claim 1, is characterized in that: preparation method is as follows:
One, prepare medicine film cream
(one), prepare Chinese medicine extract
(1), by weight, get 45～60 parts of 45～60 parts of Halloysitum Rubrums, 35～55 parts of Calaminas, 15～30 parts of Olibanum (processed with vinegar), 15～30 parts of Myrrhas, 40～50 parts of Radix Et Rhizoma Rhei, 45～55 parts of Rhizoma Coptidis, 40～60 parts of Radix Sanguisorbaes, 40～60 parts of Euphorbia kozlowii Prok, 10～30 parts of Radix Notoginseng, 40～60 parts of Ramulus Sambuci Williamsii and itea orientalis Hemsl., standby;
(2), by the Halloysitum Rubrum, Calamina, Olibanum (processed with vinegar) and the Myrrha that take out in step (1)
Mix, be crushed to 200～400 orders, standby;
(3), by the Radix Et Rhizoma Rhei, Rhizoma Coptidis, Radix Sanguisorbae, Euphorbia kozlowii Prok, Radix Notoginseng, Ramulus Sambuci Williamsii and the itea orientalis Hemsl. mix homogeneously that take out in step (1), after pulverizing, cross 10 mesh sieves, then the medical material after sieving is inserted in percolator, adding concentration is that 10～100% ethanol soaks, the addition of ethanol, for soaking 1.2～1.5 times of medical material volume, is soaked after 12～48 hours, then adds the ethanol that the concentration of 3～10 times of immersion medical material original volumes is 10～100%, carry out percolation, collect percolate standby;
(4), percolate that above-mentioned steps (3) is collected sends in vacuum decompressioning and concentrating tank, carries out concentrating under reduced pressure, being evaporated to density is 1.10～1.30g/cm
3thick paste, density measurement is carried out in the time of 50 ℃, reclaims ethanol simultaneously, the thick paste making is standby;
(5), the medicated powder prepared with step (2) of thick paste that above-mentioned steps (4) is made mixs homogeneously, and dries, then is ground into 200～400 object fine powders, makes Chinese medicine extract;
(two), preparation substrate
(1), by weight, 5～10 parts of the glacial acetic acid solutions that to get 5～10 parts of polyvidones, 40～70 parts of purified water, 1～5 part of polyvinyl alcohol, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 2～10 parts of Borneolum Syntheticums, 8～15 parts of chitosans, concentration be 1～2%, standby;
(2), polyvidone and 10～20 parts of purified water of taking out in step (1) are added in reactor, be warming up to 60～70 ℃, stir 30～60 minutes, make it abundant swelling, obtain polyvidone swelling solution, standby;
(3), the polyvinyl alcohol and the glycerol that take out in step (1) are added in reactor, be warmed up to 70 ℃, stir 30min, mix homogeneously, obtains alcohol oil solution, standby;
(4) glacial acetic acid solution and 30～50 parts of purified water that by micropowder silica gel, Borneolum Syntheticum, chitosan, the concentration of taking out in step (1), are, 1～2%, add in reactor, stir 1～2 minute, the alcohol oil solution that adds again above-mentioned steps (3) to make, be warmed up to 40～70 ℃, stir 2～10 minutes, stop stirring and static 2～5 minutes; Again the mixed solution in reactor is warming up to 50 ℃ afterwards, the polyvidone swelling solution that adds above-mentioned steps (2) to make, stirs 2～10 minutes, makes substrate;
(three), prepare medicine film cream
Get by weight percentage substrate prepared by the above-mentioned steps (two) of Chinese medicine extract prepared by 30～50% above-mentioned steps () and 50～70%; First substrate is added in reactor, make the substrate in reactor be warming up to 45～55 ℃, then Chinese medicine extract is added in reactor, stir 20～40 minutes, make medicine film cream;
Two, preparation is with the medicine film layer of medicine film overcoat
The medicine film cream that above-mentioned steps one is made, evenly spreads upon on non-woven fabrics, is then cut into the shape and size that need, and makes medicine film layer, and wherein, the smearing thickness of medicine film cream is 0.5～5mm; The film overcoat of getting it filled afterwards, makes the silicone oil of medicine film overcoat facing to medicine film cream, then covers on medicine film cream, and medicine film cream is between non-woven fabrics and medicine film overcoat, makes the medicine film layer with medicine film overcoat;
Three, prepare heating layer
(one), preparation heating material
By ratio of weight and the number of copies, get 22 parts, 35～50 parts of iron powders, 10～20 parts of coke blackings, 5～15 parts, kieselguhr, 2 parts, sodium chloride and water, insert in container, mix homogeneously, making heating material, and mixing process carries out under nitrogen protection;
(two), prepare heating layer
Get the heating material making in step (), uniform spreading is located in the cloth bag that non-woven fabrics makes, cloth bag is sealed, and cloth bag is sewn with line into the cage of 4 * 4cm, make heating layer, prepare the process of heating layer and carry out under nitrogen protection, wherein in non-woven bag, the laying depth of heating material is 0.1～0.5 ㎝;
Four, prepare backing layer
Get non-woven fabrics, according to the shape and size of reserving in advance, cut out in flakes, in the surrounding of a face of non-woven fabrics of cutting out, the wide adhesive sticker of one circle 2～5 ㎝ is set, make backing layer;
Five, preparation heating overcoat
Get the plastic foil that one side is provided with adhesive sticker, according to the shape and size of reserving in advance, cut out in flakes, make heating overcoat;
Six, prepare first aid dressing
(one), get that above-mentioned steps two makes with one of the medicine film layer of medicine film overcoat, on work platform for placing, wherein, medicine film overcoat under, medicine film layer is upper;
(two), get one of the heating layer that above-mentioned steps three prepares, heating layer is pasted on the nonwoven cloth cover of medicine film layer;
(three), get one of the backing layer that above-mentioned steps four prepares, backing layer surrounding is pasted on heating layer with the one side of adhesive sticker, the adhesive sticker of backing layer surrounding sticks on medicine film overcoat;
(four), get one of the heating overcoat that above-mentioned steps five prepares, the one side by heating overcoat with adhesive sticker abuts on backing layer;
(five), pack dressing into composite film packaging bag, evacuation, sealed composite film package bag;
(six), the sealed composite film package bag that dressing is housed being sent into sterilization chamber carries out
60co radiosterilization, completes the sterilization of dressing according to medical required standard, make the first aid dressing for cold district traumatic surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210252565.XA CN102755664B (en) | 2012-07-20 | 2012-07-20 | First-aid dressing used for traumatic wounds in cold area and preparation method of dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210252565.XA CN102755664B (en) | 2012-07-20 | 2012-07-20 | First-aid dressing used for traumatic wounds in cold area and preparation method of dressing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102755664A CN102755664A (en) | 2012-10-31 |
| CN102755664B true CN102755664B (en) | 2014-03-26 |
Family
ID=47050466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210252565.XA Expired - Fee Related CN102755664B (en) | 2012-07-20 | 2012-07-20 | First-aid dressing used for traumatic wounds in cold area and preparation method of dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102755664B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007337B (en) * | 2012-12-31 | 2014-11-19 | 凌峰 | Polymer dressing and dressing patch |
| CN103212105B (en) * | 2013-04-22 | 2014-11-05 | 长春吉原生物科技有限公司 | Hydrogel functional dressing for preventing pressure sores |
| CN108578056A (en) * | 2018-04-20 | 2018-09-28 | 唐明 | Spontaneous heating facial mask and preparation method thereof |
| CN109550076B (en) * | 2018-12-08 | 2023-09-01 | 郑州和济生物科技股份有限公司 | Medical silicone ozone oil vaseline dressing and wound care patch based on dressing |
| CN109938920B (en) * | 2019-04-29 | 2024-02-20 | 振德医疗用品股份有限公司 | A kind of micro negative pressure foam dressing and its manufacturing method |
| CN111743693A (en) * | 2020-06-28 | 2020-10-09 | 湖北蕲艾堂科技有限公司 | Production process of multilayer traditional Chinese medicine plaster |
| CA3138036C (en) | 2020-11-09 | 2025-06-10 | Rapid Aid Corp. | Heat pack with supercooled aqueous salt solution and glycerin |
| CN112370243A (en) * | 2020-11-19 | 2021-02-19 | 南京平港生物技术有限公司 | Sterile medical wet repair dressing and preparation method thereof |
| CN114949321A (en) * | 2021-02-28 | 2022-08-30 | 中国人民解放军联勤保障部队第九六〇医院 | First-aid dressing for cold area trauma wound and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491627A (en) * | 2003-08-28 | 2004-04-28 | 湘潭市韶山医院 | Wet keeping dressing for wound medicine |
| CN101773681A (en) * | 2010-02-05 | 2010-07-14 | 彭锡朗 | Preparation method of slow-release dressing adopting traditional Chinese medicine formula |
| WO2011101594A1 (en) * | 2010-02-17 | 2011-08-25 | Laboratoires Urgo | Use of synthetic polysulphated oligosaccharides as cleaning agents for a wound |
-
2012
- 2012-07-20 CN CN201210252565.XA patent/CN102755664B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491627A (en) * | 2003-08-28 | 2004-04-28 | 湘潭市韶山医院 | Wet keeping dressing for wound medicine |
| CN101773681A (en) * | 2010-02-05 | 2010-07-14 | 彭锡朗 | Preparation method of slow-release dressing adopting traditional Chinese medicine formula |
| WO2011101594A1 (en) * | 2010-02-17 | 2011-08-25 | Laboratoires Urgo | Use of synthetic polysulphated oligosaccharides as cleaning agents for a wound |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102755664A (en) | 2012-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102755664A (en) | First-aid dressing used for traumatic wounds in cold area and preparation method of dressing | |
| CN103083713A (en) | Sterile polymerized covering dressing for wound surface | |
| CN104306358B (en) | Antipruritic scar liniment of dispelling | |
| CN108478846A (en) | A kind of medical hemostatic antiseptic dressing and preparation method thereof | |
| CN104546802A (en) | Self-heating traditional Chinese medicine sticking plaster for treating rheumatic arthritis and preparation method thereof | |
| JP2009269904A (en) | Herbal medicinal composition for curing external wound and bedsore and method of manufacturing medicine from the composition | |
| CN104225258B (en) | A kind of Chinese medicine composition promoting wound healing | |
| CN105497960A (en) | Medical dressing with effect of promoting wound healing and manufacturing method | |
| CN103040916B (en) | Externally-applied skin-regenerated oily traditional Chinese medicament for treating various burns and scalds | |
| CN102755414B (en) | Traditional Chinese medicine ointment for trauma wound and preparation method thereof | |
| CN104688769B (en) | Compound montmorillonite povidone iodine ointment and its preparation method and application | |
| CN105560620A (en) | Trauma treatment traditional Chinese medicine preparation | |
| CN102793601B (en) | Medicine therapy combined chemical ice bag | |
| CN102552480A (en) | Ointment for treating burn and scald and preparation method thereof | |
| CN101548914B (en) | Sterilized heterogeneous medical biomembrane and preparing method thereof | |
| CN114522194A (en) | Temperature-sensitive gel containing periplaneta americana extract as well as preparation method and application of temperature-sensitive gel | |
| CN105194158A (en) | Wound scar-free repairing medicinal liquor wet tissue | |
| CN114949321A (en) | First-aid dressing for cold area trauma wound and preparation method thereof | |
| CN111991471A (en) | A topical Chinese medicinal preparation for treating knife wound, burn and scald, and its preparation method | |
| CN104983936A (en) | Traditional Chinese medicine ointment for treating third-stage bedsore in clinical nursing | |
| CN104758310B (en) | Compound montmorillonite sucrose ointment and its preparation method and application | |
| CN102688521A (en) | Potato and magnesium sulfate composition wet compressing bag | |
| CN104027298A (en) | Lentinan gelata and preparation method thereof | |
| CN203042644U (en) | Aloe wound paste | |
| CN104758243B (en) | Montmorillonite external-application ointment for treating skin ulcer and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Lei Wanjun Inventor after: Li Jun Inventor after: Hao Xiping Inventor after: Zhang Yunqing Inventor before: Lei Wanjun Inventor before: Li Jun Inventor before: Hao Xilai Inventor before: Zhang Yunqing |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LEI WANJUN LI JUN HAO XILAI ZHANG YUNQING TO: LEI WANJUN LI JUN HAO XIPING ZHANG YUNQING |
|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Lei Wanjun Inventor after: Li Jun Inventor after: Hao Xiping Inventor after: Zhang Yuqing Inventor before: Lei Wanjun Inventor before: Li Jun Inventor before: Hao Xiping Inventor before: Zhang Yunqing |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LEI WANJUN LI JUN HAO XIPING ZHANG YUNQING TO: LEI WANJUN LI JUN HAO XIPING ZHANG YUQING |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140326 Termination date: 20140720 |
|
| EXPY | Termination of patent right or utility model |