CN103189358A - 5-ht2c激动剂的快速溶解剂型 - Google Patents

5-ht2c激动剂的快速溶解剂型 Download PDF

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Publication number
CN103189358A
CN103189358A CN201180052517XA CN201180052517A CN103189358A CN 103189358 A CN103189358 A CN 103189358A CN 201180052517X A CN201180052517X A CN 201180052517XA CN 201180052517 A CN201180052517 A CN 201180052517A CN 103189358 A CN103189358 A CN 103189358A
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CN
China
Prior art keywords
salt
weight
tetrahydro
chloro
benzazepine
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Pending
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CN201180052517XA
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English (en)
Chinese (zh)
Inventor
A.C.布莱克本
S.斯特恩
单芸
A.西弗里纳
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Arena Pharmaceuticals Inc
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Arena Pharmaceuticals Inc
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Application filed by Arena Pharmaceuticals Inc filed Critical Arena Pharmaceuticals Inc
Publication of CN103189358A publication Critical patent/CN103189358A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201180052517XA 2010-09-01 2011-08-31 5-ht2c激动剂的快速溶解剂型 Pending CN103189358A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40258910P 2010-09-01 2010-09-01
US61/402,589 2010-09-01
PCT/US2011/049953 WO2012030951A1 (en) 2010-09-01 2011-08-31 Fast-dissolve dosage forms of 5-ht2c agonists

Publications (1)

Publication Number Publication Date
CN103189358A true CN103189358A (zh) 2013-07-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180052517XA Pending CN103189358A (zh) 2010-09-01 2011-08-31 5-ht2c激动剂的快速溶解剂型

Country Status (11)

Country Link
US (1) US20140148442A1 (2)
EP (1) EP2611781A1 (2)
JP (1) JP2013536858A (2)
KR (1) KR20130138768A (2)
CN (1) CN103189358A (2)
AU (1) AU2011296027A1 (2)
CA (1) CA2808900A1 (2)
IN (1) IN2013DN02552A (2)
MX (1) MX2013002430A (2)
SG (2) SG188363A1 (2)
WO (1) WO2012030951A1 (2)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103901151A (zh) * 2014-04-23 2014-07-02 湖北朗昕生化药业有限公司 一种hplc法检测氯卡色林盐酸盐含量的方法
CN104936947A (zh) * 2013-12-27 2015-09-23 杭州普晒医药科技有限公司 氯卡色林盐及其晶体、其制备方法和用途

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KR20140091458A (ko) 2010-09-01 2014-07-21 아레나 파마슈티칼스, 인크. 신장 손상을 갖는 개체에 대한 로카세린의 투여
KR20130138770A (ko) 2010-09-01 2013-12-19 아레나 파마슈티칼스, 인크. 광학적으로 활성 산을 갖는 로르카세린의 염
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
JP2013536859A (ja) 2010-09-01 2013-09-26 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストの非吸湿性塩
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management
WO2014135545A1 (en) * 2013-03-05 2014-09-12 Sandoz Ag Solid dispersion comprising amorphous lorcaserin hydrochloride
EP2999692A1 (en) * 2013-05-20 2016-03-30 LEK Pharmaceuticals d.d. Novel synthetic processes to 8-chloro-3-benzo[d]azepine via friedel-crafts alkylation of olefin
EP2868656A1 (en) * 2013-11-05 2015-05-06 LEK Pharmaceuticals d.d. Stabilized amorphous lorcaserin hydrochloride
WO2015161730A1 (zh) 2014-04-21 2015-10-29 杭州普晒医药科技有限公司 一种氯卡色林共晶及其制备方法、药物组合物和用途
TW201618787A (zh) 2014-10-30 2016-06-01 艾尼納製藥公司 組合物及方法
WO2018000094A1 (en) 2016-06-29 2018-01-04 CannScience Innovations Inc. Decarboxylated cannabis resins, uses thereof and methods of making same

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104936947A (zh) * 2013-12-27 2015-09-23 杭州普晒医药科技有限公司 氯卡色林盐及其晶体、其制备方法和用途
CN104936947B (zh) * 2013-12-27 2017-03-08 杭州普晒医药科技有限公司 氯卡色林盐及其晶体、其制备方法和用途
CN103901151A (zh) * 2014-04-23 2014-07-02 湖北朗昕生化药业有限公司 一种hplc法检测氯卡色林盐酸盐含量的方法

Also Published As

Publication number Publication date
JP2013536858A (ja) 2013-09-26
WO2012030951A1 (en) 2012-03-08
CA2808900A1 (en) 2012-03-08
US20140148442A1 (en) 2014-05-29
KR20130138768A (ko) 2013-12-19
SG10201506873WA (en) 2015-10-29
AU2011296027A1 (en) 2013-04-04
IN2013DN02552A (2) 2015-08-07
SG188363A1 (en) 2013-04-30
EP2611781A1 (en) 2013-07-10
MX2013002430A (es) 2013-07-22

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Application publication date: 20130703