CN103202842A - 通过用喹喔啉PI3Kα抑制剂抑制来治疗的方法 - Google Patents

通过用喹喔啉PI3Kα抑制剂抑制来治疗的方法 Download PDF

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Publication number: CN103202842A
Authority: CN; China
Prior art keywords: alkyl; hydrogen; chemotherapeutics; nhc; amino
Prior art date: 2007-04-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN2013101161222A

Other languages

English (en)

Chinese (zh)

Inventor

P.兰布

D.马修斯

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Exelixis Inc

Original Assignee

Exelixis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-04-11

Filing date

2008-04-08

Publication date

2013-07-17

2008-04-08 Application filed by Exelixis Inc filed Critical Exelixis Inc

2013-07-17 Publication of CN103202842A publication Critical patent/CN103202842A/zh

Status Pending legal-status Critical Current

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Classifications

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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CN2013101161222A 2007-04-11 2008-04-08 通过用喹喔啉PI3Kα抑制剂抑制来治疗的方法 Pending CN103202842A (zh)

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US92316407P	2007-04-11	2007-04-11
US60/923,164		2007-04-11

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CN2008800173944A Division CN101959516B (zh)	2007-04-11	2008-04-08	用以治疗癌症的包含喹喔啉PI3Kα抑制剂的组合治疗

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CN103202842A true CN103202842A (zh)	2013-07-17

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CN2013101161222A Pending CN103202842A (zh)	2007-04-11	2008-04-08	通过用喹喔啉PI3Kα抑制剂抑制来治疗的方法
CN2008800173944A Expired - Fee Related CN101959516B (zh)	2007-04-11	2008-04-08	用以治疗癌症的包含喹喔啉PI3Kα抑制剂的组合治疗

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Country Status (33)

Country	Link
US (1)	US8481001B2 (da)
EP (1)	EP2139483B9 (da)
JP (2)	JP5726515B2 (da)
KR (1)	KR101586774B1 (da)
CN (2)	CN103202842A (da)
AU (1)	AU2008239668B2 (da)
BR (1)	BRPI0810208A2 (da)
CA (1)	CA2684056A1 (da)
CO (1)	CO6140024A2 (da)
CR (1)	CR11099A (da)
CY (1)	CY1114608T1 (da)
DK (1)	DK2139483T3 (da)
EA (1)	EA019064B1 (da)
EC (1)	ECSP099723A (da)
ES (1)	ES2438998T3 (da)
GT (1)	GT200900263A (da)
HR (1)	HRP20131081T1 (da)
IL (1)	IL201211A (da)
MA (1)	MA31335B1 (da)
ME (1)	ME00937B (da)
MX (1)	MX2009010929A (da)
MY (1)	MY150797A (da)
NI (1)	NI200900184A (da)
NZ (1)	NZ580009A (da)
PL (1)	PL2139483T3 (da)
PT (1)	PT2139483E (da)
RS (1)	RS53020B (da)
SI (1)	SI2139483T1 (da)
SV (1)	SV2009003390A (da)
TN (1)	TN2009000399A1 (da)
UA (1)	UA98141C2 (da)
WO (1)	WO2008127594A2 (da)
ZA (1)	ZA200906765B (da)

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CN101395155A (zh) *	2005-10-07	2009-03-25	埃克塞里艾克西斯公司	PI3Kα的吡啶并嘧啶酮抑制剂
CN101528231A (zh)	2006-08-16	2009-09-09	埃克塞利希斯股份有限公司	在癌症的治疗中使用pi3k和mek调控剂
JP2010523670A (ja) *	2007-04-10	2010-07-15	エクセリクシス，インク．	Ｐｉ３ｋアルファのピリドピリミジノン阻害剤を使用した治療方法
WO2010053182A1 (ja) *	2008-11-10	2010-05-14	協和発酵キリン株式会社	キヌレニン産生抑制剤
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DE102010048800A1 (de) *	2010-10-20	2012-05-10	Merck Patent Gmbh	Chinoxalinderivate
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JP2014528451A (ja) *	2011-10-04	2014-10-27	ギリアードカリストガエルエルシー	Ｐｉ３ｋの新規キノキサリン阻害剤
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KR20140096035A (ko) *	2011-10-28	2014-08-04	노파르티스 아게	위장 기질 종양을 치료하는 방법
CN104302294A (zh) *	2011-11-01	2015-01-21	埃克塞利希斯股份有限公司	用于治疗淋巴组织增生性恶性肿瘤的作为磷脂酰肌醇3-激酶抑制剂的n-(3-{[(3-{[2-氯-5-(甲氧基)苯基]氨基}喹喔啉-2-基)氨基]磺酰基}苯基)-2-甲基丙氨酰胺
WO2013067306A1 (en) *	2011-11-02	2013-05-10	Exelixis, Inc.	Phosphatidylinositol 3-kinase inhibitors for the treatment of childhood cancers
CA2860051A1 (en) *	2011-12-27	2013-07-04	Kadmon Corporation, Llc	Methods for treatment of breast cancer nonresponsive to trastuzumab
CN103467482B (zh)	2012-04-10	2017-05-10	上海璎黎药业有限公司	稠合嘧啶类化合物，其制备方法，中间体，组合物和应用
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BRPI0617162B8 (pt)	2005-10-07	2021-05-25	Exelixis Inc	compostos inibidores de fosfatidilinositol 3-quinase composições farmacêuticas que os contem e métodos de uso dos mesmos
CN101528231A (zh) *	2006-08-16	2009-09-09	埃克塞利希斯股份有限公司	在癌症的治疗中使用pi3k和mek调控剂
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Publication number	Publication date
EP2139483A2 (en)	2010-01-06
EP2139483B1 (en)	2013-09-18
CA2684056A1 (en)	2008-10-23
RS53020B (sr)	2014-04-30
CY1114608T1 (el)	2016-10-05
NI200900184A (es)	2011-09-08
PL2139483T3 (pl)	2014-02-28
TN2009000399A1 (fr)	2010-12-31
CR11099A (es)	2010-01-19
GT200900263A (es)	2014-01-15
AU2008239668B2 (en)	2013-11-07
MX2009010929A (es)	2010-01-20
ECSP099723A (es)	2010-03-31
ME00937B (me)	2012-06-20
JP2010523669A (ja)	2010-07-15
PT2139483E (pt)	2013-12-27
ZA200906765B (en)	2010-05-26
EA200970935A1 (ru)	2010-04-30
IL201211A0 (en)	2010-05-31
CO6140024A2 (es)	2010-03-19
UA98141C2 (ru)	2012-04-25
SV2009003390A (es)	2010-05-21
JP5726515B2 (ja)	2015-06-03
MY150797A (en)	2014-02-28
CN101959516A (zh)	2011-01-26
EA019064B1 (ru)	2013-12-30
IL201211A (en)	2015-09-24
KR101586774B1 (ko)	2016-01-19
KR20100019436A (ko)	2010-02-18
JP2014074031A (ja)	2014-04-24
DK2139483T3 (da)	2014-01-13
US20110123434A1 (en)	2011-05-26
WO2008127594A3 (en)	2009-04-30
NZ580009A (en)	2012-06-29
HK1140141A1 (en)	2010-10-08
CN101959516B (zh)	2013-05-08
EP2139483B9 (en)	2014-05-21
AU2008239668A1 (en)	2008-10-23
BRPI0810208A2 (pt)	2014-10-21
SI2139483T1 (sl)	2013-11-29
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