CN1032785A - L-二羟基苯丙氨酸衍生物或其酸加成盐、其生产方法及其用途 - Google Patents

L-二羟基苯丙氨酸衍生物或其酸加成盐、其生产方法及其用途 Download PDF

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Publication number
CN1032785A
CN1032785A CN88107165A CN88107165A CN1032785A CN 1032785 A CN1032785 A CN 1032785A CN 88107165 A CN88107165 A CN 88107165A CN 88107165 A CN88107165 A CN 88107165A CN 1032785 A CN1032785 A CN 1032785A
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CN
China
Prior art keywords
dopa
acid salt
formula
derivative
phenyl
Prior art date
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Pending
Application number
CN88107165A
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English (en)
Chinese (zh)
Inventor
土屋义己
林正弘
竹花博
樋板章博
沢崎芳男
伊原正树
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MSD KK
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Banyu Phamaceutical Co Ltd
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Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Publication of CN1032785A publication Critical patent/CN1032785A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN88107165A 1987-09-18 1988-09-17 L-二羟基苯丙氨酸衍生物或其酸加成盐、其生产方法及其用途 Pending CN1032785A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP23429987 1987-09-18
JP234,299/87 1987-09-18
JP31,260/88 1988-02-13
JP3126088 1988-02-13

Publications (1)

Publication Number Publication Date
CN1032785A true CN1032785A (zh) 1989-05-10

Family

ID=26369718

Family Applications (1)

Application Number Title Priority Date Filing Date
CN88107165A Pending CN1032785A (zh) 1987-09-18 1988-09-17 L-二羟基苯丙氨酸衍生物或其酸加成盐、其生产方法及其用途

Country Status (12)

Country Link
US (1) US4966915A (2)
EP (1) EP0309827B1 (2)
JP (1) JPH02138A (2)
KR (1) KR890005031A (2)
CN (1) CN1032785A (2)
AT (1) ATE71083T1 (2)
AU (1) AU2234088A (2)
CA (1) CA1316180C (2)
DE (1) DE3867403D1 (2)
DK (1) DK517588A (2)
IL (1) IL87765A0 (2)
PT (1) PT88526B (2)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102224131B (zh) * 2008-11-10 2013-11-06 韩国海洋研究院 化合物ramalin及其应用
CN103694127A (zh) * 2013-12-30 2014-04-02 上海交通大学 链霉菌属菌种所产的化合物及该化合物的制备方法和应用

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60323339D1 (de) * 2002-02-15 2008-10-16 Darpharma Inc Monoester und asymmetrisch substituierte diester prodrugs der dopamin-d1-rezeptor-agonisten
AU2003293423A1 (en) * 2002-12-06 2004-06-30 Xenoport, Inc. Carbidopa prodrugs and uses thereof
US6970629B2 (en) 2002-12-19 2005-11-29 Corning Cable Systems Llc Optical tube assembly having a dry insert and methods of making the same
US20090190890A1 (en) 2002-12-19 2009-07-30 Freeland Riley S Fiber optic cable having a dry insert and methods of making the same
US7471862B2 (en) 2002-12-19 2008-12-30 Corning Cable Systems, Llc Dry fiber optic cables and assemblies
IL154318A (en) 2003-02-06 2010-05-31 Sarah Herzog Memorial Hospital Pharmaceutical compositions for the treatment of movement disorders
RU2365580C2 (ru) 2004-06-04 2009-08-27 Ксенопорт, Инк. Пролекарства леводопа, композиции на их основе и их применения
US7323585B2 (en) 2004-06-04 2008-01-29 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
TWI403493B (zh) 2005-12-05 2013-08-01 Xenoport Inc 左旋多巴前藥的甲磺酸鹽，其組成物，及其用途
US7829592B2 (en) 2006-12-21 2010-11-09 Xenoport, Inc. Catechol protected levodopa diester prodrugs, compositions, and methods of use
CA2673336A1 (en) 2006-12-21 2008-06-26 Xenoport, Inc. Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use
US8399513B2 (en) 2008-10-20 2013-03-19 Xenoport, Inc. Levodopa prodrug mesylate hydrate
CN102186804A (zh) 2008-10-20 2011-09-14 克塞诺波特公司 合成左旋多巴酯前药的方法
WO2011056240A2 (en) 2009-11-09 2011-05-12 Xenoport, Inc. Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use
AU2011222856B2 (en) 2010-03-04 2015-10-15 Orion Corporation Use of levodopa, carbidopa and entacapone for treating Parkinson's disease
RU2743347C2 (ru) 2014-10-21 2021-02-17 Эббви Инк. Пролекарства карбидопа и l-dopa и их применение для лечения болезни паркинсона
AU2016258179B2 (en) 2015-05-06 2021-07-01 Synagile Corporation Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of their use
WO2019097120A1 (en) 2017-11-16 2019-05-23 Orion Corporation New use and pharmaceutical dosage forms
CN113015531A (zh) 2018-11-15 2021-06-22 艾伯维公司 用于皮下施用的药物调配物
US20220213128A1 (en) * 2021-01-03 2022-07-07 RockGen Therapeutics LLC L-Dopa Enhanced with a Neuroprotective Agent as a Therapy for Parkinson's Disease
US20240415800A1 (en) * 2021-10-11 2024-12-19 The Johns Hopkins University Dopa and caffeic acid analogs as novel gcpii inhibitors
WO2025075499A1 (en) 2023-10-02 2025-04-10 Universiteit Van Amsterdam Reducing dopamine feed-back inhibition in dopaminergic cells by tadalafil.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US393923A (en) * 1888-12-04 Samuel preston
US2868818A (en) * 1953-12-15 1959-01-13 Merck & Co Inc Alpha methyl phenylalanines
US3725470A (en) * 1969-05-14 1973-04-03 Hoffmann La Roche Amino acid derivatives
CH562199A5 (2) * 1970-10-30 1975-05-30 Hoffmann La Roche
BE793426A (fr) * 1971-12-28 1973-06-28 Lannacher Heilmittel G M B H Derives de phenylalanine
US3983138A (en) * 1973-09-25 1976-09-28 Merck & Co., Inc. Amino acid esters
US3891696A (en) * 1973-11-02 1975-06-24 Interx Research Corp Novel, transient pro-drug forms of l-dopa
US3939253A (en) * 1973-11-02 1976-02-17 Interx Research Corporation Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease
US4401676A (en) * 1977-06-01 1983-08-30 Merck & Co., Inc. Novel α-amino acids
US4311706A (en) * 1980-01-22 1982-01-19 Interx Research Corporation Novel dopa/dopamine prodrugs

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102224131B (zh) * 2008-11-10 2013-11-06 韩国海洋研究院 化合物ramalin及其应用
CN103694127A (zh) * 2013-12-30 2014-04-02 上海交通大学 链霉菌属菌种所产的化合物及该化合物的制备方法和应用

Also Published As

Publication number Publication date
DE3867403D1 (de) 1992-02-13
JPH0541626B2 (2) 1993-06-24
PT88526A (pt) 1988-10-01
EP0309827B1 (en) 1992-01-02
CA1316180C (en) 1993-04-13
US4966915A (en) 1990-10-30
DK517588D0 (da) 1988-09-16
AU2234088A (en) 1989-03-23
JPH02138A (ja) 1990-01-05
EP0309827A1 (en) 1989-04-05
PT88526B (pt) 1992-11-30
DK517588A (da) 1989-03-19
KR890005031A (ko) 1989-05-11
ATE71083T1 (de) 1992-01-15
IL87765A0 (en) 1989-02-28

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C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication