CN103415521B - 用作β分泌酶（BACE）抑制剂的3,4-二氢-吡咯并[1,2-a]吡嗪-1-基胺衍生物 - Google Patents

用作β分泌酶（BACE）抑制剂的3,4-二氢-吡咯并[1,2-a]吡嗪-1-基胺衍生物 Download PDF

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CN103415521B
CN103415521B CN201280012485.5A CN201280012485A CN103415521B CN 103415521 B CN103415521 B CN 103415521B CN 201280012485 A CN201280012485 A CN 201280012485A CN 103415521 B CN103415521 B CN 103415521B
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CN103415521A (zh
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A.A.特拉班科-苏亚亚雷滋
F.德加多-吉梅内滋
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201280012485.5A 2011-03-09 2012-03-07 用作β分泌酶（BACE）抑制剂的3,4-二氢-吡咯并[1,2-a]吡嗪-1-基胺衍生物 Expired - Fee Related CN103415521B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11157418.2 2011-03-09
EP11157418 2011-03-09
PCT/EP2012/053863 WO2012120023A1 (en) 2011-03-09 2012-03-07 3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

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CN103415521A CN103415521A (zh) 2013-11-27
CN103415521B true CN103415521B (zh) 2016-01-06

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US (1) US9845326B2 (2)
EP (1) EP2683721B1 (2)
JP (1) JP5853035B2 (2)
KR (1) KR102012675B1 (2)
CN (1) CN103415521B (2)
AU (1) AU2012224632B2 (2)
BR (1) BR112013022917A2 (2)
CA (1) CA2825620C (2)
CL (1) CL2013002511A1 (2)
CO (1) CO6751283A2 (2)
EA (1) EA023824B1 (2)
ES (1) ES2534973T3 (2)
IL (1) IL228239A (2)
MX (1) MX340031B (2)
MY (1) MY163346A (2)
PH (1) PH12013501805A1 (2)
SG (1) SG193342A1 (2)
UA (1) UA109687C2 (2)
WO (1) WO2012120023A1 (2)
ZA (1) ZA201306719B (2)

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RU2572076C2 (ru) * 2014-03-26 2015-12-27 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" 1-арилпирроло[1,2-a]пиразин-3-карбоксамиды с нейропсихотропной активностью
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MY163346A (en) 2017-09-15
NZ615720A (en) 2014-08-29
CN103415521A (zh) 2013-11-27
JP5853035B2 (ja) 2016-02-09
JP2014507455A (ja) 2014-03-27
AU2012224632B2 (en) 2016-06-16
EP2683721B1 (en) 2015-01-28
EA201391296A1 (ru) 2014-01-30
CA2825620A1 (en) 2012-09-13
CA2825620C (en) 2019-04-23
IL228239A0 (en) 2013-11-25
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US20130345228A1 (en) 2013-12-26
PH12013501805A1 (en) 2013-11-18
KR20140019332A (ko) 2014-02-14
ZA201306719B (en) 2015-04-29
BR112013022917A2 (pt) 2016-12-06
MX340031B (es) 2016-06-21
WO2012120023A1 (en) 2012-09-13
AU2012224632A1 (en) 2013-08-01
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KR102012675B1 (ko) 2019-08-21
UA109687C2 (xx) 2015-09-25
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