CN104356446A - Medical grade rubber bottle plug and preparation method thereof - Google Patents

Medical grade rubber bottle plug and preparation method thereof Download PDF

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Publication number
CN104356446A
CN104356446A CN201410626139.7A CN201410626139A CN104356446A CN 104356446 A CN104356446 A CN 104356446A CN 201410626139 A CN201410626139 A CN 201410626139A CN 104356446 A CN104356446 A CN 104356446A
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CN
China
Prior art keywords
parts
medical grade
bottle stopper
grade rubber
polyethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410626139.7A
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Chinese (zh)
Inventor
金仲恩
全春兰
张帆
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Suzhou Cosmetic New Materials Co Ltd
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Suzhou Cosmetic New Materials Co Ltd
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Priority to CN201410626139.7A priority Critical patent/CN104356446A/en
Publication of CN104356446A publication Critical patent/CN104356446A/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L9/00Compositions of homopolymers or copolymers of conjugated diene hydrocarbons
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00Applications
    • C08L2203/02Applications for biomedical use
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00Polymer mixtures characterised by other features
    • C08L2205/02Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00Polymer mixtures characterised by other features
    • C08L2205/03Polymer mixtures characterised by other features containing three or more polymers in a blend
    • C08L2205/035Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Closures For Containers (AREA)

Abstract

The invention provides a medical grade rubber bottle plug and a preparation method thereof. The bottle plug is prepared from the following raw materials in parts by mass: 60-80 parts of butadiene rubber, 20-40 parts of nitrile rubber, 3-7 parts of stannous oxide, 0.6-1.5 parts of phthalic ester, 80-100 parts of calcined clay, 3-7 parts of white oil, 2-5 parts of polyethylene, 1-3 parts of triethanolamine, 3-8 parts of phenolic resin, 0.3-0.8 part of antiager, 0.1-0.3 part of anti-cracking agent and 0.5-2 parts of thyme oil. The medical grade rubber bottle plug has excellent antiaging, anti-cracking and antibacterial properties, is high in elongation at break, and is an ideal medical grade rubber bottle plug.

Description

A kind of medical grade rubber bottle stopper and preparation method thereof
Technical field
The present invention relates to medical applications field, particularly relate to a kind of medical grade rubber bottle stopper and preparation method thereof.
Background technology
Medical grade rubber bottle stopper is the heat-resistant powder filler goods with definite shape, size, for the sealing of the medicinal ampuliform vessel port such as glass, plastics.Its structure is broadly divided into taper, T-shaped and flange shape three class; Content Within Pharmaceutical Closure, biologics bottle stopper, spraying medicament bottle stopper and transfusion bottle stopper etc. can be divided into by purposes.Bottle stopper sizing material requires harmful solvends such as not leaded, mercury, arsenic, barium, with can powder charge agent inoperative, bottle stopper itself can not have ejecta.The sizing materials such as general NR, IIR and SBR make, and produce, be widely used in pharmacy and medical industry by compression molding.
In the market the easy aging yellowing of existing medical grade rubber bottle stopper, resistance to cleavage difference is easy to crack, fungistatic effect is poor, and its tensile yield is limited, and these all serve restriction to the use of bottle closure of rubber.
Summary of the invention
the technical problem solved:for the shortcoming that existing medical grade rubber bottle stopper exists, the invention provides a kind of medical grade rubber bottle stopper and preparation method thereof, the tensile yield of this bottle stopper is large, good antimicrobial effect, and the cracking resistance time is long and not easily aging.
technical scheme:a kind of medical grade rubber bottle stopper, comprises the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 60 ~ 80 parts, paracril 20 ~ 40 parts, tin protoxide 3 ~ 7 parts, phthalate 0.6 ~ 1.5 part, calcinated argil 80 ~ 100 parts, white oil 3 ~ 7 parts, polyethylene 2 ~ 5 parts, trolamine 1 ~ 3 part, 3 ~ 8 parts, resol, 0.3 ~ 0.8 part, anti-aging agent, anti-fissuring agent 0.1 ~ 0.3 part, thyme oil 0.5 ~ 2 part.
A kind of medical grade rubber bottle stopper described above, comprises the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 65 ~ 75 parts, paracril 25 ~ 35 parts, tin protoxide 4 ~ 6 parts, phthalate 0.9 ~ 1.3 part, calcinated argil 85 ~ 95 parts, white oil 4 ~ 6 parts, polyethylene 3 ~ 4 parts, trolamine 1.5 ~ 2.3 parts, 4 ~ 6 parts, resol, 0.4 ~ 0.7 part, anti-aging agent, anti-fissuring agent 0.15 ~ 0.25 part, thyme oil 1 ~ 1.7 part.
A kind of medical grade rubber bottle stopper described above, comprises the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 68 parts, paracril 28 parts, tin protoxide 4.3 parts, phthalate 1 part, calcinated argil 88 parts, white oil 4.5 parts, polyethylene 3.2 parts, trolamine 1.7 parts, 4.5 parts, resol, 0.5 part, anti-aging agent, anti-fissuring agent 0.18 part, thyme oil 1.3 parts.
A kind of medical grade rubber bottle stopper described above, comprises the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 70 parts, paracril 30 parts, tin protoxide 5 parts, phthalate 1.1 parts, calcinated argil 90 parts, white oil 5 parts, polyethylene 3.5 parts, trolamine 2 parts, 5 parts, resol, 0.55 part, anti-aging agent, anti-fissuring agent 0.2 part, thyme oil 1.4 parts.
The preparation method of a kind of medical grade rubber bottle stopper described above, comprise the steps: to obtain mixture by after the mixing of cis-1,4-polybutadiene rubber, paracril, tin protoxide, phthalate, calcinated argil, white oil, polyethylene, trolamine, resol, anti-aging agent, anti-fissuring agent and thyme oil, by mixture rotating speed be 200 ~ 220r/min, temperature be 80 ~ 100 DEG C at stir 6 ~ 10min, then join blended in twin screw extruder, extrude, and carry out granulation, obtain particulate material; Again the particulate material obtained is made bottle stopper.
Described above by mixture rotating speed be 210r/min, temperature stirs 8min at being 90 DEG C.
beneficial effect:compared with prior art, a kind of medical grade rubber bottle stopper provided by the invention and preparation method thereof, this bottle stopper has excellent ageing-resistant, cracking resistance, bacteriostasis property, and its tensile yield is large, is a kind of desirable medical grade rubber bottle stopper.
Embodiment
embodiment 1
A kind of medical grade rubber bottle stopper, comprises the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 60 parts, paracril 20 parts, tin protoxide 3 parts, phthalate 0.6 part, calcinated argil 80 parts, white oil 3 parts, polyethylene 2 parts, trolamine 1 part, 3 parts, resol, 0.3 part, anti-aging agent, anti-fissuring agent 0.1 part, thyme oil 0.5 part.
A kind of preparation method of medical grade rubber bottle stopper, comprise the steps: to obtain mixture by after the mixing of cis-1,4-polybutadiene rubber, paracril, tin protoxide, phthalate, calcinated argil, white oil, polyethylene, trolamine, resol, anti-aging agent, anti-fissuring agent and thyme oil, by mixture rotating speed be 200r/min, temperature stirs 6min at being 80 DEG C, then join blended in twin screw extruder, extrude, and carry out granulation, obtain particulate material; Again the particulate material obtained is made bottle stopper.
embodiment 2
A kind of medical grade rubber bottle stopper, comprises the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 80 parts, paracril 40 parts, tin protoxide 7 parts, phthalate 1.5 parts, calcinated argil 100 parts, white oil 7 parts, polyethylene 5 parts, trolamine 3 parts, 8 parts, resol, 0.8 part, anti-aging agent, anti-fissuring agent 0.3 part, thyme oil 2 parts.
A kind of preparation method of medical grade rubber bottle stopper, comprise the steps: to obtain mixture by after the mixing of cis-1,4-polybutadiene rubber, paracril, tin protoxide, phthalate, calcinated argil, white oil, polyethylene, trolamine, resol, anti-aging agent, anti-fissuring agent and thyme oil, by mixture rotating speed be 220r/min, temperature stirs 10min at being 100 DEG C, then join blended in twin screw extruder, extrude, and carry out granulation, obtain particulate material; Again the particulate material obtained is made bottle stopper.
embodiment 3
A kind of medical grade rubber bottle stopper, comprises the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 65 parts, paracril 25 parts, tin protoxide 4 parts, phthalate 0.9 part, calcinated argil 85 parts, white oil 4 parts, polyethylene 3 parts, trolamine 1.5 parts, 4 parts, resol, 0.4 part, anti-aging agent, anti-fissuring agent 0.15 part, thyme oil 1 part.
A kind of preparation method of medical grade rubber bottle stopper, comprise the steps: to obtain mixture by after the mixing of cis-1,4-polybutadiene rubber, paracril, tin protoxide, phthalate, calcinated argil, white oil, polyethylene, trolamine, resol, anti-aging agent, anti-fissuring agent and thyme oil, by mixture rotating speed be 200r/min, temperature stirs 6min at being 80 DEG C, then join blended in twin screw extruder, extrude, and carry out granulation, obtain particulate material; Again the particulate material obtained is made bottle stopper.
embodiment 4
A kind of medical grade rubber bottle stopper, comprises the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 75 parts, paracril 35 parts, tin protoxide 6 parts, phthalate 1.3 parts, calcinated argil 95 parts, white oil 6 parts, polyethylene 4 parts, trolamine 2.3 parts, 6 parts, resol, 0.7 part, anti-aging agent, anti-fissuring agent 0.25 part, thyme oil 1.7 parts.
A kind of preparation method of medical grade rubber bottle stopper, comprise the steps: to obtain mixture by after the mixing of cis-1,4-polybutadiene rubber, paracril, tin protoxide, phthalate, calcinated argil, white oil, polyethylene, trolamine, resol, anti-aging agent, anti-fissuring agent and thyme oil, by mixture rotating speed be 220r/min, temperature stirs 10min at being 100 DEG C, then join blended in twin screw extruder, extrude, and carry out granulation, obtain particulate material; Again the particulate material obtained is made bottle stopper.
embodiment 5
A kind of medical grade rubber bottle stopper, comprises the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 68 parts, paracril 28 parts, tin protoxide 4.3 parts, phthalate 1 part, calcinated argil 88 parts, white oil 4.5 parts, polyethylene 3.2 parts, trolamine 1.7 parts, 4.5 parts, resol, 0.5 part, anti-aging agent, anti-fissuring agent 0.18 part, thyme oil 1.3 parts.
A kind of preparation method of medical grade rubber bottle stopper, comprise the steps: to obtain mixture by after the mixing of cis-1,4-polybutadiene rubber, paracril, tin protoxide, phthalate, calcinated argil, white oil, polyethylene, trolamine, resol, anti-aging agent, anti-fissuring agent and thyme oil, by mixture rotating speed be 210r/min, temperature stirs 8min at being 90 DEG C, then join blended in twin screw extruder, extrude, and carry out granulation, obtain particulate material; Again the particulate material obtained is made bottle stopper.
embodiment 6
A kind of medical grade rubber bottle stopper, comprises the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 70 parts, paracril 30 parts, tin protoxide 5 parts, phthalate 1.1 parts, calcinated argil 90 parts, white oil 5 parts, polyethylene 3.5 parts, trolamine 2 parts, 5 parts, resol, 0.55 part, anti-aging agent, anti-fissuring agent 0.2 part, thyme oil 1.4 parts.
A kind of preparation method of medical grade rubber bottle stopper, comprise the steps: to obtain mixture by after the mixing of cis-1,4-polybutadiene rubber, paracril, tin protoxide, phthalate, calcinated argil, white oil, polyethylene, trolamine, resol, anti-aging agent, anti-fissuring agent and thyme oil, by mixture rotating speed be 210r/min, temperature stirs 8min at being 90 DEG C, then join blended in twin screw extruder, extrude, and carry out granulation, obtain particulate material; Again the particulate material obtained is made bottle stopper.
performance test
Test the performance of the embodiment of the present invention 1 ~ 6 product, test result is in table 1.
Table 1 product performance test data
Above to invention has been detailed introduction, for one of ordinary skill in the art, according to the thought of the embodiment of the present invention, all will change in specific embodiments and applications, in sum, this description should not be construed as limitation of the present invention.

Claims (6)

1. a medical grade rubber bottle stopper, is characterized in that comprising the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 60 ~ 80 parts, paracril 20 ~ 40 parts, tin protoxide 3 ~ 7 parts, phthalate 0.6 ~ 1.5 part, calcinated argil 80 ~ 100 parts, white oil 3 ~ 7 parts, polyethylene 2 ~ 5 parts, trolamine 1 ~ 3 part, 3 ~ 8 parts, resol, 0.3 ~ 0.8 part, anti-aging agent, anti-fissuring agent 0.1 ~ 0.3 part, thyme oil 0.5 ~ 2 part.
2. a kind of medical grade rubber bottle stopper according to claim 1, is characterized in that comprising the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 65 ~ 75 parts, paracril 25 ~ 35 parts, tin protoxide 4 ~ 6 parts, phthalate 0.9 ~ 1.3 part, calcinated argil 85 ~ 95 parts, white oil 4 ~ 6 parts, polyethylene 3 ~ 4 parts, trolamine 1.5 ~ 2.3 parts, 4 ~ 6 parts, resol, 0.4 ~ 0.7 part, anti-aging agent, anti-fissuring agent 0.15 ~ 0.25 part, thyme oil 1 ~ 1.7 part.
3. a kind of medical grade rubber bottle stopper according to claim 1, is characterized in that comprising the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 68 parts, paracril 28 parts, tin protoxide 4.3 parts, phthalate 1 part, calcinated argil 88 parts, white oil 4.5 parts, polyethylene 3.2 parts, trolamine 1.7 parts, 4.5 parts, resol, 0.5 part, anti-aging agent, anti-fissuring agent 0.18 part, thyme oil 1.3 parts.
4. a kind of medical grade rubber bottle stopper according to claim 1, is characterized in that comprising the following raw material according to mass fraction meter: cis-1,4-polybutadiene rubber 70 parts, paracril 30 parts, tin protoxide 5 parts, phthalate 1.1 parts, calcinated argil 90 parts, white oil 5 parts, polyethylene 3.5 parts, trolamine 2 parts, 5 parts, resol, 0.55 part, anti-aging agent, anti-fissuring agent 0.2 part, thyme oil 1.4 parts.
5. the preparation method of a kind of medical grade rubber bottle stopper as claimed in claim 1, it is characterized in that comprising the steps: to obtain mixture by after the mixing of cis-1,4-polybutadiene rubber, paracril, tin protoxide, phthalate, calcinated argil, white oil, polyethylene, trolamine, resol, anti-aging agent, anti-fissuring agent and thyme oil, by mixture rotating speed be 200 ~ 220r/min, temperature be 80 ~ 100 DEG C at stir 6 ~ 10min, then join blended in twin screw extruder, extrude, and carry out granulation, obtain particulate material; Again the particulate material obtained is made bottle stopper.
6. the preparation method of a kind of medical grade rubber bottle stopper according to claim 5, is characterized in that: by mixture rotating speed be 210r/min, temperature stirs 8min at being 90 DEG C.
CN201410626139.7A 2014-11-10 2014-11-10 Medical grade rubber bottle plug and preparation method thereof Pending CN104356446A (en)

Priority Applications (1)

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Application Number Priority Date Filing Date Title
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111019255A (en) * 2019-12-31 2020-04-17 东莞市特谱峰实业有限公司 Antibacterial rubber material and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0331335A (en) * 1989-06-28 1991-02-12 Nippon Zeon Co Ltd rubber composition
CN101376730A (en) * 2007-08-31 2009-03-04 谷其昌 Thermoplastic elastomer material, preparation thereof and method for manufacturing medicinal bottle stopper by using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0331335A (en) * 1989-06-28 1991-02-12 Nippon Zeon Co Ltd rubber composition
CN101376730A (en) * 2007-08-31 2009-03-04 谷其昌 Thermoplastic elastomer material, preparation thereof and method for manufacturing medicinal bottle stopper by using the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
颜丽 等: ""医药包装用丁基橡胶瓶塞的材料选择"", 《制品与工艺》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111019255A (en) * 2019-12-31 2020-04-17 东莞市特谱峰实业有限公司 Antibacterial rubber material and preparation method thereof

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Application publication date: 20150218