CN104780902A - Composition for external use - Google Patents

Abstract

A composition for external use which comprises (a) an acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea and which is practically sufficiently inhibited from suffering a decrease in viscosity with the lapse of time and a decrease in use feeling or humectant performance which accompanies the viscosity decrease.

Description

Composition for external use

technical field

The present invention relates to a composition containing acidic mucopolysaccharides, which is a composition for external use in which properties of acidic mucopolysaccharides are kept stable.

Background technique

Dryness, itching, rashes, ulcers, prickly heat caused by various factors such as skin exposure to ultraviolet rays, extrinsic factors such as changes in temperature and humidity, and intrinsic factors such as aging, which reduce moisture retention or skin barrier function And other troubles. In order to improve these symptoms, the first thing to do is to eliminate the cause, but it is effective to normalize the moisture retention function and skin barrier function by applying pharmaceuticals and cosmetics containing moisturizing ingredients.

As the compound having a moisturizing effect, mucopolysaccharides such as hyaluronic acid, chondroitin sulfate, heparin, dermatan sulfate, heparan sulfate, and keratan sulfate are used. When hyaluronic acid is described as a representative example, hyaluronic acid is a mucopolysaccharide containing glucuronic acid and N-acetylglucosamine, and it is a joint substance filled between cells and fibers in the living body It is a substance that exists in large quantities in the dermis and is also confirmed in the epidermis, and has high water retention and viscoelasticity. Based on such properties, it is used in the medical field as a component of eye drops for treating corneal epithelial disorders, injections for treating osteoarthritis, and the like, and in the field of cosmetics as a moisturizer.

Thus, mucopolysaccharides are polysaccharide thickeners commonly used as humectants for external preparations. It is known that surfactants are often added to external preparations from the standpoint of formulation and usability, but mucopolysaccharides are used in combination with surfactants to lower the viscosity. This decrease in viscosity is particularly remarkable when the composition is exposed to light or heat. Since the viscosity of mucopolysaccharides decreases, there is a problem that the feeling of moisturization and firmness, which are the sense of use of the composition containing mucopolysaccharides, decrease. In addition, there is also a problem that the moisturizing function of the mucopolysaccharide-containing composition is impaired.

On the other hand, various methods for suppressing the time-dependent viscosity decrease of mucopolysaccharides have been proposed.

For example, Patent Document 1 teaches that an external preparation for skin containing high-molecular-weight hyaluronic acid, low-molecular-weight hyaluronic acid, a polyhydric alcohol, and an edetate is suppressed from decreasing in viscosity over time and has excellent moisture retention performance.

In addition, Patent Document 2 teaches that by blending a specific vegetable oil in a composition for applying to mucous membranes containing hyaluronic acid or a salt thereof, the viscosity decrease of the composition is suppressed even when a surfactant is included.

In addition, Patent Document 3 teaches that by blending a fat-soluble vitamin in a liquid composition for mucous membrane application containing hyaluronic acid and a surfactant, the decrease in the viscosity of the composition is suppressed.

However, the compositions described in these documents are not practically sufficient to suppress the decrease in viscosity of mucopolysaccharides over time and the accompanying deterioration in usability and moisturizing performance. In addition, since the compositions of Patent Documents 2 and 3 contain fat-soluble substances such as vegetable oil and fat-soluble vitamins, it is difficult to maintain the transparency of the compositions, and it is difficult to use them as external compositions such as cosmetics.

prior art literature

patent documents

Patent Document 1: Japanese Patent Application Laid-Open No. 1-190614

Patent Document 2: Japanese Patent Laid-Open No. 2006-117656

Patent Document 3: Japanese Patent Laid-Open No. 2004-359629

Contents of the invention

The problem to be solved by the invention

An object of the present invention is to provide an acidic mucopolysaccharide-containing composition for external use in which the decrease in viscosity over time and the accompanying decrease in usability and moisturizing performance over time are sufficiently suppressed practically.

method used to solve the problem

The inventors of the present invention conducted repeated studies to solve the above-mentioned problems, and found that when a compound having a polyoxyalkylene group is blended into acidic mucopolysaccharides, the viscosity of the composition tends to decrease over time, but by further blending a hydroxyalkylurea, The decrease in the viscosity of the composition over time is significantly suppressed.

This invention was completed based on the said knowledge, and provides the following external composition.

Item 1. A composition for external use comprising (a) an acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea.

Item 2. The external composition according to Item 1, wherein the hydroxyalkylurea is N-(2-hydroxyethyl)urea.

Item 3. The external composition according to Item 1 or 2, wherein the acidic mucopolysaccharide is selected from the group consisting of hyaluronic acid, chondroitin sulfate, and salts thereof.

Item 4. The composition for external use according to any one of Items 1 to 3, wherein the compound having a polyoxyalkylene group is polyoxybutylene polyoxyethylene polyoxypropylene glycerin.

Item 5. The composition for external use according to any one of Items 1 to 4, which contains 0.0001 to 2,000 parts by weight of hydroxyalkylurea with respect to 1 part by weight of the compound having a polyoxyalkylene group.

Item 6. The composition for external use according to any one of Items 1 to 5, which contains 0.01 to 10,000 parts by weight of hydroxyalkylurea based on 1 part by weight of the acidic mucopolysaccharide.

Item 7. The external composition according to any one of Items 1 to 6, which contains 0.000001 to 1% by weight of acidic mucopolysaccharides based on the total amount of the composition.

Item 8. The composition for external use according to any one of Items 1 to 7, which contains 0.001 to 30% by weight of hydroxyalkyl urea based on the total amount of the composition.

Item 9. The external composition according to any one of Items 1 to 8, which contains a compound having a polyoxyalkylene group in an amount of 0.01 to 20% by weight based on the total amount of the composition.

Item 10. The external composition according to any one of Items 1 to 9, which is used for moisturizing.

Item 11. The composition for external use according to any one of Items 1 to 9, which is used for imparting firmness to the skin.

Item 12. A method for treating human skin by applying to human skin an external composition containing (a) acidic mucopolysaccharides, (b) a compound having a polyoxyalkylene group, and (c) hydroxyalkylurea Moisturizes or imparts moisture, volume or firmness to the skin.

Item 13. The method according to Item 12, which is a non-therapeutic method.

Item 14. A combination of (a) acidic mucopolysaccharides, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea as a skin moisturizer or to impart moisture, swelling, or firmness to the skin Non-therapeutic use of sensation-imparting agents.

Item 15. Combination of (a) acidic mucopolysaccharides, (b) compounds having polyoxyalkylene groups, and (c) hydroxyalkylurea is useful in the production of skin moisturizers or in imparting moisture, swelling, or tightness to the skin. Application in sensitization imparting agent.

Invention effect

Acidic mucopolysaccharides are general-purpose components added to external compositions for imparting viscosity and moisturizing properties. On the other hand, since the compound which has a polyoxyalkylene group functions as a nonionic surfactant, for example, it is generally used as a component of an external use composition. However, when a compound having a polyoxyalkylene group is added to a composition containing acidic mucopolysaccharides, the viscosity of the acidic mucopolysaccharides is impaired, especially the viscosity of the composition when exposed to heat or light. will be significantly reduced.

The composition for external use of the present invention further contains hydroxyalkyl urea in addition to the acidic mucopolysaccharide and the compound having a polyoxyalkylene group, thereby reducing the viscosity of the composition even when exposed to heat or light was also significantly suppressed. As a result, the moisturizing performance can be maintained for a long time, and the skin can be given a moist feeling, a plump feeling, and a firm feeling for a long time. In particular, it can impart firmness.

Description of drawings

FIG. 1 is a diagram illustrating a method of measuring viscosity in Examples.

FIG. 2 is a graph showing the effect of hydroxyethylurea on suppressing a decrease in the viscosity of a composition. The vertical axis represents relative viscosity (%).

Fig. 3 is a graph showing the effect of hydroxyethylurea on suppressing a decrease in the viscosity of the composition. The vertical axis represents relative viscosity (%).

Fig. 4 is a graph showing the effect of hydroxyethylurea on suppressing a decrease in the viscosity of the composition. The vertical axis represents relative viscosity (%).

Fig. 5 is a graph showing the effect of hydroxyethylurea on suppressing a decrease in the viscosity of the composition. The vertical axis represents relative viscosity (%).

FIG. 6 is a graph showing the effect of hydroxyethylurea on suppressing a decrease in the viscosity of the composition. The vertical axis represents relative viscosity (%).

Fig. 7 is a graph showing the effect of hydroxyethylurea on suppressing a decrease in the viscosity of the composition. The vertical axis represents relative viscosity (%).

Detailed ways

The present invention will be described in detail below.

The external composition of the present invention is a composition containing (a) acidic mucopolysaccharides, (b) a compound having a polyoxyalkylene group, and (c) hydroxyalkylurea.

(a) Acidic mucopolysaccharides

Acidic mucopolysaccharides are polysaccharides containing amino sugar and uronic acid in their basic skeleton. Specific examples of acidic mucopolysaccharides include hyaluronic acid, chondroitin sulfate, heparin, heparin analogs, dermatan sulfate, heparan sulfate, and keratan sulfate I and II.

Acidic mucopolysaccharides may be not only natural products, but also those obtained by decomposing natural products by physical methods such as acid or alkali, enzymes, ultrasonic waves, or shearing, or derivatives of natural products.

For example, hyaluronic acid can be prepared by hydrolyzing natural high-molecular hyaluronic acid in the presence of an acid such as hydrochloric acid, treating it with an enzyme such as hyaluronidase, or physically cutting it with ultrasonic waves or shearing. Breaks down hyaluronic acid. The decomposed hyaluronic acid can also be purchased as a commercial product such as Hiarooligo (Kubi Co., Ltd.).

Moreover, examples of derivatives of natural products include acetylated hyaluronic acid, hydroxypropyltrimethylammonium chloride hyaluronic acid, and the like.

Acidic mucopolysaccharides may be natural products, decomposed products of natural products, and salts of their derivatives. This salt may be a pharmaceutically or biologically acceptable salt, for example: alkali metal salts such as sodium and potassium; alkaline earth metal salts such as magnesium and calcium; zinc salts; ammonium salts; alkanolamines such as monoethanolamine salt etc. Among them, alkali metal salts are preferable, and sodium salts are more preferable.

Preferable specific examples of acidic mucopolysaccharide salts include sodium hyaluronate, potassium hyaluronate, calcium hyaluronate, magnesium hyaluronate, zinc hyaluronate, ammonium hyaluronate, and monoethanolamine hyaluronate. , Sodium Acetylated Hyaluronate, Potassium Acetylated Hyaluronate, Calcium Acetylated Hyaluronate, Magnesium Acetylated Hyaluronate, Zinc Acetylated Hyaluronate, Ammonium Acetylated Hyaluronate, Monoethanolamine Acetylated Hyaluronate , Chondroitin Sulfate Sodium, Chondroitin Sulfate Potassium, Dermatan Sulfate Sodium, Dermatan Sulfate Potassium, Chitosan Ascorbic Acid, Chitosan Glycolic Acid, Chitosan Lactic Acid, Hydroxypropyltrimethylammonium Chloride Chitosan, Sodium heparan sulfate, potassium heparan sulfate, etc.

Among acidic mucopolysaccharides, hyaluronic acid, sodium hyaluronate, chondroitin sulfate, sodium chondroitin sulfate, sodium acetylated hyaluronate, potassium acetylated hyaluronate, calcium acetylated hyaluronate, and hyaluronan acetylated Magnesium hyaluronate, zinc acetylated hyaluronate, more preferably hyaluronic acid, sodium hyaluronate, chondroitin sulfate, sodium chondroitin sulfate, sodium acetylated hyaluronate, potassium acetylated hyaluronate, acetylated hyaluronic acid Zinc, and more preferably hyaluronic acid and sodium hyaluronate.

Acidic mucopolysaccharides can be used alone or in combination of two or more.

The source of acidic mucopolysaccharides is not particularly limited, and may be acidic mucopolysaccharides usable in the fields of pharmaceuticals, quasi-drugs, or cosmetics.

The average molecular weight of acidic mucopolysaccharides is not particularly limited, and is, for example, about 10 million to 4 million, preferably about 10 million to 3 million, more preferably about 50 million to 3 million, particularly preferably about 50 million to 2 million.

The content of the acidic mucopolysaccharide in the composition for external use is preferably at least 0.000001% by weight, more preferably at least 0.001% by weight, and even more preferably at least 0.01% by weight, based on the total amount of the composition. When it exists in this range, sufficient viscosity and moisturizing performance can be provided to an external composition. In addition, the content of acidic mucopolysaccharides in the composition for external use is preferably 1% by weight or less, more preferably 0.5% by weight or less, and even more preferably 0.25% by weight or less, based on the total amount of the composition. When it exists in this range, stickiness can be suppressed and a favorable usability can be provided.

(b) Compounds having polyoxyalkylene groups

The polyoxyalkylene group is a functional group represented by the following general formula (1).

(O(CH ₂ )m)n- (1)

In the functional group represented by the said formula (1) in the compound which has a polyoxyalkylene group used for this invention, m is 1-4, Preferably it is 2-4. Specifically, a polyoxymethylene group, a polyoxyethylene group, a polyoxypropylene group, a polyoxybutylene group, etc. are mentioned.

Moreover, in said formula (1), n is 2-150, for example, Preferably it is 5-100, More preferably, it is 10-30.

Typical examples of compounds having a polyoxyalkylene group include polyoxyalkylene glyceryl ethers in which polyoxyalkylene groups are ether-bonded to 1 to 3 of the three carbons of glycerin. A fatty acid may be ester-bonded to a carbon to which the polyoxyalkylene group is not bonded.

Specifically, polyoxymethylene glyceryl ether, polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxybutylene glyceryl ether, polyoxymethylene·polyoxyethylene glyceryl ether , Polyoxymethylene·polyoxypropylene glyceryl ether, polyoxymethylene·polyoxybutylene glyceryl ether, polyoxyethylene·polyoxypropylene glyceryl ether, polyoxyethylene·polyoxyethylene Butylene Glyceryl Ether, Polyoxypropylene Polyoxybutylene Glyceryl Ether, Polyoxymethylene Polyoxyethylene Polyoxypropylene Glyceryl Ether, Polyoxymethylene Polyoxyethylene Polyoxybutylene glyceryl ether, polyoxypropylene·polyoxyethylene·polyoxybutylene glyceryl ether, polyoxypropylene·polyoxymethylene·polyoxybutylene glyceryl ether, etc.

Among them, glycerin ethers having a polyoxybutylene group are preferable, and polyoxymethylene·polyoxyethylene·polyoxybutylene glycerin ether, polyoxybutylene·polyoxyethylene·polyoxypropylene glycerin are more preferable Ether, polyoxypropylene, polyoxymethylene, polyoxybutylene glyceryl ether, and more preferably polyoxybutylene, polyoxyethylene, polyoxypropylene glyceryl ether.

As a commercially available polyoxybutylene, polyoxyethylene, polyoxypropylene glyceryl ether, for example, Wilbride S-753 (manufactured by NOF Corporation; polyoxybutylene polyoxyethylene polyoxyethylene Propyl glyceryl ether (3B.O) (8E.O) (5P.O)) etc.

In addition, examples of polyoxyalkylene glyceryl ethers containing fatty acid residues include polyoxyethylene glycerin distearate, polyoxyethylene glycerin tristearate, polyoxyethylene glycerin isostearate, and polyoxyethylene glycerin isostearate. Glyceryl triisostearate, polyoxyethylene glyceryl triisostearate, polyoxyethylene glyceryl isostearate, polyoxyethylene glyceryl diisostearate, polyoxyethylene triisostearate Ethyl glyceride, polyoxyethylene glyceride trioleate, polyoxyethylene monococo fatty acid glyceride, etc.

The compound which has a polyoxyalkylene group can be used individually by 1 type or in combination of 2 or more types.

The content of the compound having a polyoxyalkylene group in the composition for external use is preferably at least 0.01% by weight, more preferably at least 0.05% by weight, and even more preferably at least 0.1% by weight, based on the total amount of the composition. When it exists in this range, the effect of the compound which has a polyoxyalkylene group can fully be acquired normally. In addition, the content of the compound having a polyoxyalkylene group in the composition for external use is preferably 20% by weight or less, more preferably 15% by weight or less, and even more preferably 10% by weight or less, based on the total amount of the composition. When it exists in this range, a favorable usability can be provided.

(c) Hydroxyalkylurea

Hydroxyalkyl urea refers to a compound in which at least one of the hydrogen atoms of urea is substituted with a hydroxyalkyl group. That is, the hydroxyalkyl urea in the present invention is a compound represented by the following general formula (2).

R ¹ R ² N-CO-NR ³ R ⁴ (2)

(In the formula, R ¹ , R ² , R ³ and R ⁴ each independently represent a hydrogen atom, an alkyl group with 1 to 4 carbon atoms or a hydroxyalkyl group with 2 to 6 carbon atoms, and R ¹ , R ² , At least one of ^R3 and ^R4 is a hydroxyalkyl group with 2 to 6 carbon atoms)

Specific examples of the hydroxyalkyl group include a hydroxyethyl group, a hydroxypropyl group, a hydroxybutyl group, a dihydroxybutyl group, a hydroxypentyl group, and a hydroxyhexyl group. Among them, the hydroxyethyl group is preferable.

More specifically, N-(2-hydroxyethyl)urea, N-(2-hydroxypropyl)urea, N-(3-hydroxypropyl)urea, N-( 2,3-Dihydroxypropyl)urea, N-(2-hydroxybutyl)urea, N-(3-hydroxybutyl)urea, N-(4-hydroxybutyl)urea, N-(2,3 -Dihydroxybutyl)urea, N-(2,4-dihydroxybutyl)urea, N-(3,4-dihydroxybutyl)urea, N-ethyl-N'-(2-hydroxyethyl ) urea, N,N-bis(2-hydroxyethyl)urea, N,N'-bis(2-hydroxyethyl)urea, N,N-bis(2-hydroxypropyl)urea, N,N' -Bis(2-hydroxypropyl)urea, N,N-bis(2-hydroxyethyl)-N'-propylurea, N,N'-bis(2-hydroxypropyl)-N'-(2 -Hydroxyethyl)urea, N-tert-butyl-N'-(2-hydroxyethyl)-N'-(2-hydroxypropyl)urea, N,N-bis(2-hydroxyethyl)-N ',N'-dimethylurea, N,N,N',N'-tetrakis(2-hydroxyethyl)urea and N,N-bis(2-hydroxyethyl)-N',N'-bis (2-hydroxypropyl) urea, etc.

The number of hydroxyalkyl groups in the hydroxyalkyl urea is preferably 1 to 3, more preferably 1 to 2, and still more preferably 1 (monohydroxyalkyl urea). Among them, hydroxyethylurea is preferable.

Hydroxyalkyl ureas can be used alone or in combination of two or more.

The content of the hydroxyalkylurea in the composition for external use is preferably at least 0.001% by weight, more preferably at least 0.01% by weight, and even more preferably at least 0.1% by weight, based on the total amount of the composition. When it exists in this range, the effect of this invention (suppression of the viscosity of a composition, moisturizing performance, and the time-dependent decrease in the performance of imparting a moisturizing feeling and firm feeling) can fully be acquired. In addition, the content of the hydroxyalkylurea in the composition for external use is preferably 30% by weight or less, more preferably 20% by weight or less, and even more preferably 10% by weight or less, based on the total amount of the composition. When it exists in this range, the effect of the said invention of this application can fully be acquired.

In addition, the ratio of the content of hydroxyalkylurea to the content of the compound having a polyoxyalkylene group is preferably 0.0001 parts by weight or more, more preferably 0.01 parts by weight or more, based on 1 part by weight of the compound having a polyoxyalkylene group. Even more preferably, it is 0.1 part by weight or more. When it exists in this range, the effect of this invention (suppression of the viscosity of a composition, moisturizing performance, and the time-dependent decrease in the performance of imparting a moisturizing feeling and firm feeling) can fully be acquired. In addition, the ratio of the content of hydroxyalkylurea to the content of the compound having a polyoxyalkylene group is preferably 500 parts by weight or less, more preferably 200 parts by weight or less, based on 1 part by weight of the compound having a polyoxyalkylene group. Still more preferably, it is 100 parts by weight or less. When it exists in this range, the effect of the said invention of this application can fully be acquired.

In addition, the ratio of the content of hydroxyalkylurea to the content of acidic mucopolysaccharides is preferably 0.01 parts by weight or more, more preferably 1 part by weight or more, and even more preferably 10 parts by weight relative to 1 part by weight of acidic mucopolysaccharides. servings or more. When it exists in this range, the effect of this invention (suppression of the viscosity of a composition, moisturizing performance, and the time-dependent decrease in the performance of imparting a moisturizing feeling and firm feeling) can fully be acquired. In addition, the ratio of the content of hydroxyalkylurea to the content of acidic mucopolysaccharides is preferably 10000 parts by weight or less, more preferably 500 parts by weight or less, and even more preferably 100 parts by weight relative to 1 part by weight of acidic mucopolysaccharides. servings or less. When it exists in this range, the effect of the said invention of this application can fully be acquired.

preparation

The composition for external use of the present invention can be prepared, for example, by mixing the ingredients (a) to (c) described above with a base or carrier usable in cosmetics, and additives and other active ingredients as needed, to prepare, for example, composition for external use.

The properties of the composition are not particularly limited, and can be made into liquid, fluid or semi-solid preparations, such as liquids, suspensions, emulsions, creams, ointments, gels, liniments, washes, etc. Agents, aerosol agents, and film agents obtained by impregnating a liquid medicine on a non-woven fabric. Among them, emulsions, creams, emulsions, ointments, gels, and lotions are preferred, and creams, emulsions, ointments, and gels are particularly preferred.

The specific use of cosmetics is not particularly limited, and examples include lotion, lotion, gel, cream, beauty serum, sunscreen cosmetics, peel-off pack, mask, hand cream, body lotion, body moisturizer, etc. Basic cosmetics such as cream; washing cosmetics such as cleansing products, makeup removers, body soap, shampoo, conditioner, and repair products; makeup cosmetics such as base makeup and various pastel colors, etc.

base or carrier

Examples of bases or carriers include paraffin, liquid paraffin, squalane, white wax, gelled hydrocarbons (such as ラスチベース), ozokerite, pure ceresin, vaseline, stearin, microcrystalline wax, and α-olefin oligomerization hydrocarbons such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid and isostearic acid; ), triglycerides of fatty acids such as tri(caprylic acid/capric acid) glyceride; higher alcohols such as cetyl alcohol, stearyl alcohol, and behenyl alcohol; methyl polysiloxane, high polymer methyl polysiloxane, Dimethicone·methyl(polyoxyethylene)siloxane·methyl(polyoxypropylene)siloxane copolymer, dimethylsiloxane·methyl(polyoxyethylene) ) siloxane copolymer, dimethylsiloxane methyl (polyoxypropylene) siloxane copolymer, polyoxyethylene methyl polysiloxane copolymer, poly (oxyethylene Oxypropylene) methylpolysiloxane copolymer, dimethylsiloxane methylcetyloxysiloxane copolymer, dimethylsiloxane methylstearoxysiloxane Oxane copolymer, alkyl acrylate copolymer methyl polysiloxane ester, cross-linked methyl polysiloxane, cross-linked methylphenyl polysiloxane, cross-linked polyether modified silicone , Cross-linked alkyl polyether modified silicone, cross-linked alkyl modified silicone, decamethylcyclopentasiloxane, ethyltrisiloxane, methylpolytrimethicone, methyl Polysiloxane Network Polymer, Polyoxyethylene Methylpolysiloxane Copolymer, Polymethylhydrogensiloxane, Triethoxysilylethyl Polydimethylsiloxyethylhexyl Silicone oils such as Dimethicone and Dimethicone; Ethylene Glycol Monoacetate, Ethylene Glycol Diacetate, Triethylene Glycol Diacetate, Hexylene Glycol Diacetate esters and diol acetates such as 2-methyl-2-propene-1,1-diol diacetate; triethylene glycol dipivaltate, 2,2,4-trimethyl-1, Diol esters such as 3-pentanediol monoisobutyrate, 2,2,4-trimethyl-1,3-pentanediol diisobutyrate; ethylene glycol diacrylate, diethylene glycol Diol acrylates such as diacrylate, propylene glycol monoacrylate, 2,2-dimethyl-trimethylene glycol diacrylate and 1,3-butanediol diacrylate; ethylene glycol dinitrate, Diol dinitrates such as diethylene glycol dinitrate, triethylene glycol dinitrate and propylene glycol dinitrate; 2,2'-[1,4-Phenylenedioxy]diethanol; ethyl Cellulose derivatives such as cellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose; polyvinylpyrrolidone; carrageenan; polyvinyl butyral; polyethylene glycol; dioxane; Glycol adipate polyester; Isopropyl myristate, Octyldodecyl myristate, Isopropyl palmitate, Cetyl palmitate, Isononyl isononanoate, Tetra-2-ethylhexyl esters such as pentaerythritol ester; polysaccharides such as dextrin and maltodextrin; lower alcohols such as ethanol and isopropanol; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, Diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol Glycol ethers such as alcohol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether; water-based base agents such as water, etc.

Among them, hydrocarbons (especially α-olefin oligomers, squalane, light liquid paraffin, liquid paraffin), triglycerides of fatty acids (especially triglycerides of 2-ethylhexanoate, tri(caprylic/capric acid) are preferred. ) glycerides), higher alcohols (especially cetyl alcohol, stearyl alcohol, behenyl alcohol), silicone oil (especially methyl polysiloxane, alkyl acrylate copolymer methyl polysiloxane, crosslinked Type methylpolysiloxane, decamethylcyclopentasiloxane, ethyltrisiloxane, methylpolytrimethicone, methylsiloxane network polymer, polyoxyethylene Methylpolysiloxane Copolymer, Polymethylhydrogensiloxane, Triethoxysilylethyl Dimethicone Ethylhexyl Dimethicone, Dimethicone ), esters (especially isononyl isononanoate, pentaerythritol tetra-2-ethylhexanoate), polysaccharides (especially dextrin, maltodextrin), glycol ethers (especially diethylene glycol mono ether), water.

A base or a carrier may be used alone or in combination of two or more.

additive

To the external composition of the present invention, known additives added to cosmetics, such as antioxidants, surfactants, thickeners, preservatives, pH adjusters, stabilizers, Irritation reducing agents, preservatives, coloring agents, fragrances, pearlescent imparting agents, etc.

Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, ascorbic acid derivatives, tocopherol, tocopherol derivatives, erythorbic acid, and L-cysteine hydrochloride wait.

Examples of surfactants include: sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, penta- Sorbitan fatty acid esters such as 2-ethylhexanoic acid diglyceryl sorbitan ester and tetra-2-ethylhexanoic acid diglyceryl sorbitan ester; Fatty acid propylene glycol ester such as propylene glycol monostearate class; glycerol alkyl ether; alkyl glucoside; amines such as stearylamine and oleylamine; polyoxyethylene methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxane Silicone surfactants such as polydimethylsiloxane, PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, etc.

Examples of thickeners include guar gum, locust bean gum, carrageenan, xanthan gum, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, alkyl acrylate methacrylate copolymer, polyethylene glycol Glycol, bentonite, alginic acid, polyethylene glycol (Macrogol) and cellulosic thickeners (methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose , hydroxypropylmethylcellulose, carboxymethylcellulose and carboxyethylcellulose, etc.) and their salts.

Examples of preservatives and preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl p-hydroxybenzoate, isopropyl p-hydroxybenzoate, butyl p-hydroxybenzoate, p-hydroxybenzene Ethyl Formate, Propylparaben, Benzylparaben, Methylparaben, Phenoxyethanol, Benzyl Alcohol, Chlorobutanol, Sorbic Acid and Its Salts, Chlorhexidine Gluconate, Chain Alkanediols and fatty acid glycerides, etc.

Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.) ), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.), etc.

Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole, edetate, and the like.

Examples of the irritation reducing agent include licorice extract, sodium alginate, and the like.

The additives may be used alone or in combination of two or more.

other active ingredients

The composition for external use of the present invention may contain other active ingredients within the range not impairing the effects of the present invention. Specific examples of active ingredients include moisturizing ingredients, anti-inflammatory ingredients, antibacterial ingredients, vitamins, peptides or derivatives thereof, cell activation ingredients, anti-aging ingredients, blood circulation promoting ingredients, keratin softening ingredients, whitening ingredients, astringent ingredients etc.

Examples of moisturizing ingredients include: macromolecular compounds such as collagen, elastin, keratin, chitin, and chitosan; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidone carboxylate; Lipids; plant extracts such as chamomile extract, witch hazel extract, tea extract, perilla extract, etc.

Examples of anti-inflammatory components include components derived from plants (such as daisy), allantoin, glycyrrhizic acid or derivatives thereof, zinc oxide, pyridoxine hydrochloride, tocopheryl acetate, salicylic acid or derivatives thereof, ε-aminocaproic acid, etc.

As antibacterial or bactericidal ingredients, ethanol, chlorhexidine, salicylic acid, benzalkonium chloride, rivanol, sulfur, resorcinol, benzethonium chloride, adapalene, benzoyl peroxide, gram Linmycin, cresol, gluconic acid and its derivatives, povidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitive element 101, photosensitive element 201, para Hydroxybenzoate, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, chlorhexidine gluconate, zinc p-phenolsulfonate, etc.

Examples of vitamins include retinol derivatives such as retinol, retinyl acetate, and retinyl palmitate, retinal, retinoic acid, methyl retinoate, and ethyl retinoate , Retinoic acid retinyl ester, d-δ-tocopheryl retinoate, α-tocopheryl retinoate, β-tocopheryl retinoate and other vitamin A; dl-α-tocopherol, dL - Vitamin E such as α-tocopheryl acetate, dl-α-tocopheryl succinate, dl-α-tocopheryl calcium succinate; riboflavin, flavin mononucleotide, flavin adenine dinucleotide , riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-sodium phosphate, riboflavin tetranicotinate and other vitamin B2; DL-α-tocopheryl nicotinate, benzyl nicotinate , methyl nicotinate, nicotinic acid β-butoxyethyl ester, nicotinic acid 1-(4-methylphenyl) ethyl ester and other nicotinic acids; ascorbyl-A, ascorbyl stearate, ascorbyl palmitate , dipalmitic acid L-ascorbyl ester and other vitamin C; methyl hesperidin, ergocalciferol and cholecalciferol and other vitamin D; phylloquinone, acaquinone and other vitamin K, γ-oryzanol, dibenzo Thiamine, Dibenzoyl Thiamine Hydrochloride; Thiamine Hydrochloride, Thiamine Hexadecyl Hydrochloride, Thiamine Thiocyanate, Thiamine Lauryl Hydrochloride , Thiamine Nitrate, Thiamine Monophosphate, Thiamine Lysine, Thiamine Triphosphate, Thiamine Monophosphate Phosphate, Thiamine Monophosphate, Thiamine Diphosphate Esters, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate and other vitamin B1; pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5' -Pyridoxal phosphate, pyridoxamine hydrochloride and other vitamin B6; cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin and other vitamin B12; folic acid, pteroyl glutamic acid and other folic acid; niacin, nicotinamide, etc. Niacin; pantothenic acid, calcium pantothenate, panthenol, D-pantethein, D-pantethine, coenzyme A, panthenyl ether and other pantothenic acids; biotin, biological Biotins such as cytosine (Biochinsin); vitamin C as ascorbic acid derivatives such as ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbyl phosphate, and magnesium ascorbyl phosphate; carnitine, ferulic acid, α-lipoic acid , orotic acid and other vitamin-like action factors.

Examples of peptides or derivatives thereof include keratin-decomposing peptides, hydrolyzed keratin, collagen, fish-derived collagen, truncated collagen, gelatin, elastin, elastin-decomposing peptides, collagen-decomposing peptides, and hydrolyzed collagen Protein, hydroxypropylammonium chloride hydrolyzed collagen, elastin decomposing peptide, conchiolin decomposing peptide, hydrolyzed conchiolin, silk protein decomposing peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, hydrolyzed soybean protein , wheat protein, wheat proteolytic peptide, hydrolyzed wheat protein, casein decomposition peptide, acylated peptide (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.), etc.

Examples of cell activation components include vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acid; α-hydroxy acids such as glycolic acid and lactic acid; tannin, flavonoids, saponins, Allantoin, photosensitive element 301, etc.

Examples of anti-aging ingredients include panthionine, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, etc. .

Examples of blood circulation-promoting components include those derived from plants (such as Korean ginseng, ashitaba, arnica flower, ginkgo, fennel, chamomile, Dutch oak, chamomile, Roman chamomile, carrot, gentian, Burdock, rice, hawthorn, shiitake mushroom, Western hawthorn, Western juniper, Chuanxiong, Chinese medicine, thyme, clove, tangerine peel, angelica, peach kernel, orange peel, ginseng, garlic, false leaf tree, grape, peony, horse chestnut, honeysuckle flower, grapefruit, coix seed, rosemary, rosehip, tangerine peel, angelica, orange peel, peach, apricot, walnut, corn); glucosyl hesperidin, etc.

Examples of the keratin softening component include salicylic acid, glycolic acid, fruit acid, phytic acid, sulfur and the like.

Examples of whitening components include ascorbic acid and derivatives thereof, arbutin, tocopherol, and the like.

Examples of the astringent component include zinc p-phenolsulfonate, zinc oxide, menthol, ethanol, and the like.

The other active ingredients can be used alone or in combination of two or more.

Instructions

The method of using the composition for external use of the present invention varies depending on the skin condition, age, sex, etc. of the user, and the following methods can be used, for example. That is, an appropriate amount (eg, about 0.05 g to about 5 g) may be applied (coated, sprayed, pasted, etc.) on the skin several times a day (eg, about 1 to 5 times, preferably 1 to 3 times). In addition, the composition may be applied so that the daily usage-amount of the acidic mucopolysaccharide is, for example, about 0.00005 g to about 0.025 g.

The topical compositions of the present invention may also be applied to any skin of the face, neck, hands, feet, fingers, trunk, scalp, and the like.

use

The composition for external use of the present invention can be used, for example, as a composition for external use for moisturizing or for imparting a feeling of moisture, swelling or firmness to the skin.

Firmness refers to a state in which the applied preparation remains between the fingers and the skin after gently spreading the preparation applied on the skin with fingers or palms to rub it into the skin, and there is a feeling of Adsorption feeling that the skin to which the preparation is applied adheres to the finger or palm when the finger or palm spread by the preparation is released from the skin.

The present invention includes the application (coating, spraying, , sticking, etc.) to the skin of the face, neck, hands, feet, fingers, body, scalp, etc. to moisturize the skin and to give the skin a moisturizing, plumping, or firming feeling. These methods can be non-therapeutic methods.

The usage method of the external use composition of this invention among these methods is as having demonstrated about the external use composition of this invention.

In addition, the present invention includes a combination of (a) acidic mucopolysaccharides, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea as a skin moisturizer and for imparting a moist feeling, a swelling feeling, or Non-therapeutic use of a firming sensation imparting agent.

In addition, the combination of (a) acidic mucopolysaccharides, (b) a compound having a polyoxyalkylene group, and (c) hydroxyalkylurea in the present invention is useful in the production of skin moisturizers and in imparting moisturizing and swelling sensations to the skin. Or the application of a firming agent.

The components, dosage forms, and usage methods of these formulations are as described for the external composition of the present invention.

Example

Hereinafter, although an Example is given and this invention is demonstrated in more detail, this invention is not limited to these Examples.

Test example 1 (thermal stability test)

(1) Preparation of the composition

The composition of each Example and Comparative Example is shown in Table 1 and Table 2 below. In addition, all the numerical values in Table 1 and Table 2 represent weight%.

[Table 1]

[Table 2]

(2) Test method

(viscosity measurement)

Each composition of Examples and Comparative Examples having the compositions shown in Table 1 and Table 2 was prepared.

Both the sample immediately after preparation and the stored product (samples stored at 60° C. for one week) of each composition left to stand on the condition of 25° C.±1° C. for 12 hours, and then measured the viscosity. Regarding the decrease in viscosity, the viscosity immediately after preparation was defined as 100%, and the viscosity of the stored product (storage at 60° C. for one week) was expressed by relative viscosity. That is, the relative viscosity of each composition was calculated by the following formula.

Relative viscosity (%)

= (viscosity of stored product (60°C, one week)/viscosity immediately after preparation)×100

The viscosity measurement conditions are as follows.

Using RE85 (Toki Sangyo ) to measure the viscosity. That is, the measurement temperature is under the condition of 25° C.±1° C. During the measurement, the viscosity is measured every minute until 3 minutes, and the average value of three times is used.

Basically, as shown in Figure 1, the sample is placed in the gap of the angle α between the cone 1 and the flat circular plate 2, and the cone 1 or the flat circular plate 2 is rotated at a constant angular velocity ω or torque T, and the measurement reaches The torque or angular velocity received by the flat circular plate 2 or the cone 1 in a steady state is calculated from the following formula to calculate the viscosity η of the sample.

η=100×(3α/2πR3)·(T/ω)

η: Viscosity of sample (mPa·s) (Pa·s=103mPa·s)

α: the angle formed by the flat circular plate 2 and the cone 1 (rad)

π: pi

R: Radius of the cone (cm)

T: Torque acting on flat circular plate 2 or cone 1 surface (10-7N m)

ω: angular velocity (rad/s)

(usability test)

For the compositions of Examples and Comparative Examples used in the viscosity test of Test 1, three examiners dripped 0.5 ml of each composition on the inside of the forearm, spread it into a range of 2 cm × 2 cm, and after 5 minutes, according to the following The "tight feeling" was evaluated using the evaluation criteria of the feeling index.

5: Quite a "tight feeling".

4: It has a "tight feeling".

3: There is a "tight feeling" in general.

2: It does not have a "tight feeling" so much.

1: There is no "tight feeling".

(3) Test results

(viscosity measurement)

The measurement results of the viscosity are shown in FIGS. 2 to 5 .

It can be clearly seen from Figures 2 to 5 that it contains sodium hyaluronate and polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.O) (8E.O) (5P.O), does not contain hydroxyethyl The compositions of Comparative Examples 1 to 4 of urea showed a remarkable decrease in viscosity over time, but the compositions of Examples 1 to 6 in which hydroxyethylurea was blended showed a significant decrease in viscosity over time. inhibition.

(usability test)

The results are shown in Table 3 below. As a result of comparing changes in "tight feeling" immediately after preparation and stored products (storage at 60°C for one week), the usability index of the examples was higher than that of the comparative examples in either case. The effect of suppressing the reduction of the "tight feeling" due to heat aging by blending hydroxyethyl urea was confirmed.

[table 3]

Test example 2 (light stability test)

(1) Preparation of the composition

The composition of each Example and Comparative Example is shown in Table 4 below. In addition, all the numerical values in Table 4 represent weight%.

[Table 4]

(2) Test method

(viscosity measurement)

Each composition of Examples and Comparative Examples having the composition shown in Table 4 was prepared.

Each composition was filled in a glass container with a capacity of 30 mL, and the viscosity at 25° C. was measured and used as the initial viscosity. Then, after performing light irradiation corresponding to 10000 kJ/m ² by SUNTEST XLS+ (Toyo Seiki Seisakusho), the viscosity at 25° C. was measured immediately thereafter.

Viscosity measurements of the non-irradiated sample and the irradiated sample were carried out at 25°C±1°C. Viscosity measurement conditions are the same as in Test Example 1. Regarding the decrease in viscosity, the viscosity of the non-irradiated sample was defined as 100%, and the viscosity after irradiation was expressed as a relative viscosity. That is, the relative viscosity of each composition was calculated by the following formula.

Relative viscosity (%)=(viscosity of irradiated sample/viscosity of unirradiated sample)×100

(usability test)

For the Examples and Comparative Examples used in the viscosity test of Test 2, three panelists dripped 0.5 ml of each composition on the inside of the forearm, spread it into a range of 2 cm × 2 cm, and after 5 minutes, according to the following The "tight feeling" was evaluated using the evaluation criteria of the feeling index. The method of the usability test is the same as that of Test Example 1.

(3) Test results

(viscosity measurement)

The results of viscosity measurement are shown in FIGS. 6 and 7 . It can be clearly seen from Figure 6 and Figure 7 that it contains sodium hyaluronate and polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.O) (8E.O) (5P.O), does not contain hydroxyl The compositions of Comparative Examples 2 and 5 containing ethyl urea had a marked drop in viscosity over time, but the compositions of Examples 7 and 8 in which hydroxyethylurea was blended showed no decrease in viscosity over time. Significantly suppressed.

(usability test)

The results are shown in Table 5 below. As a result of comparing the changes in the "tight feeling" of the ultraviolet ray irradiated sample and the unirradiated sample, in either case, the usability index of the examples is higher than that of the comparative examples. The effect of suppressing the reduction of the "tight feeling" due to heat aging by blending hydroxyethyl urea was confirmed.

[table 5]

Recipe

Hereinafter, the specific formulation example of the composition for external use of this invention is illustrated. The unit of content of the component of a recipe example is "weight%".

Formulation Example 1 Cosmetic Liquid

Formulation Example 2 Emulsion

Recipe Example 3 Gel Cream

Formulation example 4 emulsion

The microcapsules containing the organic fluorescent agent were produced by the method described in Example 1 of WO2012/102397.

Recipe Example 5 Gel lotion

The microcapsules containing the organic fluorescent agent were produced by the method described in Example 1 of WO2012/102397.

Recipe Example 6 Gel Beauty Serum

The microcapsules containing the organic fluorescent agent were produced by the method described in Example 2 of WO2012/102397.

Formulation example 7 emulsion

The microcapsules containing the organic fluorescent agent were produced by the method described in Example 2 of WO2012/102397.

Formulation example 8 cream

The microcapsules containing the organic fluorescent agent were produced by the method described in Example 3 of WO2012/102397.

Formulation Example 9 Cream

The microcapsules containing the organic fluorescent agent were produced by the method described in Example 4 of WO2012/102397.

Industrial availability

The composition for external use of the present invention suppresses the decrease in the viscosity of acidic mucopolysaccharides over time, and can maintain a viscous and good usability for a long period of time. In addition, along with this, the decrease in the moisturizing performance and the performance of imparting a moist feeling or firmness to the skin is also suppressed. In this way, the external composition of the present invention is a product with high commercial value because the properties of acidic mucopolysaccharides are not deteriorated by distribution and storage.

Claims (15)

1. A composition for external use comprising (a) an acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea. 2. The composition for external use according to claim 1, wherein the hydroxyalkylurea is N-(2-hydroxyethyl)urea. 3. The composition for external use according to claim 1 or 2, wherein the acidic mucopolysaccharide is selected from the group consisting of hyaluronic acid, chondroitin sulfate, and salts thereof. 4. The composition for external use according to any one of claims 1 to 3, wherein the compound having a polyoxyalkylene group is polyoxybutylene polyoxyethylene polyoxypropylene glycerin. The composition for external use in any one of Claims 1-4 containing 0.0001-2000 weight part of hydroxyalkyl urea with respect to 1 weight part of compounds which have a polyoxyalkylene group. 6. The composition for external use according to any one of claims 1 to 5, which contains 0.01 to 10000 parts by weight of hydroxyalkyl urea with respect to 1 part by weight of the acidic mucopolysaccharide. 7. The composition for external use according to any one of claims 1 to 6, which contains acidic mucopolysaccharides in an amount of 0.000001 to 1% by weight based on the total amount of the composition. 8. The composition for external use according to any one of claims 1 to 7, which contains 0.001 to 30% by weight of hydroxyalkyl urea based on the total amount of the composition. 9. The composition for external use according to any one of claims 1 to 8, which contains a compound having a polyoxyalkylene group in an amount of 0.01 to 20% by weight based on the total amount of the composition. 10. The composition for external use according to any one of claims 1 to 9, which is used for moisturizing. 11. The composition for external use according to any one of claims 1 to 9, which is used to provide firmness to the skin. 12. A method for treating human skin by applying to human skin an external composition comprising (a) acidic mucopolysaccharides, (b) a compound having a polyoxyalkylene group, and (c) hydroxyalkylurea Hydrates or imparts moisture, plump or firmness to the skin. 13. The method of claim 12 which is a non-therapeutic method. 14. A combination of (a) acidic mucopolysaccharides, (b) a compound having a polyoxyalkylene group, and (c) hydroxyalkylurea as a skin moisturizer or for imparting a moisturizing, swelling, or firming feeling to the skin Non-therapeutic use of imparting agents. 15. Combination of (a) acidic mucopolysaccharides, (b) compounds having polyoxyalkylene groups, and (c) hydroxyalkylurea for use in the production of skin moisturizers or in imparting moisture, swelling, or firmness to the skin Application in sensory imparting agent.