CN105055184A - Composition with effect of removing eyelid pouches and application of composition - Google Patents
Composition with effect of removing eyelid pouches and application of composition Download PDFInfo
- Publication number
- CN105055184A CN105055184A CN201510568757.5A CN201510568757A CN105055184A CN 105055184 A CN105055184 A CN 105055184A CN 201510568757 A CN201510568757 A CN 201510568757A CN 105055184 A CN105055184 A CN 105055184A
- Authority
- CN
- China
- Prior art keywords
- composition
- eyes
- eye
- effect
- bags
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 230000000694 effects Effects 0.000 title claims abstract description 31
- 210000000744 eyelid Anatomy 0.000 title description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 16
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 15
- 229960000458 allantoin Drugs 0.000 claims abstract description 15
- 239000008367 deionised water Substances 0.000 claims abstract description 14
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 14
- 238000002360 preparation method Methods 0.000 claims abstract description 12
- 239000002537 cosmetic Substances 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims description 4
- 239000000498 cooling water Substances 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- FDHNLHLOJLLXDH-JIYHLSBYSA-N (e)-3-(3-hydroxy-4-methoxyphenyl)-1-[2-hydroxy-6-methoxy-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxyphenyl]prop-2-en-1-one Chemical compound C1=C(O)C(OC)=CC=C1\C=C\C(=O)C(C(=C1)OC)=C(O)C=C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)O1 FDHNLHLOJLLXDH-JIYHLSBYSA-N 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- 229940076640 hesperidin methylchalcone Drugs 0.000 claims 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 239000012071 phase Substances 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 210000001508 eye Anatomy 0.000 abstract description 87
- GUMSHIGGVOJLBP-SLRPQMTOSA-N methyl hesperidin Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 GUMSHIGGVOJLBP-SLRPQMTOSA-N 0.000 abstract description 15
- MFYAQFYIDXXKQG-MLCQCVOFSA-N (2s)-2-[[(2s)-4-amino-2-[[(2s)-2-[[(2s)-2-(hexadecanoylamino)-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]propanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(O)=O MFYAQFYIDXXKQG-MLCQCVOFSA-N 0.000 abstract description 13
- DQFBYFPFKXHELB-UHFFFAOYSA-N Chalcone Natural products C=1C=CC=CC=1C(=O)C=CC1=CC=CC=C1 DQFBYFPFKXHELB-UHFFFAOYSA-N 0.000 abstract description 13
- 108010016626 Dipeptides Proteins 0.000 abstract description 13
- 108010075308 N-palmitoyl-seryl-seryl-asparaginyl-alanine Proteins 0.000 abstract description 13
- 235000005513 chalcones Nutrition 0.000 abstract description 13
- 230000017531 blood circulation Effects 0.000 abstract description 7
- 230000008595 infiltration Effects 0.000 abstract description 2
- 238000001764 infiltration Methods 0.000 abstract description 2
- 230000007794 irritation Effects 0.000 abstract description 2
- 239000006071 cream Substances 0.000 description 17
- 230000000052 comparative effect Effects 0.000 description 10
- 230000032683 aging Effects 0.000 description 5
- 206010040880 Skin irritation Diseases 0.000 description 4
- 238000004945 emulsification Methods 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 230000036556 skin irritation Effects 0.000 description 4
- 231100000475 skin irritation Toxicity 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- HOVAGTYPODGVJG-UVSYOFPXSA-N (3s,5r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical compound COC1OC(CO)[C@@H](O)C(O)[C@H]1O HOVAGTYPODGVJG-UVSYOFPXSA-N 0.000 description 2
- UDOOPSJCRMKSGL-ZHACJKMWSA-N (e)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one Chemical compound OC1=CC=CC=C1\C=C\C(=O)C1=CC=CC=C1 UDOOPSJCRMKSGL-ZHACJKMWSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 210000005252 bulbus oculi Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical compound C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- NKEQOUMMGPBKMM-UHFFFAOYSA-N 2-hydroxy-2-[2-(2-hydroxy-3-octadecanoyloxypropoxy)-2-oxoethyl]butanedioic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CC(O)(C(O)=O)CC(O)=O NKEQOUMMGPBKMM-UHFFFAOYSA-N 0.000 description 1
- 208000026889 Cell metabolism disease Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940081733 cetearyl alcohol Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 201000010251 cutis laxa Diseases 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- -1 polyoxyethylene Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
本发明具体公开了一种具有祛眼袋功效的组合物及其应用。该组合物由如下组分制成：甲基橙皮苷查尔酮、二胜肽、棕榈酰四胜肽、尿囊素、乳化剂、去离子水。该组合物用于制备眼部护理用化妆品，能从加强眼部血液循环、降低毛细血管水分渗入、收紧皮肤和降低刺激等方面协同综合作用，具有强效祛眼袋功能，使用一段时间后，眼袋能得到明显改善。The invention specifically discloses a composition with the effect of removing bags under the eyes and an application thereof. The composition is prepared from the following components: methyl hesperidin chalcone, dipeptide, palmitoyl tetrapeptide, allantoin, emulsifier and deionized water. The composition is used for the preparation of cosmetics for eye care, which can synergistically enhance eye blood circulation, reduce capillary water infiltration, tighten skin and reduce irritation, etc., and has a strong function of removing eye bags. After a period of use, Eye bags can be significantly improved.
Description
技术领域 technical field
本发明涉及一种复配的组合物，该组合物具有祛眼袋功效，可以应用于化妆品的配制，达到祛眼袋的目的。 The invention relates to a compound composition, which has the effect of removing bags under the eyes and can be applied to the preparation of cosmetics to achieve the purpose of removing bags under the eyes.
背景技术 Background technique
眼睛是心灵的窗口，是展现个人神采的最重要部分。眼部的衰老主要表现在皱纹、眼袋和眼袋，所以眼部护理化妆品主要强调祛皱、祛眼袋和祛眼袋等方面的功能。 Eyes are the window to the soul and the most important part of showing one's brilliance. The aging of the eyes is mainly manifested in wrinkles, bags under the eyes and bags under the eyes, so eye care cosmetics mainly emphasize the functions of removing wrinkles, bags under the eyes and bags under the eyes.
眼袋会影响一个人的美观，对于爱美的女人来说是不想有眼袋的，所以祛眼袋的化妆品很受消费者欢迎。 Bags under the eyes will affect a person's appearance. For women who love beauty, they don't want to have bags under the eyes, so cosmetics for removing bags under the eyes are very popular among consumers.
眼袋的类型主要有如下几种：（1）天生型眼袋：也就是天生就是下眼睑内脂肪肥厚而导致的眼袋。（2）浮肿型眼袋：主要是眼部肌肤水分过多、血液循环不畅和皮肤刺激导致。由于眼睑皮肤比脸部其他皮肤薄，当眼部血液循环受阻，细胞代谢发生障碍形成的废物毒素眼部沉积，眼袋就形成了。（3）老化松弛型眼袋：由于老化及遗传原因使得眼部周围的肌肉松弛，让眼球往下掉，压迫到眼球下部的脂肪，造成脂肪往前突出，在视觉上就会看到下眼皮部位鼓出。 The main types of bags under the eyes are as follows: (1) Natural bags under the eyes: that is, bags under the eyes caused by fat hypertrophy in the lower eyelid. (2) Puffy bags under the eyes: mainly caused by excessive moisture in the eye skin, poor blood circulation and skin irritation. Since the skin of the eyelids is thinner than the rest of the face, bags under the eyes are formed when the blood circulation in the eyes is blocked, and the waste toxins formed by cell metabolism disorders are deposited in the eyes. (3) Aging and loose bags under the eyes: due to aging and genetic reasons, the muscles around the eyes relax, causing the eyeballs to fall down, oppressing the fat in the lower part of the eyeballs, causing the fat to protrude forward, and the lower eyelid will be seen visually bulge out.
对于天生型眼袋，一般只能通过手术进行治疗，而浮肿型眼袋和老化松弛型眼袋，则不建议手术，而是通过注意日常生活习惯和使用祛眼袋化妆品来改善。导致浮肿型眼袋和老化松弛型眼袋的原因，总体来说主要是血液循环不畅、毛细血管脆弱、皮肤松弛和皮肤刺激等多方面。所以，预防眼袋要从多方面着手，要祛除已经形成的眼袋则应从加强血液循环、降低毛细血管水分渗入、收紧皮肤和降低刺激等方面综合作用。 For natural bags under the eyes, surgery is generally the only way to treat them. For puffy bags under the eyes and aging and loose bags under the eyes, surgery is not recommended. Instead, it can be improved by paying attention to daily habits and using cosmetics to remove bags under the eyes. Generally speaking, the causes of puffy eye bags and aging sagging eye bags are mainly due to poor blood circulation, fragile capillaries, loose skin and skin irritation. Therefore, prevention of bags under the eyes should start from many aspects. To get rid of the bags under the eyes that have already formed, it should be comprehensively affected by strengthening blood circulation, reducing capillary water infiltration, tightening the skin and reducing irritation.
发明内容 Contents of the invention
本发明的目的是提供一种具有祛眼袋功效的组合物及其制备方法。 The object of the present invention is to provide a composition with the effect of removing eye bags and a preparation method thereof.
为达到本发明的目的，本发明采用了如下技术方案： For achieving the purpose of the present invention, the present invention adopts following technical scheme:
一种具有祛眼袋功效的组合物，其特征在于由如下重量百分比的组分制成：甲基橙皮苷查尔酮0.05-10%，二胜肽0.01-7%，棕榈酰四胜肽0.01-8%，尿囊素0.1-0.5%，乳化剂0.3-8%，去离子水66.5-99.53%。 A composition with the effect of removing eye bags is characterized in that it is made of the following components in weight percentage: methyl hesperidin chalcone 0.05-10%, dipeptide 0.01-7%, palmitoyl tetrapeptide 0.01% -8%, allantoin 0.1-0.5%, emulsifier 0.3-8%, deionized water 66.5-99.53%.
优选的，一种具有祛眼袋功效的组合物，其特征在于由如下重量百分比的组分制成：甲基橙皮苷查尔酮0.1-8%，二胜肽0.05-6%，棕榈酰四胜肽0.05-7%，尿囊素0.1-0.4%，乳化剂0.5-5%，去离子水73.6-98.9%。 Preferably, a composition having the effect of removing bags under the eyes is characterized in that it is made of the following components by weight percentage: methyl hesperidin chalcone 0.1-8%, dipeptide 0.05-6%, palmitoyl tetra Peptide 0.05-7%, Allantoin 0.1-0.4%, Emulsifier 0.5-5%, Deionized water 73.6-98.9%.
优选的，一种具有祛眼袋功效的组合物，其特征在于由如下重量百分比的组分制成：甲基橙皮苷查尔酮0.2-5%，二胜肽0.08-5%，棕榈酰四胜肽0.08-5%，尿囊素0.1-0.4%，乳化剂0.8-4%，去离子水80.6-98.74%。 Preferably, a composition with the effect of removing bags under the eyes is characterized in that it is made of the following components by weight percentage: methyl hesperidin chalcone 0.2-5%, dipeptide 0.08-5%, palmitoyl tetra Peptide 0.08-5%, Allantoin 0.1-0.4%, Emulsifier 0.8-4%, Deionized water 80.6-98.74%.
优选的，一种具有祛眼袋功效的组合物，其特征在于由如下重量百分比的组分制成：甲基橙皮苷查尔酮0.5-5%，二胜肽0.1-4%，棕榈酰四胜肽0.1-4%，尿囊素0.1-0.4%，乳化剂0.5-2.5%，去离子水84.1-98.7%。 Preferably, a composition with the effect of removing bags under the eyes is characterized in that it is made of the following components in weight percentage: methyl hesperidin chalcone 0.5-5%, dipeptide 0.1-4%, palmitoyl tetra Peptide 0.1-4%, Allantoin 0.1-0.4%, Emulsifier 0.5-2.5%, Deionized water 84.1-98.7%.
所述的乳化剂为硬脂醇聚醚、甲基葡萄糖苷倍半硬脂酸酯、甲基葡萄糖苷聚氧乙烯(20)醚倍半硬脂酸酯、鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、鲸蜡硬脂基葡糖苷、吐温-20、鲸蜡硬脂醇、甘油硬脂酸酯柠檬酸酯中的一种或多种的混合物。 Described emulsifier is steareth, methyl glucoside sesquistearate, methyl glucoside polyoxyethylene (20) ether sesquistearate, cetearyl olive oil , Sorbitan Olivate, Cetearyl Glucoside, Tween-20, Cetearyl Alcohol, Glyceryl Stearate Citrate or a mixture of one or more.
上述组合物制备方法步骤如下： Above-mentioned composition preparation method step is as follows:
（1）将二胜肽、甲基橙皮苷查尔酮、尿囊素溶于去离子水中后，加热至80-90℃，为水相； (1) After dissolving dipeptide, methylhesperidin chalcone and allantoin in deionized water, heat to 80-90°C to form the water phase;
（2）将棕榈酰四胜肽、乳化剂混合，加热至80-90℃，熔化均匀后为油相； (2) Mix palmitoyl tetrapeptide and emulsifier, heat to 80-90°C, melt evenly and form the oil phase;
（3）将油相加入水相中，均质2-8分钟后，通入冷却水，搅拌冷却至40℃，即可。 (3) Add the oil phase to the water phase, homogenize for 2-8 minutes, pour in cooling water, stir and cool to 40°C.
本发明另一目的是将上述具有祛眼袋功效的组合物用于配制化妆品，为了达到本发明的这一目的，本发明采用了如下技术方案： Another object of the present invention is to use the above-mentioned composition having the effect of removing bags under the eyes for preparing cosmetics. In order to achieve this object of the present invention, the present invention adopts the following technical solutions:
一种具有祛眼袋功效的组合物在化妆品中的应用，其特征在于化妆品中含有上述的组合物，其用量为0.01~10%，优选用量为0.1~5%。除了含有上述具有祛眼袋功效的组合物以外，可以根据需要适当地添加适合化妆品使用的通常成分，如润肤剂、水、乳化剂、防腐剂、香精、色素等基质成分。 An application of a composition having the effect of removing eye bags in cosmetics, characterized in that the cosmetics contain the above-mentioned composition, and the dosage thereof is 0.01-10%, preferably 0.1-5%. In addition to the above-mentioned composition having the effect of removing bags under the eyes, common ingredients suitable for cosmetic use, such as emollients, water, emulsifiers, preservatives, essences, pigments and other matrix components, can be appropriately added as required.
本发明的有益效果：甲基橙皮苷查尔酮具有非常好的维持血管通透性、提高毛细血管抵抗力和增强毛细血管的作用，而且具有良好的美白功效；二胜肽能改善血液循环，促进眼下皮肤排水，改善眼袋及浮肿；棕榈酰四胜肽能抗水肿，改善微循环，加强血液循环，有非常好的消炎作用，同时具有加强肌肤弹性及紧致度，做到紧实，提拉的效果，减少幼纹及皱纹的功效；尿囊素能软化角质层，促进有效成分的吸收，而且具有非常好的抗过敏、降低刺激性的功效。通过以上多种成分的协同作用，达到祛眼袋的目的。 Beneficial effects of the present invention: methyl hesperidin chalcone has very good effects of maintaining vascular permeability, improving capillary resistance and strengthening capillaries, and has good whitening effect; dipeptide can improve blood circulation , promote skin drainage under the eyes, improve eye bags and edema; palmitoyl tetrapeptide can resist edema, improve microcirculation, strengthen blood circulation, have a very good anti-inflammatory effect, and at the same time enhance skin elasticity and firmness, achieve firmness, Lifting effect, reducing fine lines and wrinkles; allantoin can soften the cuticle, promote the absorption of active ingredients, and has very good anti-allergic and anti-irritant effects. Through the synergistic effect of the above multiple ingredients, the purpose of removing bags under the eyes is achieved.
具体实施方式 Detailed ways
以下通过具体实施例来对本发明作进一步的说明，但这些实施例只是为了说明，不是对本发明的限制。 The present invention will be further described below through specific examples, but these examples are only for illustration, not limitation of the present invention.
实施例1一种具有祛眼袋功效的组合物（Ⅰ）Example 1 A composition (I) with the effect of removing eye bags
一种具有祛眼袋功效的组合物（Ⅰ），其特征在于由如下重量百分比的组分制成：甲基橙皮苷查尔酮2.5%，二胜肽1.8%，棕榈酰四胜肽1.2%，尿囊素0.3%，乳化剂1%，去离子水93.2%。 A composition (I) with the effect of removing eye bags, characterized in that it is made of the following components in weight percentage: methyl hesperidin chalcone 2.5%, dipeptide 1.8%, palmitoyl tetrapeptide 1.2% , allantoin 0.3%, emulsifier 1%, deionized water 93.2%.
制备方法： Preparation:
（1）将二胜肽、甲基橙皮苷查尔酮、尿囊素溶于去离子水中后，加热至80-90℃，为水相； (1) After dissolving dipeptide, methylhesperidin chalcone and allantoin in deionized water, heat to 80-90°C to form the water phase;
（2）将棕榈酰四胜肽、乳化剂混合，加热至80-90℃，熔化均匀后为油相； (2) Mix palmitoyl tetrapeptide and emulsifier, heat to 80-90°C, melt evenly and form the oil phase;
（3）将油相加入水相中，均质2-8分钟后，通入冷却水，搅拌冷却至40℃，即可。 (3) Add the oil phase to the water phase, homogenize for 2-8 minutes, pour in cooling water, stir and cool to 40°C.
实施例2一种具有祛眼袋功效的组合物（Ⅱ）Example 2 A composition (II) with the effect of removing bags under the eyes
一种具有祛眼袋功效的组合物（Ⅱ），其特征在于由如下重量百分比的组分制成：甲基橙皮苷查尔酮3%，二胜肽1%，棕榈酰四胜肽1.5%，尿囊素0.3%，乳化剂1%，去离子水93.2%。 A composition (II) with the effect of removing eye bags, which is characterized in that it is made of the following components in weight percentage: 3% methyl hesperidin chalcone, 1% dipeptide, and 1.5% palmitoyl tetrapeptide , allantoin 0.3%, emulsifier 1%, deionized water 93.2%.
制备方法：与实施例1一致。 Preparation method: consistent with Example 1.
实施例3一种具有祛眼袋功效的组合物（Ⅲ）Example 3 A composition (Ⅲ) with the effect of removing bags under the eyes
一种具有祛眼袋功效的组合物（Ⅲ），其特征在于由如下重量百分比的组分制成：甲基橙皮苷查尔酮3.5%，二胜肽1.5%，棕榈酰四胜肽0.8%，尿囊素0.3%，乳化剂0.8%，去离子水93.3%。 A composition (Ⅲ) with the effect of removing eye bags, which is characterized in that it is made of the following components in weight percentage: methyl hesperidin chalcone 3.5%, dipeptide 1.5%, palmitoyl tetrapeptide 0.8% , allantoin 0.3%, emulsifier 0.8%, deionized water 93.3%.
制备方法：与实施例1一致。 Preparation method: consistent with Example 1.
实施例4一种具有祛眼袋功效的组合物（Ⅳ）Example 4 A composition with the effect of removing bags under the eyes (Ⅳ)
一种具有祛眼袋功效的组合物（Ⅳ），其特征在于由如下重量百分比的组分制成：甲基橙皮苷查尔酮2.7%，二胜肽1%，棕榈酰四胜肽1.5%，尿囊素0.3%，乳化剂1.5%，去离子水93%。 A composition ( IV ) with the effect of removing eye bags, characterized in that it is made of the following components in weight percentage: 2.7% methyl hesperidin chalcone, 1% dipeptide, 1.5% palmitoyl tetrapeptide , allantoin 0.3%, emulsifier 1.5%, deionized water 93%.
制备方法：与实施例1一致。 Preparation method: consistent with Example 1.
对比例1组合物Composition of Comparative Example 1
一种具有祛眼袋功效的组合物（Ⅰ），其特征在于由如下重量百分比的组分制成：甲基橙皮苷查尔酮5.5%，尿囊素0.3%，乳化剂1%，去离子水93.2%。 A composition (I) with the effect of removing eye bags, characterized in that it is made of the following components in weight percentage: 5.5% methyl hesperidin chalcone, 0.3% allantoin, 1% emulsifier, deionized Water 93.2%.
制备方法：将以上物质分别溶于水中，搅拌均匀，即可。 Preparation method: Dissolve the above substances in water respectively, and stir evenly.
实施例5祛眼袋眼霜Example 5 eye bag dispelling eye cream
表1给出含有本发明的一种具有祛眼袋功效的组合物的祛眼袋眼霜配方，各物质的用量用质量分数表： Table 1 provides the eye bag removing eye cream formula that contains a kind of composition of the present invention that has the effect of removing bags under eyes, and the consumption of each material uses mass fraction table:
表1 Table 1
制备方法：A相80℃溶解混合均匀，B相80℃溶解混合均匀，环聚二甲基硅氧烷乳化前加入B相，乳化时B相加入A相并均质5min，降温至50℃时加入C相并均质2分钟，出料，陈化24h后包装，即可。 Preparation method: Dissolve phase A at 80°C and mix evenly, dissolve phase B at 80°C and mix evenly, add phase B before emulsification of cyclopolydimethylsiloxane, add phase B to phase A during emulsification and homogenize for 5 minutes, cool down to 50°C Add phase C and homogenize for 2 minutes, discharge, age for 24 hours, and pack.
对比例2普通眼霜Comparative example 2 ordinary eye cream
表2给出含有对比例1制备的组合物的普通眼霜配方，各物质的用量用质量分数表示： Table 2 provides the common eye cream formula containing the composition prepared in Comparative Example 1, and the consumption of each material is represented by mass fraction:
表2 Table 2
制备方法：A相80℃溶解混合均匀，B相80℃溶解混合均匀，环聚二甲基硅氧烷乳化前加入B相，乳化时B相加入A相并均质5分钟，降温至50℃时加入C相并均质2分钟，陈化24h后包装，即可。 Preparation method: Dissolve phase A at 80°C and mix evenly, dissolve phase B at 80°C and mix evenly, add phase B before emulsification of cyclopolydimethylsiloxane, add phase B to phase A during emulsification and homogenize for 5 minutes, cool down to 50°C Add phase C and homogenize for 2 minutes, age for 24 hours and pack.
实验例1皮肤刺激性实验Experimental example 1 skin irritation test
选取年龄在20~50岁的有过敏史的志愿者25名（男性10名，女性15名），用注射器取0.03ml样品置于斑试胶带的药室内，立即将置有样品的斑试胶带从下部开始纵向贴于左前臂的正常皮肤上，同时逐个轻压药室以驱除空气，并使试验物均匀分布。试验部位做好标记，以便观察。每隔24小时贴肤一次，揭开贴片后半个小时，则按照CTFA指南（1981年）的术语进行了检查。共进行了6次斑贴实验，贴肤结束后的第6天，为了观察迟发反应，进行了追加检查。数据则利用最后一次检查结果，进行了比较。鉴定以表3为标准进行。试验样品分别为实施例5制备的祛眼袋眼霜和对比例1制备的普通眼霜，结果如表4所示。 Select 25 volunteers (10 males and 15 females) aged 20 to 50 with a history of allergies, take a 0.03ml sample with a syringe and put it in the medicine room of the spot test tape, and immediately place the spot test tape with the sample Stick it longitudinally on the normal skin of the left forearm from the lower part, and at the same time lightly press the drug chambers one by one to drive out the air and distribute the test substance evenly. Mark the test site for easy observation. The skin was applied every 24 hours, and half an hour after the patch was removed, the inspection was carried out according to the terms of the CTFA guidelines (1981). A total of 6 patch tests were performed, and an additional test was performed on the 6th day after the skin patch was completed to observe delayed reactions. Data were compared using the results of the last inspection. The identification is carried out according to the standard in Table 3. The test samples were the bag-removing eye cream prepared in Example 5 and the ordinary eye cream prepared in Comparative Example 1, and the results are shown in Table 4.
表3 table 3
表4 Table 4
通过本试验结果，可了解到空白实验无刺激，实施例5制备的祛眼袋眼霜，而对比例1制备的普通眼霜对皮肤的刺激反而有两次可疑反应，说明添加有本发明的一种具有祛眼袋功效的组合物的祛眼袋眼霜是安全的。 By the results of this test, it can be understood that the blank experiment has no stimulation, and the eye bag dispelling eye cream prepared in Example 5, while the common eye cream prepared in Comparative Example 1 has twice suspicious reactions to skin irritation, indicating that the addition of a kind of the present invention has The bag-removing eye cream of the composition having the effect of removing bags under the eyes is safe.
实验例2祛眼袋人体试用评价实验Experimental Example 2 Human Trial Evaluation Experiment of Removing Eye Bags
1、实验方法 1. Experimental method
实施例5制备的祛眼袋眼霜和对比例2制备的普通眼霜分别进行人体试用盲测评价。选取年龄在30~50岁的有明显眼袋的志愿者20名（男性10名，女性10名）。使用方法为每日洁面后使用，每天使用两次（早上起床后和晚上睡觉前各一次），左眼使用按实施例5制备的祛眼袋眼霜，右眼使用按对比例2制备的普通眼霜。实验期为8周，用VISIA面部图像分析仪对志愿者眼部使用前后进行拍照比对。 The bag-removing eye cream prepared in Example 5 and the ordinary eye cream prepared in Comparative Example 2 were subjected to human blind test evaluation respectively. 20 volunteers (10 males and 10 females) aged 30-50 with obvious bags under the eyes were selected. The method of use is to use after cleansing every day, twice a day (once after getting up in the morning and once before going to bed at night), use the eye bag removing eye cream prepared according to Example 5 for the left eye, and use the ordinary eye cream prepared according to Comparative Example 2 for the right eye. The experimental period is 8 weeks, and the VISIA facial image analyzer is used to compare the photos of the volunteers' eyes before and after use.
2、实验结果 2. Experimental results
结果见表5所示。 The results are shown in Table 5.
表5 table 5
结果表明，使用含有本发明的一种具有祛眼袋功效的组合物的眼霜（实施例5）后，志愿者的眼袋具有明显改善率达到40%，有改善率为35%，总有效率达到75%；而用对比例2制备的普通眼霜的志愿者的眼袋具有明显改善率为5%，有改善率为30%，总有效率达到35%。 The results show that after using the eye cream (Example 5) containing a composition of the present invention with the effect of removing bags under the eyes, the volunteers' bags under the eyes have an obvious improvement rate of 40%, an improvement rate of 35%, and a total effective rate of 75%. %; and the eye bags of the volunteers prepared with the common eye cream of Comparative Example 2 have a significant improvement rate of 5%, an improvement rate of 30%, and a total effective rate of 35%.
含有实例1制备的组合物的眼霜（实施例5）比含有对比例1的眼霜（对比例2）的明显改善率和总有效率均高得多。这说明，在总用量不变的情况下，使用甲基橙皮苷查尔酮、二胜肽、棕榈酰四胜肽组合后比单独使用甲基橙皮苷查尔酮对祛眼袋的效果好得多，说明组合后起到了协同增效的作用。 The eye cream containing the composition prepared in Example 1 (Example 5) has much higher apparent improvement rate and total effective rate than the eye cream containing Comparative Example 1 (Comparative Example 2). This shows that the combination of methyl hesperidin chalcone, dipeptide and palmitoyl tetrapeptide has a better effect on removing eye bags than the use of methyl hesperidin chalcone alone Much more, indicating that the combination has played a synergistic effect.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510568757.5A CN105055184A (en) | 2015-09-09 | 2015-09-09 | Composition with effect of removing eyelid pouches and application of composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510568757.5A CN105055184A (en) | 2015-09-09 | 2015-09-09 | Composition with effect of removing eyelid pouches and application of composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105055184A true CN105055184A (en) | 2015-11-18 |
Family
ID=54484876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510568757.5A Pending CN105055184A (en) | 2015-09-09 | 2015-09-09 | Composition with effect of removing eyelid pouches and application of composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105055184A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929580A (en) * | 2017-11-20 | 2018-04-20 | 艾因特丽（苏州）生物科技有限公司 | It is a kind of that there is novel compound preparation for alleviating eye strain and its preparation method and application |
| CN109464304A (en) * | 2018-12-29 | 2019-03-15 | 杭州菲丝凯化妆品有限公司 | A kind of face cream and its preparation process |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083317A (en) * | 2014-06-27 | 2014-10-08 | 郑州市嘉蓓丽生物科技有限公司 | White bud tea eye care cream and preparation method thereof |
-
2015
- 2015-09-09 CN CN201510568757.5A patent/CN105055184A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083317A (en) * | 2014-06-27 | 2014-10-08 | 郑州市嘉蓓丽生物科技有限公司 | White bud tea eye care cream and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 王培义: "《化妆品--原理 配方 生产工艺》", 31 March 2006 * |
| 齐琳: "《护肤秀发美甲彩妆装扮一本全》", 31 January 2014 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929580A (en) * | 2017-11-20 | 2018-04-20 | 艾因特丽（苏州）生物科技有限公司 | It is a kind of that there is novel compound preparation for alleviating eye strain and its preparation method and application |
| CN109464304A (en) * | 2018-12-29 | 2019-03-15 | 杭州菲丝凯化妆品有限公司 | A kind of face cream and its preparation process |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2492461C (en) | Fruit and/or vegetable derived composition | |
| EP2352485B1 (en) | Composition for the treatment of hair loss and baldness | |
| US7060303B2 (en) | Use of purslane to treat facial wrinkles | |
| CN103142431B (en) | Tree peony hydrolat | |
| CN104812398A (en) | Topical compositions and methods of use thereof | |
| CN104523450B (en) | A kind of new hair washing hair care and nourishing combination | |
| KR102359906B1 (en) | Shampoo composite and manufacturing method therefore | |
| US20040180026A1 (en) | Topical skin care composition | |
| CN105078868A (en) | Whitening and moisturizing freckle removal lotion and preparation method thereof | |
| JP3596835B2 (en) | Hair restorer | |
| CN103385832B (en) | A kind of take Herba Lysimachiae foenum-graeci extract as the anti-aging cosmetics of main active | |
| KR100581316B1 (en) | Hair loss prevention and hair shampoo composition | |
| CN105055184A (en) | Composition with effect of removing eyelid pouches and application of composition | |
| JPH08507044A (en) | Hair treatment composition | |
| KR102296279B1 (en) | Shampoo composite and manufacturing method therefore | |
| JPH11269043A (en) | Cosmetic for scalp and hair | |
| CN104490710A (en) | A kind of cleansing facial mask and preparation method thereof | |
| JPH11269042A (en) | Cosmetic for scalp and hair | |
| US6482420B2 (en) | Composition having bactericidal action, cosmetics containing said composition and ultraviolet ray screening agent | |
| JPS6322510A (en) | External preparation for skin | |
| JP5855949B2 (en) | Keratin production promoter, hair dye and nail polish | |
| CN105267122B (en) | A kind of natural moisture preserving pore refining gel and preparation method thereof | |
| CN104825370B (en) | A kind of Chinese herbal medicine skin moisturizer and preparation method thereof | |
| JPH11255621A (en) | Cosmetic for scalp and hair | |
| JP2003277280A (en) | Singlet oxygen elimination agent and skin care preparation for aging prevention |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20151118 |