CN105123710B - A kind of composition pesticide containing flufenzine and preparation method thereof - Google Patents

Abstract

The present invention relates to the technical field of pesticides, in particular to a pesticide composition containing flufenazine, the components of which mainly include: 0.1-50% of flufenazine, 0.1-50% of pyriproxyfen, Auxiliary 0～99.8%. In the pesticide composition, flufenazine and pyriproxyfen are compounded, and the synergistic effect is remarkable, the duration of effect is long, and the environmental compatibility is good. The present invention also provides a method for preparing a pesticide composition containing flufenazine. After the pesticide is made into a wettable powder, a water-dispersible granule or a suspension, it is beneficial for spraying the pesticide; It can increase its duration of effectiveness, and can also strengthen its slow-release effect, thereby enhancing the pesticide properties, so as to solve the problems of poor killing ability of insect eggs and large amount of pesticide application. The pesticide composition can efficiently kill various harmful mites and their eggs on common fruit trees such as apples, oranges, cotton, pear trees and tea trees.

Description

A kind of pesticide composition containing flufenazine and its preparation method

technical field

The invention relates to the technical field of pesticides, in particular to a pesticide composition containing flufenazine and a preparation method thereof.

Background technique

Acarids are also called dragon worms, red spiders, yellow spiders, etc., and belong to the order Arachnida. There are many kinds of harmful mites, among which the serious damage to garden plants are Tetranychus hawthorne, Tetranychus urticae, Tetranychus cinnabarinus, Panonychus citrus, tea mites, pear psyllid, etc., which belong to Tetranychidae and Eriodidae. It mainly harms various garden plants such as apples, citrus, cotton, pear trees, and tea trees. Harmful mites suck the branches and leaves of plants and are the main pests that harm the leaves. They often cause damage to the leaves of garden plants and affect photosynthesis. Many pest mites also spread plant virus diseases and fungal diseases.

In the actual process of agricultural production, the most likely problem in the control of pest mites is the generation of resistance to pest mites. The early experience is to apply multiple pesticides alternately, but the actual operation is cumbersome. Therefore, compounding different types of pesticides has become a very common method for controlling resistant pest mites today. The compounding of different ingredients can be divided into three types of effects according to the actual application effect: synergistic effect, additive effect and antagonistic effect. Most of the current compound effects of mite-removing pesticides are additive effects, and there are very few compounds that really have synergistic effects, especially those with very obvious synergistic effects. In addition, the current mite-removing pesticides are not ideal for killing mite eggs, and there are still disadvantages such as narrow insecticidal spectrum, poor environmental compatibility, large amount of pesticides, and short duration.

In view of this, the present invention is proposed.

Contents of the invention

The first object of the present invention is to provide a pesticide composition containing flufenazine, which compounded flufenazine and pyriproxyfen, so as to solve the problem that the synergistic effect of the existing pesticides for killing mites is not significant and persists. Short validity period, poor safety to crops, and poor environmental compatibility.

The second object of the present invention is to provide a preparation method of a pesticide composition containing flufenazine, after the pesticide is made into a wettable powder, a water-dispersible granule or a suspension, which is beneficial to pesticide spraying; It can be washed by rainwater to solve the problem of short duration of effect; it can also increase its slow-release effect and enhance the property of pesticides, so as to solve the problems of poor killing ability of insect eggs and large amount of pesticide application.

The third object of the present invention is to provide an application of a pesticide composition containing flufenazine and pyriproxyfen, which can be used on various kinds of common fruit trees such as apple, citrus, cotton, pear tree and tea tree. Harmful mites and their eggs have a high-efficiency killing effect.

In order to achieve the above object, the present invention adopts the following technical solutions:

A pesticide composition containing flufenazine, its components mainly include:

0.1-50% of flufenazine, 0.1-50% of pyriproxyfen, and 0-99.8% of additives.

Flufenzine chemical name: N-(2-methyl-5-chlorophenyl)-2,4-dinitro-6-trifluoromethylaniline. The compound has the effect of inhibiting the molting of the harmful mite and the oviposition of the harmful mite at a low concentration. This product has a strong contact effect, a wide spectrum of killing acarids, and strong knockdown power. It is effective against adult mites, nymphs, juvenile mites and eggs, and has a long-lasting effect, low toxicity, low residue, and good safety.

Pyriproxyfen (pyriproxyfen) chemical name: 4-phenoxyphenyl (RS)-[2-(2-pyridyloxy)propyl] ether, has a strong ovicidal effect, and also has systemic transfer activity, It is a chitin synthesis inhibitor of juvenile hormone type, which can inhibit the development of mite egg embryos, so as to effectively control and achieve the purpose of mite control. It has a wide insecticidal spectrum, and is effective against public health pests, such as cockroaches, mosquitoes, flies, midges, and gnats. It has high activity against cotton whitefly and greenhouse whitefly, and has good activity against agricultural pests such as pear yellow psyllid, red wax scale, peach aphid, codling moth, spodoptera litura, potato beetle, cotton yellow thrips, citrus psyllid, etc. Control effect. The drug has a lasting effect of about one month, is convenient to use, and has no peculiar smell. It is a better drug for killing mosquitoes and flies. It also has the characteristics of low toxicity, long duration, safety to crops, low toxicity to fish, and little impact on the ecological environment.

In the actual process of agricultural production, the most likely problem in the control of pest mites is the generation of resistance to pest mites. Combining ingredients from different species is a very common way to control resistant pest mites. When flufenazine and pyriproxyfen are compounded, and the parts by weight are both 0.1-50%, not only the problem of easy generation of drug resistance is overcome, but also the synergistic effect is remarkable (see Table 5 for details). Both flufenazin and pyriproxyfen have low toxicity, so they have excellent environmental compatibility; both pesticides have a long duration and obvious contact effect, which greatly reduces the amount of pesticides used.

In addition, in terms of weight percentage, the preferred components of the present application mainly include: 0.1-40% of flufenazine, 0.1-40% of pyriproxyfen, and 20-99.8% of auxiliary agents.

Further preferably, in terms of weight percentage, the components of the present application mainly include: 0.1-25% of flufenazine, 0.1-25% of pyriproxyfen, and 50-99.8% of auxiliary agents.

Preferably, the above-mentioned pesticide composition containing flufenazine, the auxiliary agent includes a kind of dispersant, wetting agent, disintegrant, defoamer, thickener, antifreeze agent, emulsifier, filler or more.

Dispersant is a kind of surfactant, its function is to reduce the surface tension of the drug solution, make the drug particles wet quickly, and make the drug solution easy to wet and spread on the surface of the application target, helping the drug to penetrate;

The wetting agent for pesticides can make the water-insoluble original medicine wet by water and suspend in water. When the medicine solution is sprayed on the crops, it can moisten the crop surface and insect bodies, and improve the control effect;

Disintegrant is a commonly used water-dispersible granule additive, usually a compound product of anionic surfactant and polymer dispersant. Make water-dispersible granules easier to disintegrate in water;

The defoamer can dissolve the large amount of foam generated during the processing and use of the pesticide suspension, and solve the problem of feeding difficulties and the problem of excessive foam affecting pesticide spraying when farmers use it;

The thickener has good emulsifying, stabilizing and thickening effects on pesticide products; has excellent penetration function; can improve the cohesive force of the product and has high resistance to hard water;

Antifreeze can be used to prevent the problem of pesticide freezing at low temperature;

The emulsifier can disperse the oil containing the original drug in water in a very small granular form, and become a uniform and stable white emulsion;

Filler refers to the inert solid filler used to dilute the original drug in the processing of dosage forms. The filler not only acts as a diluent, but also improves the physical properties, which is beneficial to the pulverization and dispersion of the original drug.

Preferably, the above-mentioned pesticide composition containing flufenazine, in terms of weight percentage, its components mainly include:

Flufenazine and pyriproxyfen 0.2-50.1%, dispersant 2-12%, wetting agent 1-10%, disintegrant 0-10%, defoamer 0-1%, thickener 0-2%, Antifreeze 0-8%, emulsifier 0-5%, filler 0-94.8%, water 0-95%.

Wherein, the types of components are matched according to different pesticide formulations configured. E.g:

When made into wettable powder, its components mainly include: 0.2-50.1% of flufenazine and pyriproxyfen, 5-10% of dispersant, 2-10% of wetting agent, and 8-92% of filler in terms of weight percentage ;

When made into water-dispersible granules, the components mainly include: 0.2-50.1% of flufenazine and pyriproxyfen, 3-12% of dispersant, 1-8% of wetting agent, and 1% of disintegrating agent in terms of weight percentage. ~10%, filler 10~94%.

Further preferably, the above-mentioned pesticide composition containing flufenazine, in terms of weight percentage, its components mainly include:

Flufenazine and pyriproxyfen 0.2-50.1%, dispersant 2-12%, wetting agent 2-10%, defoamer 0.1-1%, thickener 0.1-2%, antifreeze agent 0.1-8%, Emulsifier 0.5-5%, water 11.9-95%.

This component can be used as the main component of the suspension dosage form.

Preferably, the above-mentioned pesticide composition containing flufenazine:

The dispersant includes alkyl naphthalene sulfonate, bis(alkyl) naphthalene sulfonate formaldehyde condensate, naphthalene sulfonate formaldehyde condensate, arylphenol polyoxyethylene succinate sulfonate, octylphenol polyoxyethylene sulfonate Oxyvinyl ether sulfate, polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene pyrimaldehyde condensate sulfate, alkylbenzenesulfonate calcium salt, naphthalenesulfonic acid formaldehyde condensate sodium salt, alkyl One or more of phenol polyoxyethylene pyrimide, fatty amine polyoxyethylene pyrimide, fatty acid polyoxyethylene ester, and ester polyoxyethylene pyrimide;

and / or;

The wetting agent includes sodium lauryl sulfate, sodium dodecylbenzenesulfonate, pull-open powder BX, washing powder, agricultural milk 2000 ^# series, sodium lauryl sulfate, wetting and penetrating agent F, wetting agent T, One or more of saponins powder, tea Kut, silkworm excrement, Sapindus sativa powder;

And/or; the disintegrating agent includes one or more of bentonite, urea, ammonium sulfate, aluminum chloride, glucose;

And/or; the defoamer includes one or more of silicones, C _{8 to 10} fatty alcohols, C _{10 to 20} saturated fatty acids (such as capric acid) and amides, silicone oil, and silicone compounds ;

And/or; the thickener includes one or more of xanthan gum, hydroxymethyl cellulose, hydroxyethyl cellulose, methyl cellulose, magnesium aluminum silicate, polyvinyl alcohol;

and / or;

Described antifreezing agent comprises one or more in ethylene glycol, propylene glycol, glycerol, polyethylene glycol;

and / or;

The emulsifier includes calcium alkylbenzene sulfonate, nonylphenol polyoxyethylene ether phosphate, phenylphenol polyoxyethyl ether phosphate, styrene polyoxyethylene ether ammonium sulfate, alkyl diphenyl ether disulfide Magnesium acid salt, triethanolamine salt, benzyl dimethylphenol polyoxyethyl ether, phenylphenol polyoxyethyl ether, alkylphenol formaldehyde resin polyoxyethyl ether, phenylethylphenol formaldehyde resin polyoxyethyl ether Ether, Phenylphenol Polyoxyethyl Polypropylene Ether, Ethylene Oxide-Propylene Oxide Block Copolymer, Nonylphenol Ethoxylate, Castor Oil Ethoxylate, Alkylaryl Polyoxypropylene One of polyoxyethylene ether, alkylaryl polyoxyethylene polyoxypropylene ether, sorbitan monostearate, sorbitan fatty acid ester polyoxyethylene ether, fatty alcohol polyoxyethylene ether, or various;

and / or;

The filler includes one or more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch, light calcium carbonate, and vegetable oil.

A preparation method of the flufenazine-containing pesticide composition according to claim 1, mainly comprising the following steps:

Flufenazine, pyriproxyfen and auxiliary agents are mixed, pulverized and prepared to obtain a pesticide composition containing flufenazine.

The preparation method of the above-mentioned pesticide composition containing flufenazine, the described step of mixing flufenazine, pyriproxyfen and auxiliary agents, pulverizing, and preparing the preparation specifically includes:

Mix flufenazine, pyriproxyfen, dispersant, wetting agent, and filler uniformly in a mixing tank, pulverize through a jet mill, and then mix uniformly to obtain a wettable powder of a pesticide composition containing flufenazine;

or;

Flufenazine, pyriproxyfen, dispersant, wetting agent, disintegrant, and filler are crushed together by airflow to obtain granulation materials; the materials are quantitatively sent to a fluidized bed granulation dryer for granulation and drying, Prepare the water-dispersible granules of the pesticide composition containing flufenazine;

or;

Dispersant, wetting agent, defoamer, thickener, antifreeze and emulsifier are sheared and mixed evenly, then added flufenazine and pyriproxyfen, ball milled in a ball mill for 2 to 3 hours, added water and mixed evenly, A suspension concentrate of a pesticide composition containing flufenazine is prepared.

Among them, the wettable powder is a dosage form in which the original pesticide, inert filler and a certain amount of additives are fully mixed and pulverized in proportion to reach a certain powder fineness. From the point of view of shape, it is no different from powder, but due to the addition of additives such as wetting agent and dispersant, it can be wetted, dispersed and formed into a suspension after being added to water, which can be sprayed and applied;

Water-dispersible granules have the characteristics of high active ingredient content, good dispersibility, high suspension rate, no dust flying, easy packaging, easy measurement, non-stick packaging and weighing containers, safe for operators, and less environmental pollution. It solves the problem of sedimentation and agglomeration during storage and freezing at low temperature, and it is convenient for transportation;

Pesticide suspension concentrates use water as the medium to disperse solid pesticides in water through grinding and grinding to form a highly dispersed multi-phase complex system, which has small particle size, good dispersibility, good fluidity, high suspension rate, High biological activity, low dosage, rain-resistant, low residue. Features such as safety to humans and animals. This dosage form can not only give full play to the functional characteristics of the original drug, but also has no dust drift during production and use, is non-flammable and explosive, and improves the safety of packaging, transportation and storage.

The main technical indicators of the above-mentioned different dosage forms are as described in Table 1.

Within a certain range, the drug effect is inversely proportional to the particle size. The smaller the powder of the contact insecticide, the larger the contact surface between the agent and the insect body per unit weight, and the better the contact effect. In gastric toxic pesticides, the smaller the drug particles, the easier it is to be swallowed by diseases and insect pests, and the easier it is to be absorbed by the intestinal tract after ingestion to exert its toxic effect. In this application, the fineness of wettable powder and water-dispersible granule is limited to below 45 μm, and the fineness of suspension concentrate is limited to below 1.5 μm (the national standard is below 5 μm), which can effectively improve the insecticidal effect of pesticides.

Table 1 Main technical indicators of each dosage form

Pesticide wetting performance is also one of its important indicators. The so-called wettability of wettable powder refers to the ability of wettable powder to be wetted by water. After the wettable powder is added to normal temperature water, it can be completely wetted by water in a short time without stirring, and no dry powder floats on the water surface, indicating that the wettability is qualified. Pesticide technical materials are generally insoluble in water, have high hydrophobicity, and are difficult to wet and disperse in water, so they cannot be directly used for field spraying. The wetting time of the three dosage forms of the present application is all controlled within 1.5 minutes, which can facilitate the preparation and use of pesticides.

Suspension rate refers to the ratio of the active ingredients of pesticides suspended in water to the active ingredients of pesticides added within a certain period of time. The higher the suspension rate, the more uniform the distribution of pesticide particles in the water, the more uniform the spraying concentration, and the higher the efficacy. If the suspension rate is too low, the pesticide particles will quickly settle at the bottom of the sprayer, and the local concentration will be too high, resulting in uneven application concentration in the field, affecting the control effect, and sometimes even causing phytotoxicity. Pesticides with a very low suspension rate flocculate into particles in the sprayer and block the nozzle of the sprayer. In the present application, the suspension rates of the three dosage forms are respectively controlled at more than 85%, 80% and 95%, which is beneficial to the efficacy and spraying of the pesticide.

The above-mentioned pesticide composition containing flufenazine and pyriproxyfen and its three dosage forms are used for controlling pest mites and corresponding pest mite eggs on apples, citrus, cotton, pear trees and tea trees.

Among them, harmful mites include Tetranychus hawthorne, Tetranychus urticae, Tetranychus cinnabarinus, Panonychus citrus, tea mite, and pear psyllid.

After reasonable compounding, the pesticide composition can achieve broad-spectrum acaricidal effect. In particular, due to its strong permeability and good toxicity, it has a good killing effect on various harmful acarid eggs, and can be used for various garden plants. pest control work.

Compared with prior art, the beneficial effect of the present invention is:

1) After compounding flufenazine and pyriproxyfen, harmful mites are not easy to develop drug resistance, and have obvious synergistic and sustained effects.

A single acaricidal pesticide is easy to manually screen harmful mites to induce drug resistance. In this application, two pesticides, flufenazine and pyriproxyfen, are compounded. When the weight ratio is 25:1, the co-toxicity coefficient can reach 208:1, which has remarkable technical effects.

Pesticides have systemic and contact modes of action in terms of insecticidal or bactericidal. Contact killing refers to killing by contact with pests. Therefore, the disadvantage of only contact pesticides is that they work wherever they are sprayed, and the pesticides cannot be absorbed by crops; the systemic nature of pesticides means that pesticides pass through leaves or The phenomenon of inhalation into the plant body by the stalk. For piercing-sucking mouthparts pests such as mites, the systemic nature of pesticides can effectively increase the range of action of pesticides, so if pesticides do not have systemic or penetrative properties, the pesticide juice cannot enter the plant. Stomach poison doesn't work, it can only use contact killing to kill insects. Although flufenazine has good contact property, its systemic property is relatively weak and only has moderate systemic property; pyriproxyfen has strong systemic property, but only when insects do not secrete or rarely secrete juvenile hormone Pyriproxyfen can play a better role when it is used, but flufenazine has no such limitation. Therefore, flufenazine and pyriproxyfen can cooperate and complement each other, so as to achieve a better effect of killing mites.

2), expanded insecticidal spectrum. It has a high effect on cotton, tea tree, cucumber, citrus, apple, pear tree hawthorn Tetranychus, Tetranychus urticae, Tetranychus cinnabarinus, Panonychus citrus, tea mite, pear psyllid, scale insects, citrus axe active.

3) Strong ability to kill insect eggs. The pesticide formulated by the pesticide composition formulation method proposed in this application, combined with the beneficial combination effect of flufenazine and pyriproxyfen itself, can effectively penetrate into insect eggs, and has a strong ability to kill insect eggs.

4), reducing the dosage of pesticides and reducing the residues of pesticides on crops. The pesticide composition formulated by the three dosage form configuration methods proposed in this application is more convenient for pesticide spraying, and effectively improves the adhesive force and sustained release effect of the pesticide composition, greatly reducing the amount of pesticide used.

5) Good environmental compatibility. The European Union is the region with the strictest pesticide controls, but the most widely used acaricide compound in the European Union today is flufenazine. Both flufenazine and pyriproxyfen have good killing effects at low doses, and both have the characteristics of low toxicity, low residue, and good safety.

detailed description

Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only for illustrating the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased from the market.

Example 1

50% of flufenazine and 50% of pyriproxyfen are uniformly mixed to prepare a pesticide composition containing flufenazine.

Example 2

Mix the raw materials with the raw material compositions shown in 1-1 to 1-4 in Table 2, mix them uniformly in a mixing tank, pulverize them with a jet mill and then mix them uniformly to produce flufenazine pyripridine Ether wettable powder products.

Example 3

The raw materials having the raw material compositions shown in 2-1 to 2-4 in Table 3 were pulverized together by air flow to obtain the granulation materials. Quantitatively send the material into the fluidized bed granulation dryer for granulation and drying to obtain the flufenazine pyriproxyfen water-dispersible granule product.

Example 4

Mix the dispersants, wetting agents, defoamers, thickeners, antifreeze agents, and emulsifiers shown in 3-1 to 3-10 in Table 4 evenly after high-speed shearing, and add 3-1 to 3- 10 Corresponding percentages of flufenazine and pyriproxyfen are ball-milled in a ball mill for 2 to 3 hours, so that the particle size of all the particles is below 1.5 μm, and the flufenazine-pyriproxyfen suspension product of the present invention is prepared.

Table 2 Examples of wettable powder formulations

Table 3 water dispersant formula example

Table 4 Suspension Concentrate Formulation Example

Experimental example 1 Toxicity determination of different ratios of flufenazine and pyriproxyfen to spider mite

The embodiment of the present invention adopts the method combining indoor virulence determination and field test. Firstly, through the indoor toxicity test, the co-toxicity coefficient (CTC) after the two agents are compounded in a certain proportion is clarified. CTC<80 means antagonistic effect, 80≤CTC≤120 means additive effect, and CTC>120 For the synergistic effect, the combined toxic effect of the two agents was judged by the CTC value.

Experimental method: Dilute the mother liquor prepared corresponding to 3-1 to 3-9 in Example 4 into five series of concentrations, and place them in beakers for later use. Using the method of soaking the leaves first and then inoculating them, soak leaves of the same size that have not been exposed to any chemical agent in the prepared medicinal solution for 5 seconds, take them out, dry them naturally, put them into the insect breeding box, and then connect them with the larvae for testing. Breeding under the condition of 25°C, each treatment was repeated three times, and the number of test insects used in each repetition was 50, and a blank control was set at the same time, the number of dead insects was checked at 72 hours, the mortality rate and the corrected mortality rate were calculated, and the virulence regression equation was obtained and calculated. Calculate _LC50 values. If the control mortality rate was greater than 10%, the experiment was considered invalid. Calculated as follows:

Actual toxicity index ATI = LD ₅₀ of standard drug / LD ₅₀ of mixed drug × 100%;

Toxicity index TTI = LC ₅₀ of the standard drug / LC ₅₀ of the tested drug × 100%;

Theoretical toxicity index TTI = toxicity index of standard drug × percentage of standard drug in the mixed combination + toxicity index of the tested drug × percentage of the tested drug in the mixed combination;

Co-toxicity coefficient CTC=ATI/TTI×100%.

It can be seen from Table 5 that when the compounding ratio of flufenazine and pyriproxyfen for controlling aphids is 50:1 to 1:50, the co-toxicity coefficients are all greater than 120, indicating that the two are mixed within the range of 50:1 to 1:50. The synergistic effect is shown when the ratio of flufenazine and pyriproxyfen is between 50:1 and 1:50, the synergistic effect is more prominent, and when the weight ratio of flufenazine to pyriproxyfen When it is 25:1, the co-toxicity coefficient is the largest, and the synergistic effect is the most obvious. The experimenter found that the combination of flufenazine and pyriproxyfen is effective in preventing and controlling mites such as hawthorn spider mite, two-spotted spider mite, cinnabarinous spider mite, and panonychia. It has a good synergistic effect, and the co-toxicity coefficients are all greater than 120.

Table 5 Toxicity determination results of different ratios of flufenazine and pyriproxyfen to spider mite

Test drug Flufenazine: pyriproxyfen co-toxicity coefficient Flufenazine —— —— pyriproxyfen —— —— Example 4 (3-1) 50:1 146.2 Example 4 (3-2) 40:1 135 Example 4 (3-3) 25:1 208.1 Example 4 (3-4) 10:1 142.7 Example 4 (3-5) 1:1 193.6 Example 4 (3-6) 1:10 198 Example 4 (3-7) 1:25 131.8 Example 4 (3-8) 1:40 134.4 Example 4 (3-9) 1:50 156.9

Experimental example 2 Flufenazine and pyriproxyfen and their compound efficacy experiment on controlling citrus spider mite

This experiment is arranged in the suburbs of Jingzhou City, Hubei Province. The test agent is the pesticide composition corresponding to the formulations of 3-1 and 3-9 in Example 4. The control agent is 50.1% flufenazine suspension and 50.1% pyriproxyfen suspension. medicament, the auxiliaries used in the control medicament and the content of the auxiliaries are the same as formula 3-1.

The test adopts the conventional spraying method, investigates the mite index of citrus red spider mite before the application of the drug, sprays it at the early stage of the disease, investigates the mite index 3 days, 7 days, 15 days, and 30 days after the application, and calculates the control effect. The experimental results are as follows:

Table 6 Effects of flufenazine, pyriproxyfen and their compound on controlling citrus spider mite

deal with 1 day after medicine 7 days after medicine 15 days after taking medicine 30 days after medicine Example 4 (3-1) 82.33% 93.29% 97.61% 99.99% 50.1% Flufenazine Suspension Concentrate 71.60% 80.46% 86.12% 88.35% Example 4 (3-9) 84.33% 92.29% 97.86% 99.99% 50.1% pyriproxyfen suspension concentrate 64.91% 75.08% 81.06% 84.54%

The percentage is the percentage of dead pest mites to the total amount of initial pest mites.

It can be seen from Table 6 that the combination of flufenazine and pyriproxyfen can effectively prevent and control citrus spider mites. The experimenter found that the combination of flufenazine and pyriproxyfen has a better control effect on the control of citrus spider mites. The 30-day control effect is as high as 99%, and the control effect is better than that of a single dose, and the control effect lasts for a long time. There is no adverse effect on the target crops within the scope of the test drug.

Experimental example 3 Flufenazine and pyriproxyfen and their compound efficacy experiment on apple spider mite control

This experiment is arranged in the suburbs of Yan'an City, Shaanxi Province. The test medicament is the pesticide composition configured in the formulas corresponding to 3-1 and 3-9 in Example 4, and the control medicaments are 50.1% flufenazine suspension concentrate and 50.1% pyriproxyfen suspension concentrate. , the adjuvant and the content of the adjuvant used in the control medicament are the same as in formula 3-1.

The test adopts the conventional spraying method, investigates the index of apple red spider mite before the application of the drug, applies the drug at the early stage of the disease, investigates the index of the mite 3 days, 7 days, 15 days, and 30 days after the application, and calculates the control effect. The experimental results are as follows:

Table 7 Effects of flufenazine, pyriproxyfen and their compound on controlling apple spider mite

deal with 1 day after medicine 7 days after medicine 15 days after taking medicine 30 days after medicine Example 4 (3-1) 88.42% 95.71% 98.93% 100% 50.1% Flufenazine Suspension Concentrate 79.15% 86.53% 87.30% 89.26% Example 4 (3-9) 82.31% 91.92% 97.36% 100% 50.1% pyriproxyfen suspension concentrate 63.06% 81% 83.80% 85.41%

The percentage is the percentage of dead pest mites to the total amount of initial pest mites.

It can be seen from Table 3 that the combination of flufenazine and pyriproxyfen can effectively prevent and control citrus spider mites. The applicant found that the compounding of flufenazine and pyriproxyfen has a better control effect on apple spider mites. The control effect reaches 100% within 30 days, and the control effect is better than that of a single agent, and the control effect lasts for a long time. There is no adverse effect on the target crops within the scope of the test drug.

To sum up, the present application provides a pesticide compound with significant synergistic effect and a preparation method thereof by rationally compounding flufenazine and pyriproxyfen. The compound has wide insecticidal spectrum, strong ability to kill insect eggs, low pesticide dosage and good environmental compatibility, and is a pesticide composition worthy of popularization.

While particular embodiments of the invention have been illustrated and described, it should be appreciated that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims (9)

1. a kind of composition pesticide containing flufenzine, it is characterised in that according to percent by weight, its component mainly includes：

Flufenzine 0.1~50%, Nylar 0.1~50%, auxiliary agent 0~99.8%；

Wherein, the mass ratio of flufenzine and Nylar is 1:50~50:1.

2. the composition pesticide containing flufenzine as claimed in claim 1, it is characterised in that according to percent by weight, its group Part mainly includes：

Flufenzine 0.1~40%, Nylar 0.1~40%, auxiliary agent 20~99.8%.

3. the composition pesticide containing flufenzine as claimed in claim 2, it is characterised in that according to percent by weight, its group Part mainly includes：

Flufenzine 0.1~25%, Nylar 0.1~25%, auxiliary agent 50~99.8%.

4. the composition pesticide containing flufenzine as described in any one of claims 1 to 3, it is characterised in that the auxiliary agent includes One or more in dispersant, wetting agent, disintegrant, defoamer, thickener, antifreeze, emulsifying agent, filler.

5. the composition pesticide containing flufenzine as claimed in claim 4, it is characterised in that according to percent by weight, its group Part mainly includes：

Flufenzine and Nylar 0.2~50.1%, dispersant 2~12%, wetting agent 1~10%, disintegrant 0~10%, defoaming Agent 0~1%, thickener 0~2%, antifreeze 0~8%, emulsifying agent 0~5%, filler 0~94.8%, water 0~95%.

6. the composition pesticide containing flufenzine as claimed in claim 5, it is characterised in that according to percent by weight, its group Part mainly includes：

Flufenzine and Nylar 0.2~50.1%, dispersant 2~12%, wetting agent 2~10%, defoamer 0.1~1%, thickening Agent 0.1~2%, antifreeze 0.1~8%, emulsifying agent 0.5~5%, water 11.9~95%.

A kind of 7. preparation method of the composition pesticide according to claim 6 containing flufenzine, it is characterised in that main bag Include following steps：

By flufenzine, Nylar mix, crush with auxiliary agent, and carry out preparation, obtain the composition pesticide containing flufenzine.

8. the preparation method of the composition pesticide containing flufenzine as claimed in claim 7, it is characterised in that described by fluorine mite Piperazine, Nylar are mixed with auxiliary agent, crushed, and are specifically included the step of carry out preparation：

Flufenzine and Nylar, dispersant, wetting agent, filler are well mixed in mixed cylinder, after airslide disintegrating mill crushes Remix the wettable powder that the composition pesticide containing flufenzine is uniformly made；

Or；

By flufenzine and Nylar, dispersant, wetting agent, disintegrant, filler together through air-flow crushing, materials of pelletizing are obtained；Will Item is quantitatively sent into granulation in fluidized bed granulating dryer and dried, and the water-dispersible grain of the composition pesticide containing flufenzine is made Agent；

Or；

Dispersant, wetting agent, defoamer, thickener, antifreeze and emulsifying agent are added into flufenzine after shear-mixed is uniform Ball milling 2~3 hours, addition water are well mixed in ball mill with Nylar part, and the outstanding of the composition pesticide containing flufenzine is made Floating agent.

9. the evil mite on preventing and treating apple, citrus, cotton, pear tree, tea tree of the composition pesticide containing flufenzine described in claim 6 And the application in corresponding evil mite worm's ovum.