CN105123714A - Abamectin and etoxazole compound suspending agent and preparation method thereof - Google Patents

Abamectin and etoxazole compound suspending agent and preparation method thereof Download PDF

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Publication number
CN105123714A
CN105123714A CN201510623474.6A CN201510623474A CN105123714A CN 105123714 A CN105123714 A CN 105123714A CN 201510623474 A CN201510623474 A CN 201510623474A CN 105123714 A CN105123714 A CN 105123714A
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China
Prior art keywords
suspending agent
etoxazole
abamectin
parts
preparation
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Pending
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CN201510623474.6A
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Chinese (zh)
Inventor
徐长才
毛堂富
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ANHUI MEILAND AGRICULTURAL DEVELOPMENT Co Ltd
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ANHUI MEILAND AGRICULTURAL DEVELOPMENT Co Ltd
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Priority to CN201510623474.6A priority Critical patent/CN105123714A/en
Publication of CN105123714A publication Critical patent/CN105123714A/en
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Abstract

The invention discloses an abamectin and etoxazole compound suspending agent and a preparation method of the abamectin and etoxazole compound suspending agent, which relate to the technical field of red spider prevention. The abamectin and etoxazole compound suspending agent is prepared from the following components in parts by weight: 3 parts of abamectin, 12 parts of etoxazole, 3 parts of fatty alcohol-polyoxyethylene ether, 3 parts of cinnamenyl phenol polyoxyethylene ether, 0.3 part of xanthan gum, 0.3 part of sodium benzoate, 0.3 part of antifoaming agent and 78.1 parts of deionized water. The preparation method comprises the steps of sucking all materials in a preparation kettle, preliminarily grinding the raw materials through a colloid mill after mixing and stirring the raw materials, finely grinding the raw materials through a sand mill, carrying out sampling analysis, filtering after qualified grinding, metering, packaging and warehousing. According to the abamectin and etoxazole compound suspending agent disclosed by the invention, the insect killing and knocking speed is fast, the duration is longer, and the red spider prevention effect is better.

Description

A kind of Avermectin and the composite suspending agent of second mite azoles and preparation method thereof
Technical field
The present invention relates to two spotted spider mite Prevention Technique field, specifically relate to a kind of Avermectin and the composite suspending agent of second mite azoles and preparation method thereof.
Background technology
At present, the existing insecticide for preventing and treating two spotted spider mite, such as " CN102283216A " discloses one " miticide composition containing Avermectin and second mite azoles ", adopts weight ratio to be that the Avermectin of 1:500 ~ 10:1 and second mite azoles carry out composite Chinese patent.Separately there is Chinese patent " CN101856029A " to disclose one " composition pesticide containing second mite azoles and Avermectin ", adopt weight ratio to be that the second mite azoles of 50:1 ~ 1:1 and Avermectin are carried out composite.
Inventor verifies through long term test, and this above-mentioned several Pesticidal combination mainly exists following defect:
1), by several concrete proportioning disclosed in above-mentioned several Pesticidal combination test, find cannot play good control efficiency to the control of two spotted spider mite.
2), for several formulations disclosed in above-mentioned several Pesticidal combination, find through verification experimental verification the defect that all there is different problem.Such as, wetting powder easily causes product to bond, not easily dispersion suspension in water, or blocking shower nozzle, the phenomenon such as reason precipitation in sprayer, cause spray irregular.
3), composite problem, by several concrete proportioning disclosed in above-mentioned several Pesticidal combination carry out virulence test, heat storage stability test and mixture co-toxicity coefficient measure find, all cannot reach obvious synergistic effect.
Summary of the invention
An object of the present invention is to provide a kind of Avermectin and the composite suspending agent of second mite azoles, and this suspending agent is reasonable in design, good to the control efficiency of two spotted spider mite, and can realize the notable synergistic effect of Avermectin and second mite azoles.
For achieving the above object, present invention employs following technical scheme:
A kind of Avermectin and the composite suspending agent of second mite azoles, be made up of following component according to weight portion:
Avermectin is the preparation with acaricidal activity material that a kind of actinomycete fermentation produces, and has and tags and stomach poison function, and have faint fumigation action, have very strong osmosis to blade.Second mite azoles has ovicidal effect, and if all have good preventive effect to the children mite of various developmental condition, and there is good lasting effect.With conventional miticide without cross resistance.The two compound insecticidal knocks down speed, and the lasting period is longer, and control two spotted spider mite effect is better.
Avermectin of the present invention and the composite suspending agent of second mite azoles, its beneficial effect shows:
1) suspending agent that, prepared by the present invention is all obviously better than the product prepared by other proportionings in suspensibility, persistent foamability, wet screening test etc. and heat storage stability etc.
2), verify by experiment, Avermectin and second mite azoles with 1:4 proportioning mixed composite 15% time Avermectin and the composite suspending agent of second mite azoles, notable synergistic sphere of action can be played, and the preparation that other proportioning is mixed, all cannot reach notable synergistic sphere of action.Meanwhile, the actual toxicity of different ratio does not promote along with the enhancing of theoretical toxicity, there is no regular change between actual toxicity and theoretical toxicity.
Another object of the present invention is to the preparation method that a kind of Avermectin and the composite suspending agent of second mite azoles are provided, just grind after raw material suction preparation still mix and blend through colloid mill, again through sand mill fine grinding, sample analysis, qualified rear filtration, metering, packaging, warehouse-in.
The preparation method of Avermectin of the present invention and the composite suspending agent of second mite azoles, preparation technology is comparatively easy, is easy to suitability for industrialized production.
Embodiment
Below with reference to embodiment, the present invention is described in detail.But; embodiment content is only citing made for the present invention and explanation; affiliated those skilled in the art make various amendment to described specific embodiment or supplement or adopt similar mode to substitute; only otherwise depart from the design of invention or surmount this scope as defined in the claims, protection scope of the present invention all should be belonged to.
One, the preparation of Avermectin and the composite suspending agent of second mite azoles, and testing result, the heat storage stability result of the test of all technical of suspending agent prepared by each embodiment.
Embodiment 1
15% Avermectin and the composite suspending agent of second mite azoles, each component and weight proportion as follows:
Composition Weight portion
Avermectin 3
Second mite azoles 12
Fatty alcohol-polyoxyethylene ether 3
Styrylphenol polyoxyethylene ether 3
Xanthans 0.3
Sodium Benzoate 0.3
Defoamer 0.3
Deionized water 78.1
Preparation method: just grind after raw material suction preparation still mix and blend through colloid mill, then through sand mill fine grinding, sample analysis, qualified rear filtration, metering, packaging, warehouse-in.
Embodiment 2
15.1% Avermectin and the composite suspending agent of second mite azoles, each component and weight proportion as follows:
Composition Weight portion
Avermectin 2.9
Second mite azoles 12.2
Fatty alcohol-polyoxyethylene ether 3.1
Styrylphenol polyoxyethylene ether 2.9
Xanthans 0.29
Sodium Benzoate 0.31
Defoamer 0.31
Deionized water 77.99
Preparation method is with embodiment 1.
Embodiment 3
14.9% Avermectin and the composite suspending agent of second mite azoles, each component and weight proportion as follows:
Composition Weight portion
Avermectin 3.1
Second mite azoles 11.8
Fatty alcohol-polyoxyethylene ether 3.2
Styrylphenol polyoxyethylene ether 3.1
Xanthans 0.31
Sodium Benzoate 0.29
Defoamer 0.32
Deionized water 77.88
Preparation method is with embodiment 1.
Embodiment 4
15.3% Avermectin and the composite suspending agent of second mite azoles, each component and weight proportion as follows:
Composition Weight portion
Avermectin 3.2
Second mite azoles 12.1
Fatty alcohol-polyoxyethylene ether 2.8
Styrylphenol polyoxyethylene ether 3.2
Xanthans 0.32
Sodium Benzoate 0.28
Defoamer 0.28
Deionized water 77.82
Preparation method is with embodiment 1.
Embodiment 5
14.7% Avermectin and the composite suspending agent of second mite azoles, each component and weight proportion as follows:
Composition Weight portion
Avermectin 2.8
Second mite azoles 11.9
Fatty alcohol-polyoxyethylene ether 2.9
Styrylphenol polyoxyethylene ether 2.8
Xanthans 0.28
Sodium Benzoate 0.32
Defoamer 0.29
Deionized water 78.71
Preparation method is with embodiment 1.
Avermectin prepared by embodiment 1 ~ 5 and the composite suspending agent of second mite azoles, the testing result of product all technical is as shown in table 1, and product heat storage stability result of the test is as shown in table 2.
The testing result of a table 15 embodiment preparing product all technical
A table 25 embodiment preparing product heat storage stability result of the test
Can be found out by table 1 and 2, product prepared by embodiment 1 is all obviously better than the product prepared by other embodiments in suspensibility, persistent foamability, wet screening test etc. and heat storage stability etc.
Two, toxicological information
Rat acute per os LD 50male is 3830mg/kg, and female is 3160mg/kg, and toxicity test belongs to malicious class such as low grade.
Rat acute percutaneous toxicity test: LD 50femalely/male be all greater than 2000mg/kgBW, belong to malicious class such as low grade.
Rabbits with Acute eye irritant test nonirritant.
Rabbits with Acute Skin Irritation Test: skin irritatin mean scores is 0, and this sample is to guinea pig skin nonirritant.
Guinea pig skin allergy is tested: skin sensitization rate (%)=0, belongs to I grade of weak sensitizer.
According to China's pesticide toxicity grading criteria, 15% Avermectin second mite azole suspending agent belongs to hypotoxicity agricultural chemicals.
Three, Avermectin and the composite synergy indoor measurement of second mite azoles
1, experiment purpose
Just after Avermectin and second mite azoles two kinds of pharmacy mix, the synergy of two spotted spider mite and optimum proportioning are tested.
2, experiment condition
2.1 reagent agent
The former medicine of 95% Avermectin, the former medicine of 93% second mite azoles (above medicine provides by former medicine portion of Anhui Meilan Agricultural Development Co., Ltd., composite suspending agent actual production all adopt above-mentioned two kinds of former medicines).
2.2 for examination insect
Two spotted spider mite, from little Miao town, Feixi County, Hefei City Guai Gang village ornamental flower Tanaka random acquisition two spotted spider mite nymph, selects and grows normally, and it is relatively consistent that polypide enlivens size, and the individual nymph that vitality is strong does toxicity test examination worm.
3, assay method
The medicament first prepared by embodiment 1-5 is that mother liquor made by solvent respectively with acetone, is stored in refrigerator for subsequent use.With mother liquor acetone diluted, medicament is designed to 5-6 series concentration.Two spotted spider mite is put into culture dish (1/culture dish), with micro intravenous drip instrument by liquid drop in the two spotted spider mite chest back side.Before formal mensuration, first carry out the preliminary experiment of measures range mensuration.During mensuration, each concentration process 20 larvas, and make blank with acetone.Check result after 24 hours is cultivated in 26 DEG C of insulating boxs.Calculate lethality according to the dead borer population of total borer population, correct by contrast lethality.Carry out linear regression with lethality value and dosage logarithm, calculate LD 50value, calculates co-toxicity coefficient (C.T.C)
4, results and analysis
4.1 Avermectin virulence to two spotted spider mite larva mixed with second mite azoles
In each determined different ratio, the highest (LD of virulence of suspending agent prepared by embodiment 1 50be 3.40411/), the virulence obviously (LD on the low side of suspending agent prepared by embodiment 2-5 50be followed successively by 5.33258/, 5.19568/, 5.45671/, 5.66531/).
The synergy mixed with second mite azoles of 4.2 Avermectin is reacted
The synergy reaction of two or more pharmacy mix represents with co-toxicity coefficient (C.T.C), synergy reaction is divided into three types, i.e. antagonism (C.T.C<70), summation action (C.T.C70 ~ 150) and synergistic effect (C.T.C>150).In determined 5 mixed preparations, the co-toxicity coefficient of suspending agent prepared by embodiment 1 reaches 200.2, belongs to notable synergistic sphere of action, and the co-toxicity coefficient of suspending agent prepared by embodiment 2-5 is the highest also can only reach 100, substantially belongs to summation action.

Claims (2)

1. Avermectin and the composite suspending agent of second mite azoles, is characterized in that: this suspending agent is made up of following component according to weight portion:
2. prepare the method for Avermectin and the composite suspending agent of second mite azoles as claimed in claim 1 for one kind, it is characterized in that: just grind after raw material suction preparation still mix and blend through colloid mill, again through sand mill fine grinding, sample analysis, qualified rear filtration, metering, packaging, warehouse-in.
CN201510623474.6A 2015-09-25 2015-09-25 Abamectin and etoxazole compound suspending agent and preparation method thereof Pending CN105123714A (en)

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106332887A (en) * 2016-08-25 2017-01-18 安徽美兰农业发展股份有限公司 Cyhalofop-butyl and pyriftalid compound suspending agent and preparation method thereof
CN106342829A (en) * 2016-08-25 2017-01-25 安徽美兰农业发展股份有限公司 Oxadiazon-triafamone compounded suspending agent and preparation method thereof
CN106342812A (en) * 2016-08-25 2017-01-25 安徽美兰农业发展股份有限公司 Cyazofamid and fluopicolide compound suspending agent and preparation method thereof
CN106342876A (en) * 2016-08-25 2017-01-25 安徽美兰农业发展股份有限公司 Triticonazole/silthiopham compound suspending agent and preparation method thereof
CN106376589A (en) * 2016-08-25 2017-02-08 安徽美兰农业发展股份有限公司 Methoxyfenozide and indoxacarb compound suspending agent and preparation method thereof
CN106561640A (en) * 2016-11-07 2017-04-19 北京明德立达农业科技有限公司 Micro-capsule suspension-suspending agent containing abamectin and etoxazole and preparation method of micro-capsule suspension-suspending agent
CN107318861A (en) * 2016-04-28 2017-11-07 江苏龙灯化学有限公司 A kind of Pesticidal combination
CN109042694A (en) * 2018-06-28 2018-12-21 安徽瑞然生物药肥科技有限公司 A kind of etoxazole AVM hereinafter suspending agent
CN110800741A (en) * 2019-12-06 2020-02-18 李玉洁 Efficient pesticide for preventing and treating field red spiders and preparation method thereof
CN112913617A (en) * 2021-02-02 2021-06-08 新疆农垦科学院 Planting method for increasing soybean yield

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101856029A (en) * 2010-07-07 2010-10-13 吴明龙 Pesticide combination containing etoxazole and abamectin
CN102283216A (en) * 2010-06-19 2011-12-21 海利尔药业集团股份有限公司 Acaricidal composition containing abamectin and etoxazole
CN102484990A (en) * 2010-12-01 2012-06-06 联保作物科技有限公司 A compound acaricide for farmland and fruit trees

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102283216A (en) * 2010-06-19 2011-12-21 海利尔药业集团股份有限公司 Acaricidal composition containing abamectin and etoxazole
CN101856029A (en) * 2010-07-07 2010-10-13 吴明龙 Pesticide combination containing etoxazole and abamectin
CN102484990A (en) * 2010-12-01 2012-06-06 联保作物科技有限公司 A compound acaricide for farmland and fruit trees

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107318861A (en) * 2016-04-28 2017-11-07 江苏龙灯化学有限公司 A kind of Pesticidal combination
CN106332887A (en) * 2016-08-25 2017-01-18 安徽美兰农业发展股份有限公司 Cyhalofop-butyl and pyriftalid compound suspending agent and preparation method thereof
CN106342829A (en) * 2016-08-25 2017-01-25 安徽美兰农业发展股份有限公司 Oxadiazon-triafamone compounded suspending agent and preparation method thereof
CN106342812A (en) * 2016-08-25 2017-01-25 安徽美兰农业发展股份有限公司 Cyazofamid and fluopicolide compound suspending agent and preparation method thereof
CN106342876A (en) * 2016-08-25 2017-01-25 安徽美兰农业发展股份有限公司 Triticonazole/silthiopham compound suspending agent and preparation method thereof
CN106376589A (en) * 2016-08-25 2017-02-08 安徽美兰农业发展股份有限公司 Methoxyfenozide and indoxacarb compound suspending agent and preparation method thereof
CN106561640A (en) * 2016-11-07 2017-04-19 北京明德立达农业科技有限公司 Micro-capsule suspension-suspending agent containing abamectin and etoxazole and preparation method of micro-capsule suspension-suspending agent
CN109042694A (en) * 2018-06-28 2018-12-21 安徽瑞然生物药肥科技有限公司 A kind of etoxazole AVM hereinafter suspending agent
CN110800741A (en) * 2019-12-06 2020-02-18 李玉洁 Efficient pesticide for preventing and treating field red spiders and preparation method thereof
CN112913617A (en) * 2021-02-02 2021-06-08 新疆农垦科学院 Planting method for increasing soybean yield

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Application publication date: 20151209