CN105142639A - Irak抑制剂和其用途 - Google Patents

Irak抑制剂和其用途 Download PDF

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Publication number: CN105142639A
Authority: CN; China
Prior art keywords: compound; certain embodiments; nitrogen; unit; sulfur
Prior art date: 2013-01-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN201480003428.XA

Other languages

English (en)

Chinese (zh)

Inventor

杰里米·罗伯特·格林伍德

杰拉尔丁·C·哈里曼

罗萨娜·卡佩勒-利伯曼

克雷格·E·马斯

肖奈希·罗宾逊

多纳·L·罗曼罗

米·雪莱

罗纳德·T·威斯特

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nimbus Iris Inc

Original Assignee

Nimbus Iris Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-01-10

Filing date

2014-01-08

Publication date

2015-12-09

2014-01-08 Application filed by Nimbus Iris Inc filed Critical Nimbus Iris Inc

2015-12-09 Publication of CN105142639A publication Critical patent/CN105142639A/zh

Status Pending legal-status Critical Current

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Classifications

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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Oncology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

CN201480003428.XA 2013-01-10 2014-01-08 Irak抑制剂和其用途 Pending CN105142639A (zh)

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US201361751000P	2013-01-10	2013-01-10
US61/751,000		2013-01-10
PCT/US2014/010652 WO2014110114A1 (en)	2013-01-10	2014-01-08	Irak inhibitors and uses thereof

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US (2)	US9175007B2 (2)
EP (1)	EP2943202A4 (2)
JP (1)	JP2016505012A (2)
CN (1)	CN105142639A (2)
AU (1)	AU2014205577A1 (2)
BR (1)	BR112015014034A2 (2)
CA (1)	CA2890911A1 (2)
HK (1)	HK1216859A1 (2)
WO (1)	WO2014110114A1 (2)

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WO2019001461A1 (zh) *	2017-06-27	2019-01-03	南京明德新药研发股份有限公司	Irak4抑制剂
CN109891238A (zh) *	2016-10-25	2019-06-14	生物技术Rna制药有限公司	免疫治疗剂的剂量确定
CN113423427A (zh) *	2018-11-30	2021-09-21	凯麦拉医疗公司	Irak降解剂和其用途
CN117659010A (zh) *	2018-01-29	2024-03-08	默克专利股份有限公司	Gcn2抑制剂及其用途
US12497402B2 (en)	2021-02-15	2025-12-16	Kymera Therapeutics, Inc.	IRAK4 degraders and uses thereof

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Publication number	Priority date	Publication date	Assignee	Title
NZ772688A (en)	2010-06-03	2022-09-30	Pharmacyclics Llc	The use of inhibitors of bruton’s tyrosine kinase (btk)
US8940742B2 (en)	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
HK1210696A1 (en)	2012-07-11	2016-05-06	Nimbus Iris, Inc.	Irak inhibitors and uses thereof
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CA2890911A1 (en)	2014-07-17
AU2014205577A1 (en)	2015-05-28
US9175007B2 (en)	2015-11-03
US20160068543A1 (en)	2016-03-10
EP2943202A1 (en)	2015-11-18
WO2014110114A1 (en)	2014-07-17
US20140194417A1 (en)	2014-07-10
HK1216859A1 (zh)	2016-12-09
JP2016505012A (ja)	2016-02-18
US9751892B2 (en)	2017-09-05
EP2943202A4 (en)	2016-08-24
BR112015014034A2 (pt)	2017-07-11

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Publication	Publication Date	Title
US9790234B2 (en)	2017-10-17	IRAK inhibitors and uses thereof
US9751892B2 (en)	2017-09-05	IRAK inhibitors and uses thereof
US9067948B2 (en)	2015-06-30	IRAK inhibitors and uses thereof
RU2595718C2 (ru)	2016-08-27	Ингибиторы pi3-киназы и их применение
US9518065B2 (en)	2016-12-13	IRAK inhibitors and uses thereof
CN106413715A (zh)	2017-02-15	Irak抑制剂和其用途
CN113348021B (zh)	2025-07-11	Tyk2抑制剂和其用途
CN113271940A (zh)	2021-08-17	Tyk2抑制剂和其用途
WO2014194201A2 (en)	2014-12-04	Cdk8 inhibitors and uses thereof
WO2017004133A1 (en)	2017-01-05	Irak inhibitors and uses thereof
WO2014011911A2 (en)	2014-01-16	Irak inhibitors and uses thereof
WO2014194242A2 (en)	2014-12-04	Flt3 inhibitors and uses thereof
CN116888116A (zh)	2023-10-13	Gpr84拮抗剂和其用途
CN118922420A (zh)	2024-11-08	Tyk2抑制剂合成及其中间体

CN105142639A - Irak抑制剂和其用途 - Google Patents

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