CN105167166A - Buccal cigarette containing tobacco full-component extract and preparation method of buccal cigarette - Google Patents

Abstract

The invention belongs to the field of tobacco products, and discloses snus containing tobacco full-component extracts and a preparation method thereof. A snus containing tobacco full-component extracts, including functional ingredients, fillers, flavoring agents, lubricants, and binders; the functional ingredients are tobacco extracts and tobacco extract particles; the tobacco extracts The object particles include at least two substrate layers with different contents of tobacco extract; the substrate layers are coated layer by layer, the surface of the substrate layer is coated with a coating layer, and the substrate layer contains excipients; The tobacco extract content of the tobacco extract particle gradually decreases from the inside to the outside of the substrate layer. Tobacco components in snus containing tobacco full-component extracts are provided by both tobacco extract and tobacco extract particles. Provides a consistent and even taste.

Description

A kind of snus containing tobacco full component extract and its preparation method

technical field

The invention belongs to the field of tobacco products, and more specifically relates to a snus containing tobacco full-component extract and a preparation method thereof.

Background technique

At present, most of the smokeless tobacco products on the foreign market are tobacco powder products, and most of them exist in the form of bagged snus, bulk snus, and snuff. As an important supplement form of smokeless tobacco products, tobacco chewing gum improves the uniformity of nicotine release through the chewing process, improves the taste coordination of smokeless tobacco products, satisfies the physiological needs of tobacco consumers, and increases the number of tobacco consumers. The process of eating is enjoyable, and at the same time, it can also clean teeth, freshen breath, and prevent dental caries.

However, tobacco extracts are generally directly added in the form of paste or powder in existing smokeless tobacco products. However, in smokeless tobacco products, due to changes in consumers’ intake of nicotine and other substances in the product, if tobacco extracts are directly added to the product, nicotine and other substances will be released quickly and continuously in the consumer’s mouth. The time is short and the taste is strong. For example, the taste is strong at the entrance, the strength and irritation are too large, the taste will become weaker in a few minutes, the harmony will be worse, and the enjoyment of the process will be poor, which seriously affects consumers' comfort requirements for smokeless tobacco products.

Existing slow-release tobacco microcapsules or micro-smoke sheets usually simply use a coating material to coat tobacco extract or tobacco leaves. However, the existing products lose the sustained-release function after the coating dissolves. For smokeless tobacco products containing the above-mentioned microcapsules or micro-smoke tablets, at the initial stage of the consumption process, the content of microcapsules or micro-smoke tablets in the product is still relatively large, and the contact area with the mouth or saliva is also relatively large. Therefore, the initial stage The released nicotine and other substances are more, and the taste is still relatively irritating. After eating for a period of time, as the volume and quantity of microcapsules or micro-smoke tablets decrease, the release speed and amount of nicotine also decrease accordingly. , Consumers can still obviously feel the decline in taste and quality during use, and they cannot achieve the same experience as smoking.

Contents of the invention

The technical problem to be solved by the present invention is to overcome the defects of the prior art, and provide a snus containing a full-component extract of tobacco, which can effectively control the presence of nicotine in The release speed in the mouth increases the process of uniform dissolution of nicotine and other ingredients.

Another object of the present invention is to provide a method for preparing the snus containing the whole tobacco component extract.

The present invention is realized through the following technical solutions:

A snus containing full-component tobacco extracts, including functional ingredients, fillers, flavoring agents, lubricants, and binders; the functional ingredients are tobacco extracts and tobacco extract particles;

The tobacco extract accounts for 3% to 15% of the mass of the snus; the tobacco extract particles account for 5% to 30% of the mass of the snus;

The tobacco extract particles include at least two substrate layers with different tobacco extract contents; the substrate layers are coated layer by layer, the surface of the substrate layer is coated with a coating layer, and the substrate layer contains Excipient; the tobacco extract content of the tobacco extract particles gradually decreases from the inside to the outside of the substrate layer;

The tobacco extract is a mixture of tobacco extracted with a polar solvent and a non-polar solvent.

The tobacco components in the snus containing tobacco full component extracts of the present invention are provided by both tobacco extract and tobacco extract particles, and the tobacco extract is uniformly dispersed in the snus containing tobacco full component extracts In the smoke, the tobacco extract particles are evenly distributed in the snus containing the whole tobacco component extract in the form of particles. During the consumption process, as the initial tobacco extract content gradually decreases, the tobacco extract in the tobacco extract particles is gradually released, thereby maintaining the content of tobacco components released by the snus containing the full component extract of tobacco, as Consumers are provided with a consistent and uniform taste.

The coating layer can avoid the volatilization loss of active ingredients in the tobacco extract particles during the production and processing of snus containing tobacco full-component extracts, and facilitate the storage of tobacco extracts; prevent nicotine, etc. It is dissolved into the snus containing the whole component extract of tobacco to ensure the mouthfeel of the tobacco product; in addition, the coating layer also plays a role of sustained release, which can improve the release uniformity of the tobacco extract particles during consumption or use.

The content of tobacco extract in the tobacco extract particles gradually decreases from the inside to the outside, which can effectively control the release of active ingredients, and provide uniform taste and long-lasting flavor during the consumption of snus containing full-component tobacco extracts. Fragrance. For example, the content of the tobacco extract particles gradually decreases from the inside to the outside, which can overcome the problem that the content of the tobacco extract particles is relatively large and the particle surface area is large in the initial stage of consumption of snus containing the whole component extract of tobacco. The dissolution and release rate of the microparticles is relatively high, which makes the energy stronger; and in the middle and late stages of consumption, the content of the microparticles decreases, the surface area of the particles decreases, the dissolution and release rate of the microparticles is small, the energy is too small and the fragrance is insufficient.

The tobacco used in the invention is one or more of burley tobacco, flue-cured tobacco and oriental tobacco.

Preferably, the snus containing the whole tobacco component extract is composed of the following substances in mass percentage:

Tobacco extract 3% ~ 15%; tobacco extract particles 5% ~ 30%; filler 10% ~ 50%; flavoring agent 0% ~ 5%; lubricant 1% ~ 5%; binder 1% ~ 5% The tobacco extract particles include at least two substrate layers with different tobacco extract contents; the substrate layers are coated layer by layer, the surface of the substrate layer is coated with a coating layer, and in the substrate layer It contains excipients; the content of tobacco extract in the base material layer of the tobacco extract particles gradually decreases from the inside to the outside.

Further preferably, 6% to 12% of tobacco extract; 9% to 23% of tobacco extract particles; 18% to 42% of filler; 1% to 3% of flavoring agent; 1% to 3% of lubricant; % to 5%; the tobacco extract particles include three substrate layers with different contents of tobacco extract; the substrate layers are coated layer by layer, the surface of the substrate layer is coated with a coating layer, and the substrate layer The material layer contains excipients; the content of the tobacco extract particles gradually decreases from the inside to the outside of the base material layer.

Preferably, the particle diameter of the tobacco extract particles is 100um-1000um. Further preferably, the particle size of the tobacco extract particles is 400um-600um.

Preferably, the tobacco extract is in the form of extract, amorphous powder, solution or the like.

Preferably, the mass fraction of nicotine in the tobacco extract is 8%; the mass fraction of nicotine in the tobacco extract particles is 6%.

Preferably, the filler is one or more of milk powder, xylitol, powdered sugar, mannitol, maltose, lactose, sucrose or starch.

Preferably, the flavoring agent is peppermint oil, rose oil, fruit enzymes (such as papaya enzyme, pineapple enzyme and comprehensive enzyme) and the like. Preferably, the lubricant is magnesium stearate.

Preferably, the binder is PVP-K30, hydroxypropyl methylcellulose.

Due to different extraction methods and extraction processes, the components of the extracts that can be obtained are significantly different. Since the consumption of snus containing tobacco full-component extracts is different from traditional cigarettes, in order to meet the needs of smokers (the main component is nicotine) as in traditional cigarettes, while avoiding the generation of other miscellaneous flavors and destroying the taste, And it is unfavorable for the subsequent flavoring and flavoring of snus containing tobacco full component extract. In the present invention, two steps are used for extraction, and water and ethanol (both polar solvents) with high nicotine solubility are used as extractants in the two extraction steps, which can effectively reduce nicotine while ensuring sufficient extraction of nicotine. The dissolution of other non-essential oily components in tobacco.

Preferably, the extraction method of tobacco extract comprises the following steps:

S11. Adding a non-polar solvent to the tobacco, soaking it at 60°C-70°C, cooling, ultrasonic extraction at no higher than 30°C, and filtering to obtain filter residue a and filtrate a;

S12. After adding a polar solvent to the filter residue a of S11, perform ultrasonic extraction at a temperature not higher than 30° C. and then filter to obtain filter residue b and filtrate b;

S13. The filtrate a and the filtrate b are mixed and concentrated to obtain the tobacco extract.

According to the principle of phase equilibrium of substance diffusion, the present invention adopts two-step extraction technology, which can more effectively extract effective components such as nicotine in tobacco. Soaking in a non-polar solvent at 60°C to 70°C can moisten the tobacco the fastest and reduce the reaction between tobacco components; moreover, the non-polar solvent is less volatile and can effectively avoid active ingredients in tobacco. of volatilization. The tobacco structure after ultrasonic extraction is relatively loose, so that the polar solvent can quickly reach the interior of the tobacco, without re-immersing, the effective components such as nicotine inside the tobacco can be further extracted, and the extraction rate can be improved.

Preferably, the non-polar solvent is selected from one or more of petroleum ether, acetone, chloroform, hexane, ethyl acetate, dichloromethane, and the like.

Preferably, the polar solvent is selected from one or more of water, ethanol and the like.

In order to improve the extraction efficiency and prevent the loss of active ingredients during the ultrasonic extraction process, the ultrasonic extraction temperature is preferably not higher than 30°C.

Preferably, the excipient is selected from one or more of starch, sugar powder, dextrin, lactose, modified starch, microcrystalline cellulose, mannitol, sorbitol and erythrose.

Preferably, the coating material is microcrystalline cellulose, gum arabic, sodium alginate, carrageenan, dextrin, modified starch, gelatin, casein, polyvinyl alcohol, sodium carboxymethylcellulose, ethyl Any one or more of cellulose or methyl cellulose.

In order to control the sustained release rate of tobacco extract, during the consumption of snus containing tobacco full-component extract, the release of extract from tobacco extract particles and the snus containing tobacco full-component extract The release of the extract in the base material has a gentle transition. Preferably, the coating material also contains a porogen; so that the coating layer has certain pores, which is beneficial to the dissolution of the tobacco extract.

Preferably, the porogen is one or more of sucrose, sorbitol, mannitol, polyethylene glycol, hydroxypropylmethylcellulose, and hydroxypropylcellulose.

Preferably, the mass ratio of the absolute dry mass of the tobacco in S11 to the non-polar solvent is 1:13-15; the mass ratio of the absolute dry mass of the filter residue a to the polar solvent in S12 is 1:6-8; S11 and S12 The power of the ultrasonic wave is 250W-350W, the ultrasonic time is 30min-70min; the ultrasonic temperature is 20°C-30°C.

Further preferably, the mass ratio of the absolute dry mass of the tobacco described in S11 to the non-polar solvent is 1:14; the mass ratio of the absolute dry mass of the filter residue a to the polar solvent in S12 is 1:7; in S11 and S12 The power of the ultrasound is 300W, and the temperature of the ultrasound is 25° C.; the time of the S11 ultrasound is 60 minutes; the time of the S12 ultrasound is 30 minutes. The ratio of the tobacco to the non-polar solvent can fully moisten and expand the tobacco, and can make the two-phase concentration difference of the active ingredients such as nicotine in the non-polar solvent and the tobacco relatively large, thereby improving the ultrasonic extraction efficiency. At the same time, the loss of active ingredients caused by subsequent concentration of a large amount of extract is avoided, and energy consumption can be reduced.

A preparation method of the tobacco extract particles, comprising the following steps:

S21. Mix the tobacco extract and excipient evenly, add water to make soft material;

S22. Put the soft material prepared in S21 into an extrusion-spheronizer to granulate, then dry and sieve to obtain a core material;

S23. Preparation of a first fluid dynamic mixture of tobacco extract and excipients;

Put the core material prepared by S22 into the fluidized bed granulator, adjust the parameters of the fluidized bed granulator, make the core material in a fluidized state, spray the first flow dynamic mixture, and form on the surface of the core material after drying The first base material layer is sieved to obtain the first particles;

S24. Prepare the Nth flow-dynamic mixture of tobacco extract and excipient, said N≥2;

Put the first particles prepared in S23 into a fluidized bed granulator, adjust the parameters of the fluidized bed granulator, make the first particles in a fluidized state, spray into the Nth fluid dynamic mixture, and dry them in the next The Nth substrate layer is formed on the surface of a particle, and the Nth particle is obtained by sieving;

S25. Prepare a coating solution;

Put the Nth particles prepared in S24 into the fluidized bed granulator, adjust the parameters of the fluidized bed granulator, make the Nth particles in a fluidized state, spray into the coating solution, and dry the Nth particles A coating layer is formed on the surface, and the tobacco extract particles are obtained by sieving;

Wherein, the tobacco extract content of the core material>the tobacco extract content of the first substrate layer>the tobacco extract content of the Nth substrate layer.

The core material of the tobacco extract particles of the present invention is granulated by an extrusion-spheronizer, so that the core material is denser and has the largest content of tobacco extract, which is beneficial to prolong the release time of the tobacco extract and provide a release amount, It ensures the taste and flavor of the new tobacco products at the end of consumption or use.

The core material is sprayed on the fluidized bed more than once, and the surface of the core material is coated with multiple base material layers, and the concentration of tobacco extracts in different base material layers from the inside to the outside gradually decreases, so that the new tobacco The product can have a uniform taste and aroma during consumption or use. A more uniform coating effect can be obtained by using a fluidized bed granulator.

Preferably, in S23 and S24, the particle diameters of the first particle and the Nth particle gradually increase, and further preferably, the particle diameters of the different particles increase in a range of 100 um to 110 um. In order to ensure a uniform change in taste and uniform quality of the same batch of particles, preferably, the respective particle diameters of the first particle and the Nth particle are within a range of not more than 100 um. Preferably, the particle diameter of the first particle is 400um-500um, and the particle diameter of the second particle is 500um-600um.

Preferably, the core material is coated with the substrate layer three times, that is, N is 3.

Since different tobacco extract particles have different degrees of dissolution or release at the same time, in order to obtain a uniform taste, this requires that the concentration difference between the core material and different substrate layers be within a reasonable range. Based on the technical solution of the present invention, preferably, the tobacco extract content of the core material, the first base material layer, and the Nth base material layer differs by 10% to 15%.

Preferably, the extrusion-spheronizer in S22 has an extrusion sieve aperture of 0.2-0.4mm; extrusion speed of 80r/min-150r/min; spheronization speed of 250r/min-350r/min; spheronization time of 3 minutes to 6 minutes; the drying temperature is 40 to 45° C.; the particle size of the core material is 300 um to 500 um.

Further preferably, the extrusion-spheronizing granulator in S22 has an extrusion sieve aperture of 0.3mm; extrusion speed of 120r/min; spheronization speed of 300r/min; spheronization time of 5min; drying temperature of 42°C; The particle size of the core material is 300um-400um.

Preferably, the process conditions of the fluidized bed granulator in S23, S24 and S25 are: the air intake volume is 500m ³ /h-800m ³ /h, the fluidization temperature is 40-45°C, and the atomizing gas pressure is 0.2Mpa- 0.4Mpa; the concentration of the first fluid dynamic mixture, the Nth fluid dynamic mixture, and the coating liquid is 6% to 10%, and the spray flow rate is 0.6ml/min to 0.9ml/min.

Further preferably, the process conditions of the fluidized bed granulator in S23, S24 and S25 are: the air intake rate is 600m ³ /h, the fluidization temperature is 43°C, and the atomizing gas pressure is 0.3Mpa; the first fluid dynamic mixture, the second The concentration of the N fluid mixture and the coating solution is 7%, and the spray flow rate is 0.8ml/min.

Preferably, the solvent used in the coating solution is water or ethanol, and a surfactant is also added.

In order to obtain the best sustained-release effect and uniform taste change, preferably, the core material, the first substrate layer and the Nth substrate layer account for the same mass fraction of the tobacco extract particles.

A method for preparing snus containing tobacco full-component extracts, comprising the following steps:

S31. Take the tobacco extract, filler, flavoring agent, and binder according to the mass percentage, mix them uniformly, add water and/or ethanol and stir, and make a soft material;

S32. After uniformly mixing the soft material prepared in S31 with tobacco extract particles, granulate, add a lubricant, mix evenly, press into tablets, and dry to obtain snus containing all components of tobacco extract.

In the present invention, auxiliary materials such as tobacco extract, flavoring agent, and tobacco extract particles are successively added into the snus containing the whole component extract of tobacco in two steps, on the one hand, it is beneficial to the uniform distribution of auxiliary materials such as tobacco extract and flavoring agent ; On the other hand, to prevent the tobacco extract, flavoring agent and other auxiliary materials from covering the tobacco extract particles in large quantities, resulting in uneven distribution, agglomeration and other defects; moreover, firstly mix the tobacco extract, flavoring agent and other auxiliary materials with the filler After uniformity, mixing the tobacco extract particles is beneficial to reduce the mixing time of the particles in the buccal tablet, reduce the dissolution or destruction of the coating of the tobacco extract particles, avoid the dissolution of the tobacco extract inside the particles, and give the tobacco extract containing all components The flavors of the snus extracts wreak havoc.

Compared with the prior art, the present invention has the following beneficial effects:

The tobacco components in the snus containing tobacco full-component extracts of the present invention are provided by both tobacco extracts and tobacco extract particles, and the release processes of the two complement each other, maintaining the content of tobacco full-component extracts. The content of tobacco components in snus provides consumers with a consistent and uniform taste.

The tobacco extract particles in the snus containing tobacco full-component extracts have a base layer and a coating layer, and the concentration of the tobacco extract in the base layer gradually decreases from the inside to the outside, so that the tobacco extract in the particles The release amount and release rate are uniform, which ensures the uniformity of taste and aroma of new tobacco products.

The porogen in the coating layer enables a smooth transition between the release of the extract from the tobacco extract particles and the release of the extract from the base material of the novel tobacco product.

The extraction solvent and method of the tobacco extract can fully extract active ingredients such as nicotine, and at the same time avoid the generation of other miscellaneous flavors, improve the taste and facilitate the coordinated use of tobacco extract and other flavor additives, and the product is sterile and residue-free, hygienic Safety.

The step-by-step granulation method adopted by the present invention has a multi-layered structure, and can effectively control the tobacco extract content of different substrate layers and the thickness of the substrate layer, etc., ensuring that the prepared tobacco extract particles have Very good uniformity, thereby ensuring the mouthfeel and flavor of the novel tobacco product added with the tobacco extract particles.

The snus containing tobacco full component extract of the present invention is small and easy to carry, does not need to be burned to avoid fire, has no smoke and does not affect people around, avoids second-hand smoke, and has a wide range of applications.

Detailed ways

The present invention will be further described below in conjunction with specific examples. Unless otherwise specified, the raw materials, equipment and methods used in the examples of the present invention are commercially available raw materials, commonly used equipment and methods in the art.

Example 1

(1) Preparation of tobacco extract

S11. Take flue-cured tobacco with an absolute dry mass of 100g, add 1400g of acetone to soak at 60°C for 25min, cool to about 20°C, and extract it ultrasonically for 60min at 25±2°C. The power of the ultrasonic wave is 300W, and then vacuum suction and filter , to obtain filter residue a and filtrate a;

S12. After adding ethanol 7 times the absolute dry mass of the filter residue a to the filter residue a of S11, ultrasonically extract for 30 minutes at 25±2°C, the power of the ultrasonic wave is 300W, and then vacuum suction and filter to obtain the filter residue b and filtrate b ;

S13. Mix the filtrate a and the filtrate b, and concentrate in vacuum at 25°C to a solid content of 15%, to obtain the tobacco extract.

(2) Preparation of tobacco extract particles

S21. Mix the tobacco extract prepared in (1) with the starch evenly, and add an appropriate amount of water to make a soft material;

S22. Put the soft material prepared in S21 into an extrusion-spheronizer to granulate. The extrusion sieve plate aperture of the extrusion-spheronizer in S2 is 0.3mm; the extrusion speed is 120r/min; The rotation speed is 300r/min; the spheronization time is 5min; then the drying temperature is 42°C; the core material with a particle size of 300um-400um is obtained by sieving, and the content of tobacco extract in the core material is 50%.

S23. preparing a first fluid dynamic mixture of tobacco extract and starch;

Put the core material prepared by S22 into a fluidized bed granulator, adjust the parameters of the fluidized bed granulator, make the core material in a fluidized state, and spray the first flow of dynamic mixture. The main technological conditions of the fluidized bed granulator are: the air intake volume is 500m ³ /h, the fluidization temperature is 40°C, the atomizing gas pressure is 0.2Mpa; the concentration of the first fluid dynamic mixture is 8%, and the spray flow rate is 0.9ml /min. After drying, a first substrate layer is formed on the surface of the core material, and the first particles with a particle size of 400um to 500um are obtained by sieving, and the content of tobacco extract in the first substrate layer is 40%.

S24. Prepare a second fluid mixture of tobacco extract and excipient;

Put the first particles prepared in S23 into a fluidized bed granulator, adjust the parameters of the fluidized bed granulator, make the first particles in a fluidized state, and spray into the second fluidized mixture. The main process conditions of the fluidized bed granulator are: the air intake volume is 600m ³ /h, the fluidization temperature is 43°C, the atomizing gas pressure is 0.3Mpa; the concentration of the second flow dynamic mixture is 7%, and the spray flow rate is 0.8 ml/min. After drying, a second substrate layer is formed on the surface of the first particles, and the second particles with a particle size of 600um-700um are obtained by sieving, and the content of tobacco extract in the second substrate layer is 30%.

S25. Prepare a third fluid dynamic mixture of tobacco extract and excipient;

Put the second particles prepared in S24 into a fluidized bed granulator, adjust the parameters of the fluidized bed granulator, make the second particles in a fluidized state, and spray them into the third fluid dynamic mixture. The main technological conditions of the fluidized bed granulator are: the air intake volume is 800m ³ /h, the fluidization temperature is 45°C, the atomizing gas pressure is 0.4Mpa; the concentration of the third fluid dynamic mixture is 9%, and the spray flow rate is 0.6 ml/min. After drying, a third substrate layer is formed on the surface of the second particle, and the third particle with a particle size of 700um-800um is obtained by sieving, and the content of tobacco extract in the third substrate layer is 20%.

S26. Prepare a coating solution; the coating solution is composed of microcrystalline cellulose, polyvinyl alcohol and an appropriate amount of water, the mass ratio of microcrystalline cellulose to polyvinyl alcohol is 9:1, and the concentration of the coating solution is 9%.

Put the third granules prepared in S25 into a fluidized bed granulator, adjust the parameters of the fluidized bed granulator, make the third granules in a fluidized state, and spray into the coating solution. The main technological conditions of the fluidized bed granulator are: the air intake volume is 800m ³ /h, the fluidization temperature is 45°C, the atomizing gas pressure is 0.4Mpa; the spray flow rate is 0.6ml/min. After drying, a coating layer is formed on the surface of the third granules, and sieved to obtain tobacco extract granules with a particle size of 800um-900um.

The core material, the first base material layer, the second base material layer and the third base material layer account for the same mass fraction of the tobacco extract particles.

(3) Preparation of snus containing tobacco full-component extract

S31. After mixing 10 g of tobacco extract, 30 g of starch, 1 g of peppermint oil, and 303 g of PVP-K, add an appropriate amount of ethanol and stir to make a soft material;

S32. After uniformly mixing the soft material prepared in S31 with 15 g of tobacco extract particles, granulate, add 4 g of magnesium stearate, mix evenly, press into tablets, and dry to obtain snus containing all components of tobacco extract.

Embodiment 2～3 and comparative example 1～3

The preparation steps of the tobacco extracts and tobacco extract particles of Examples 2-3 of the present invention and Comparative Examples 1-3 are similar to those of Example 1, except that they are as shown in the following table:

Process parameters Example 2 Example 3 Comparative example 1 Comparative example 2 Comparative example 3 S11 non-polar solvent, amount added, g Hexane, 1300 Ethyl acetate, 1500 Acetone, 1200 Hexane, 1600 Ethyl acetate, 1500 S12 Polar solvent, adding amount, times water, 6 ethanol, 8 ethanol, 5 water, 9 ethanol, 8 S11/S12 ultrasonic temperature, ℃ 20±2 25±2 20±2 35±2 25±2 S11/S12 ultrasonic power, W 250 350 300 250 300 S21 Excipients dextrin microcrystalline cellulose dextrin microcrystalline cellulose microcrystalline cellulose S22 extrusion speed, r/min 80 150 70 160 150 S22 Rolling speed, r/min 250 350 240 360 350 S23/ S24/ S25 fluidization temperature, ℃ 40 45 35 50 45 S23/ S24/ S25 spray flow ml/min 0.6 0.9 0.5 1.0 0.9 S23/ S24/ S25 atomizing gas pressure, Mpa 0.2 0.4 0.1 05 0.4 S26 Coating material/pore former Gum Arabic/Sorbitol Polyvinyl Alcohol/Methyl Cellulose Gum Arabic/Sorbitol polyvinyl alcohol/no Polyvinyl Alcohol/Methyl Cellulose Whether S22～S26 are screened separately yes yes yes yes no

The preparation process of snus containing tobacco full component extract is as follows:

Example 2 Example 3 Comparative example 1 Comparative example 2 Comparative example 3 Tobacco Extract 3g Tobacco Extract 15g Tobacco Extract 10g Tobacco Extract 3g Tobacco Extract 15g Xylitol 10g Mannitol 50g Starch 30g Xylitol 10g Mannitol 50g rose oil 1g Papaya Enzyme 5g none rose oil 1g Papaya Enzyme 5g Hydroxypropyl methylcellulose 1g PVP-K30 5g PVP-K30 3g Hydroxypropyl methylcellulose 1g PVP-K30 5g Magnesium stearate 1g Magnesium Stearate 5g Magnesium stearate 3g Magnesium stearate 1g Magnesium Stearate 5g Tobacco extract particles 5g Tobacco extract particles 30g Tobacco extract particles 17g Tobacco extract particles 5g Tobacco extract particles 30g

Comparative example 4

(1) Preparation of tobacco extract

S11. Take flue-cured tobacco with an absolute dry mass of 100g, add 1400g of acetone to soak at 60°C for 25min, cool to about 20°C, then add 700g of ethanol solution, and extract it ultrasonically for 90min at 25±2°C. The power of the ultrasonic wave is 300W, then vacuum suction filtration to obtain filter residue a and filtrate a;

S12. Concentrate the filtrate a under vacuum at 25°C to a solid content of 15% to obtain a tobacco extract.

(2) Preparation of tobacco extract particles: refer to the steps and method of Example 1 to prepare tobacco extract particles.

(3) Preparation of snus containing full-component tobacco components: refer to the steps and methods in Example 1 to prepare snus containing full-component tobacco components.

Comparative example 5

(1) Preparation of tobacco extract: refer to the steps and method of Example 1 to prepare tobacco extract.

(2) Preparation of tobacco extract particles

S21. Mix the tobacco extract and starch prepared in (1) evenly to make a mixture with a concentration of 8%;

S22. Granulate the mixture prepared in S21 with a fluidized bed granulator. The main technological conditions of the fluidized bed granulator are: the air intake volume is 500m ³ /h, the fluidization temperature is 40°C, the atomizing gas pressure is 0.2Mpa; the concentration of the first fluid dynamic mixture is 8%, and the spray flow rate is 0.9ml /min. After drying, sieve to obtain particles with a particle size of 700um-800um, the content of tobacco extract in the particles is 35% (the average value of the tobacco extract content of each layer of the tobacco extract particles in Example 1).

S23. Prepare a coating solution; the coating solution is composed of microcrystalline cellulose, polyvinyl alcohol and an appropriate amount of water, the mass ratio of microcrystalline cellulose to polyvinyl alcohol is 9:1, and the concentration of the coating solution is 9%.

Put the particles prepared in S22 into a fluidized bed granulator, adjust the parameters of the fluidized bed granulator to make the particles in a fluidized state, and spray into the coating solution. The main technological conditions of the fluidized bed granulator are: the air intake volume is 800m ³ /h, the fluidization temperature is 45°C, the atomizing gas pressure is 0.4Mpa; the spray flow rate is 0.6ml/min. After drying, a coating layer is formed on the surface of the third granules, and sieved to obtain tobacco extract granules with a particle size of 800um-900um.

(3) Preparation of snus containing full-component tobacco components: refer to the steps and methods in Example 1 to prepare snus containing full-component tobacco components.

Comparative example 6

(1) Preparation of tobacco extract: refer to the steps and method of Example 1 to prepare tobacco extract.

(2) Preparation of tobacco extract particles: refer to the steps and method of Example 1 to prepare tobacco extract particles.

(3) Preparation of snus containing tobacco full-component extract

S31. After taking 15g of tobacco extract particles, 10g of tobacco extract, 30g of starch, 1g of peppermint oil, and 303g of PVP-K, mix evenly, add an appropriate amount of ethanol and stir, make a soft material, granulate, and add magnesium stearate 3 g was mixed, pressed into tablets, and dried to obtain snus containing all tobacco components extracts.

Effect evaluation

Select 15 assessors who usually have the habit of eating buccal tablets, each take 1 tablet/time and put it in the mouth for tasting. Score and obtain the average value recorded in the table below. After each sample was consumed, the mouth was rinsed and another sample was evaluated after a 30-minute interval. evaluation standard:

Aroma: strong aroma (10-8 points), moderate aroma (6-4 points), light aroma (2-1 points)

Strength: moderate strength (10-8 points), high strength (2-1 points), low strength (2-1 points)

Flavor retention (that is, the release persistence of tobacco extract in snus containing all tobacco components extracts): release time of 8-10 minutes (10-8 minutes), release time of less than 6 minutes (6-4 minutes) , release time 4 minutes (2 to 1 minute)

Uniformity of taste (that is, the fluctuation and change of taste during consumption, and evaluate the release uniformity of tobacco extract particles): uniform taste (10-8 points), relatively uniform taste (6-4 points), large taste fluctuation (2 ~1 point)

Irritation: small (10-8 points), medium (6-4 points), large (2-1 points)

Miscellaneous odors: slight (10-8 points), heavy (6-4 points), severe (2-1 points)

Texture: no obvious graininess (10-8 points), grainy feeling (6-4 points), obvious graininess (2-1 point)

The evaluation results are as follows:

Sample/Indicator Example 1 Example 2 Example 3 Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4 Comparative example 5 Comparative example 6 aroma 10 9 10 4 2 2 1 1 5 energy 10 10 8 4 4 1 1 1 1 Fragrance 10 8 9 6 2 2 4 1 4 uniformity of taste 10 9 10 4 5 1 5 2 1 irritant 10 10 9 5 5 2 1 1 4 Miscellaneous 10 9 10 4 3 1 1 1 1 texture 10 10 9 6 5 1 6 1 3 total 70 61 65 33 26 10 19 8 19

According to the above analysis and evaluation, it can be seen that the tobacco extract particles in the snus containing tobacco full-component extracts prepared in Examples 1 to 3 of the present invention have uniform release amount and release rate, long-lasting sustained release effect, long-lasting aroma and no miscellaneous taste . Tobacco extract particles in snus containing tobacco full-component extracts prepared in Comparative Examples 1 and 2 are poor in multiple indicators of tobacco extract particles due to the inability to coordinate the production process conditions, and the coating of Comparative Example 2 has no With the use of porogens, the release uniformity is even worse, and the release of tobacco extract in snus containing tobacco full-component extracts and the release of tobacco extract in particulates cannot be smooth and excessive, and the irritation is greater; The extraction temperature of ratio 2 is higher than 30°C, so that more volatile tobacco active ingredients are lost during the extraction process, resulting in poor aroma concentration. In Comparative Example 3, because the particles were not screened in each link during the particle preparation process, the content of tobacco extract in the final tobacco extract particles was uneven, and the density of the particles was also quite different, making the strength and taste uniformity As well as off-flavors and textures etc. are poor. In Comparative Example 4, due to the one-step extraction of tobacco, the content of active ingredients in the tobacco extract is relatively low, and there are many impurities, which makes the evaluation of its aroma concentration, strength, and miscellaneous taste very poor. Comparative Example 5 adopts the process of direct spray granulation, and the strength of the tobacco extract particles is relatively large, and the evaluation of sustained release effect, taste uniformity and texture are all poor. The snus containing the whole tobacco component extract prepared in Comparative Example 6 is mixed with tobacco extract particles and other auxiliary materials at the same time. , so that the coating of the particles is dissolved, and the snus containing the full-component extract of tobacco is mixed with the tobacco extract in the particles, so that the snus containing the full-component extract of tobacco has indicators such as strength, uniformity of taste, etc. worse.

Claims (10)

1. the buccal cigarette containing tobacco full constituent extract, is characterized in that, comprise functional components, filler, flavor enhancement, lubricant, binder; Described functional components is tobacco extract and tobacco extract particulate;

Described tobacco extract accounts for 3% ~ 15% of buccal cigarette quality; Tobacco extract particulate accounts for 5% ~ 30% of buccal cigarette quality;

Described tobacco extract particulate comprises the substrate layer that at least two kinds have different tobacco extract content; Described substrate layer is successively coated, and the Surface coating of substrate layer has coatings, containing excipient in described substrate layer; Described tobacco extract particulate is reduced gradually by tobacco extract content in interior substrate layer outward;

Described tobacco extract is tobacco through the mixture of polar solvent and non-polar solvent extract.

2. the buccal cigarette according to claim 1 containing tobacco full constituent extract, is characterized in that, the described buccal cigarette containing tobacco full constituent extract is made up of the material of following mass percent:

Tobacco extract 3% ~ 15%; Tobacco extract particulate 5% ~ 30%; Filler 10% ~ 50%; Flavor enhancement 0% ~ 5%; Lubricant 1% ~ 5%; Binder 1% ~ 5%;

Described tobacco extract particulate comprises the substrate layer that at least two kinds have different tobacco extract content; Described substrate layer is successively coated, and the Surface coating of substrate layer has coatings, containing excipient in described substrate layer; Described tobacco extract particulate is reduced gradually by tobacco extract content in interior substrate layer outward.

3. the buccal cigarette according to claim 1 containing tobacco full constituent extract, it is characterized in that, the extracting method of described tobacco extract comprises the following steps:

S11. add after non-polar solven soaks in 60 DEG C ~ 70 DEG C in tobacco, cooling, filter after ultrasonic extraction under not higher than 30 DEG C of conditions, obtain filter residue a and filtrate a;

S12., after adding polar solvent in the filter residue a of S11, filter after ultrasonic extraction under not higher than 30 DEG C of conditions, obtain filter residue b and filtrate b;

S13. filtrate a and filtrate b is mixed, concentrated, obtain described tobacco extract.

4. the buccal cigarette according to claim 1 containing tobacco full constituent extract, it is characterized in that, the particle diameter of described tobacco extract particulate is 100um ~ 1000um.

5. the buccal cigarette according to claim 1 containing tobacco full constituent extract, is characterized in that, also containing pore-foaming agent in the material of described dressing; Described pore-foaming agent is one or more in sucrose, sorbierite, mannitol, polyethylene glycol, hydroxypropyl methylcellulose, hydroxypropyl cellulose.

6. the buccal cigarette according to claim 2 containing tobacco full constituent extract, it is characterized in that, in S11, the absolute dry mass of tobacco and the mass ratio of non-polar solven are 1:13 ~ 15; In S12, the absolute dry mass of filter residue a and the mass ratio of polar solvent are 1:6 ~ 8; In S11 and S12, hyperacoustic power is 250W ~ 350W, and the ultrasonic time is 30min ~ 70min, and ultrasonic temperature is 20 DEG C ~ 30 DEG C.

7. a preparation method for tobacco extract particulate described in claim 1 ~ 6 any one, is characterized in that, comprise the following steps:

S21. described tobacco extract and mixed with excipients is even, add water and make softwood;

S22. softwood obtained for S21 is put into extrude-round as a ball comminutor granulates, then drying, sieving obtains core;

S23. the first-class dynamic mixtures of tobacco extract and excipient is prepared;

Fluidized bed pelletizer put into by the core that S22 is obtained, and each parameter of adjustment fluidized bed pelletizer, makes core be in fluidized state, spray into first-class dynamic mixtures, form the first substrate layer after drying at core surfaces, sieve and obtain the first particulate;

S24. the N flowable state mixture of tobacco extract and excipient is prepared, described N >=2;

Fluidized bed pelletizer put into by the first particulate that S23 is obtained, and each parameter of adjustment fluidized bed pelletizer, makes the first particulate be in fluidized state, spray into N flowable state mixture, form N substrate layer, sieve and obtain N particulate after drying at the first microparticle surfaces;

S25. coating solution is prepared;

Fluidized bed pelletizer put into by the N particulate that S24 is obtained, and each parameter of adjustment fluidized bed pelletizer, makes N particulate be in fluidized state, spray into coating solution, forms coatings, sieve and obtain described tobacco extract particulate after drying at N microparticle surfaces;

Wherein, the tobacco extract content of the tobacco extract content > N substrate layer of tobacco extract content > first substrate layer of described core.

8. the preparation method of tobacco extract particulate according to claim 7, is characterized in that, extrude in S22-hole diameter of sieve (perforated) plate of extruding of round as a ball comminutor is 0.2 ~ 0.4mm; Extruding rotating speed is 80r/min ~ 150r/min; Round as a ball rotating speed is 250r/min ~ 350r/min; The round as a ball time is 3min ~ 6min; Baking temperature is 40 ~ 45 DEG C; The particle diameter of described core is 300um ~ 500um.

9. the preparation method of tobacco extract particulate according to claim 8, it is characterized in that, in S23, S24 and S25, the process conditions of fluidized bed pelletizer are: intake is 500m ³/ h ~ 800m ³/ h, stream temperature is 40 ~ 45 DEG C, and atomization gas pressure is 0.2Mpa ~ 0.4Mpa; The concentration of first-class dynamic mixtures, N flowable state mixture, coating solution is 6% ~ 10%, and mist flow is 0.6ml/min ~ 0.9ml/min.

10. the preparation method of the buccal cigarette containing tobacco full constituent extract described in claim 1 ~ 6 any one, is characterized in that, comprise the following steps:

S31. get tobacco extract by mass percent, after filler, flavor enhancement, binder mix, add after water and/or ethanol stirs, make soft material;

S32., after being mixed with tobacco extract particulate by the soft material that S31 is obtained, granulation, adding lubricant mixing, compressing tablet, drying obtains the buccal cigarette containing tobacco full constituent extract.