CN105188701A - 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 - Google Patents

3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 Download PDF

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Publication number
CN105188701A
CN105188701A CN201380072027.5A CN201380072027A CN105188701A CN 105188701 A CN105188701 A CN 105188701A CN 201380072027 A CN201380072027 A CN 201380072027A CN 105188701 A CN105188701 A CN 105188701A
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CN
China
Prior art keywords
methyl
imidazo
trifluoromethyl
phenyl
ylethynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380072027.5A
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English (en)
Chinese (zh)
Inventor
C.K.默里
L.W.罗扎马斯
J.J.沙伯
P.夏尔马
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ariad Pharmaceuticals Inc
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Ariad Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50929140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN105188701(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ariad Pharmaceuticals Inc filed Critical Ariad Pharmaceuticals Inc
Priority to CN202210369530.8A priority Critical patent/CN115043843A/zh
Publication of CN105188701A publication Critical patent/CN105188701A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380072027.5A 2012-12-12 2013-12-12 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 Pending CN105188701A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210369530.8A CN115043843A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261736543P 2012-12-12 2012-12-12
US61/736,543 2012-12-12
US201261737007P 2012-12-13 2012-12-13
US61/737,007 2012-12-13
US201361788208P 2013-03-15 2013-03-15
US61/788,208 2013-03-15
PCT/US2013/074571 WO2014093579A2 (en) 2012-12-12 2013-12-12 Crystalline forms of 3-(imidazo[1,2-b] pyridazin-3-ylethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl)benzamide and its mono hydrochloride salt

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210369530.8A Division CN115043843A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Publications (1)

Publication Number Publication Date
CN105188701A true CN105188701A (zh) 2015-12-23

Family

ID=50929140

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380072027.5A Pending CN105188701A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形
CN202210369530.8A Pending CN115043843A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202210369530.8A Pending CN115043843A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Country Status (9)

Country Link
US (9) US9493470B2 (2)
JP (5) JP6447508B2 (2)
CN (2) CN105188701A (2)
CA (3) CA2815506C (2)
CL (1) CL2015001643A1 (2)
HK (1) HK1218878A1 (2)
MX (11) MX391445B (2)
NZ (1) NZ709648A (2)
WO (2) WO2014093579A2 (2)

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CN104496994A (zh) * 2014-01-06 2015-04-08 广东东阳光药业有限公司 一种炔类杂芳基化合物的新晶型
CN111004240A (zh) * 2019-12-13 2020-04-14 山东铂源药业有限公司 一种泊那替尼中间体3-乙炔基咪唑并[1,2-b]哒嗪的合成方法
CN112292388A (zh) * 2018-04-02 2021-01-29 隐形生物治疗公司 用于合成elamipretide的结晶二肽

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DK1973545T3 (da) 2005-12-23 2013-02-25 Ariad Pharma Inc Bicykliske heteroarylforbindelser
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
CA2815506C (en) 2012-12-12 2018-12-11 Ariad Pharmaceuticals, Inc. Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
EP3016954B1 (en) * 2013-07-04 2018-10-31 Sandoz AG Crystalline forms of ponatinib hydrochloride
EA201991197A1 (ru) * 2016-12-15 2020-01-13 Ариад Фармасьютикалз, Инк. БЕНЗИМИДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ c-Kit
US10221184B2 (en) 2017-01-20 2019-03-05 Apicore Us Llc Polymorphs of ponatinib hydrochloride
US11072620B2 (en) 2017-06-20 2021-07-27 Apotex Inc. Crystalline forms of Ponatinib hydrochloride
EP3781568A1 (en) 2018-06-22 2021-02-24 Johnson Matthey Public Limited Company Form of ponatinib
US12240869B2 (en) 2018-11-01 2025-03-04 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2020223235A1 (en) 2019-04-29 2020-11-05 Incyte Corporation Mini-tablet dosage forms of ponatinib

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US8114874B2 (en) * 2005-12-23 2012-02-14 Ariad Pharmaceuticals, Inc. Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors
CN102770129A (zh) * 2009-10-30 2012-11-07 阿里亚德医药股份有限公司 治疗癌症的方法和组合物

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CN101389338A (zh) * 2005-12-23 2009-03-18 阿里亚德医药股份有限公司 双环杂芳基化合物
US8114874B2 (en) * 2005-12-23 2012-02-14 Ariad Pharmaceuticals, Inc. Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104496994A (zh) * 2014-01-06 2015-04-08 广东东阳光药业有限公司 一种炔类杂芳基化合物的新晶型
CN112292388A (zh) * 2018-04-02 2021-01-29 隐形生物治疗公司 用于合成elamipretide的结晶二肽
CN112292388B (zh) * 2018-04-02 2024-04-19 隐形生物治疗公司 用于合成elamipretide的结晶二肽
CN111004240A (zh) * 2019-12-13 2020-04-14 山东铂源药业有限公司 一种泊那替尼中间体3-乙炔基咪唑并[1,2-b]哒嗪的合成方法

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MX2021002255A (es) 2021-05-27
JP2016503010A (ja) 2016-02-01
JP2018168191A (ja) 2018-11-01
US10662197B2 (en) 2020-05-26
MX2021002253A (es) 2021-05-27
HK1218878A1 (zh) 2017-03-17
US11192896B2 (en) 2021-12-07
WO2014093583A2 (en) 2014-06-19
US11192897B2 (en) 2021-12-07
US20210340149A1 (en) 2021-11-04
US20210277011A1 (en) 2021-09-09
WO2014093583A3 (en) 2014-08-07
US11279705B2 (en) 2022-03-22
MX2021002256A (es) 2021-05-27
MX2021002258A (es) 2021-05-27
US20210024527A1 (en) 2021-01-28
JP2022037122A (ja) 2022-03-08
CN115043843A (zh) 2022-09-13
US11192895B2 (en) 2021-12-07
US11384086B2 (en) 2022-07-12
JP2026010061A (ja) 2026-01-21
US20210277010A1 (en) 2021-09-09
MX2021002259A (es) 2021-05-27
CL2015001643A1 (es) 2015-10-02
US20190169196A1 (en) 2019-06-06
CA2815506A1 (en) 2014-06-12
JP2023179498A (ja) 2023-12-19
US20210277012A1 (en) 2021-09-09
NZ709648A (en) 2020-05-29
JP6447508B2 (ja) 2019-01-09
US20150315194A1 (en) 2015-11-05
CA3167093A1 (en) 2014-06-12
JP7042175B2 (ja) 2022-03-25
CA2815506C (en) 2018-12-11
MX2021002264A (es) 2021-05-27
JP7352841B2 (ja) 2023-09-29
US20170190707A1 (en) 2017-07-06
US9493470B2 (en) 2016-11-15
MX2021002254A (es) 2021-05-27
MX391445B (es) 2025-03-21
WO2014093579A2 (en) 2014-06-19
US10125136B2 (en) 2018-11-13
MX2015007578A (es) 2016-03-21
MX2021002261A (es) 2021-05-27
US20240083902A1 (en) 2024-03-14
WO2014093579A3 (en) 2014-07-10
MX359147B (es) 2018-09-17
CA3022250A1 (en) 2014-06-12
MX2021002257A (es) 2021-05-27

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