CN1052116A - 三唑基硫代酰胺衍生物 - Google Patents

三唑基硫代酰胺衍生物 Download PDF

Info

Publication number
CN1052116A
CN1052116A CN90109404A CN90109404A CN1052116A CN 1052116 A CN1052116 A CN 1052116A CN 90109404 A CN90109404 A CN 90109404A CN 90109404 A CN90109404 A CN 90109404A CN 1052116 A CN1052116 A CN 1052116A
Authority
CN
China
Prior art keywords
general formula
amino
alkyl
compound
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN90109404A
Other languages
English (en)
Chinese (zh)
Inventor
约瑟夫·巴考茨
约瑟夫·拉里特
莱司罗·旁哥
路泽·皮托茨
弗里耶斯·格里高里
马顿·非克特
盖伯·吉来尔
艾司瓦·盖萨里
艾司瓦·吉里亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egis Gyógyszergyár Zrt
Original Assignee
Egis Gyógyszergyár Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyógyszergyár Zrt filed Critical Egis Gyógyszergyár Zrt
Publication of CN1052116A publication Critical patent/CN1052116A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN90109404A 1989-11-24 1990-11-24 三唑基硫代酰胺衍生物 Pending CN1052116A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU6163/89 1989-11-24
HU896163A HU206096B (en) 1989-11-24 1989-11-24 Process for producing triazolylcarboxylic acid thioamide derivatives and pharmaceutical compositions comprising same

Publications (1)

Publication Number Publication Date
CN1052116A true CN1052116A (zh) 1991-06-12

Family

ID=10971287

Family Applications (1)

Application Number Title Priority Date Filing Date
CN90109404A Pending CN1052116A (zh) 1989-11-24 1990-11-24 三唑基硫代酰胺衍生物

Country Status (22)

Country Link
US (2) US5175163A (2)
EP (1) EP0434982B1 (2)
JP (1) JPH03209371A (2)
KR (1) KR910009674A (2)
CN (1) CN1052116A (2)
AT (1) ATE119888T1 (2)
BG (1) BG60318B2 (2)
CA (1) CA2030775A1 (2)
CZ (1) CZ280559B6 (2)
DE (1) DE59008718D1 (2)
DK (1) DK0434982T3 (2)
ES (1) ES2029778T3 (2)
FI (1) FI905800A7 (2)
GR (1) GR910300109T1 (2)
HU (1) HU206096B (2)
IL (1) IL96452A0 (2)
IN (1) IN171500B (2)
PH (1) PH27376A (2)
PL (1) PL166887B1 (2)
RU (1) RU2045521C1 (2)
TW (1) TW210335B (2)
ZA (1) ZA909409B (2)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0710654A4 (en) * 1993-07-23 1996-08-28 Green Cross Corp TRIAZOLE DERIVATIVE AND ITS PHARMACEUTICAL USE
NZ526624A (en) * 2000-12-22 2005-07-29 Ortho Mcneil Pharm Inc Substituted triazole diamine derivatives as kinase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2352944A (en) * 1942-07-04 1944-07-04 Gen Electric Triazole derivatives
GB949170A (en) * 1960-03-15 1964-02-12 France Etat Carbamyl and thiocarbamyl substances, methods for producing same and applications thereof
US4421753A (en) * 1982-01-15 1983-12-20 American Cyanamid Company 1-(5-Amino-4H-1,2,4-triazol-3-yl)-4-substituted-piperazines
DD205905A1 (de) * 1982-08-17 1984-01-11 Univ Rostock Verfahren zur herstellung von substituierten 1,2,4-triazolo (2,3-a)-1,3,5-triazinen

Also Published As

Publication number Publication date
CA2030775A1 (en) 1991-05-25
ZA909409B (en) 1991-09-25
HUT59112A (en) 1992-04-28
CZ280559B6 (cs) 1996-02-14
PL287909A1 (en) 1991-09-23
GR910300109T1 (en) 1991-12-10
US5276030A (en) 1994-01-04
PH27376A (en) 1993-06-21
JPH03209371A (ja) 1991-09-12
DK0434982T3 (da) 1995-05-22
ES2029778T1 (es) 1992-10-01
PL166887B1 (pl) 1995-06-30
IL96452A0 (en) 1991-08-16
EP0434982A2 (de) 1991-07-03
FI905800A7 (fi) 1991-05-25
US5175163A (en) 1992-12-29
EP0434982B1 (de) 1995-03-15
RU2045521C1 (ru) 1995-10-10
EP0434982A3 (en) 1991-12-18
HU896163D0 (en) 1990-02-28
KR910009674A (ko) 1991-06-28
HU206096B (en) 1992-08-28
FI905800A0 (fi) 1990-11-23
ATE119888T1 (de) 1995-04-15
DE59008718D1 (de) 1995-04-20
CZ583990A3 (en) 1995-11-15
TW210335B (2) 1993-08-01
ES2029778T3 (es) 1995-06-01
BG60318B2 (bg) 1994-07-25
IN171500B (2) 1992-10-31

Similar Documents

Publication Publication Date Title
CN1022488C (zh) 抗毒蕈碱支气管扩张药丙酸3-奎宁环基酯的制备方法
CN1198807C (zh) 作为环加氧酶－2抑制剂的5－芳基－1h－1,2,4－三唑化合物及含有它们的药物组合物
CN1077713A (zh) 嘧啶衍生物及其制备方法
CN1133837A (zh) 取代的1h-咪唑
CN1221417A (zh) 具有抗糖尿病、降低血脂、抗高血压性能的噻唑烷二酮化合物,其制备方法及其药物组合物
CN1175252A (zh) 作为蛋白激酶特别是egf－r酪氨酸激酶的抑制剂的咪唑衍生物
CN1455769A (zh) 用作β－3肾上腺素能受体激动剂的环胺磺酰胺
CN1293674A (zh) 三唑并衍生物和含有它们作为有效组分的趋化因子抑制剂
CN1556797A (zh) 取代的异噁唑化合物及其作为抗生素的应用
CN1093357A (zh) 新颖的选择性芳香酶抑制化合物
CN1922138A (zh) 芳氧基烷基氨基甲酸酯类衍生物,它们的制备方法与治疗用途
CN1777576A (zh) 用于治疗代谢紊乱的化合物
CN1023010C (zh) 4-杂五环-4-[n-(苯基)酰氨基]哌啶衍生物的制备方法
CN1756740A (zh) 具有2,6－二取代苯乙烯基的含氮杂环衍生物
CN1023219C (zh) 取代的咪唑衍生物的制备方法
CN1753886A (zh) 多元碱化合物的酸加成盐的制造方法
CN1043990C (zh) 咪唑啉酮衍生物、其酸的加成盐及老年痴呆症的治疗药物
CN1228338C (zh) 咪唑衍生物或其盐以及含有该衍生物或其盐的药物
CN1126738C (zh) 苯甲酰胺衍生物及含有它们的药物
CN85107866A (zh) 1，4-二氢吡啶-羟基胺，它们的制备方法及其在医药上的应用
CN1107843A (zh) 二氢化茚衍生物和其制法及合成该衍生物的中间体
HK1040706A1 (zh) Fkbp抑制剂
CN1615296A (zh) 甲脒衍生物及其在治疗血管疾病中的用途
CN1030700A (zh) 一种药物组合物的制法
CN87100363A (zh) 2-苯并咪唑基烷硫基(或亚硫酰基或磺酰剂)衍生物，其制备方法和药物应用

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication