CN1052868A - 利用天然神经节苷脂或其衍生物来稳定并维持神经生长因子的生物学活性 - Google Patents

利用天然神经节苷脂或其衍生物来稳定并维持神经生长因子的生物学活性 Download PDF

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Publication number: CN1052868A
Authority: CN; China
Prior art keywords: sialo; sphingolipids; complex compound; ngf; acid
Prior art date: 1989-11-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

CN90110048A

Other languages

English (en)

Chinese (zh)

Inventor

弗朗切斯科·德拉·瓦莱

兰弗兰科·卡列加罗

奥雷利奥·罗密欧

阿尔贝特·莱昂

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fidia SpA

Original Assignee

Fidia SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-14

Filing date

1990-11-14

Publication date

1991-07-10

1989-11-14 Priority claimed from IT04855589A external-priority patent/IT1238347B/it

1990-11-14 Application filed by Fidia SpA filed Critical Fidia SpA

1991-07-10 Publication of CN1052868A publication Critical patent/CN1052868A/zh

Status Withdrawn legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Biotechnology (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Zoology (AREA)
Psychiatry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

CN90110048A 1989-11-14 1990-11-14 利用天然神经节苷脂或其衍生物来稳定并维持神经生长因子的生物学活性 Withdrawn CN1052868A (zh)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT48555A/89		1989-11-14
IT04855589A IT1238347B (it)	1989-11-14	1989-11-14	Stabilizzazione e mantenimento dell'attivita' biologica del fattore di crescita nervoso mediante gangliosidi naturali o loro derivati.
IN954CA1990 IN172427B (2)	1989-11-14	1990-11-13

Publications (1)

Publication Number	Publication Date
CN1052868A true CN1052868A (zh)	1991-07-10

Family

ID=26324373

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN90110048A Withdrawn CN1052868A (zh)	1989-11-14	1990-11-14	利用天然神经节苷脂或其衍生物来稳定并维持神经生长因子的生物学活性

Country Status (8)

Country	Link
EP (1)	EP0433113B1 (2)
JP (1)	JPH03179000A (2)
CN (1)	CN1052868A (2)
AT (1)	ATE122056T1 (2)
AU (1)	AU629714B2 (2)
CA (1)	CA2029965A1 (2)
DE (1)	DE69019122T2 (2)
IN (1)	IN172427B (2)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1046734C (zh) *	1995-03-24	1999-11-24	中国科学院上海生理研究所	一种含神经节苷脂为主的糖脂类物质的生产方法
CN103083724A (zh) *	2013-01-31	2013-05-08	东华大学	一种负载gm1和ngf双营养因子的神经组织修复支架的制备方法
CN108498523A (zh) *	2017-02-24	2018-09-07	上海交通大学	含不饱和脂肪酸链的神经节苷脂衍生物的制备方法及其应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5981485A (en) *	1997-07-14	1999-11-09	Genentech, Inc.	Human growth hormone aqueous formulation
US5763394A (en) *	1988-04-15	1998-06-09	Genentech, Inc.	Human growth hormone aqueous formulation
SE9201073D0 (sv) *	1992-04-03	1992-04-03	Kabi Pharmacia Ab	Protein formulation
IT1259176B (it) *	1992-10-23	1996-03-11	Fidia Spa	Composizioni farmaceutiche comprendenti monosialoganglioside gm1 (o suo derivato) e fattore neuronotrofico ciliare (cntf) atte al trattamento di patologie del sistema nervoso
FR2703682B1 (fr) *	1993-04-06	1995-05-12	Atochem Elf Sa	Procédé de préparation de (méth)acrylate(s) d'alkylimidazolidone.
US10709770B2 (en)	2013-07-31	2020-07-14	Mead Johnson Nutrition Company	Nutritional compositions containing a prebiotic and lactoferrin and uses thereof
US9609888B2 (en)	2013-07-31	2017-04-04	Mead Johnson Nutrition Company	Nutritional compositions containing synergistic combination and uses thereof
US10582714B2 (en)	2015-07-10	2020-03-10	Mead Johnson Nutrition Company	Nutritional compositions and methods for promoting cognitive development
US10617701B2 (en)	2015-07-10	2020-04-14	Mead Johnson Nutrition Company	Nutritional compositions containing phosphatidylethanolamine, sphingomyelin and docosahexaenoic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4716223A (en) *	1981-08-04	1987-12-29	Fidia, S.P.A.	Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
IT1199116B (it) *	1984-07-03	1988-12-30	Fidia Farmaceutici	Derivati di gangliosidi
IT1219839B (it) *	1988-02-08	1990-05-24	Fidia Farmaceutici	Purificazione,caratterizazione e applicazione di un fattore neuronotrofico derivato da cervello di nammifero
US5073543A (en) *	1988-07-21	1991-12-17	G. D. Searle & Co.	Controlled release formulations of trophic factors in ganglioside-lipsome vehicle

1990
- 1990-11-13 IN IN954CA1990 patent/IN172427B/en unknown
- 1990-11-14 AT AT90403221T patent/ATE122056T1/de not_active IP Right Cessation
- 1990-11-14 CN CN90110048A patent/CN1052868A/zh not_active Withdrawn
- 1990-11-14 DE DE69019122T patent/DE69019122T2/de not_active Expired - Fee Related
- 1990-11-14 CA CA002029965A patent/CA2029965A1/en not_active Abandoned
- 1990-11-14 AU AU66628/90A patent/AU629714B2/en not_active Ceased
- 1990-11-14 EP EP90403221A patent/EP0433113B1/en not_active Expired - Lifetime
- 1990-11-14 JP JP2310148A patent/JPH03179000A/ja active Pending

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1046734C (zh) *	1995-03-24	1999-11-24	中国科学院上海生理研究所	一种含神经节苷脂为主的糖脂类物质的生产方法
CN103083724A (zh) *	2013-01-31	2013-05-08	东华大学	一种负载gm1和ngf双营养因子的神经组织修复支架的制备方法
CN108498523A (zh) *	2017-02-24	2018-09-07	上海交通大学	含不饱和脂肪酸链的神经节苷脂衍生物的制备方法及其应用
CN108498523B (zh) *	2017-02-24	2023-06-20	上海交通大学	含不饱和脂肪酸链的神经节苷脂衍生物的制备方法及其应用

Also Published As

Publication number	Publication date
DE69019122T2 (de)	1995-10-05
AU629714B2 (en)	1992-10-08
IN172427B (2)	1993-07-24
CA2029965A1 (en)	1991-05-15
EP0433113A1 (en)	1991-06-19
EP0433113B1 (en)	1995-05-03
JPH03179000A (ja)	1991-08-02
ATE122056T1 (de)	1995-05-15
DE69019122D1 (de)	1995-06-08
AU6662890A (en)	1991-05-23

Legal Events

Date	Code	Title
1991-07-10	C06	Publication
1991-07-10	PB01	Publication
1993-02-03	C10	Entry into substantive examination
1993-02-03	SE01	Entry into force of request for substantive examination
1997-05-21	C03	Withdrawal of patent application (patent law 1993)
1997-05-21	WW01	Invention patent application withdrawn after publication

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