CN105688103A - Traditional Chinese medicine preparation for treating thoracic vertebrae tuberculosis - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating thoracic vertebrae tuberculosis.The traditional Chinese medicine preparation is prepared from 20-30 g of radix rehmanniae praeparata, 10-20 g of herba cistanche, 5-10 g of glossy privet fruit, 10-20 g of semen raphani, 5-10 g of herba epimedii, 5-10 g of radix achyranthis bidentatae, 5-10 g of radix clematidis, 5-10 g of licorice roots, 10-20 g of ground beetles, 8-15 g of squama manis, 8-12 g of scorpions, 8-12 g of radix stemonae, 8-12 g of kudzuvine roots, 8-12 g of cortex eucommiae, 8-12 g of fructus hordei germinatus, 8-12 g of radix notoginseng powder, 10-15 g of flos carthami, 10-15 g of radix curcumae, 8-12 g of radix gentianae macrophyllae and 10-20 g of rhizoma corydalis.All the medicinal materials are excellent in compatibility and reasonable in formula and jointly achieve the effects of tonifying the liver and benefiting the kidney, nourishing the blood and promoting blood circulation, removing stasis and pus, astringing an ulcer and relieving pain and eliminating necrotic tissues and promoting granulation to jointly achieve the purposes of improving the immunologic defense capacity of an organism, promoting blood circulation and killing mycobacterium tuberculosis in a diseased area, and then the purpose of curing the thoracic vertebrae tuberculosis is achieved.
Description
Technical field
The invention belongs to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating thoracic tuberculosis。
Background technology
Thoracic tuberculosis belongs to the one of bone tuberculosis, is that tulase invades, through various approach, the infection that thoracic vertebra causes, and is the general disease form of expression in local。Incidence rate is up to about 39.6% in spinal tuberculosis for tuberculosis of spine, and especially child is in the majority。Due to intrathoracic negative pressure, mediastinum internal organs beat, thoracic outlet adjacent structure is complicated and the factor such as convex after thoracic vertebra physiological, tuberculosis of spine is easily formed vertebra side and its place's gravitation abscess, thoracic vertebra side abscess scope is typically more extensive, and bibliographical information incidence rate is 86.5%-98.5%。Tuberculosis of spine is equally apt to occur in vertebral body with other spinal tuberculosis, based on before destroying spinal column, center pillar, again due to convex after the physiological that itself exists, stress concentrates on the front side of vertebral body, causes collapse of vertebra after heavy burden, causes that kyphosis deformity is fairly obvious。
Current Therapeutic Method mostly is anti-consumptive disease and some folk prescription among the people plus traditional treatment modes such as operations, result makes patient can not get effective treatment for a long time, prolonged application due to anti-scarring agent, easily cause system injury and seriously damage liver system, what have also can damage the 8th pair of cranial nerve, cause auditory dysesthesia and deaf, operative treatment not only costly and also patient suffering is very big, disability。Therefore, in recent years, we according to the traditional Chinese medical science debate disease treat, the principle for the treatment of both the principal and secondary aspects of a disease, utilize the different pharmacological properties of various medical herbs, treat thoracic tuberculosis by Chinese medicine decoction, achieve good therapeutic effect, the deep welcome by patient and accreditation。
Summary of the invention
The invention solves the technical deficiency existed in treatment thoracic tuberculosis at present, it is provided that a kind of instant effect, short treating period, cure rate height and the Chinese drugs agentia having no side effect。
The technical solution adopted in the present invention is:
A kind of Chinese medicine preparation treating thoracic tuberculosis, it is characterised in that described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
20-30 gram of Radix Rehmanniae Preparata, Herba Cistanches 10-20 gram, Fructus Ligustri Lucidi 5-10 gram, Semen Raphani 10-20 gram, Herba Epimedii 5-10 gram, Radix Achyranthis Bidentatae 5-10 gram, Radix Clematidis 5-10 gram, 5-10 gram of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 10-20 gram, Squama Manis 8-15 gram, Scorpio 8-12 gram, Radix Stemonae 8-12 gram, Radix Puerariae 8-12 gram, Cortex Eucommiae 8-12 gram, 8-12 gram of Fructus Hordei Germinatus, Radix Notoginseng powder 8-12 gram, 10-15 gram of Flos Carthami, Radix Curcumae 10-15 gram, Radix Gentianae Macrophyllae 8-12 gram, Rhizoma Corydalis 10-20 gram。
As a kind of prioritization scheme, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
20 grams of Radix Rehmanniae Preparata, Herba Cistanches 10 grams, Fructus Ligustri Lucidi 5 grams, Semen Raphani 10 grams, Herba Epimedii 5 grams, Radix Achyranthis Bidentatae 5 grams, Radix Clematidis 5 grams, 5 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 10 grams, Squama Manis 8 grams, Scorpio 8 grams, the Radix Stemonae 8 grams, Radix Puerariae 8 grams, the Cortex Eucommiae 8 grams, 8 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 8 grams, 10 grams of Flos Carthami, Radix Curcumae 10 grams, Radix Gentianae Macrophyllae 8 grams, Rhizoma Corydalis 10 grams。
As a kind of prioritization scheme, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
22 grams of Radix Rehmanniae Preparata, Herba Cistanches 12 grams, Fructus Ligustri Lucidi 6 grams, Semen Raphani 12 grams, Herba Epimedii 6 grams, Radix Achyranthis Bidentatae 6 grams, Radix Clematidis 6 grams, 6 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 12 grams, Squama Manis 9 grams, Scorpio 9 grams, the Radix Stemonae 9 grams, Radix Puerariae 9 grams, the Cortex Eucommiae 9 grams, 9 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 9 grams, 11 grams of Flos Carthami, Radix Curcumae 11 grams, Radix Gentianae Macrophyllae 9 grams, Rhizoma Corydalis 12 grams。
As a kind of prioritization scheme, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
24 grams of Radix Rehmanniae Preparata, Herba Cistanches 14 grams, Fructus Ligustri Lucidi 7 grams, Semen Raphani 14 grams, Herba Epimedii 7 grams, Radix Achyranthis Bidentatae 7 grams, Radix Clematidis 8 grams, 7 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 14 grams, Squama Manis 11 grams, Scorpio 9 grams, the Radix Stemonae 9 grams, Radix Puerariae 9 grams, the Cortex Eucommiae 8 grams, 8 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 8 grams, 12 grams of Flos Carthami, Radix Curcumae 12 grams, Radix Gentianae Macrophyllae 9 grams, Rhizoma Corydalis 12 grams。
As a kind of prioritization scheme, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
26 grams of Radix Rehmanniae Preparata, Herba Cistanches 16 grams, Fructus Ligustri Lucidi 8 grams, Semen Raphani 16 grams, Herba Epimedii 8 grams, Radix Achyranthis Bidentatae 9 grams, Radix Clematidis 8 grams, 8 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 16 grams, Squama Manis 12 grams, Scorpio 10 grams, the Radix Stemonae 10 grams, Radix Puerariae 11 grams, the Cortex Eucommiae 10 grams, 10 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 11 grams, 13 grams of Flos Carthami, Radix Curcumae 13 grams, Radix Gentianae Macrophyllae 10 grams, Rhizoma Corydalis 13 grams。
As a kind of prioritization scheme, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
28 grams of Radix Rehmanniae Preparata, Herba Cistanches 18 grams, Fructus Ligustri Lucidi 9 grams, Semen Raphani 18 grams, Herba Epimedii 9 grams, Radix Achyranthis Bidentatae 9 grams, Radix Clematidis 9 grams, 9 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 18 grams, Squama Manis 14 grams, Scorpio 11 grams, the Radix Stemonae 11 grams, Radix Puerariae 11 grams, the Cortex Eucommiae 11 grams, 11 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 11 grams, 14 grams of Flos Carthami, Radix Curcumae 14 grams, Radix Gentianae Macrophyllae 11 grams, Rhizoma Corydalis 18 grams。
As a kind of prioritization scheme, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
30 grams of Radix Rehmanniae Preparata, Herba Cistanches 20 grams, Fructus Ligustri Lucidi 10 grams, Semen Raphani 20 grams, Herba Epimedii 10 grams, Radix Achyranthis Bidentatae 10 grams, Radix Clematidis 10 grams, 10 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 20 grams, Squama Manis 15 grams, Scorpio 12 grams, the Radix Stemonae 12 grams, Radix Puerariae 12 grams, the Cortex Eucommiae 12 grams, 12 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 12 grams, 15 grams of Flos Carthami, Radix Curcumae 15 grams, Radix Gentianae Macrophyllae 12 grams, Rhizoma Corydalis 20 grams。
The instructions of taking of said medicine is: by Radix Rehmanniae Preparata, Herba Cistanches, Fructus Ligustri Lucidi, Semen Raphani, Herba Epimedii, Radix Achyranthis Bidentatae, Radix Clematidis, Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga, Squama Manis, Scorpio, the Radix Stemonae, Radix Puerariae, the Cortex Eucommiae, Fructus Hordei Germinatus, Radix Notoginseng powder, Flos Carthami, Radix Curcumae, Radix Gentianae Macrophyllae, Rhizoma Corydalis according to after constant weight proportioning (adding and subtracting with disease) mixing, the traditionally method decocting system of fried Chinese medicine, first boil with big fire, little fire decocts, spice is stirred 2-3 time when decocting, decocting time is 60-90min, complete to decoct rear elimination medicinal residues, taking liquid。Decocting potion, divided 2 decoction being taken warmly, within 30 days, was a course for the treatment of every day。
The raw material Chinese medicine of said medicine:
Radix Rehmanniae Preparata, sweet in the mouth, slightly warm in nature；Return liver, kidney channel。There is nourishing the blood and yin, effect of vital essence replenishing and marrow benifiting。
Herba Cistanches, sweet in the mouth, salty, warm in nature；Return kidney, large intestine channel。There is kidney invigorating and YANG supporting, strong benefiting essence-blood, effect of loosening bowel to relieve constipation。
Fructus Ligustri Lucidi, nature and flavor are sweet, bitter, flat；Return liver, kidney channel。There is liver and kidney tonifying, clearind deficient heat, strong waist knee joint, bright knowledge, effect of crow beard and hair。
Semen Raphani, acrid in the mouth, sweet, property is put down；Return spleen, stomach, lung meridian。There is the de-swelling that helps digestion, effect of lowering the adverse-rising QI to resolve phlegm。Modern pharmacological research, raphanin can induce generation II phase enzyme (detoxification enzyme)-glutathione transferase (GST) and quinone reductase (QR) in each histoorgan of animal body, thus eliminating the infringement of chemical carcinogen, esophageal carcinoma, colon cancer, breast carcinoma etc. are shown good active anticancer。
Herba Epimedii, acrid in the mouth, sweet, warm in nature；Return liver, kidney channel。There is effect of kidney invigorating and YANG supporting, expelling wind and removing dampness, strong muscles and bones。
Radix Achyranthis Bidentatae, bitter in the mouth, acid, property is put down；Return liver, kidney channel。There is nourishing the liver and kidney, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, effect of inducing diuresis for treating stranguria syndrome。" Bencao Jingshu ": Radix Achyranthis Bidentatae, walks and can mend, and property is apt to descending, therefore enters Liver and kidney。Main cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs, gonalgia unable to flex and stretch the extremities person, liver spleen is suffered from a deficiency of the kidney, then the heresy visitor of cold-damp form numbness, and sick spasm of the limbs, gonalgia unable to flex and stretch the extremities。This property of medicine is walked and descending, and it can also must by eliminating impediment by cold-damp。Top capping liver then muscle relaxes, descending, manages knee joint, and promoting the circulation of blood then pain is only。By vim and vigour, still cloud can lead to qi stagnation hemagglutination also。The detailed property of medicine, gas is used as numbness。Fire of getting mildewed in warm conditions is rotten, the shrivelled disease of blood also, blood and lives, pain is from stopping。
Radix Clematidis, acrid in the mouth, hardship salty, micro-, warm in nature；Mild toxicity；Return bladder, Liver Channel。Radix Clematidis has wind-damp dispelling, the meridian dredging, the bone that disappears is choked three large effects, because its property is walked to alter, pharmacology confirms that it also has the effect releasing esophagus, bronchus, ureter, stomach and biliary tract etc. smooth muscle spasm, and has stronger anti-inflammatory analgetic effect。
Radix Glycyrrhizae, sweet in the mouth, property is put down；GUIXIN, spleen, lung, stomach warp。There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription, have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer。Glycyrrhizic acid is topmost active component in Radix Glycyrrhizae。Glycyrrhizic acid and series of products thereof, have inhibitory action to sarcoma, growth of cancer cells, to the suppression ratio of acquired immune deficiency syndrome (AIDS) more up to 90%, has stronger increase immune function of human body effect。
Eupolyphaga Seu Steleophaga, salty in the mouth, cold in nature；Return Liver Channel。There is removing blood stasis with potent drugs blood, effect of reuniting the fractured tendons and bones。
Squama Manis, salty in the mouth, cold nature；Return liver, stomach warp。There is promoting blood circulation to restore menstrual flow, stimulating milk secretion, effect of detumescence and apocenosis。Squama Manis energy priming is descending, through intralesional, attacks cancerization tumor so that lump fast softening reduces, has good antitumaous effect。
Scorpio, acrid in the mouth, property is put down；Return Liver Channel。There is relieving spasm by subduing liver-wind, detoxicating and resolving stagnation of pathogens, effect of removing obstruction in the collateral to relieve pain。Pharmaceutical research proves, scorpion extraction liquid can strengthen heart contraction tension force, has suppression animal thrombosis to be formed and anticoagulation。
The Radix Stemonae, sweet in the mouth, hardship, slightly warm in nature；Return lung meridian。There is effect of nourishing the lung to arrest cough。In vitro tests shows: streptococcus pneumoniae, beta hemolytic streptococcus, meningococcus, staphylococcus aureus, Staphylococcus albus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli, Bacillus proteus, diphtheria corynebacterium, pneumobacillus, bacillus pestis, anthrax bacillus, bacillus subtilis and vibrio cholera, Bacillus tuberculosis etc. are all had inhibitory action in various degree by Radix Stemonae decoct and alcohol preserved material。Some pathomycete is had certain inhibitory action by Radix stemonae japonicae infusion in vitro。Radix Stemonae decoct can reduce the Asia influenza A virus pathogenicity to mice, and the mice infected also is had therapeutical effect。
Radix Puerariae, sweet in the mouth cool in nature is pungent, and having induces sweat brings down a fever, and promotes the production of body fluid, the several functions such as rash, yang invigorating antidiarrheal, can control fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, heat rash, the multiple disease such as have loose bowels。The flavone proposed in Radix Puerariae can increase brain and crown vascular flow amount, reduces vascular resistance。Contained daidzein has spasmolysis, moreover it is possible to reduces blood glucose, and has antipyretic and estrogen-like effects。
The Cortex Eucommiae, sweet in the mouth, warm in nature。Return liver, kidney, stomach warp。Effect liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, solid through antiabortive。The lumbago and skelalgia or aching and limp unable that treatment insufficiency of kidney-YANG causes。The diseases such as born of the same parents' tire that deficiency of liver-QI causes is not solid, scrotum pruritus due to damp pathogen。
Fructus Hordei Germinatus, sweet in the mouth, property is put down；Return spleen, stomach, Liver Channel。There is promoting digestion and invigorating the stomach, effect of galactopoiesis relieving distension。
Radix Notoginseng powder, sweet in the mouth, micro-hardship, temperature；GUIXIN, liver, spleen channel。There is removing stasis to stop bleeding, effect of reducing swelling and alleviating pain。
Flos Carthami, acrid in the mouth, warm in nature；GUIXIN, Liver Channel。There is promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain。" medicineization justice ": Flos Carthami, kind tonneau passages through which vital energy circulates, for gas medicine in blood, can rush down and can mend, being respectively arranged with wonderful justice。Flos Carthami promoting blood circulation to restore menstrual flow, scattered silt pain relieving, for lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache。The present invention mainly utilizes Flos Carthami effect of invigorating blood circulation to strengthen blood circulation and skin metabolism。
Radix Curcumae is the gas medicine of blood system, both regulates the flow of vital energy, again blood stasis dispelling, dialectical for the conventional this product of qi depression to blood stasis person。There is the disease of qi depression to blood stasis clinically, such as myocarditis, coronary heart disease feeling of oppression and pain in the chest or companion's angina pectoris, chronic hepatopathy or companion's portal hypertension, immunological disease lung damage or companion pulmonary hypertension, Chronic Cholecystitis & Cholelithiasis, associated with acute ureterolithiasis hematuria etc., these all need to treat by the method for regulating the flow of QI to dissipate blood stasis, Radix Curcumae is to be suitable for medicine, can be equal to use with Radix Bupleuri, the Radix Paeoniae Alba。Modern pharmacology proves, Radix Curcumae volatile oil injection can strengthen fibrinolytic, and substantially suppresses platelet aggregation by improving CAMP content, thus can play anticoagulant effect。
Radix Gentianae Macrophyllae, hardship can be let out, and pungent energy dissipates, tepor energy tonneau, therefore main cold and heat pathogen, cold-damp migratory arthralgia, arthrodynia of the extremities, lower water, diuresis, can expelling wind and removing dampness。Also can dissipating ailment said due to cold or exposure all over the body, the through sick institute of priming, with the product of nourshing blood and promoting blood circulation, strengthening vital QI to eliminate pathogenic factors, dispelling wind and removing obstruction in the collateral Zhitan。
Rhizoma Corydalis, acrid in the mouth, hardship, warm in nature；Return liver, spleen channel。There is regulating QI to relieve pain, effect of promoting blood circulation to remove blood stasis。
Tuberculosis of spine is a kind of type very common in spinal tuberculosis and bone tuberculosis, betides the Tuberculous purulent disease between B&J。Because it becomes after pus, can fleeing gap near pathological changes or farther out and form abscess, after breakage, pus is thin in expectorant, therefore belongs to the traditional Chinese medical science " tuberculosis of bone and joint ", " bone tuberculosis "。The traditional Chinese medical science is thought, its cause of disease mostly is congenital defect or prolonged illness damage of kidney-YIN, and bone marrow does not fill, and exopathogen is taken advantage of a weak point, the turbid cohesion of expectorant；Or injury from falling down, disharmony between QI and blood and bring out。Disease is not swollen micro-swollen from the beginning of local acid, red, not hot, not bitterly；Of a specified duration then unrestrained swollen pain becomes pus, Surrounding muscles atrophy；Later stage can with hectic fever, night sweat, the yin deficiency hyperactivity of fire such as weak card, and the local clear rare pus of diabrosis stream and worn-out cotton wadding for quilt sample thing, then form sinus tract for a long time, not easily close up。Treatment is when application righting and eliminating evil two big rules, and namely righting transfers Abwehrkraft des Koepers, strengthens immunologic function, reaches the purpose of the strong body of anti-consumptive disease；Eliminating evil namely dispel internal toxic dampness and heat, anti-inflammation and sterilization, hold back infections pain relieving。
In medicine of the present invention, Radix Rehmanniae Preparata, Herba Cistanches, Fructus Ligustri Lucidi, Herba Epimedii, Radix Achyranthis Bidentatae, the Cortex Eucommiae are all the key medicine of nourishing, can kidney-supplementing liver-boosting, nourishing the blood and yin, strengthening and nourishing marrow and essence, play that mediation punching is appointed, conditioning viscera function, righting are got rid of evils, the effect of enhancing human body immunity power and resistivity。Radix Clematidis, Radix Gentianae Macrophyllae, Scorpio expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, disperse toxic dampness and heat in body；The Radix Stemonae, Radix Puerariae heat-clearing and toxic substances removing, moisturize parasite killing, multiple coccus, tubercule bacillus, dermatophytes etc. are all had inhibitory action, there is good antiphlogistic antibacterial effect；Squama Manis, Eupolyphaga Seu Steleophaga, Rhizoma Corydalis, Radix Notoginseng powder, Flos Carthami, Radix Curcumae energy blood circulation promoting and blood stasis dispelling, dredge the meridian passage, detumescence toxin expelling, play improvement and recover tuberculose focus blood circulation, make medicine better permeate, and then strengthening the effect except removing blood stasis and expelling pus。Semen Raphani, Fructus Hordei Germinatus eliminate indigestion and phlegm, stomach function regulating spleen invigorating, play conditioning viscera function, and dredging three is burnt, eliminates and condenses the turbid virus of expectorant in vertebra；Radix Achyranthis Bidentatae, Squama Manis again can priming descending, strengthen removing blood stasis, dredge the meridian passage merit；Radix Glycyrrhizae can invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, again can coordinating the actions of various ingredients in a prescription, make the bias of all medicines be alleviated, and so as to coordinated with each other, jointly complete its therapeutical effect。
We utilize Chinese medical discrimination theoretical, by circulation of qi promoting, the blood supply solving thoracic with soft tissue of enriching blood, the reason of the kidney generating marrow and dominating bone it is primarily due to by the kidney invigorating, obstructed by venation around blood circulation promoting and blood stasis dispelling, active solution bone of promoting blood circulation, solve internal toxic dampness and heat by wind-damp dispelling, heat-transformation poison, kill tuberculosis pathogenic bacteria。All medicine compatibilities are superior, reasonable recipe, play altogether the liver and the kidney tonifying, nourshing blood and promoting blood circulation, except stasis of blood evacuation of pus, hold back infections pain relieving, effect of removing the necrotic tissue and promoting granulation, reaches to improve immunity of organism defence capability, blood circulation promoting jointly, kill the tubercule bacillus in sufferer district, and then reach to cure the purpose of thoracic tuberculosis。
For investigating the clinical efficacy of medicine of the present invention further, we have selected 78 examples be in hospital and outpatient service tuberculosis of spine patient, 24～67 years old age, the mean age (35.4 ± 16.2) year。Wherein male 30 example, women 48 example。All patients all has thoracic vertebra local pain in various degree and tubercle bacillus affection symptom, is often accompanied by flushed face, night sweat, becomes thin, coughs, breathes hard, the symptom such as weak。Preoperative carry out the imaging examination such as x-ray, CT, the vertebral bodies destroyed of showed different, wherein T3-4 thoracic vertebra 13 example, T5-6 thoracic vertebra 17 example, T7-8 thoracic vertebra 22 example, T8-9 thoracic vertebra 11 example, T9-10 thoracic vertebra 7 example, T10-11 thoracic vertebra 8 example。The course of disease 5～48 months。Being grouped at random, be divided into treatment group and each 39 examples of matched group, two groups of patients, in sex, age, disease etc., compare through statistics and there was no significant difference (P > 0.05), have comparability。
Therapeutic Method:
Treatment group: by Radix Rehmanniae Preparata, Herba Cistanches, Fructus Ligustri Lucidi, Semen Raphani, Herba Epimedii, Radix Achyranthis Bidentatae, Radix Clematidis, Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga, Squama Manis, Scorpio, the Radix Stemonae, Radix Puerariae, the Cortex Eucommiae, Fructus Hordei Germinatus, Radix Notoginseng powder, Flos Carthami, Radix Curcumae, Radix Gentianae Macrophyllae, Rhizoma Corydalis according to after constant weight proportioning (adding and subtracting with disease) mixing, the traditionally method decocting system of fried Chinese medicine, first boil with big fire, little fire decocts, spice is stirred 2-3 time when decocting, decocting time is 60～90min, complete to decoct rear elimination medicinal residues, taking liquid。Decocting potion, divided 2 decoction being taken warmly, within 30 days, was a course for the treatment of every day。
Matched group: oral isoniazid tablets, by the body weight oral the highest 0.3g of 5mg/kg. (3) every day；Rifampicin capsules, 0.45g～0.60g on the one, on an empty stomach decoction being taken at a draught, every day is less than 1.2g；Pyrazinamide tablet, every day 15～30mg/kg decoction being taken at a draught, or 50～70mg/kg, 2～3 times weekly；Daily the highest every day 2g, 3 the highest each 3g of person weekly, takes weekly 2 the highest each 4g of person；Streptomycin sheet, 20mg/kg on the one, the next day medication, simultaneously oral vitamin C, every day 2 times, every time a piece of。
Criterion of therapeutical effect:
1. recovery from illness: clinical symptom disappearance, freedom of movement, ulceration person heals。Image: destruction region is contracted to disappearance, bone density recovers normal, and abscess disappears, and follows up a case by regular visits to and does not recur half a year more than。
2. effective: transference cure, limited being obviously improved of taking action, ulceration place healing 2/3。Image: edge is clearer, destruction region just reduces, and bone density gradually recovers, and abscess reduces。
3. effective: symptom takes a turn for the better, limited making moderate progress of taking action, heal less than 1/2 in ulceration place。Image: slight change or maintenance former state。
4. invalid: symptom such as image maintains former state without change。
Efficacy result:
1, Clinical efficacy comparison:
After treatment, treatment group cures 8 examples, effective 12 examples, effective 14 examples, and invalid 5 examples, cure rate is 20.5%, and effective percentage reaches 87.2%；Matched group cures 2 examples, effective 9 examples, effective 16 examples, invalid 12 examples, and cure rate is 5.1%, and effective percentage is 41.0%；Treatment group cure rate and effective percentage are significantly better than that matched group, and two groups of results compare P < 0.05, and difference is statistically significant。Detailed results is in Table 1。
Efficacy result synopsis after 1: two group of case treatment of table
| Group | Number of cases | Cure n (%) | Effective n (%) | Effective n (%) | Invalid n (%) | Total effective rate (%) |
| Treatment group | 39 | 8(20.5) | 12(30.8) | 14(35.9) | 5(12.8) | 87.2 |
| Matched group | 39 | 2(5.1) | 9(23.1) | 16(41.0) | 12(30.8) | 69.2 |
2, side effect is compared
Observing the side reaction in two groups of patient treatment procedure, treatment group does not occur that obvious adverse reaction, matched group have 18 examples to occur that gastrointestinal upset reacts, and does not affect normal therapeutic after taking anti symptom treatment。
It is shown that Chinese medicine preparation of the present invention, it is used for treating thoracic tuberculosis syndrome definite effect, cure rate and effective percentage are high, and toxic and side effects is little, decreases misery and the disability rate of tuberculosis of spine patient, substantially increasing life quality, patient is prone to recover labour force, clinic promotion and application。
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine preparation treating thoracic tuberculosis, chooses 20 grams of Radix Rehmanniae Preparata, Herba Cistanches 10 grams, Fructus Ligustri Lucidi 5 grams, Semen Raphani 10 grams, Herba Epimedii 5 grams, Radix Achyranthis Bidentatae 5 grams, Radix Clematidis 5 grams, 5 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 10 grams, Squama Manis 8 grams, Scorpio 8 grams, the Radix Stemonae 8 grams, Radix Puerariae 8 grams, the Cortex Eucommiae 8 grams, 8 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 8 grams, 10 grams of Flos Carthami, Radix Curcumae 10 grams, Radix Gentianae Macrophyllae 8 grams, Rhizoma Corydalis 10 grams。
Embodiment 2: a kind of Chinese medicine preparation treating thoracic tuberculosis, chooses 22 grams of Radix Rehmanniae Preparata, Herba Cistanches 12 grams, Fructus Ligustri Lucidi 6 grams, Semen Raphani 12 grams, Herba Epimedii 6 grams, Radix Achyranthis Bidentatae 6 grams, Radix Clematidis 6 grams, 6 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 12 grams, Squama Manis 9 grams, Scorpio 9 grams, the Radix Stemonae 9 grams, Radix Puerariae 9 grams, the Cortex Eucommiae 9 grams, 9 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 9 grams, 11 grams of Flos Carthami, Radix Curcumae 11 grams, Radix Gentianae Macrophyllae 9 grams, Rhizoma Corydalis 12 grams。
Embodiment 3: a kind of Chinese medicine preparation treating thoracic tuberculosis, chooses 24 grams of Radix Rehmanniae Preparata, Herba Cistanches 14 grams, Fructus Ligustri Lucidi 7 grams, Semen Raphani 14 grams, Herba Epimedii 7 grams, Radix Achyranthis Bidentatae 7 grams, Radix Clematidis 8 grams, 7 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 14 grams, Squama Manis 11 grams, Scorpio 9 grams, the Radix Stemonae 9 grams, Radix Puerariae 9 grams, the Cortex Eucommiae 8 grams, 8 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 8 grams, 12 grams of Flos Carthami, Radix Curcumae 12 grams, Radix Gentianae Macrophyllae 9 grams, Rhizoma Corydalis 12 grams。
Embodiment 4: a kind of Chinese medicine preparation treating thoracic tuberculosis, chooses 26 grams of Radix Rehmanniae Preparata, Herba Cistanches 16 grams, Fructus Ligustri Lucidi 8 grams, Semen Raphani 16 grams, Herba Epimedii 8 grams, Radix Achyranthis Bidentatae 9 grams, Radix Clematidis 8 grams, 8 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 16 grams, Squama Manis 12 grams, Scorpio 10 grams, the Radix Stemonae 10 grams, Radix Puerariae 11 grams, the Cortex Eucommiae 10 grams, 10 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 11 grams, 13 grams of Flos Carthami, Radix Curcumae 13 grams, Radix Gentianae Macrophyllae 10 grams, Rhizoma Corydalis 13 grams。
Embodiment 5: a kind of Chinese medicine preparation treating thoracic tuberculosis, chooses 28 grams of Radix Rehmanniae Preparata, Herba Cistanches 18 grams, Fructus Ligustri Lucidi 9 grams, Semen Raphani 18 grams, Herba Epimedii 9 grams, Radix Achyranthis Bidentatae 9 grams, Radix Clematidis 9 grams, 9 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 18 grams, Squama Manis 14 grams, Scorpio 11 grams, the Radix Stemonae 11 grams, Radix Puerariae 11 grams, the Cortex Eucommiae 11 grams, 11 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 11 grams, 14 grams of Flos Carthami, Radix Curcumae 14 grams, Radix Gentianae Macrophyllae 11 grams, Rhizoma Corydalis 18 grams。
Embodiment 6: a kind of Chinese medicine preparation treating thoracic tuberculosis, chooses 30 grams of Radix Rehmanniae Preparata, Herba Cistanches 20 grams, Fructus Ligustri Lucidi 10 grams, Semen Raphani 20 grams, Herba Epimedii 10 grams, Radix Achyranthis Bidentatae 10 grams, Radix Clematidis 10 grams, 10 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 20 grams, Squama Manis 15 grams, Scorpio 12 grams, the Radix Stemonae 12 grams, Radix Puerariae 12 grams, the Cortex Eucommiae 12 grams, 12 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 12 grams, 15 grams of Flos Carthami, Radix Curcumae 15 grams, Radix Gentianae Macrophyllae 12 grams, Rhizoma Corydalis 20 grams。
Below by concrete case, the curative effect of medication of the present invention is verified further:
Case 1
Lee, man, 36 years old。Patient starts overall pain occur without obvious inducement the year before, alleviates after lying up；Hypnalgia increases the weight of, and pain can be radiated along spinal nerves, and upper cervical spine emits to rear pillow part, Cervical vertebra emits to shoulder or arm。Examination in hospital finds that certain damage occurs in T3-4 thoracic vertebra, diagnoses as tuberculosis of spine。Taking after hospital opens Drug therapy one month, symptom alleviates。But after drug withdrawal about 1 week, disease recurred, and minimal invasive treatment can not pay no attention to gradually, day by day becomes thin。Recommend to take Drug therapy of the present invention through people, take 22 grams of Radix Rehmanniae Preparata, Herba Cistanches 12 grams, Fructus Ligustri Lucidi 6 grams, Semen Raphani 12 grams, Herba Epimedii 6 grams, Radix Achyranthis Bidentatae 6 grams, Radix Clematidis 6 grams, 6 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 12 grams, Squama Manis 9 grams, Scorpio 9 grams, the Radix Stemonae 9 grams, Radix Puerariae 9 grams, the Cortex Eucommiae 9 grams, 9 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 9 grams, 11 grams of Flos Carthami, Radix Curcumae 11 grams, Radix Gentianae Macrophyllae 9 grams, Rhizoma Corydalis 12 grams, taking after decocting, every day, potion divided sooner or later oral。After treating one month, patient condition is clearly better, and physical distress improves, and heating such as is breathed hard at the transference cure, and lower-limb muscular strength recovers gradually。After continuing to take 2 months, all diseases of patient disappear, and check T3-4 thoracic vertebra pathological changes disappears。Follow up a case by regular visits to half a year without recurrence。
Case 2
Liu, man, 48 years old。Patient did not have the appearance neck back pain of any inducement to check that MRI shows that breast 2-4 tuberculosis of spine is with the other swelling of vertebra, gives antituberculosis therapy, without being clearly better in locality to local hospital before 10 months, breast flank pain increases the weight of, and breast waist, stretches, lateral bending is limited, increases the weight of during walking。Under friend recommendation, take Drug therapy of the present invention, observe patients symptomatic, take 26 grams of Radix Rehmanniae Preparata, Herba Cistanches 16 grams, Fructus Ligustri Lucidi 8 grams, Semen Raphani 16 grams, Herba Epimedii 8 grams, Radix Achyranthis Bidentatae 9 grams, Radix Clematidis 8 grams, 8 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 16 grams, Squama Manis 12 grams, Scorpio 10 grams, the Radix Stemonae 10 grams, Radix Puerariae 11 grams, the Cortex Eucommiae 10 grams, 10 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 11 grams, 13 grams of Flos Carthami, Radix Curcumae 13 grams, Radix Gentianae Macrophyllae 10 grams, Rhizoma Corydalis 13 grams, taking after decocting, every day, potion divided sooner or later oral。After treating one month, patient body pain is improved, and movable function has certain recovery, it is possible to normally walk, and lower-limb muscular strength recovers gradually。After continuing to take 2 months, all diseases of patient disappear, and check breast 2-4 Vertebral body disappears。Follow up a case by regular visits to half a year without recurrence。
Case 3
China certain, female, 40 years old。Patient is approximately in 1 year front left and right without bright inducement generation back pain, in distending pain, twinge, sharp ache, every time outbreak last for several minutes to 1 hour is not etc., in night-time attack, without feeling sick, vomiting, without frequent micturition, dysurea and gross hematuria, check no abnormal to local hospital, give analgesic treatment, without being clearly better, hereafter flank pain shows effect often, find after municipal hospital checks: breast 8～9 tuberculosis of spine companion's cold abscess is formed, because abscess area is bigger, give isoniazid temporarily, rifampicin, ethambutol, pyrazinamide is administered orally, operation after abscess is limited to。Taking medicine more than January, lumbago is alleviated to some extent, but physical symptom improves inconspicuous, owing to patient refuses operative treatment, then recommends to start to take Drug therapy of the present invention through people。Take 30 grams of Radix Rehmanniae Preparata, Herba Cistanches 20 grams, Fructus Ligustri Lucidi 10 grams, Semen Raphani 20 grams, Herba Epimedii 10 grams, Radix Achyranthis Bidentatae 10 grams, Radix Clematidis 10 grams, 10 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 20 grams, Squama Manis 15 grams, Scorpio 12 grams, the Radix Stemonae 12 grams, Radix Puerariae 12 grams, the Cortex Eucommiae 12 grams, 12 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 12 grams, 15 grams of Flos Carthami, Radix Curcumae 15 grams, Radix Gentianae Macrophyllae 12 grams, Rhizoma Corydalis 20 grams, taking after decocting, every day, potion divided sooner or later oral。After treating a course for the treatment of, patient's waist pain is obviously improved, it is possible to stand up voluntarily, and check display thoracic vertebra soldier's line and abscess reduce, and patient's great rejoicing holds on and takes this medicine after two months, and check lesions showed all eliminates, clinical cure。Effect of follow-up visit by telephone has no recurrence half a year。
Claims (7)
1. the Chinese medicine preparation treating thoracic tuberculosis, it is characterised in that described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
20-30 gram of Radix Rehmanniae Preparata, Herba Cistanches 10-20 gram, Fructus Ligustri Lucidi 5-10 gram, Semen Raphani 10-20 gram, Herba Epimedii 5-10 gram, Radix Achyranthis Bidentatae 5-10 gram, Radix Clematidis 5-10 gram, 5-10 gram of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 10-20 gram, Squama Manis 8-15 gram, Scorpio 8-12 gram, Radix Stemonae 8-12 gram, Radix Puerariae 8-12 gram, Cortex Eucommiae 8-12 gram, 8-12 gram of Fructus Hordei Germinatus, Radix Notoginseng powder 8-12 gram, 10-15 gram of Flos Carthami, Radix Curcumae 10-15 gram, Radix Gentianae Macrophyllae 8-12 gram, Rhizoma Corydalis 10-20 gram。
2. Chinese medicine preparation according to claim 1, it is characterised in that described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
20 grams of Radix Rehmanniae Preparata, Herba Cistanches 10 grams, Fructus Ligustri Lucidi 5 grams, Semen Raphani 10 grams, Herba Epimedii 5 grams, Radix Achyranthis Bidentatae 5 grams, Radix Clematidis 5 grams, 5 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 10 grams, Squama Manis 8 grams, Scorpio 8 grams, the Radix Stemonae 8 grams, Radix Puerariae 8 grams, the Cortex Eucommiae 8 grams, 8 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 8 grams, 10 grams of Flos Carthami, Radix Curcumae 10 grams, Radix Gentianae Macrophyllae 8 grams, Rhizoma Corydalis 10 grams。
3. Chinese medicine preparation according to claim 1, it is characterised in that described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
22 grams of Radix Rehmanniae Preparata, Herba Cistanches 12 grams, Fructus Ligustri Lucidi 6 grams, Semen Raphani 12 grams, Herba Epimedii 6 grams, Radix Achyranthis Bidentatae 6 grams, Radix Clematidis 6 grams, 6 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 12 grams, Squama Manis 9 grams, Scorpio 9 grams, the Radix Stemonae 9 grams, Radix Puerariae 9 grams, the Cortex Eucommiae 9 grams, 9 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 9 grams, 11 grams of Flos Carthami, Radix Curcumae 11 grams, Radix Gentianae Macrophyllae 9 grams, Rhizoma Corydalis 12 grams。
4. Chinese medicine preparation according to claim 1, it is characterised in that described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
24 grams of Radix Rehmanniae Preparata, Herba Cistanches 14 grams, Fructus Ligustri Lucidi 7 grams, Semen Raphani 14 grams, Herba Epimedii 7 grams, Radix Achyranthis Bidentatae 7 grams, Radix Clematidis 8 grams, 7 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 14 grams, Squama Manis 11 grams, Scorpio 9 grams, the Radix Stemonae 9 grams, Radix Puerariae 9 grams, the Cortex Eucommiae 8 grams, 8 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 8 grams, 12 grams of Flos Carthami, Radix Curcumae 12 grams, Radix Gentianae Macrophyllae 9 grams, Rhizoma Corydalis 12 grams。
5. Chinese medicine preparation according to claim 1, it is characterised in that described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
26 grams of Radix Rehmanniae Preparata, Herba Cistanches 16 grams, Fructus Ligustri Lucidi 8 grams, Semen Raphani 16 grams, Herba Epimedii 8 grams, Radix Achyranthis Bidentatae 9 grams, Radix Clematidis 8 grams, 8 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 16 grams, Squama Manis 12 grams, Scorpio 10 grams, the Radix Stemonae 10 grams, Radix Puerariae 11 grams, the Cortex Eucommiae 10 grams, 10 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 11 grams, 13 grams of Flos Carthami, Radix Curcumae 13 grams, Radix Gentianae Macrophyllae 10 grams, Rhizoma Corydalis 13 grams。
6. Chinese medicine preparation according to claim 1, it is characterised in that described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
28 grams of Radix Rehmanniae Preparata, Herba Cistanches 18 grams, Fructus Ligustri Lucidi 9 grams, Semen Raphani 18 grams, Herba Epimedii 9 grams, Radix Achyranthis Bidentatae 9 grams, Radix Clematidis 9 grams, 9 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 18 grams, Squama Manis 14 grams, Scorpio 11 grams, the Radix Stemonae 11 grams, Radix Puerariae 11 grams, the Cortex Eucommiae 11 grams, 11 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 11 grams, 14 grams of Flos Carthami, Radix Curcumae 14 grams, Radix Gentianae Macrophyllae 11 grams, Rhizoma Corydalis 18 grams。
7. Chinese medicine preparation according to claim 1, it is characterised in that described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
30 grams of Radix Rehmanniae Preparata, Herba Cistanches 20 grams, Fructus Ligustri Lucidi 10 grams, Semen Raphani 20 grams, Herba Epimedii 10 grams, Radix Achyranthis Bidentatae 10 grams, Radix Clematidis 10 grams, 10 grams of Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 20 grams, Squama Manis 15 grams, Scorpio 12 grams, the Radix Stemonae 12 grams, Radix Puerariae 12 grams, the Cortex Eucommiae 12 grams, 12 grams of Fructus Hordei Germinatus, Radix Notoginseng powder 12 grams, 15 grams of Flos Carthami, Radix Curcumae 15 grams, Radix Gentianae Macrophyllae 12 grams, Rhizoma Corydalis 20 grams。
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| CN105435027A (en) * | 2014-09-20 | 2016-03-30 | 王少朋 | Traditional Chinese medicine composition treating osseous tuberculosis |
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Application publication date: 20160622 |