CN105726354B - A kind of hydrogel mask matrix and preparation method thereof - Google Patents

Abstract

The invention provides a hydrogel facial mask matrix and a preparation method thereof: an aqueous solution of sodium alginate with a mass fraction of 2%, an aqueous solution of sodium glycerophosphate with a mass fraction of 56%, and sodium carboxymethylcellulose with a mass fraction of 5%. The aqueous solution, the polyvinyl alcohol aqueous solution with a mass fraction of 8%, and the chitosan solution with a mass fraction of 2% are uniformly mixed, poured into a mold, solidified in a water bath, and repeatedly frozen and thawed for 2 to 4 times. The matrix raw material components used in the present invention are natural, green and harmless ingredients such as biopolymers with excellent biocompatibility and skin affinity, which are safe and harmless to the human body, ensuring that the mask matrix is non-sensitizing, and the prepared The matrix material has the characteristics of uniformity, good gloss, and beautiful jade texture; and the surface viscosity and mechanical strength are suitable, the film-forming property and stretchability meet the requirements, and the peeling integrity is good.

Description

A kind of hydrogel facial mask matrix and preparation method thereof

technical field

The invention relates to a gel base for facial application, in particular to a hydrogel mask base and a preparation method thereof.

Background technique

As a facial application product, facial mask has a higher content of functional ingredients than daily skin care products, and can solve skin problems to a certain extent. Therefore, the application of facial mask is becoming more and more common. The mask uses the short time covered on the face to temporarily isolate the outside air and pollution, increase the temperature of the skin and expand pores, promote the secretion and metabolism of sweat glands, and increase the oxygen content of the skin. The moisture in the mask penetrates into the stratum corneum of the skin to make it soft and increase elasticity; the sticky ingredients or powdery adsorbent in the mask can adhere to the dirt, metabolic waste and excess oil on the skin surface and pores, and Get it out of the way. At present, the main forms of commercially available facial masks can be divided into tear-off facial masks, mud cream facial masks, cream facial masks, gel facial masks and stick-type facial masks according to the dosage form, among which the most popular is the stick-type facial mask. The stick-on mask overcomes the shortcomings of other types of masks, and has the advantages of being easy to use, cleaning without tearing, and being able to quickly remove all of it. The stick-on mask contains a mask base material and a functional liquid. The mask base material acts as a medium to absorb the functional liquid, and can be fixed on a specific position on the face to form a closed layer to promote the absorption of the functional liquid. Non-woven fabrics or related fibers are often woven into cloth sheets as matrix materials for stick-type masks. Related fibers include silk, concept invisible silk, pure cotton fiber, viscose fiber, tencel and bamboo charcoal fiber. This type of matrix material has the problems of small absorption of essence, insufficient water retention capacity, poor skin fit, and easy waste of cosmetic active ingredients.

As the matrix of the mask, hydrogel retains water in the form of a three-dimensional network space. It has the characteristics of large absorption of essence and good water retention, and the beauty ingredients are not easy to lose. At the same time, the hydrogel structure has good elasticity and certain viscosity. Adhesive, easy to adhere to the skin; the hydrogel is smooth and cool after application, with excellent skin affinity and comfort. Whitening and anti-aging functional ingredients are added to the hydrogel matrix to make a variety of functional facial masks. However, there are problems such as insufficient physical strength; because the hydrogel itself is smooth, the adhesion is low; some components in the hydrogel formulation also have possible potential hazards, such as the chemical cross-linking agent glutaraldehyde.

Contents of the invention

The object of the present invention is to provide a hydrogel facial mask matrix and a preparation method thereof.

To achieve the above object, the present invention adopts the following technical solutions:

A hydrogel facial mask matrix, the hydrogel facial mask matrix is made of the following raw materials: a penetration enhancer, a 2% sodium alginate aqueous solution with a mass fraction of 56% sodium glycerophosphate aqueous solution, and a mass fraction of 5% % carboxymethylcellulose sodium aqueous solution, mass fraction of 8% polyvinyl alcohol aqueous solution and mass fraction of 2% chitosan solution; according to parts by volume, the sodium alginate aqueous solution is 1 to 5 parts, the The sodium glycerophosphate aqueous solution is 1 to 5 parts, the carboxymethylcellulose sodium aqueous solution is 1 to 10 parts, the polyvinyl alcohol aqueous solution is 6 to 30 parts, and the chitosan solution is 1 to 5 parts; The consumption of described penetration enhancer is described sodium alginate aqueous solution, described sodium glycerophosphate aqueous solution, described sodium carboxymethylcellulose aqueous solution, described polyvinyl alcohol aqueous solution and described chitosan solution total mass 0～ 3%; the solvent used in the chitosan solution is 0.5-1% (volume fraction) acetic acid or hydrochloric acid aqueous solution.

Preferably, the sodium alginate aqueous solution is 1 to 3 parts, the sodium glycerophosphate aqueous solution is 2 to 5 parts, the carboxymethylcellulose sodium aqueous solution is 2.5 to 7.5 parts, and the polyvinyl alcohol aqueous solution is 15 parts ～30 parts, the chitosan solution is 2～5 parts.

Preferably, the amount of the penetration enhancer is the total mass of the sodium alginate aqueous solution, the sodium glycerophosphate aqueous solution, the sodium carboxymethylcellulose aqueous solution, the polyvinyl alcohol aqueous solution and the chitosan solution 0.1 to 3% of the total.

Preferably, the deacetylation degree of the chitosan is 80-95%.

Preferably, the polyvinyl alcohol is selected from PVA 1750±50.

Preferably, the penetration enhancer is selected from any one of azone, lecithin, lauryl alcohol, amino acids, menthol, and ethanol.

The preparation method of above-mentioned hydrogel facial mask matrix, comprises the following steps:

1) Add the sodium glycerophosphate aqueous solution to the sodium alginate aqueous solution under the condition of ice bath and stirring, continue to stir for 5-50 minutes until the mixture is uniform, and then add the sodium carboxymethylcellulose aqueous solution and penetration enhancer , and continue to stir for 5-50 minutes until the mixture is uniform, and the mixture A is obtained;

2) Add the polyvinyl alcohol aqueous solution to the chitosan solution under stirring conditions in an ice bath, and continue stirring for 5 to 50 minutes until the mixture is evenly mixed to obtain a mixed solution B;

3) Add the mixed solution B into the mixed solution A under the conditions of ice bath and stirring, and continue to stir for 5-50 minutes until the mixture is evenly mixed to obtain the mixed solution C;

4) Pour the mixed solution C into the mold, then place the mold in a 30-80°C water bath to solidify the mixed solution C in a water bath, and freeze and thaw repeatedly 2-4 times after solidification to obtain a hydrogel mask matrix.

The curing time in the water bath is 10-60 minutes.

The specific steps of freezing and thawing are as follows: after the mixed solution C is solidified, the mold is frozen at -10 to -50° C. for 5 to 20 hours, and then thawed at room temperature.

The beneficial effects of the present invention are reflected in:

The matrix raw material components used in the present invention are natural, green and harmless components such as biopolymers with excellent biocompatibility and skin affinity, which are safe and harmless to human body, ensuring that the mask matrix is non-sensitizing. At the same time, through the designed raw material formula and dosage ratio, combined with the preparation process of water bath solidification and repeated freezing and thawing, the prepared matrix material has uniformity, good gloss, and beautiful jade texture; and the surface viscosity and mechanical strength are suitable. Membrane and stretchability meet the requirements, and the peeling integrity is good.

Detailed ways

The present invention will be described in detail below in conjunction with the embodiments.

Example 1

Add 50mL of sodium glycerophosphate (GP) aqueous solution with a mass fraction of 56% to 25mL of a 2% sodium alginate (SA) aqueous solution in an ice bath with stirring, and continue stirring for 30 minutes to make it evenly mixed, and then add a mass fraction of 75mL of 5% carboxymethylcellulose sodium (CMC-Na) aqueous solution and 3g of azone were stirred for 30 minutes to make them evenly mixed to obtain a mixed solution A, which was set aside. Add 300 mL of an 8% mass fraction of polyvinyl alcohol (PVA 1750 ± 50) aqueous solution to a 50 mL mass fraction of 2% chitosan (CS, with a degree of deacetylation of 80 to 95%) under stirring conditions in an ice bath, and continue Stir for 30 minutes to make it evenly mixed to obtain the mixed liquid B, which is set aside. The solvent that described chitosan solution adopts is 1% (mL/mL) hydrochloric acid aqueous solution, and azone consumption accounts for 0.5% of the total mass of five kinds of solutions of SA, GP, CMC-Na, CS, PVA.

Under the condition of ice bath and stirring, add the mixed solution B to the mixed solution A dropwise, and continue to stir for 30 minutes after the dropwise addition, so that it is fully mixed and uniform, and the mixed solution C is obtained. Pour the mixed solution C into a mold (such as a glass petri dish) with a thickness of 1-2mm, and place it in a water bath at 45°C for 30 minutes to solidify. After solidification, place the mold at –50°C for 10 hours, take it out and thaw it at room temperature ( 30min～60min), repeated freezing and thawing twice to obtain a white hydrogel, that is, the hydrogel mask matrix.

Example 2

Add 50 mL of GP aqueous solution with a mass fraction of 56% to 30 mL of a 2% SA aqueous solution in an ice bath with stirring, and continue stirring for 30 minutes to make it evenly mixed, then add 50 mL of a 5% CMC-Na aqueous solution and 5 g Menthol, continue to stir 30min, make it to mix uniformly, get mixed solution A, for subsequent use. Add 200mL of an 8% mass fraction of PVA (PVA 1750±50) aqueous solution to 50mL of a mass fraction of 2% CS (80-95%) solution in an ice bath with stirring, and continue stirring for 30min to mix Evenly, the mixture B is obtained and set aside. The solvent that described chitosan solution adopts is 0.5% (mL/mL) acetic acid aqueous solution, and menthol consumption accounts for 1% of the gross mass of five kinds of solutions of SA, GP, CMC-Na, CS, PVA.

Under the condition of ice bath and stirring, add the mixed solution B to the mixed solution A dropwise, and continue to stir for 30 minutes after the dropwise addition, so that it is fully mixed and uniform, and the mixed solution C is obtained. Pour the mixed solution C into a mold (such as a glass petri dish) with a thickness of 1-2mm, and place it in a water bath at 50°C for 30 minutes to solidify. After solidification, place the mold at –30°C for 12 hours, take it out and thaw it at room temperature ( 30min～60min), repeated freezing and thawing three times to obtain a white hydrogel, that is, the hydrogel mask matrix.

Example 3

Add 50 mL of GP aqueous solution with a mass fraction of 56% to 25 mL of a 2% SA aqueous solution in an ice bath with stirring, and continue stirring for 30 minutes to make it evenly mixed, then add 25 mL of a 5% CMC-Na aqueous solution and 2 g Lecithin, continue to stir for 30min, make it mix evenly, get mixed solution A, set aside. Add 150mL of 8% mass fraction of PVA (PVA 1750±50) aqueous solution to 50mL of 2% mass fraction of CS (deacetylation degree is 80-95%) solution under ice bath and stirring condition, and continue to stir for 30min to make it mix Evenly, the mixture B is obtained and set aside. The solvent that described chitosan solution adopts is 1% (mL/mL) hydrochloric acid aqueous solution, and lecithin consumption accounts for 0.7% of the total mass of five kinds of solutions of SA, GP, CMC-Na, CS, PVA.

Under the condition of ice bath and stirring, add the mixed solution B to the mixed solution A dropwise, and continue to stir for 30 minutes after the dropwise addition, so that it is fully mixed and uniform, and the mixed solution C is obtained. Pour the mixed solution C into a mold (such as a glass petri dish) with a thickness of 1-2 mm, and place it in a water bath at 60°C for 15 minutes to solidify. After solidification, place the mold at –20°C for 20 hours, take it out and thaw it at room temperature ( 30min～60min), repeated freezing and thawing three times to obtain a white hydrogel, that is, the hydrogel mask matrix.

Example 4

Add 20 mL of GP aqueous solution with a mass fraction of 56% to 10 mL of a 2% SA aqueous solution in an ice bath with stirring, and continue stirring for 30 min to make it evenly mixed, then add 30 mL of a 5% CMC-Na aqueous solution, and continue Stir for 30 minutes to make it evenly mixed to obtain the mixed solution A, which is set aside. Add 160mL of an 8% mass fraction of PVA (PVA 1750±50) aqueous solution to 20mL of a 2% mass fraction of CS (80-95% deacetylation) solution in an ice bath with stirring, and continue stirring for 30 minutes to mix Evenly, the mixture B is obtained and set aside. The solvent that described chitosan solution adopts is 0.5% (mL/mL) acetic acid aqueous solution.

Under the condition of ice bath and stirring, add the mixed solution B to the mixed solution A dropwise, and continue to stir for 30 minutes after the dropwise addition, so that it is fully mixed and uniform, and the mixed solution C is obtained. Pour the mixed solution C into a mold (such as a glass petri dish) with a thickness of 1-2mm, and place it in a water bath at 40°C for 40 minutes to solidify. After solidification, place the mold at –20°C for 20 hours, take it out and thaw it at room temperature ( 30min～60min), repeated freezing and thawing twice to obtain a white hydrogel, that is, the hydrogel mask matrix.

For the above example:

1. PVA has an effect on the formation and adhesion of hydrogel matrix. The higher the PVA content, the more viscous the obtained hydrogel is, but at the same time, the more the tear-off residue is, and a small amount adheres to the glass, which is difficult to remove. CMC-Na has an effect on gel film formation. Increasing the ratio of CMC-Na will enhance the film-forming properties of the gel and enhance the stretchability of the film. When the amount of CMC-Na added increases to a certain extent, the effect of the gel will be affected, and wrinkles will appear on the surface. SA has an effect on the adhesion of the hydrogel matrix. The addition of SA will improve the adhesion of the hydrogel and play a role in increasing the viscosity, but with the increase of the amount, white flocs appear in the system, and the curing strength of the hydrogel matrix decreases due to the poor uniformity of the system. In addition, factors such as peeling integrity of the hydrogel matrix also need to be considered. Therefore, the dosages of SA, PVA, CMC-Na, etc. in the above examples are preferred values determined by comprehensively considering the above factors.

2. In the present invention, the hydrogel is prepared by heating and solidifying and then repeatedly freezing and thawing. On the one hand, it is beneficial to the effective water retention of the hydrogel matrix; Low, and then through freezing and thawing to promote the formation of ordered structures of polymer segments in some micro-domains in the hydrogel matrix, improve the crystallinity of the hydrogel matrix, thereby improving the mechanical strength of the hydrogel.

3. The hydrogel matrix prepared by the present invention has the characteristics of uniformity, good gloss, beautiful jade texture, suitable surface viscosity and mechanical strength, satisfactory film-forming and stretchability, and good peeling integrity. It has obvious moisturizing effect when attached to the skin, and it only needs to be peeled off when it is removed, without any discomfort on the skin.

Claims (9)

1. A hydrogel facial mask matrix, characterized in that: the hydrogel facial mask matrix is made of the following raw materials: a penetration enhancer, a massfraction of 2% sodium alginate aqueous solution, a massfraction of 56% sodium glycerophosphate Aqueous solution, mass fraction are 5% sodium carboxymethyl cellulose aqueous solution, mass fraction are 8% polyvinyl alcohol aqueous solution and mass fraction are 2% chitosan solution; According to volume fraction, described sodium alginate aqueous solution is 1 to 5 parts, the sodium glycerophosphate aqueous solution is 1 to 5 parts, the sodium carboxymethylcellulose aqueous solution is 1 to 10 parts, the polyvinyl alcohol aqueous solution is 15 to 30 parts, the chitosan solution 1 to 5 parts; the amount of the penetration enhancer is the sodium alginate aqueous solution, the sodium glycerophosphate aqueous solution, the carboxymethylcellulose sodium aqueous solution, the polyvinyl alcohol aqueous solution and the chitosan 0-3% of the total mass of the solution; the solvent used in the chitosan solution is 0.5-1% acetic acid or hydrochloric acid aqueous solution. 2. A kind of hydrogel mask matrix according to claim 1, characterized in that: the sodium alginate aqueous solution is 1 to 3 parts, the sodium glycerophosphate aqueous solution is 2 to 5 parts, and the carboxymethyl fiber The plain sodium aqueous solution is 2.5-7.5 parts, the polyvinyl alcohol aqueous solution is 15-30 parts, and the chitosan solution is 2-5 parts. 3. a kind of hydrogel mask matrix according to claim 1, is characterized in that: the consumption of described penetration enhancer is described sodium alginate aqueous solution, described sodium glycerophosphate aqueous solution, described sodium carboxymethyl cellulose 0.1-3% of the total mass of the aqueous solution, the polyvinyl alcohol aqueous solution and the chitosan solution. 4. A hydrogel facial mask matrix according to claim 1, characterized in that: the degree of deacetylation of the chitosan is 80-95%. 5. A kind of hydrogel mask matrix according to claim 1, characterized in that: said polyvinyl alcohol is selected from PVA1750±50. 6. a kind of hydrogel facial mask matrix according to claim 1, is characterized in that: described permeation enhancer is selected from any one in azone, lecithin, lauryl alcohol, amino acid, menthol, ethanol. 7. a preparation method of hydrogel facial mask matrix as claimed in claim 1, is characterized in that: comprise the following steps: 1) Add the sodium glycerophosphate aqueous solution, the sodium carboxymethylcellulose aqueous solution and a penetration enhancer to the sodium alginate aqueous solution under ice bath and stirring conditions, and continue to stir until the mixture is evenly mixed to obtain a mixed solution A; 2) Add the polyvinyl alcohol aqueous solution to the chitosan solution under stirring conditions in an ice bath, and continue to stir until the mixture is evenly mixed to obtain a mixed solution B; 3) Add the mixed solution B into the mixed solution A under the conditions of ice bath and stirring, and continue to stir until the mixture is evenly mixed to obtain the mixed solution C; 4) Pour the mixed solution C into the mold, then place the mold in a 30-80°C water bath to solidify the mixed solution C in a water bath, and freeze and thaw repeatedly 2-4 times after solidification to obtain a hydrogel mask matrix. 8. The method according to claim 7, characterized in that: the curing time in the water bath is 10-60 minutes. 9. The method according to claim 7, characterized in that: the specific step of freezing and thawing is: freezing the mold at -10 to -50°C for 5 to 20 hours, and then thawing at room temperature.