CN105794792A - Bactericidal composition containing fluxapyroxad and oxadixyl and application of bactericidal composition - Google Patents

Abstract

The invention discloses a bactericidal composition containing flufenpyroxad and oxadaxyl and application thereof. The bactericidal composition uses flufenapyroxad and oxadaxyl as main active ingredients, wherein the mass ratio of flufenapyroxad to oxafaxyl is 1-70:1-50. The bactericidal composition can be applied to the prevention and treatment of cereals, fruit trees, and vegetable diseases, has a high synergistic effect, overcomes and delays the drug resistance of pathogens, has fast sterilization speed, long-lasting effect, reduces application costs, and has good control effect. Significantly better than its single dose use. The invention can be used to prevent and control fungal diseases on crops, especially fungal diseases such as sheath blight, gray mold, cucumber downy mildew and potato late blight, and the effect is significantly better than that of a single dose.

Description

A bactericidal composition containing flufenpyroxad and oxaxyl and its application

Technical field:

The invention relates to a bactericidal composition and its application, in particular to a bactericidal composition with flufenapyramide and oxaxyl as main active ingredients and its application.

Background technique

Fluxapyroxad, chemical formula: C ₁₈ H ₁₂ F ₅ N ₃ O, chemical name: 3-(difluoromethyl)-1-methyl-N-(3',4',5'-tri Fluorobiphenyl-2-yl)pyrazole-4-carboxamide.

Flufenapyramide belongs to the formamide fungicides and is a succinate dehydrogenase inhibitor. It is a broad-spectrum fungicide with excellent therapeutic and systemic activity. It is effective against various crop sheath blight and gray mold All have good control effects.

Oxadixyl, molecular formula: C ₁₄ H ₁₈ N ₂ O ₄ , chemical name: 2-methoxy-N-(2-oxo-1,3-oxazolidin-3-′yl)acetamide- N-(2',6'-Dimethylbenzene). Structural formula:

Oxafaxyl is a systemic fungicide with protective and therapeutic effects, long-lasting effect, and good activity against pathogenic bacteria of the order Peronospora.

At present, the prevention and control of plant pathogens is becoming more and more difficult. On the one hand, with the change of planting structure, the planting area of economic crops such as melons, fruits and vegetables has gradually expanded, and the degree and number of diseases have increased, making the prevention and control more difficult. On the other hand, the resistance of pathogenic bacteria is increasing year by year under the continuous pressure of agent selection, the control effect of single agent is greatly reduced, and the control of plant diseases is facing a major challenge.

Invention content:

The purpose of the present invention is to provide a plant fungicidal composition containing flufenpyroxystrobin and oxaxyl, which has a wide application range, low cost and good effect in view of the above technical problems.

Another object of the present invention is to provide the application of the fungicidal composition in the prevention and treatment of fungal diseases caused by plant fungi, especially in the prevention and treatment of fungal diseases such as sheath blight, gray mold, cucumber downy mildew and potato late blight.

The purpose of the present invention is to realize through the following technical solutions:

A bactericidal composition containing flufenapyroxad and oxafaxyl, the bactericidal composition uses flufenapyroxad and oxafaxyl as main active ingredients, wherein the mass ratio of flufenapyroxad to oxafaxyl is 1-70 : 1-50, wherein the effective ingredients in the bactericidal composition are present in the composition in a synergistically effective amount.

The bactericidal composition, wherein the mass ratio of flufenapyroxad and oxadaxyl is preferably 1-50: 1-50, more preferably 1-20: 6-50, even more preferably 1-20: 20- 50.

The preferred mass ratio of flufenapyroxad and oxaxyl can also be: 70:1, 50:1, 30:1, 20:1, 10:1, 5:1, 2.5:1, 1:1, 1 :2, 1:4, 1:6, 1:10, 1:20, 1:30, 1:50.

In the composition of the present invention, flufenapyroxad and oxadaxyl account for 2-80% by weight of the composition. Preferably 5 to 70%.

The bactericidal composition, in which flufenapyroxad and oxadaxyl are used as main active ingredients and known adjuvants and excipients are compounded into any dosage form allowed on pesticides. These known auxiliary agents and excipients include dispersants, diffusing agents, defoamers, wetting agents, disintegrating agents, etc. Calcium dodecylbenzenesulfonate, alkylphenol polyoxyethylene ether, benzyl Base phenol polyoxyethylene ether, phenethylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether and similar products, fatty amine polyoxyethylene ether, fatty acid ethylene oxide adduct, polyoxyethylene polyoxypropylene Block compounds, castor oil polyoxyethylene ether, nonylphenol polyoxyethylene ether, Tween series, fatty alcohol polyoxyethylene ether, polyethylene glycol series, sulfonates, carboxylates, sulfates, phosphates , phosphite, lignosulfonate, xanthan gum, phenol formaldehyde condensate, ammonium salt, quaternary ammonium salt type, etc., excipients include cyclohexanone, xylene, various solvents Oil, water, antifreeze (such as propylene glycol), deionized water, etc. The above auxiliaries, excipients and other auxiliary materials can be used alone or in combination.

The dosage form of the bactericidal composition is emulsifiable concentrate, wettable powder, suspension, water emulsion or water dispersible granule.

Application of the above-mentioned fungicidal composition in the preparation of medicines for preventing and controlling plant fungal diseases. Especially the application in the prevention and control of diseases of cereals, fruit trees and vegetable crops has remarkable effects.

In the above application, the plant fungal disease is at least one of sheath blight, gray mold, cucumber downy mildew, and potato late blight.

The characteristics of the bactericidal composition of the present invention:

1. The flufenapyroxad and oxaxyl used in the present invention have different mechanisms of action, and mixing with each other will not cause low sensitivity, and can synergize, reduce dosage and cost.

2. The scope of application of the composition of the present invention is increased, and it is suitable for preventing and treating resistant fungal diseases of cereals, fruit trees, and vegetables, especially for preventing and controlling sheath blight, gray mold, cucumber downy mildew, and potato late blight. . The bactericidal composition of the present invention has good control effects on fungal diseases such as Ascomycetes, Basidiomycetes, and Deuteromycetes; and inhibits the generation of resistance of pests or fungi to a single agent (either flufenapyroxam or oxaxaxyl) . The fungicidal composition of the present invention can produce higher synergistic effect, and the dosage of the mixture is much lower than that of the individual active compounds, that is, the activity of the mixture is greater than that of the individual components.

Compared with the prior art, the present invention has the beneficial effects: (1) Compared with a single agent, the composition has obvious effects on fungal diseases such as sheath blight, gray mold, cucumber downy mildew, potato late blight, etc. The synergistic effect overcomes and delays drug resistance, expands the control spectrum, and significantly improves the control effect; (2) reduces the cost of control labor and medication; (3) can replace conventional and easily resistant pesticides; (4) and Compared with a single agent, the cost of production and use is reduced; (5) the effect of inhibiting fungal drug resistance is obviously higher than that of a single agent.

detailed description

The present invention will be further described below in conjunction with the examples. The preparation methods of the dosage forms in the examples are all conventional methods, and the "%" mentioned in the present invention are all mass percentages.

Indoor Biotest:

The mycelial growth rate method was used in the room to measure the EC ₅₀ value of different agents on the strains, and the co-toxicity coefficient (CTC) of the mixture was calculated by the calculation method of the co-toxicity coefficient to determine the synergy of the mixture. The specific calculation method is as follows :

Using a single agent in the mixture as the standard drug (usually choose the one with the lower EC ₅₀ ), do the calculation:

Single-dose toxicity index = standard drug EC ₅₀ / certain single-dose EC ₅₀ × 100

Theoretical toxicity index = toxicity index of single agent A × proportion of single agent A in the mixture + toxicity index of single agent B × proportion of single agent B in the mixture

Measured toxicity index = EC ₅₀ value of standard single agent/EC ₅₀ value of mixture × 100

Co-toxicity coefficient = measured toxicity index / theoretical toxicity index × 100

Grading of co-toxicity coefficient: when CTC is greater than 120, the mixture has synergistic effect, when CTC is less than 80, it is antagonistic, and when CTC is between 80-120, it is additive.

According to the active ingredient flufenapyroxad (A): oxaxyl (B) mass ratio is: 80:1, 70:1, 50:1, 30:1, 20:1, 10:1, 5:1, 2.5: 1, 1: 1, 1: 2, 1: 4, 1: 6, 1: 10, 1: 20, 1: 30, 1: 50, 1: 60 were tested to determine their effect on cucumber downy mildew ( Co-toxicity coefficient of Pseudoperonosporacubensis (Berk. et Curt.) Rostov.).

Table 1: Indoor bioassay results of flufenapyroxad + oxaxyl in different ratios against cucumber downy mildew

potion Virulence regression equation EC50(mg/L) co-toxicity coefficient 25% Flufenapyr SC Y=4.020+1.202X 6.532 - 25% Oxaxyl EC Y=3.672+2.356X 3.660 - A:B＝80:1 Y=3.932+1.247X 7.190 89.98 A:B=70:1 Y＝4.846+0.287X 3.451 187.20 A:B=50:1 Y=3.604+2.365X 3.892 165.29 A:B=30:1 Y=3.903+1.547X 5.117 124.51 A:B=20:1 Y=3.585+2.365X 3.965 158.79 A:B=10:1 Y=4.175+1.634X 3.197 190.69 A:B=5:1 Y=3.739+2.301X 3.532 163.53 A:B＝2.5:1 Y=4.232+1.547X 3.135 170.18 A:B=1:1 Y=3.681+2.932X 2.817 166.53 A:B=1:2 Y=3.193+3.596X 3.181 134.82 A:B=1:4 Y=1.896+3.233X 3.148 127.49 A:B=1:6 Y=3.901+2.546X 2.702 144.56 A:B=1:10 Y=4.910+0.217X 2.601 146.59 A:B=1:20 Y=3.281+4.578X 2.374 157.49 A:B=1:30 Y=4.034+2.650X 2.314 160.44 A:B=1:50 Y=4.460+1.556X 2.225 165.93 A:B=1:60 Y=3.401+2.559X 4.214 87.49

Field efficacy test:

The test of controlling cucumber downy mildew with the pesticide preparation that above-mentioned embodiment makes.

1. Test treatment: In this test, three treatment concentrations were set according to the different components. The control chemicals were single doses of pesticides, 25% flufenapyramide SC and 25% oxaxyl EC, and blank water test.

2. Test method The area of each plot is 66.7m ² , repeated 3 times; the method of investigation before spraying and after control is as follows: 5 points are randomly sampled in the test treatment area, and the disease is classified according to the relevant standards of national field tests , to calculate the prevention effect. The test results are shown in Table 2:

Table 2 field test effect

The results of indoor bioassay and field drug efficacy show that the composition of flufenapyroxad and oxaxyl has obvious synergistic effect, and the control effect of the composition is excellent, and the control effect is better than that of single-dose varieties. Value.

The two active compounds can be processed into any permissible dosage form. The preparations processed by the two active ingredients are described below with specific examples, but the preparations that can be processed by the two active ingredients are not limited to the following list.

Example 1: 15% flufenapyroxalaxyl wettable powder (1:2)

Fluxapyroxad 5g, oxaxyl 10g, detergent LS (sodium p-methoxy fatty acid aminobenzene sulfonate) 2g, diffusing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon black 5g , kaolin was added to 100g of the mixture for jet milling to prepare a wettable powder with an active ingredient mass percentage of 15% flufenapyroxazyl.

Example 2: 15% flufenapyroxalaxyl wettable powder (1:4)

Add 3 g of flufenapyramide, 12 g of oxaxyl, 3 g of sodium lauryl sulfate, 4 g of diffusing agent NNO, 5 g of white carbon black, and kaolin to 100 g of the mixture for jet milling to obtain 15% mass percent of flufenazole Amide · oxadaxyl wettable powder.

Example 3: 14% flufenapyroxalaxyl wettable powder (1:6)

Add 2 g of flufenapyroxam, 12 g of oxaxaxyl, 3 g of sodium lauryl sulfate, 4 g of diffusing agent, 5 g of white carbon black, and kaolin to 100 g of the mixture and carry out jet milling to obtain 14% mass percent of flufenazole Amide · oxadaxyl wettable powder.

Example 4: 20% flufenapyroxalaxyl suspension concentrate (1:1)

Weigh 10g flufenapyramide, 10g oxaxyl, lignin 2g, polyoxyethylene polyoxypropylene ether and its sulfate 4g, xanthan gum 0.15g, ethylene glycol 5g, siloxane 0.10g, silicic acid Magnesium aluminum 0.5g, make up to 100g with water, under the action of sand mill, make the active ingredient mass percent is 20% flufenapyroxadexyl suspension concentrate.

Example 5: 55% Flufenapyr·Oxadaxyl Water Emulsion (1:10)

Weigh 5g of flufenapyramide, 50g of oxadaxyl, 3g of phenylethylphenol polyoxyethylene ether phosphate, 2g of Nongru 33#, 1g of alkylphenol polyoxyethylene ether, 13g of solvent oil, and add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing water-based emulsions and mix at high speed to prepare a water-based emulsion with a mass percentage of 55% flufenapyroxazyl. Example 6: 42% flufenapyroxamaxyl emulsifiable oil (1:20)

Weigh 2 g of flufenapyroxad, 40 g of oxaxyl, 8 g of calcium dodecylbenzenesulfonate, 5 g of phenethylphenol polyoxyethylene ether, and mineral spirits to 100 g. The above raw materials were put into a mixing kettle according to the conventional method for preparing cream and mixed to prepare a 42% flufenapyroxam·oxaxaxyl cream with a mass percentage of active ingredients.

Example 7: 70% Flufenapyr·Oxafaxyl EC (2.5:1)

Weigh 50 g of flufenapyramide, 20 g of oxaxyl, 5 g of calcium dodecylbenzenesulfonate, 2 g of phenethylphenol polyoxyethylene ether, 2 g of castor oil polyoxyethylene ether, and mineral spirits to 100 g. Put the above raw materials into a mixing kettle according to the conventional method for preparing cream, and mix them to prepare a 70% mass percent of flufenapyroxazyl-oxaxyl cream.

Example 8: 18% Flufenapyr·Oxadaxyl Water-dispersible Granules (5:1)

Weigh 15g of flufenapyramide, 3g of oxaxyl, 8g of sodium lignosulfonate, 2g of sodium lauryl sulfate, 5g of ammonium sulfate, 5g of polyvinyl alcohol, 2g of borax, and 28g of diatomaceous earth to make up to 100g. The water-dispersible granule with an active ingredient mass percentage of 17% flufenapyroxadaxyl is prepared according to the water-dispersible granule method.

Example 9: 11% flufenapyroxamaxyl emulsifiable oil (10:1)

Weigh 10 g of flufenapyramide, 1 g of oxadaxyl, 6 g of calcium dodecylbenzenesulfonate, 7 g of phenethylphenol polyoxyethylene ether, and mineral spirits to 100 g. Put the above raw materials into a mixing kettle according to the conventional method for preparing cream, and mix them to prepare the cream with 11% flufenapyroxad·oxaxaxyl by mass percentage as the active ingredient.

Example 10: 32% flufenapyroxazyl microemulsion (20:1)

Weigh 30g of flufenapyramide, 2g of oxaxyl, 6g of calcium dodecylbenzenesulfonate, 3g of phenylethylphenol polyoxyethylene ether phosphate, 2g of agricultural milk 33#, 1g of alkylphenol polyoxyethylene ether, Isopropanol 10g, add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing microemulsions, and mix them to prepare a microemulsion with an active ingredient mass percentage of 32% flufenapyroxazyl.

Example 11: 31% Flufenapyr·Oxafaxyl EC (30:1)

Weigh 30 g of flufenapyroxad, 1 g of oxaxyl, 4 g of calcium dodecylbenzenesulfonate, 4 g of phenethylphenol polyoxyethylene ether, and mineral spirits to 100 g. Put the above raw materials into a mixing kettle according to the conventional method for preparing cream, and mix them to prepare a 31% flufenapyroxam·oxaxaxyl cream with an active ingredient mass percentage.

Example 12: 51% flufenapyroxalaxyl suspension concentrate (50:1)

Weigh 50g of flufenapyramide, 1g of oxaxyl, 2g of lignin, 4g of polyoxyethylene polyoxypropylene ether and its sulfate, 0.15g of xanthan gum, 5g of ethylene glycol, 0.10g of siloxane, silicic acid Magnesium aluminum 0.5g, make up to 100g with water, under the action of sand mill, make the active ingredient mass percent is 51% flufenapyroxadexyl suspension concentrate.

Example 13: 32% Flufenapyr·oxaxyl microemulsion (1:15)

Weigh 2g of flufenapyramide, 30g of oxaxyl, 6g of calcium dodecylbenzenesulfonate, 3g of phenylethylphenol polyoxyethylene ether phosphate, 2g of agricultural milk 33#, 1g of alkylphenol polyoxyethylene ether, Isopropanol 10g, add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing microemulsions, and mix them to prepare a microemulsion with an active ingredient mass percentage of 32% flufenapyroxazyl.

Example 14: 6% flufenapyroxazyl water emulsion (1:5)

Weigh 1g of flufenapyramide, 5g of oxadaxyl, 3g of phenylethylphenol polyoxyethylene ether phosphate, 2g of Nongru 33#, 1g of alkylphenol polyoxyethylene ether, 13g of solvent oil, and add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing water-based emulsions and mix at high speed to prepare a water-based emulsion with a mass percentage of 6% flufenapyroxazyl.

Example 15: 62% flufenapyroxamaxyl microemulsion (1:30)

Weigh 2g of flufenapyramide, 60g of oxaxyl, 6g of calcium dodecylbenzenesulfonate, 3g of phenylethylphenol polyoxyethylene ether phosphate, 2g of agricultural milk 33#, 1g of alkylphenol polyoxyethylene ether, Isopropanol 10g, add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing microemulsions, and mix them to prepare a microemulsion with an active ingredient mass percentage of 62% flufenapyroxad·oxadaxyl.

Example 16: 51% flufenapyroxalaxyl suspension concentrate (1:50)

Weigh 1g flufenapyramide, 50g oxaxyl, 2g lignin, 4g polyoxyethylene polyoxypropylene ether and its sulfate, 0.15g xanthan gum, 5g ethylene glycol, 0.10g siloxane, silicic acid Magnesium aluminum 0.5g, make up to 100g with water, under the action of sand mill, make the active ingredient mass percent is 51% flufenapyroxadexyl suspension concentrate.

Example 17: 7% flufenapyroxazyl water-dispersible granules (1:2.5)

Weigh 2g of flufenapyramide, 5g of oxaxaxyl, 8g of sodium lignosulfonate, 2g of sodium lauryl sulfate, 5g of ammonium sulfate, 5g of polyvinyl alcohol, 2g of borax, 3g of white carbon black, and diatomaceous earth to make up to 100g , the above raw materials are made into water-dispersible granules with an active ingredient mass percentage of 7% flufenapyroxadyl oxadaxyl according to the water-dispersible granule method.

Claims (10)

1. A bactericidal composition containing flufenapyroxad and oxafaxyl, characterized in that the bactericidal composition uses flufenapyroxad and oxafaxyl as main active ingredients, wherein the quality of flufenapyroxad and oxafaxyl The ratio is 1-70:1-50. 2. The fungicidal composition according to claim 1, characterized in that the mass ratio of flufenapyramide to oxaxyl is 1-50:1-50. 3. The fungicidal composition according to claim 2, characterized in that the mass ratio of flufenapyroxad to oxaxyl is 1-20:6-50. 4. The fungicidal composition according to claim 3, characterized in that the mass ratio of flufenapyroxad to oxaxyl is 1-20:20-50. 5 . The fungicidal composition according to claim 1 , characterized in that the mass percentage of flufenapyroxad and oxaxyl in the composition is 2-80%. 6 . The bactericidal composition according to claim 5 , characterized in that the mass percentage of flufenapyroxad and oxaxyl in the composition is 5-70%. 7. The fungicidal composition according to claim 1, characterized in that flufenapyroxad and oxadaxyl are used as the main active ingredients and pesticide adjuvants and excipients are formulated into any dosage form allowed on pesticides. 8. The bactericidal composition according to claim 7, characterized in that the dosage form is emulsifiable concentrate, suspension concentrate, water emulsion, wettable powder or water dispersible granule. 9. the application of the bactericidal composition described in claim 1 in the preparation of the medicine for preventing and treating fungal diseases of plants. 10. The application according to claim 9, characterized in that the plant fungal disease is at least one of sheath blight, gray mold, cucumber downy mildew, and potato late blight.