CN106164283A - 制备台勾霉素的方法 - Google Patents

制备台勾霉素的方法 Download PDF

Info

Publication number: CN106164283A
Authority: CN; China
Prior art keywords: dried; solvent; water; methanol; tcm
Prior art date: 2013-12-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN201480068786.9A

Other languages

English (en)

Chinese (zh)

Inventor

艾斯本·佛里德约夫·汉森

哈佛·克里姆斯代尔

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Xellia Pharmaceuticals ApS

Original Assignee

Xellia Pharmaceuticals ApS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-12-20

Filing date

2014-12-18

Publication date

2016-11-23

2014-12-18 Application filed by Xellia Pharmaceuticals ApS filed Critical Xellia Pharmaceuticals ApS

2016-11-23 Publication of CN106164283A publication Critical patent/CN106164283A/zh

Status Pending legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 28
230000001580 bacterial effect Effects 0.000 claims abstract description 9
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 84
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 49
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 34
239000002904 solvent Substances 0.000 claims description 30
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 24
238000000855 fermentation Methods 0.000 claims description 19
230000004151 fermentation Effects 0.000 claims description 19
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
238000000638 solvent extraction Methods 0.000 claims description 7
239000000463 material Substances 0.000 claims description 6
239000011347 resin Substances 0.000 claims description 6
229920005989 resin Polymers 0.000 claims description 6
239000000284 extract Substances 0.000 claims description 5
239000003463 adsorbent Substances 0.000 claims description 4
101100313763 Arabidopsis thaliana TIM22-2 gene Proteins 0.000 claims description 3
150000002148 esters Chemical class 0.000 claims description 3
150000002576 ketones Chemical class 0.000 claims description 3
239000001963 growth medium Substances 0.000 claims 3
238000011210 chromatographic step Methods 0.000 claims 2
239000002609 medium Substances 0.000 claims 1
241001495437 Dactylosporangium Species 0.000 abstract description 14
238000000605 extraction Methods 0.000 abstract description 11
241000187844 Actinoplanes Species 0.000 abstract description 4
239000000843 powder Substances 0.000 abstract description 3
239000000047 product Substances 0.000 description 15
239000000203 mixture Substances 0.000 description 12
239000003960 organic solvent Substances 0.000 description 12
239000003125 aqueous solvent Substances 0.000 description 11
239000000243 solution Substances 0.000 description 9
239000007864 aqueous solution Substances 0.000 description 8
238000004108 freeze drying Methods 0.000 description 8
239000002002 slurry Substances 0.000 description 8
239000006228 supernatant Substances 0.000 description 8
238000005119 centrifugation Methods 0.000 description 7
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
238000001035 drying Methods 0.000 description 6
238000004128 high performance liquid chromatography Methods 0.000 description 6
238000001694 spray drying Methods 0.000 description 5
125000004432 carbon atom Chemical group C* 0.000 description 4
239000002184 metal Substances 0.000 description 4
239000007788 liquid Substances 0.000 description 3
ZVGNESXIJDCBKN-UUEYKCAUSA-N fidaxomicin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@H]([C@H]1O)OC)OCC\1=C/C=C/C[C@H](O)/C(C)=C/[C@@H]([C@H](/C(C)=C/C(/C)=C/C[C@H](OC/1=O)[C@@H](C)O)O[C@H]1[C@H]([C@@H](O)[C@H](OC(=O)C(C)C)C(C)(C)O1)O)CC)C(=O)C1=C(O)C(Cl)=C(O)C(Cl)=C1CC ZVGNESXIJDCBKN-UUEYKCAUSA-N 0.000 description 2
229960000628 fidaxomicin Drugs 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 2
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
238000003756 stirring Methods 0.000 description 2
241000183229 Actinoplanes deccanensis Species 0.000 description 1
238000013019 agitation Methods 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
238000009835 boiling Methods 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
230000001186 cumulative effect Effects 0.000 description 1
230000006837 decompression Effects 0.000 description 1
RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
150000002194 fatty esters Chemical class 0.000 description 1
239000012530 fluid Substances 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000011031 large-scale manufacturing process Methods 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000001223 reverse osmosis Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000004448 titration Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/265—Adsorption chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Exposure Of Semiconductors, Excluding Electron Or Ion Beam Exposure (AREA)
Medicines Containing Plant Substances (AREA)

CN201480068786.9A 2013-12-20 2014-12-18 制备台勾霉素的方法 Pending CN106164283A (zh)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
NO20131718		2013-12-20
NO20131718		2013-12-20
PCT/EP2014/078552 WO2015091851A1 (en)	2013-12-20	2014-12-18	Process for the preparation of tiacumicin

Publications (1)

Publication Number	Publication Date
CN106164283A true CN106164283A (zh)	2016-11-23

Family

ID=52273125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN201480068786.9A Pending CN106164283A (zh)	2013-12-20	2014-12-18	制备台勾霉素的方法

Country Status (16)

Country	Link
US (1)	US20160319318A1 (da)
EP (1)	EP3083976B1 (da)
JP (1)	JP6709731B2 (da)
KR (1)	KR102355450B1 (da)
CN (1)	CN106164283A (da)
AU (1)	AU2014368566B2 (da)
BR (1)	BR112016013582B1 (da)
CA (1)	CA2931596C (da)
DK (1)	DK3083976T3 (da)
ES (1)	ES2813823T3 (da)
HR (1)	HRP20201363T1 (da)
IL (1)	IL246188B (da)
PL (1)	PL3083976T3 (da)
RU (1)	RU2016128553A (da)
SI (1)	SI3083976T1 (da)
WO (1)	WO2015091851A1 (da)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4918174A (en) *	1986-09-26	1990-04-17	Abbott Laboratories	Tiacumicin compounds
WO1997036996A2 (en) *	1996-03-28	1997-10-09	Gist-Brocades B.V.	Process for the preparation of a granular microbial biomass and isolation of valuable compounds therefrom
WO2002006203A1 (en) *	2000-07-14	2002-01-24	Dsm N.V.	Process for the recovery of shikimic acid
CN100519757C (zh) *	2002-07-29	2009-07-29	浩鼎生技公司	台勾霉素的制备
EP2647643A2 (en) *	2012-04-05	2013-10-09	OLON S.p.A.	Procedure for the purification of tiacumicin B

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE328104T1 (de) *	1996-03-28	2006-06-15	Dsm Ip Assets Bv	Mikrobielles polyungesättigte fettsäure enthaltendes öl und verfahren zur herstellung eines öls aus pasteurisierter und granulierter biomasse

2014
- 2014-12-18 HR HRP20201363TT patent/HRP20201363T1/hr unknown
- 2014-12-18 DK DK14821152.7T patent/DK3083976T3/da active
- 2014-12-18 JP JP2016541236A patent/JP6709731B2/ja active Active
- 2014-12-18 CN CN201480068786.9A patent/CN106164283A/zh active Pending
- 2014-12-18 CA CA2931596A patent/CA2931596C/en active Active
- 2014-12-18 BR BR112016013582-2A patent/BR112016013582B1/pt active IP Right Grant
- 2014-12-18 EP EP14821152.7A patent/EP3083976B1/en active Active
- 2014-12-18 US US15/104,604 patent/US20160319318A1/en not_active Abandoned
- 2014-12-18 ES ES14821152T patent/ES2813823T3/es active Active
- 2014-12-18 AU AU2014368566A patent/AU2014368566B2/en active Active
- 2014-12-18 KR KR1020167019650A patent/KR102355450B1/ko active Active
- 2014-12-18 RU RU2016128553A patent/RU2016128553A/ru unknown
- 2014-12-18 PL PL14821152T patent/PL3083976T3/pl unknown
- 2014-12-18 WO PCT/EP2014/078552 patent/WO2015091851A1/en not_active Ceased
- 2014-12-18 SI SI201431649T patent/SI3083976T1/sl unknown
2016
- 2016-06-13 IL IL246188A patent/IL246188B/en active IP Right Grant

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4918174A (en) *	1986-09-26	1990-04-17	Abbott Laboratories	Tiacumicin compounds
WO1997036996A2 (en) *	1996-03-28	1997-10-09	Gist-Brocades B.V.	Process for the preparation of a granular microbial biomass and isolation of valuable compounds therefrom
WO2002006203A1 (en) *	2000-07-14	2002-01-24	Dsm N.V.	Process for the recovery of shikimic acid
CN100519757C (zh) *	2002-07-29	2009-07-29	浩鼎生技公司	台勾霉素的制备
EP2647643A2 (en) *	2012-04-05	2013-10-09	OLON S.p.A.	Procedure for the purification of tiacumicin B

Also Published As

Publication number	Publication date
WO2015091851A1 (en)	2015-06-25
ES2813823T3 (es)	2021-03-25
DK3083976T3 (da)	2020-09-07
AU2014368566A1 (en)	2016-06-16
AU2014368566B2 (en)	2018-05-17
HRP20201363T1 (hr)	2020-12-25
KR102355450B1 (ko)	2022-01-24
BR112016013582A2 (da)	2017-08-08
CA2931596C (en)	2023-03-28
SI3083976T1 (sl)	2020-10-30
JP2017501707A (ja)	2017-01-19
PL3083976T3 (pl)	2020-11-16
KR20160099098A (ko)	2016-08-19
IL246188A0 (en)	2016-07-31
RU2016128553A (ru)	2018-01-25
EP3083976A1 (en)	2016-10-26
BR112016013582B1 (pt)	2022-04-19
EP3083976B1 (en)	2020-07-15
IL246188B (en)	2021-02-28
CA2931596A1 (en)	2015-06-25
US20160319318A1 (en)	2016-11-03
JP6709731B2 (ja)	2020-06-17

Legal Events

Date	Code	Title	Description
2016-11-23	C06	Publication
2016-11-23	PB01	Publication
2016-12-21	C10	Entry into substantive examination
2016-12-21	SE01	Entry into force of request for substantive examination
2020-07-03	RJ01	Rejection of invention patent application after publication
2020-07-03	RJ01	Rejection of invention patent application after publication	Application publication date: 20161123

Publication	Publication Date	Title
EP0459564A2 (en)	1991-12-04	Process for reduction of echinocandin type cyclohexapeptide compounds
US20170260394A1 (en)	2017-09-14	A new process for producing gardenia blue pigment
CN107141335A (zh)	2017-09-08	一种环肽化合物及其制备方法和应用
CN106164283A (zh)	2016-11-23	制备台勾霉素的方法
CN104387396B (zh)	2016-08-24	源于米曲霉的吲哚萜speradine E及应用
CN104370917B (zh)	2016-08-24	源于米曲霉的吲哚萜speradine H及应用
CN101367716A (zh)	2009-02-18	一类炭壳菌聚酮及其制法和用途
CN102633793B (zh)	2014-06-04	从吐根中提取分离盐酸吐根碱和盐酸吐根酚碱的一种制备方法
JP2011050350A (ja)	2011-03-17	エルゴチオネインの製造方法
CN104370916B (zh)	2016-08-24	源于米曲霉的吲哚萜speradine B及应用
CN102452916B (zh)	2013-10-09	一类芳香聚酮及其提取方法和应用
CN121575062B (zh)	2026-04-24	一种促进长松萝内生真菌YAFEF048产Hypothemycin的方法
CN116747550B (zh)	2025-11-11	一种优质鸡胆膏的制备方法
CN101921815B (zh)	2011-10-05	链霉菌获得黄酮类化合物的方法
KR101273071B1 (ko)	2013-06-10	넓패 유래 신규 화합물 및 이의 제조방법
CN105330722A (zh)	2016-02-17	系列广谱抗菌肽的制备、纯化、鉴定及其用途
JP2015120655A (ja)	2015-07-02	プロアントシアニジンおよびその製造方法
KR101158503B1 (ko)	2012-06-20	포몹시스 롱지콜라로부터 분리한 신규 화합물 및 그의 제조방법
CN103145716B (zh)	2016-03-30	桑黄菌中环二肽c6的高压反相制备分离技术
CN103524600A (zh)	2014-01-22	新环脂肽抗生素罗克霉素（locillomycin）A、B、C及其制造方法
CN105111267A (zh)	2015-12-02	一种灵芝醇b的制备方法
CN104211630B (zh)	2016-05-04	一种源于桔绿木霉的生物碱类化合物及其应用
CN103282371A (zh)	2013-09-04	纯化的心肌生成素异构体及相关方法
WO2012011619A1 (ko)	2012-01-26	마황으로부터 에페드린을 고수율로 분리하는 방법 및 에페드린을 유효 성분으로 하는 면역증강보조제
CN110563575A (zh)	2019-12-13	一种利用巨大芽孢杆菌分离提取苯乙酸的方法