CN106901866A - Compound dural patch for preventing adhesion and preparation method thereof - Google Patents
Compound dural patch for preventing adhesion and preparation method thereof Download PDFInfo
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- CN106901866A CN106901866A CN201510974426.1A CN201510974426A CN106901866A CN 106901866 A CN106901866 A CN 106901866A CN 201510974426 A CN201510974426 A CN 201510974426A CN 106901866 A CN106901866 A CN 106901866A
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- compound
- preventing adhesion
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- dural patch
- functional layer
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000010410 layer Substances 0.000 claims abstract description 35
- 239000002346 layers by function Substances 0.000 claims abstract description 23
- 239000002121 nanofiber Substances 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 12
- 238000004132 cross linking Methods 0.000 claims abstract description 11
- 239000012528 membrane Substances 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims description 19
- 239000002131 composite material Substances 0.000 claims description 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 8
- 238000010041 electrostatic spinning Methods 0.000 claims description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- -1 shitosan Polymers 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- 108010022355 Fibroins Proteins 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 238000000071 blow moulding Methods 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 238000007334 copolymerization reaction Methods 0.000 claims description 2
- 238000007766 curtain coating Methods 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 229920001610 polycaprolactone Polymers 0.000 claims description 2
- 239000004632 polycaprolactone Substances 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 2
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 claims 1
- 241000790917 Dioxys <bee> Species 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 238000009987 spinning Methods 0.000 abstract description 5
- 210000004027 cell Anatomy 0.000 abstract description 4
- 230000010261 cell growth Effects 0.000 abstract description 3
- 238000010276 construction Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 230000007547 defect Effects 0.000 description 5
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 239000000835 fiber Substances 0.000 description 5
- 241001269524 Dura Species 0.000 description 4
- 238000007731 hot pressing Methods 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 210000005013 brain tissue Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- QGHDLJAZIIFENW-UHFFFAOYSA-N 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxy-3-prop-2-enylphenyl)propan-2-yl]-2-prop-2-enylphenol Chemical group C1=C(CC=C)C(O)=CC=C1C(C(F)(F)F)(C(F)(F)F)C1=CC=C(O)C(CC=C)=C1 QGHDLJAZIIFENW-UHFFFAOYSA-N 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 210000001951 dura mater Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of compound dural patch for preventing adhesion and preparation method thereof, including antiblocking layers and functional layer, wherein, described antiblocking layers are the cerebripetal one layer of dense film in face, described functional layer is the cerebripetal one layer of nano fibrous membrane of the back of the body, and described antiblocking layers are compound by crosslinking method with described functional layer.Present invention also offers its preparation method.Compound dural patch for preventing adhesion of the invention and preparation method thereof, cerebripetal one layer of face is designed for dense film, and surface is smooth, can more be prevented adhesion with respect to other spinning or establishment class product, effectively prevents cerebrospinal fluid seepage；Cerebripetal one layer is carried on the back for nanofiber functional layer, is favorably adhered to cell, promote cell growth, accelerate endocranium reparation；And dense film is compound with the crosslinking of nanofiber functional layer, its preventing adhesiving effect more preferably, can more prevent the problem of seepage, very with practical value.
Description
Technical field
The present invention relates to field of medical materials, more particularly to a kind of compound dural patch for preventing adhesion and preparation method thereof.
Background technology
Dura defect is one of neurosurgery common disease, lies in wound, tumour, cranial vascular disease, other nervous system diseases more
Disease etc. is needed caused by operation of opening cranium.Dura defect need to be repaired in time in case cerebrospinal fluid seepage and extraneous compressing, can otherwise draw
The complication, entail dangers to human life when serious such as hair intracranial infection, brain adhesion, hypohydropses.
Current duramater reparation class material mainly has nonabsorable material, the major class of absorbable material two.Nonabsorable material, implantation
After can forever retain in vivo, as foreign matter, local organization inflammation and infection can be caused after inserting.Absorbable material then can be by
Absorption of human body, the more sticking patch class absorbable material of current clinical practice is animal derived material and medical macromolecular materials, animal
Property material in source cannot completely avoid the antigen of immunological rejection, residual from causing different degrees of inflammatory reaction, cause fibre modification and
Brain adhesion, easily produces stimulation to brain tissue.
Now, medical high polymer class material, by its excellent biocompatibility and the security of degraded, increasing application
In product technology in dura defect neoplasty but current, also there is many defects, such as a certain proportion of cerebrospinal fluid oozes
Leakage, cerebripetal one layer of face is not yet in effect prevents adhesion.In existing patent, though the selection for passing through different materials, possesses certain anti-
Adhesion function, but it prevents adhesion and the effect of anti-cerebrospinal fluid seepage is extremely limited.
So, a kind of compound dural patch for preventing adhesion and preparation method thereof is that very have practical value.
The content of the invention
The invention aims to provide a kind of compound dural patch for preventing adhesion and preparation method thereof.
To achieve these goals, one aspect of the present invention provides a kind of compound dural patch for preventing adhesion, it is characterised in that
Including antiblocking layers and functional layer, wherein, described antiblocking layers are the cerebripetal one layer of dense film in face, and described functional layer is
Cerebripetal one layer of nano fibrous membrane is carried on the back, described antiblocking layers are compound by crosslinking method with described functional layer.
It is preferred that described antiblocking layers thickness is 0.01~0.1mm.
It is preferred that described functional layer thickness is 0.1~0.5mm.
It is preferred that the nanofiber diameter of the described nano fibrous membrane of composition is 100nm~500nm, aperture is
50nm~200nm.
Another aspect of the present invention provides a kind of preparation method of the above-mentioned compound dural patch for preventing adhesion, it is characterised in that bag
Include following steps：
Step (1)：Using medical macromolecular materials under solution or molten condition film forming, obtain dense film；
Step (2)：Separately take medical macromolecular materials to be dissolved in solvent, obtain electrostatic spinning raw material solution, electrostatic spinning obtains nanometer
Tunica fibrosa, composite membrane is compounded to form after described dense film and described nano fibrous membrane cross-linking reaction；
Step (3)：By described composite membrane using hot-forming after the treatment of two-way heat stretching process, cut by drying, obtained
Described compound dural patch.
It is preferred that described medical macromolecular materials be PLA, polyvinyl alcohol, polyethylene glycol, polycaprolactone, polyurethane,
One or more blending or copolymerization in shitosan, cellulose, silk-fibroin, hyaluronic acid are formed.
It is preferred that described solvent is acetone, tetrahydrofuran, dimethyl sulfoxide (DMSO), dichloromethane, chloroform, hexafluoro isopropyl
One or more mixture in alcohol, Isosorbide-5-Nitrae dioxane.
It is preferred that in step (3), the parameter of two-way heat stretching process is：40~100 DEG C of temperature, extensibility is 10%~60%.
It is preferred that in step (3), hot-forming parameter is：40~100 DEG C of temperature, 0.1~10Mpa of pressure.
It is preferred that using curtain coating or blow molding process film forming in step (1).
Compound dural patch for preventing adhesion of the invention and preparation method thereof, cerebripetal one layer of face is designed for dense film, surface
It is smooth, can more be prevented adhesion with respect to other spinning or establishment class product, effectively prevent cerebrospinal fluid seepage；Cerebripetal one layer is carried on the back to receive
Rice fiber functional layer, favorably adheres to cell, promotes cell growth, accelerates endocranium reparation；And dense film and nanofiber work(
Ergosphere crosslinking is compound, and its preventing adhesiving effect more preferably, can more prevent the problem of seepage.And in its processing technology, composite patch is created
The two-way heat stretching process of use of new property, by the PROCESS FOR TREATMENT, sticking patch is more soft, and layers of nanofibers is more fluffy, is more beneficial for
Cell attached；By the hot-pressing processing under certain temperature and pressure, effectively prevent the fibre shedding of layers of nanofibers, sticking patch outward appearance is more
Neatly, more security.Its preparation method is simple, very with practical value.
Brief description of the drawings
Fig. 1 is the structure chart of compound dural patch prevented adhesion in the embodiment of the present invention 1.
Specific embodiment
In order to be more clearly understood that technology contents of the invention, specific implementation method of the invention is described further below.
Embodiment 1
Fig. 1 is the structure of dural patch in the present embodiment, as shown in figure 1, the dural patch is by functional layer 1 and antiblocking layers 2
Composition.Functional layer 1 is nano fibrous membrane, and antiblocking layers 2 are dense film.
(1) dense film is prepared：Selection polyethylene glycol modified polylactide, polyethylene glycol ratio 20%, as copolymerized macromolecule raw material,
Weight average molecular weight 200,000, is dissolved in ethyl acetate, and ultrasonic vibration, by filtering, is proportionally added into reeded polytetrafluoroethylene (PTFE)
On plate, casting film-forming is put into vacuum drying chamber, is vacuum dried 24h, the soft dense film of 0.03mm thickness is obtained, also
It is antiblocking layers 2.
(2) composite construction is prepared：Prepare electrostatic spinning raw material solution：Selection shitosan, PLA ratio 50：50, it is dissolved in hexafluoro
In isopropanol, ultrasonic vibration, filtering are stand-by.
Above-mentioned solution is added in device for spinning infusing device, regulation injection pump rate 10ml/h；High pressure generator voltage 20KV,
Reception device negative pressure 5KV, starts electrostatic spinning, the functional layer 1 being made up of nanofiber is obtained, by functional layer 1 and antiblocking layers
2 crosslinkings, are obtained with antiblocking layers 2 as substrate, and the thickness of functional layer 1 is the crosslinking composite construction of 0.2mm.Wherein nanofiber
Average diameter 200nm, average pore size 150nm.
By above-mentioned composite construction, it is fixed on the fixture of constant temperature stretching device, temperature 50 C, extensibility 30% carries out hot-stretch,
It is subsequently placed in hot-forming, temperature 45 C under minute surface hot-pressing roller；
Compound film sheet after shaping is the dural patch of the standby function that prevents adhesion of fixture by dry, cutting, sterilizing.
Embodiment 2
(1) dense film is prepared：Selection caprolactone modification PLA, caprolactone ratio 15%, as copolymerized macromolecule raw material, weight
Average molecular weight 200,000, heats Blown Film, and the soft dense film of 0.02mm thickness is obtained.
(2) composite construction is prepared：Prepare electrostatic spinning raw material solution：Selection PLA, PEG6000 ratios 70：30 are dissolved in trichlorine
In methane, ultrasonic vibration, filtering are stand-by.
Above-mentioned solution is added in device for spinning infusing device, regulation injection pump rate 10ml/h；High pressure generator voltage 22KV,
Reception device negative pressure 5KV, starts electrostatic spinning, and functional layer is obtained, and functional layer and antiblocking layers are crosslinked, and is obtained to prevent adhesion
Layer is substrate, and functional layer thickness is the crosslinking composite construction of 0.2mm.Wherein nanofiber average diameter 200nm, average pore size
150nm。
Above-mentioned composite construction is fixed on the fixture of constant temperature stretching device, 80 DEG C of temperature, extensibility 20% carries out hot-stretch,
It is subsequently placed in hot-forming, 100 DEG C of temperature under minute surface hot-pressing roller；
Compound film sheet after shaping is the dural patch of the standby function that prevents adhesion of fixture by dry, cutting, sterilizing.
Embodiment 3
Rabbit animal experiment is carried out with dural patch obtained in embodiment 1,2
Then selection healthy rabbits, artificial manufacturing department point dura defect under general anesthesia state is implanted into dural patch and implements repairing,
Suture is fixed.It is postoperative that routine feeding and routine observation are implemented to animal.Postoperative 6 months, tissue specimen is extracted by standard requirement,
Prepare case section.Material obvious degradation, has very small amount to remain, and collagenous fibres increase, and interface has slight cyst wall to be formed；Art
December, cutting tissue sample, remain without material afterwards, and endocranium healing is good, and rarely seen suture vestige, brain tissue is normal, invariably
Good reaction.
Compound dural patch for preventing adhesion of the invention and preparation method thereof, cerebripetal one layer of face is designed for dense film, surface
It is smooth, can more be prevented adhesion with respect to other spinning or establishment class product, effectively prevent cerebrospinal fluid seepage；Cerebripetal one layer is carried on the back to receive
Rice fiber functional layer, favorably adheres to cell, promotes cell growth, accelerates endocranium reparation；And dense film and nanofiber work(
Ergosphere crosslinking is compound, and its preventing adhesiving effect more preferably, can more prevent the problem of seepage.And in processing technology, composite patch is innovated
Property the two-way heat stretching process of use, by the PROCESS FOR TREATMENT, sticking patch is more soft, and layers of nanofibers is more fluffy, is more beneficial for thin
Born of the same parents attached；By the hot-pressing processing under certain temperature and pressure, effectively prevent the fibre shedding of layers of nanofibers, sticking patch outward appearance is more whole
It is clean, more security.Its preparation method is simple, very with practical value.
In this description, the present invention is described with reference to its specific embodiment.But it is clear that can still make various
Modification and conversion are without departing from the spirit and scope of the present invention.Therefore, specification is regarded in an illustrative, rather than a restrictive.
Claims (10)
1. a kind of compound dural patch for preventing adhesion, it is characterised in that including antiblocking layers and functional layer, wherein, it is described
Antiblocking layers are the cerebripetal one layer of dense film in face, and described functional layer is the cerebripetal one layer of nano fibrous membrane of the back of the body, and described is anti-
Adhering layer is compound by crosslinking method with described functional layer.
2. the compound dural patch for preventing adhesion according to claim 1, it is characterised in that described antiblocking layers thickness
It is 0.01~0.1mm.
3. the compound dural patch for preventing adhesion according to claim 1, it is characterised in that described functional layer thickness is
0.1~0.5mm.
4. the compound dural patch for preventing adhesion according to claim 1, it is characterised in that the described nanofiber of composition
The nanofiber diameter of film is 100nm~500nm, and aperture is 50nm~200nm.
5. a kind of preparation method of the compound dural patch for preventing adhesion according to claim 1, it is characterised in that including
Following steps：
Step (1)：Using medical macromolecular materials under solution or molten condition film forming, obtain dense film；
Step (2)：Separately take medical macromolecular materials to be dissolved in solvent, obtain electrostatic spinning raw material solution, electrostatic spinning obtains nanometer
Tunica fibrosa, composite membrane is compounded to form after described dense film and described nano fibrous membrane cross-linking reaction；
Step (3)：By described composite membrane using hot-forming after the treatment of two-way heat stretching process, cut by drying, obtained
Described compound dural patch.
6. the preparation method of the compound dural patch for preventing adhesion according to claim 5, it is characterised in that wherein, institute
The medical macromolecular materials stated be PLA, polyvinyl alcohol, polyethylene glycol, polycaprolactone, polyurethane, shitosan, cellulose,
One or more blending or copolymerization in silk-fibroin, hyaluronic acid are formed.
7. the preparation method of the compound dural patch for preventing adhesion according to claim 5, it is characterised in that wherein, institute
The solvent stated is acetone, tetrahydrofuran, dimethyl sulfoxide (DMSO), dichloromethane, chloroform, hexafluoroisopropanol, Isosorbide-5-Nitrae dioxy six
One or more mixture in ring.
8. the preparation method of the compound dural patch for preventing adhesion according to claim 5, it is characterised in that step (3)
In, the parameter of two-way heat stretching process is：40~100 DEG C of temperature, extensibility is 10%~60%.
9. the preparation method of the compound dural patch for preventing adhesion according to claim 5, it is characterised in that step (3)
In, hot-forming parameter is：40~100 DEG C of temperature, 0.1~10Mpa of pressure.
10. the preparation method of the compound dural patch for preventing adhesion according to claim 5, it is characterised in that step (1)
It is middle to use curtain coating or blow molding process film forming.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510974426.1A CN106901866A (en) | 2015-12-22 | 2015-12-22 | Compound dural patch for preventing adhesion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510974426.1A CN106901866A (en) | 2015-12-22 | 2015-12-22 | Compound dural patch for preventing adhesion and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106901866A true CN106901866A (en) | 2017-06-30 |
Family
ID=59200042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510974426.1A Pending CN106901866A (en) | 2015-12-22 | 2015-12-22 | Compound dural patch for preventing adhesion and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106901866A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108852484A (en) * | 2018-03-23 | 2018-11-23 | 山东省千佛山医院 | Bone window protective device and preparation method after a kind of 3D printing skull decompressive craniectomy |
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| CN114887119A (en) * | 2022-05-09 | 2022-08-12 | 浙江大学医学院附属第一医院 | High-molecular artificial dura mater with anti-infection capacity and preparation method thereof |
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| CN110755173A (en) * | 2018-07-27 | 2020-02-07 | 陕西佰傲再生医学有限公司 | Antibacterial anti-seepage dura mater repairing piece and preparation method thereof |
| CN109984857A (en) * | 2019-04-10 | 2019-07-09 | 华中科技大学同济医学院附属协和医院 | Establishment method and application of a precise animal model of peritoneal adhesion |
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| CN113713186A (en) * | 2021-09-24 | 2021-11-30 | 孟国路 | Surgical anti-adhesion sealing sheet |
| CN114887119A (en) * | 2022-05-09 | 2022-08-12 | 浙江大学医学院附属第一医院 | High-molecular artificial dura mater with anti-infection capacity and preparation method thereof |
| CN119818723A (en) * | 2025-01-07 | 2025-04-15 | 西安蝾螈生物技术有限公司 | Degradable anti-adhesion artificial synthetic dura mater patch and preparation method thereof |
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