CN106922708A - Compositions of the picarbutrazox with succinate dehydrogenase inhibitors series bactericidal agent and its preparation and application - Google Patents

Compositions of the picarbutrazox with succinate dehydrogenase inhibitors series bactericidal agent and its preparation and application Download PDF

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Publication number
CN106922708A
CN106922708A CN201511015593.XA CN201511015593A CN106922708A CN 106922708 A CN106922708 A CN 106922708A CN 201511015593 A CN201511015593 A CN 201511015593A CN 106922708 A CN106922708 A CN 106922708A
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China
Prior art keywords
acid
picarbutrazox
agent
preparation
bactericidal composition
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Inventor
徐群辉
郭世俭
范坤成
曹小燕
刘文静
李俊
毛晨蕾
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ZHEJIANG XINNONG CHEMICAL CO Ltd
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ZHEJIANG XINNONG CHEMICAL CO Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A01N37/22—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A01N37/22—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides
    • A01N37/24—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides containing at least one oxygen or sulfur atom being directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
    • A01N43/32—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention belongs to agriculture field, it is related to Fungicidal active compound composition, more particularly to comprising picarbutrazox and succinate dehydrogenase inhibitors class（SDHIs）The composition and its preparation of bactericide and application.A kind of bactericidal composition, said composition includes Fungicidal active compound I and Fungicidal active compound II, and the Fungicidal active compound I is picarbutrazox, and the Fungicidal active compound II is succinate dehydrogenase inhibitors class（SDHIs）Bactericide.The characteristics of microbicide compositions of the invention have wide preventing and treating spectrum, no interactions resistance, can significantly reduce the usage amount and access times of SDHI, delaying drug resistance.The present invention also provides the preparation of above-mentioned bactericidal composition, devises the formulation method for being suitable for said composition, and energy high degree plays the effect of medicament, reduces medicament usage amount.The present invention also provides the application of above-mentioned bactericidal composition and preparation, to instruct correctly taking drugs, reduces medicament and abuses abuse.

Description

Compositions of the picarbutrazox with succinate dehydrogenase inhibitors series bactericidal agent and its preparation and application
Technical field
The invention belongs to agriculture field, it is related to Fungicidal active compound composition, more particularly to comprising picarbutrazox and amber The composition of amber dehydrogenase inhibitor series bactericidal agent and its preparation and application.
Background technology
Succinate dehydrogenase inhibitors class (SDHIs) bactericide is by acting on the complexⅱ in respiratory chain i.e. succinate dehydrogenase Compound (succinate dehydrogenase；), SDH iron-sulfur protein in enzymatic activity domain SDHB is specifically interrupted Structure iron-sulfur cluster [3Fe-4S] in Ip, so as to influence the breathing of disease fungus, hinders its energy to the electron transmission between ubiquinone Amount metabolism, suppresses the growth of pathogen, causes it dead, so as to reach sterilized purpose.The series bactericidal agent has effect special, The characteristics of strong drug action, persistent, but its action site is single, is also easy to produce resistance.With widely using for the series bactericidal agent, Its resistance problem is also increasingly highlighted, as the bottleneck that the series bactericidal agent is used.Therefore by SDHI bactericide and other mechanism of action not Together, the medicament mixture of no interactions resistance, for protecting the medicament, delays drug-fast generation significant.
Picarbutrazox is the carbamate fungicide of Tso Tat Co., Ltd., Japan's exploitation, code name NF-171, in 2013 Year is open, has preferable prevention effect to downy mildew and epidemic disease.
Therefore, selection picarbutrazox and SDHIs antimicrobial combinations forms built agent, not only with reducing dosage, prolong The slow drug-fast generation of germ, the service life of extension medicament, meeting the economic benefit controlled the medicine of agricultural production one more, and having Significantly reduce environmental pollution, the social benefit for reducing labour, reducing agricultural production difficulty.
The content of the invention
Multiple diseases can not be simultaneously prevented and treated currently invention addresses the resistance prevention of SDHI bactericide, and single Fungicidal active compound Problem, through many experiments, suitable medicament is selected from existing SDHI bactericide, is compounded with picarbutrazox.This First purpose of invention there is provided a kind of bactericidal composition, and there is the bactericidal composition preventing and treating to compose the wide, spy of no interactions resistance Point, can significantly reduce the usage amount and access times of SDHI, delaying drug resistance.Second object of the present invention is to provide above-mentioned sterilization The preparation of composition, devises the formulation method for being suitable for said composition, and energy high degree plays the effect of medicament, reduces medicament Usage amount.3rd purpose is to provide the application of above-mentioned bactericidal composition and preparation, to instruct correctly taking drugs, reduces medicament and abuses Abuse.
In order to realize first above-mentioned purpose, present invention employs following technical scheme：
A kind of bactericidal composition, said composition includes Fungicidal active compound I and Fungicidal active compound II, the bactericidal activity Chemical compounds I is picarbutrazox,
The Fungicidal active compound II is selected from SDHI bactericide
1. flutolanil (flutolanil) (being known in CN101637162),
2. Boscalid (boscalid) (being known in CN101304658),
3. fluopyram (fluopyram) (being known in CN102348381),
4. isopyrazam (isopyrazam) (being known in CN103858886),
5. fluorine azoles ring bacterium amine (sedaxane) (being known in CN104255736),
6. fluxapyroxad (fluxapyroxad) (being known in CN103907610),
7. thifluzamide (thifluzamide) (being known in CN101755825),
8. biphenyl pyrrole bacterium amine (bixafen) (being known in CN103907605),
9. pyrrole metsulfovax (penthiopyrad) (being known in CN101473827),
10. fluorine azoles bacterium aniline (penflufen) (being known in CN103907632),
11. furametpyrs (furametpyr) (being known in CN101588786),
12. fenfurams (fenfuram) (being known in CN1188396),
13. benodanils (benodanil) (being known in CN102550570),
14. mebenils (mepronil) (being known in CN101707998),
15. oxycarboxins (oxycarboxin) (being known in CN1313032),
16. carboxins (carboxin) (being known in CN101473827),
17. benzo alkene fluorine bacterium azoles (benzovindiflupyr) (being known in CN104010502),
At least one in 18.isofetamid (being known in WO2014053405).
Succinate dehydrogenase inhibitors class (SDHI) bactericide provided by the present invention and picarbutrazox compositions can be with Contain conven-tional adjuvants and additive and/or diluent.
Components I of the present invention is 100: 1~1: 100 with the mass ratio of compositionⅱ.
In the presence of reactive compound is with extra fine quality ratio in bactericidal composition of the present invention, synergy highly significant.Therefore I:II matter Preferably than being 1: 10~80: 1, most preferably mass ratio is 1: 1~10: 1 to amount.
In order to realize second above-mentioned purpose, present invention employs following technical scheme：
A kind of bactericidal composition preparation, said preparation includes bactericidal composition and preparation described in above-mentioned any one technical scheme with auxiliary Material, bactericidal composition described by percentage to the quality accounts for the 1~90% of total amount；It is preferred that, described bactericidal composition accounts for total amount 5~60%.
The present composition can be prepared into agriculturally acceptable solid-like or liquid preparation.This kind of preparation can be by mixing Active component I and II is prepared with suitable auxiliary element with known method.Wettable powder of the solid-like form including powdery, Pulvis, Seed Treatment dry powder doses, Seed Treatment dispersible pulvis, water dispersible granules, granule, liquid preparation include suspending Agent, suspension emulsion, microcapsule suspending agent, Seed Treatment suspending agent, Seed Treatment microcapsule suspending agent, suspension seed-coating agent.
Auxiliary element described in the present composition include wetting agent, emulsifying agent, dispersant, thickener, solvent, antifreezing agent, into Film, cyst material, pH acid-base modifiers, disintegrant, preservative, stabilizer, defoamer, colouring agent, filler and water etc. All it is to be commonly used in preparing or agricultural and other are beneficial to the known substance that active ingredient is stablized in the formulation or reactive compound is played On allow the various composition that uses, be not particularly limited, specific composition and consumption determine as desired by experiment.
Described wetting agent is selected from EO/PO block polyethers, AEO, tallow ethyoxyl ammonium salt, alkylnaphthalene sulphur One or more in hydrochlorate, fatty alcohol polyoxyethylene ether sulfate and acyl group glutamate；
Described emulsifying agent is selected from APES, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyethenoxy ether, fat Alcohol APEO, phenethyl phenol polyethenoxy ether polyethenoxy ether, aliphatic amine polyoxyethylene ether, castor oil ethyleneoxide addition Thing and its derivative, polyol fatty acid ester and its ethylene oxide adduct, alkylbenzenesulfonate, alkylsulfonate, alkyl fourth Two acid ester sulfonates, alkyl biphenyl base ether sulfonate, naphthalene sulfonic acid-formaldehyde condensation product, aliphatic alcohol sulfate, alkylphenol-polyethenoxy Ether sulfate, aralkyl phenol polyethenoxy ether sulfate, APES phosphate, phenethyl phenol polyethenoxy ether phosphorus Acid esters, polyoxyethylene carboxylate phosphate, ethoxylated fatty amines phosphate, alkylphosphonic, alkylphenol-polyethenoxy Ether formaldehyde condensation products, aralkyl phenol polyethenoxy ether formaldehyde condensation products, biphenyl phenol polyethenoxy ether formaldehyde condensation products, polyoxyethylene Polyoxypropylene block copolymers, alkyl naphthalene sulfonic acid formaldehyde condensation products, phenol formaldehyde condensate sulfonate, APES first Aldehyde condensate sulfate, contracting methylcellulose and its derivative, alkylammonium salt, amino alcohol fatty acid derivatives, polyamines aliphatic acid Derivative, quaternary ammonium salt, tallow ethyoxyl ammonium salt, alkylnaphthalene sulfonate, amino acid, amine oxide, glycine betaine, poly alkyl alcohol One or more in oxygen ethene ether sulfate and acyl group glutamate；
The dispersant be selected from naphthalene sulfonic acid condensate sodium salt, phenolsulfonic acid condensation product sodium salt, methyl naphthalene sulfonate formaldehyde condensate, Sodium lignin sulfonate, sodium metnylene bis-naphthalene sulfonate, acrylate homopolymer sodium salt, polymeric polycarboxylic acid salt, dioctyl sodium sulfosuccinates One or more in acid sodium-salt, EO/PO block polyethers and maleic acid-acrylic acid copolymer sodium salt；
The thickener is selected from xanthans, Magnesiumaluminumsilicate, sodium carboxymethylcellulose, starch phosphate sodium, ocentyl succinic and forms sediment One or more in powder sodium and polyvinyl alcohol；
The solvent is selected from one or more in dimethylbenzene, turpentine-based vegetable oil, methyl oleate and heavy aromatic solvent oil；
The antifreezing agent is selected from one or more in ethylene glycol, propane diols, glycerine, isopropanol and urea；
The film forming agent is selected from polyvinyl alcohol, polyvinyl acetate, polyethylene glycol, polymethylacrylic acid glycol ester, carboxylic One kind in the high molecular polymer with caking property and film forming such as methylcellulose, gum arabic, xanthans and starch or It is various；
The cyst material is carbamide resin；It is by interface polymerization reaction by isocyanate-monomer with polyalcohol or polyamine It is obtained；Isocyanates includes toluene di-isocyanate(TDI), 4,4- methyl diphenylene diisocyanates, the multiple methylene polyisocyanate of many phenyl Cyanate, polyphenyl polymethylene polyisocyanates etc..
The pH acid-base modifiers are selected from the one kind in citric acid, glacial acetic acid, hydrochloric acid, ammoniacal liquor, triethanolamine and diethylenetriamine Or it is various；Institute's expense is to adjust the pH value of final products to be advisable to stability range；
The disintegrant is selected from one or more in sodium chloride, ammonium chloride, ammonium sulfate, sodium sulphate and soluble starch；
The preservative is selected from the one kind or many in Kathon CG, formaldehyde, phenyl salicylate, butyl p-hydroxybenzoate and potassium sorbate Kind；
The stabilizer is selected from epoxidized soybean oil, epoxychloropropane, triphenyl phosphite, glycidol ether and pentaerythrite One or more；
The defoamer is selected from organic silicon defoamer and/or polyether antifoam agent；
The colouring agent is selected from one or more in iron oxide, titanium oxide and azo dyes；
Described filler is selected from one or more in kaolin, diatomite, talcum powder, precipitated calcium carbonate and white carbon；
The water is running water, deionized water or distilled water.
Preparation described in the invention can be prepared with universal method.Therefore, present invention additionally comprises the preparation of above-mentioned composition preparation Method.
In order to realize the 3rd above-mentioned purpose, present invention employs following technical scheme：
Above-mentioned bactericidal composition or the purposes of bactericidal composition preparation, the bactericidal composition or bactericidal composition preparation are used to prevent and treat Plant pathogenic fungi and oomycetes disease.
Bactericidal composition of the invention or bactericidal composition preparation have extraordinary bactericidal activity, non-to plant pathogenic fungi and oomycetes Chang Youxiao, such as preventing and treating following germ：
Sac fungus in disease fungus：Venturia (Venturia), powdery mildew (Erysiphales), Gibberella (Gibberella), Sclerotinia (Sclerotinia)；
Basidiomycetes (Basidiomycetes) in disease fungus：Ustilago (Ustilago), rest fungus (Uredinales)；
Downy mildew (Peronosporales) in oomycetes：Phytophthora (Phytophthora), pythium (Pythium), list The mould category of axle (Plasmopara)；
Fungi Imperfecti (Deuteromyces) in disease fungus：Rhizoctonia (Rhizoctonia), Fusarium (Fusarium), Botrytis (Botrytis), Pyricularia Sacc. (Pyricularia), Cercospora (Cercospora), bipolaris (Bipolaris), Colletotrichum (Colletotrichum).
Within the scope of the present invention, signified crop disclosed herein preferably following species：Cereal wheat, barley, paddy rice, sorghum； Fruit tree kind apple, pears, peach, oranges and tangerines, grape, lichee, banana, longan, mango, loquat；Greengrocery cucumber, watermelon, Potyvirus, sponge gourd, muskmelon, spinach, celery, tomato, capsicum, eggplant, ginger, green onion, garlic, leek, wild cabbage, Chinese cabbage, Strawberry, asparagus lettuce, Kidney bean, cowpea, broad bean, radish, carrot, potato, Chinese yam, taro, lotus rhizome, water chestnut, wild rice stem, Sweet potato；Sugar plant class beet, sugarcane；Oil crops class soybean, peanut, rape, sesame, sunflower；Or such as tobacco, Tea.This enumerating is not offered as with any limitation.
The present composition is used for the comprehensive regulation of crop pathogenic and oomycetes disease, especially effective to following crop disease：
Potato, late blight of tomato that Phytophthora (Pyhtophthora) strain causes etc.；
Downy mildew of garpe that downy mildew (Peronosporales) causes etc.；
Tobacco that powdery mildew (Erysiphales) causes, sesame, sunflower and the powdery mildew such as melon etc.；
Various grass head blight, the rice bakanae disease such as Wheat And Barley that Gibberella (Gibberella) strain causes and corn Disease；
Apple that Venturia (Venturia) strain causes or the scab of pears etc.；
The various plants sclerotiniose that Sclerotinia (Sclerotinia) strain causes；
Wheat loose smut that Ustilago (Ustilago) strain causes etc.；
Gray mold of various plants that Botrytis (Botrytis) strain causes etc.；
The rice blast that Pyricularia Sacc. (Pyricularia) strain causes；
Beet cercospora leaf spot, the cercospora brown spot of peanut that Cercospora (Cercospora) strain causes；
Corn southern leaf blight, water rice brown spot that Bipolaris (Bipolaris) strain causes；
Cotton seedling blight and rice sheath blight disease that Rhizoctonia (Rhizoctonia) strain causes；
Apple that colletotrichum (Colletotrichum) strain causes, pears, cotton, grape, wax gourd, cucumber, capsicum, Many planting fruit-trees such as eggplant and the anthracnose of vegetables.
The method that bactericidal composition of the invention is used includes to plant to be processed or it grows place or seed or other are numerous Material is grown, to mix using the formula I comprising effective active bactericidal amount and the reactive compound of formula II.Material can be infected in fungi, oomycetes Applied before or after material, plant or seed.
Terms used herein " growth place " includes the field of growth process plant or sowing cultivated plant seed, or seed is buried The place being placed in soil.
Bactericidal composition of the invention can be used with itself concentration form or with general conventional formulations, according to target The property of disease it is different using pouring, spraying, atomizing, dress seed, spread fertilizer over the fields or smearing method, its apply total effective active dosage with Weather condition, crop condition or application process and change.
Compared to the prior art Fungicidal active compound composition of the present invention has the advantages that to protrude very much:
1. it is made up of the active ingredient of different mechanism of action, the resistance to the action of a drug that can effectively slow down disease is produced, and substantially reduces SDHI sterilized Agent and picarbutrazox are used alone the resistance risk for bringing；
2. synergy substantially, can give full play to the prophylactic-therapeutic effect of SDHI bactericide and picarbutrazox to diseases such as fungoids, and Its good protective value；
3. antibacterial or antibacterial effect are not only increased, fungicidal spectrum is have also been enlarged, the fungal disease that crop occurs can be risen simultaneously To prevention or therapeutic effect well, times for spraying is reduced, so as to play the effect of integrated control；
4. the usage amount of medicament can be reduced by compounding, mitigates pressure of the agricultural chemicals to environment, while reduces cost；
5. the tolerance of crop can be significantly improved, and the security to crop is higher；
6. can be by microelement-supplementing, so as to promote plant growth, improve resistance and disease resistance.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, present invention specific examples below and example Illustrate, described embodiment is that, in order to preferably explain the present invention, rather than limiting the scope of the invention, own Based on any modification and variation made in basic thought of the present invention and principle, claimed scope of the invention is belonged to.
Prepare embodiment：
In following term explanation embodiments of the invention, Fungicidal active compound I and II is with the composition of specific blend composition of proportions. First, the preparation of suspending agent
Embodiment 1：
By 40% reactive compound (20.0%picarbutrazox and 20.0% flutolanil composition), EO/PO block polyethers 1.0%, Acrylate homopolymer sodium salt 1.0%, polymeric polycarboxylic acid salt 4.0%, ethylene glycol 2.0%, epoxidized soybean oil 5.0%, urea 2.0%, Organic silicon defoamer 0.1%, running water is mended to 100%, is put into high shear homogeneous emulsifying machine high speed and is sheared 30 minutes, then defeated Into sand mill, circulation is sanded 1-3 times and obtains final product 40% reactive compound suspending agent.
Embodiment 2：
40% reactive compound (20.0%picarbutrazox and 20.0% fluorine azoles bacterium aniline composition), EO/PO blocks are gathered Ether 1.0%, maleic acid-acrylic acid copolymer sodium salt 5.0%, propane diols 2.0%, organic silicon defoamer 0.1%, running water mend to 100%, put into high shear homogeneous emulsifying machine high speed and shear 30 minutes, then transport to sand mill, circulation is sanded 1-3 times and obtains final product 40% reactive compound suspending agent.
Embodiment 3：
By 50% reactive compound (15.0%picarbutrazox and 35.0% furametpyr composition), aliphatic alcohol polyethenoxy Ether 2.0%, polymeric polycarboxylic acid salt 4.0%, starch phosphate sodium 0.5%, urea 2.0%, organic silicon defoamer 0.1%, go from Sub- water is mended to 100%, put into high shear homogeneous emulsifying machine high speed and shear 30 minutes, then transports to sand mill, and circulation is sanded Obtain final product 50% reactive compound suspending agent for 1-3 times.
Embodiment 4：
By 55% reactive compound (20.0%picarbutrazox and 35.0% benzo alkene fluorine bacterium azoles composition), methylene dinaphthalene Sodium sulfonate 2.0%, polymeric polycarboxylic acid salt 4.0%, Magnesiumaluminumsilicate 0.5%, urea 2.0%, polyethers infusion 0.1%, deionized water Mend to 100%, put into high shear homogeneous emulsifying machine high speed and shear 30 minutes, then transport to sand mill, circulation is sanded 1-3 It is secondary to obtain final product 55% reactive compound suspending agent.
Embodiment 5：
By 60% reactive compound (20.0%picarbutrazox and 40.0% Boscalid composition), alkylnaphthalene sulfonate 1.0%, It is fatty alcohol polyoxyethylene ether sulfate 4.0%, phenolsulfonic acid condensation product sodium salt 3.0%, xanthans 0.1%, glycerine 2.0%, poly- Ether defoaming agent 0.2%, distilled water is added to 100%, is put into high shear homogeneous emulsifying machine high speed and is sheared 30 minutes, then transports to In sand mill, circulation is sanded 1-3 times and obtains final product 60% reactive compound suspending agent.
Embodiment 6：
65% reactive compound (50.0%picarbutrazox and 15.0% fenfuram composition), fatty alcohol ethyl are aoxidized Thing 5.0%, methyl naphthalene sulfonate formaldehyde condensate 3.0%, propane diols 2.0%, organic silicon defoamer 0.1%, deionized water mend to 100%, put into high shear homogeneous emulsifying machine high speed and shear 30 minutes, then transport to sand mill, circulation is sanded 1-3 times and obtains final product 65% reactive compound suspending agent.
Embodiment 7：
By 70% reactive compound (35.0%picarbutrazox and 35.0% carboxin composition), AEO 2.0%th, polymeric polycarboxylic acid salt 4.0%, xanthans 0.05%, ethylene glycol 2.0%, organic silicon defoamer 0.1%, distilled water mend to 100%, put into high shear homogeneous emulsifying machine high speed and shear 30 minutes, then transport to sand mill, circulation is sanded 1-3 times and obtains final product 70% reactive compound suspending agent.
2nd, microcapsule suspending agent
Embodiment 8：
25% reactive compound (10.0%picarbutrazox and 15.0% thifluzamide composition) preparation method：Will Picarbutrazox10.0%, thifluzamide 15.0%, dioctyl sodium sulphosuccinate salt 1.0%, acyl group glutamate 2.0%, Organic silicon defoamer 0.1%, polyphenyl polymethylene polyisocyanates PAPI 3% and 4,4- methyl diphenylene diisocyanates MDI 2%th, Arabic gum (5%) aqueous solution 10%, deionized water 40.46% is sufficiently mixed, then puts into sand milling in sand mill, is sanded It it is 3-5 microns to D90 particle diameters.Stirring (maintaining 700 turns/min) is opened, the suspension that then will be sanded is warming up to 60 DEG C, Triethanolamine 0.04% is slowly added to simultaneously, the cyst material solidification temperature of stabilization is maintained 8 hours, and fatty alcohol polyoxy second is added afterwards Alkene ether sulphate 1.0%, methyl naphthalene sulfonate formaldehyde condensate 1.0%, urea 2.0%, glycerine 2.0%, Magnesiumaluminumsilicate (2%) The aqueous solution 10%, appropriate diluted hydrochloric acid aqueous solution adjust pH value to 6.5 or so, preservative formaldehyde 0.1%, organic silicon defoamer 0.3%, Stir, that is, 25% reactive compound microcapsule suspending agent is obtained.
Embodiment 9：
30% reactive compound (15.0%picarbutrazox and 15.0% oxycarboxin composition) preparation method：Will Picarbutrazox15.0%, oxycarboxin 15.0%, alkylnaphthalene sulfonate 2.0%, fatty alcohol polyoxyethylene ether sulfate 1.0%, The multiple methylene polyisocyanates 3% of organic silicon defoamer 0.1%, many phenyl and 4,4- methyl diphenylene diisocyanates MDI 2%, Arabic gum (5%) aqueous solution 10%, deionized water 35.46% is sufficiently mixed, then puts into sand milling in sand mill, is sanded to D90 Particle diameter is 3-5 microns.Stirring (maintaining 700 turns/min) is opened, the suspension that then will be sanded is warming up to 60 DEG C, while Be slowly added to triethanolamine 0.04%, maintain the cyst material solidification temperature of stabilization 8 hours, add afterwards lignosulfonates 1.0%, It is methyl naphthalene sulfonate formaldehyde condensate 1.0%, urea 2.0%, glycerine 2.0%, Magnesiumaluminumsilicate (2%) aqueous solution 10%, appropriate Diluted hydrochloric acid aqueous solution adjust pH value to 6.5 or so, Preservative Kathon CG(Methylchloroisothiazolinone/Methylisothiazolinone combination) 0.1%, organic silicon defoamer 0.3%, stir, i.e., 30% reactive compound microcapsule suspending agent is obtained.
3rd, the preparation of water dispersible granules
Method one: after agricultural chemicals, dispersant, disintegrant, wetting agent, binding agent etc. are well mixed, by air-flow crushing, makes Grain shaping.
Embodiment 10：
60% reactive compound (20.0%picarbutrazox and 40.0% biphenyl pyrrole bacterium amine composition), lignosulfonates 3.0%, Naphthalene sulfonate 3.0%, sodium sulphate 15.0%, talcum powder 1.0%, kaolin 18.0% are sufficiently mixed, then by air-flow crushing, make Grain is molded to obtain water dispersible granules.Contain 60% content reactive compound in water dispersible granules, product cut size is 80-120 mesh.
Embodiment 11：
70% reactive compound (30.0%picarbutrazox and 40.0% fluopyram composition), polymeric polycarboxylic acid salt 3.0%th, naphthalene sulfonate 3.0%, ammonium sulfate 5.0%, white carbon 2.0%, kaolin 17.0% are sufficiently mixed, then by air-flow crushing, Granulating and forming obtains water dispersible granules.Contain 70% content reactive compound in water dispersible granules, product cut size is 80-120 mesh.
Method two: agricultural chemicals and various auxiliary agents is ground in water, granulating and drying is obtained after being deployed into slurry.
Embodiment 12：
By 60% reactive compound (40.0%picarbutrazox and 20.0% mebenil composition), EO/PO block polyethers 6.0%, AEO 4.0%, ammonium chloride 11.0%, white carbon 2.0%, diatomite 17.0% are sufficiently mixed, and add appropriate Sand milling in high shear homogenized milk agent high speed shearing corase grind and homogeneous, then pump to sand mill is put into after distilled water, is sanded to one Determine particle diameter, then granulating and forming obtains water dispersible granules.Contain 60% content reactive compound in water dispersible granules, product cut size is 80-120 Mesh.
4th, the preparation of wettable powder
By recipe requirements, active compound, various auxiliary agents and filler etc. are sufficiently mixed in the ratio of formula, after ultra-fine pulverizer disintegrating Can obtain.
Embodiment 13：
By 30% reactive compound (20.0%picarbutrazox and 10.0%isofetamid compositions), sodium lignin sulfonate 3%th, talcum powder 1.0%, white carbon 15.0%, diatomite 51.0% are sufficiently mixed, then by ultra-fine grinding to certain particle diameter, obtain Wettable powder.Contain 30% content reactive compound in wettable powder.
Embodiment 14：
By 40% reactive compound (30.0%picarbutrazox and 10.0% pyrazole naphthalene bacteria amine composition), polymeric polycarboxylic acid Salt 3%, white carbon 1.0%, diatomite 15.0%, kaolin 41.0% are sufficiently mixed, then by ultra-fine grinding to certain particle diameter, Obtain wettable powder.Contain 40% content reactive compound in wettable powder.
Embodiment 15：
By 50% reactive compound (30.0%picarbutrazox and 20.0% benodanil composition), polymeric polycarboxylic acid salt 3%, Naphthalene sulfonic acid condensate sodium salt 1%, talcum powder 1.0%, precipitated calcium carbonate 15.0%, kaolin 30.0% are sufficiently mixed, then by super Fine powder is broken to certain particle diameter, obtains wettable powder.Contain 50% content reactive compound in wettable powder.
5th, the preparation of suspension seed-coating agent
By recipe requirements, active compound, auxiliary agent and inserts, film forming agent etc. are sufficiently mixed, in putting into high shear homogenized milk agent It is sanded in high speed shear, then pump to sand mill, suspension seed-coating agent is obtained final product after filtering.
Embodiment 16：
By 40% reactive compound (30.0%picarbutrazox and 10.0% fluorine azoles ring bacterium amine composition), alkylnaphthalene sulfonate 4.0%th, polymeric polycarboxylic acid salt 3.0%, polyvinyl acetate alcohol 2.0%, ethylene glycol 3.0%, carboxymethylcellulose calcium 0.2%, polyethers Defoamer 0.1%, titanium oxide 0.2%, deionized water are mended to 100% and are sufficiently mixed, then put into height in high shear homogenized milk agent It is sanded in speed shearing corase grind and homogeneous, then pump to sand mill, is sanded to certain particle diameter, suspension seed-coating agent is obtained final product after refiltering.It is outstanding Contain 40% content reactive compound in floating seed coat agent, D90 particle diameters are 3-5 microns.
6th, Seed Treatment dry powder doses
Embodiment 17：
By 50% reactive compound (20.0%picarbutrazox and 30.0% pyrrole metsulfovax composition), EO/PO block polyethers 7.0%th, AEO 5.0%, polyvinyl alcohol 1%, sodium sulphate 5.0%, kaolin 32.0% are sufficiently mixed, then put into Certain particle diameter is crushed to airslide disintegrating mill, Seed Treatment dry powder doses are obtained final product.Containing 50% content activity in the Seed Treatment dry powder doses Compound, product cut size is 120-200 mesh.
7th, Seed Treatment suspending agent
Embodiment 18：
By 35% reactive compound (20.0%picarbutrazox and 15.0% fluxapyroxad composition), alkylnaphthalene sulfonate 2.0%th, fatty alcohol polyoxyethylene ether sulfate 3.0%, polyvinyl alcohol 2.0%, gum arabic 1.0%, glycerine 2.0%, have Machine silicon defoaming agent 0.1%, distilled water is mended to 100%, is put into high shear homogeneous emulsifying machine high speed and is sheared 25 minutes, then pump is extremely It is sanded 60 minutes in sand mill, 35% reactive compound Seed Treatment suspending agent is obtained final product after filtering.
8th, the preparation of suspension emulsion
Embodiment 19：
35% reactive compound (25.0%picarbutrazox and 10.0% flutolanil composition) suspension emulsion preparation method: will Picarbutrazox50.0%, EO/PO block polyether 2.0%, methyl naphthalene sulfonate formaldehyde condensate 3.0%, acrylate homopolymer Sodium salt 1.0%, propane diols 2.0%, xanthans 0.3%, potassium sorbate 0.1%, polyether antifoam agent 0.1%, deionized water are mended to 100% It is sufficiently mixed, then puts into sand milling in high shear homogenized milk agent high speed shearing corase grind and homogeneous, then pump to sand mill, is sanded To certain particle diameter, suspending agent is obtained final product after refiltering.Contain 50%picarbutrazox in suspending agent, D90 particle diameters are 3-5 microns. Again by 50.0% 50.0%picarbutrazox suspending agents, flutolanil 10.0%, methyl oleate 15.0%, tallow ethyoxyl Ammonium salt 3.0%, AEO 4.0%, glycerine 2.0%, sodium carboxymethylcellulose 0.3%, polyether antifoam agent 0.1%, Deionized water 15.6% is sufficiently mixed, high speed shear, and emulsifying, filtering are obtained suspension emulsion, work of the suspension emulsion containing 35% content Property compound.
Assays Example：
Biologicall test example 1：
Rhizoctonia solani Kuhn Rhizoctonia solani Kuhn (Rhizoctonia solani) activity test
Test method：Reference《People's Republic of China (PRC) agricultural industry criteria NY/T1156.2-2006》Mycelial growth rate method. EC is calculated using DPS data handling systems50, synergy ratio SR is calculated according to Wadley methods, evaluate synergy.SR is more than 1.5 is synergistic effect, and SR is summation action between 0.5~1.5, and SR is antagonism less than 0.5.
(EC is calculated using the DPS in this example in following instance50Mixture synergy is evaluated with Wadley methods)
Result of the test shows：Picarbutrazox is with flutolanil, thifluzamide, fluorine azoles bacterium aniline, mebenil mixture to paddy rice Banded sclerotial blight pathogen has synergistic function, and in the range of surveying, mixed effect is preferable, especially at 1: 1~20: 1, Synergy significantly, can effectively reduce consumption (being shown in Table 1, table 2, table 3, table 4).
The picarbutrazox of table 1 is with flutolanil mixture to rice sheath blight disease Toxicity Determination
The picarbutrazox of table 2 is with thifluzamide mixture to rice sheath blight disease Toxicity Determination
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 8.520 / /
II thifluzamides 0:1 0.043 / /
I∶II 1:10 0.030 0.047 1.576
I∶II 1:5 0.032 0.052 1.611
I∶II 1:2 0.037 0.064 1.739
I∶II 1:1 0.048 0.086 1.783
I∶II 10:1 0.246 0.450 1.830
I∶II 20:1 0.463 0.820 1.772
I∶II 40:1 0.884 1.467 1.659
I∶II 80:1 1.551 2.481 1.600
The picarbutrazox of table 3 is with fluorine azoles bacterium aniline mixture to rice sheath blight disease Toxicity Determination
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 8.520 / /
II fluorine azoles bacterium aniline 0:1 1.421 / /
I∶II 1:10 1.016 1.537 1.513
I∶II 1:5 1.074 1.650 1.537
I∶II 1:2 1.237 1.967 1.591
I∶II 1:1 1.502 2.436 1.622
I∶II 10:1 3.549 5.859 1.651
I∶II 20:1 4.348 6.883 1.583
I∶II 40:1 4.859 7.595 1.563
I∶II 80:1 5.184 8.025 1.548
The picarbutrazox of table 4 is with mebenil mixture to rice sheath blight disease Toxicity Determination
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 8.520 / /
II mebenils 0:1 0.390 / /
I∶II 1:10 0.278 0.427 1.536
I∶II 1:5 0.289 0.464 1.605
I∶II 1:2 0.337 0.572 1.697
I∶II 1:1 0.416 0.746 1.793
I∶II 10:1 1.622 2.943 1.814
I∶II 20:1 2.374 4.276 1.801
I∶II 40:1 3.427 5.648 1.648
I∶II 80:1 4.391 6.776 1.543
Biologicall test example 2：
Wheat powdery mildew (Blumeria graminis) activity test
Test method：Reference《People's Republic of China (PRC) agricultural industry criteria NY/T 1156.4-2006》Pot-culture method.
Result of the test shows：Picarbutrazox and Boscalid, biphenyl pyrrole bacterium amine mixture to the activity of wheat powdery mildew all It is significantly improved, with synergistic function, does not have antagonism, is matching for have synergistic effect at 1: 10~80: 1, especially Its at 1: 1~20: 1, picarbutrazox and Boscalid mixture, it is possible to decrease the consumption of Boscalid, delaying drug resistance Produce, improve using effect (being shown in Table 5).Picarbutrazox is significantly improved with biphenyl pyrrole bacterium amine mixture activity, especially Picarbutrazox is matched in 1: 2~20: 1 synergy significantly (being shown in Table 6) with biphenyl pyrrole bacterium amine.
The picarbutrazox of table 5 is with Boscalid mixture to wheat powdery mildew virulence
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 32.941 / /
II Boscalids 0:1 3.682 / /
I∶II 1:10 2.550 4.005 1.571
I∶II 1:5 2.650 4.322 1.631
I∶II 1:1 3.658 6.624 1.811
I∶II 10:1 10.215 19.125 1.872
I∶II 20:1 13.716 23.898 1.742
I∶II 80:1 18.617 29.998 1.611
The picarbutrazox of table 6 is with biphenyl pyrrole bacterium amine mixture to wheat powdery mildew virulence
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 32.941 / /
II biphenyl pyrrole bacterium amine 0:1 1.125 / /
I∶II 1:10 0.790 1.233 1.561
I∶II 1:5 0.820 1.341 1.635
I∶II 1:2 0.980 1.659 1.693
I∶II 1:1 1.220 2.176 1.783
I∶II 10:1 5.050 9.225 1.827
I∶II 20:1 8.160 14.037 1.720
I∶II 80:1 15.150 24.416 1.612
Biologicall test example 3：
Rice seedling blight (Fusarium oxysporium Schelcht) activity test
Test method：Reference《People's Republic of China (PRC) agricultural industry criteria NY/T 1156.2-2006》Mycelial growth rate method.
Result of the test shows：Picarbutrazox is significantly improved with fluorine azoles ring bacterium amine mixture to rice wilt pathogens activity, proportioning There is preferable activity between 1: 10~80: 1, especially 1: 1~10: 1 proportioning synergy is substantially (being shown in Table 7).
The picarbutrazox of table 7 is with fluorine azoles ring bacterium amine mixture to rice wilt pathogens virulence
Biologicall test example 4：
Cucumber powdery mildew's pathogen (Sphaerotheca fuliginea) activity test
Test method：Reference《People's Republic of China (PRC) agricultural industry criteria NY/T1156.11-2008》Pot-culture method.
Result of the test shows: picarbutrazox is mixed with fluxapyroxad, isopyrazam, fluopyram, furametpyr Significantly improved with activity, especially picarbutrazox and fluxapyroxad, isopyrazam, fluopyram, furametpyr Proportioning synergy all at 1: 1~10: 1 is notable (being shown in Table 8, table 9, table 10, table 11).
The picarbutrazox of table 8 is with fluxapyroxad mixture to cucumber powdery mildew's pathogen virulence
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 42.842 / /
II fluxapyroxads 0:1 12.290 / /
I∶II 1:10 8.230 13.142 1.597
I∶II 1:5 8.352 13.948 1.670
I∶II 1:1 11.041 19.100 1.730
I∶II 10:1 19.413 34.944 1.800
I∶II 20:1 20.706 38.306 1.850
I∶II 80:1 24.026 41.564 1.730
The picarbutrazox of table 9 is with isopyrazam mixture to cucumber powdery mildew's pathogen virulence
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 42.842 / /
II isopyrazams 0:1 0.057 / /
I∶II 1:10 0.039 0.063 1.607
I∶II 1:5 0.042 0.068 1.628
I∶II 1:1 0.067 0.114 1.699
I∶II 10:1 0.348 0.619 1.778
I∶II 20:1 0.694 1.166 1.680
I∶II 80:1 2.656 4.173 1.571
The picarbutrazox of table 10 is with fluopyram mixture to cucumber powdery mildew's pathogen virulence
The picarbutrazox of table 11 is with furametpyr mixture to cucumber powdery mildew's pathogen virulence
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 42.842 / /
II furametpyrs 0:1 1.287 / /
I∶II 1:10 0.906 1.411 1.558
I∶II 1:5 0.950 1.535 1.616
I∶II 1:1 1.380 2.499 1.811
I∶II 10:1 5.891 10.887 1.848
I∶II 20:1 9.832 16.883 1.717
I∶II 80:1 19.861 30.632 1.542
Biologicall test example 5：
Botrytis cinerea pers (Botrytis cinerea) activity test
Test method：Reference《People's Republic of China (PRC) agricultural industry criteria NY/T 1156.9-2008》Blade method
Result of the test shows：Picarbutrazox is significantly improved with pyrrole metsulfovax mixture activity, especially picarbutrazox with Pyrrole metsulfovax is matched 1:2~10:Synergy is notable (being shown in Table 12) when 1.
The picarbutrazox of table 12 is with pyrrole metsulfovax mixture to botrytis cinerea pers virulence
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 1.224 / /
II pyrrole metsulfovax 0:1 0.243 / /
I∶II 1:10 0.165 0.262 1.588
I∶II 1:5 0.168 0.280 1.669
I∶II 1:2 0.186 0.332 1.783
I∶II 1:1 0.220 0.405 1.843
I∶II 10:1 0.474 0.895 1.889
I∶II 20:1 0.591 1.027 1.737
I∶II 80:1 0.759 1.166 1.536
Biologicall test example 6：
Phytophthora capsici (Phytophthora capsic) activity test
Test method：Reference《People's Republic of China (PRC) agricultural industry criteria NY/T 1156.1-2006》Spore germination method
Result of the test shows：Picarbutrazox is improved with fenfuram mixture to capsicum epidemic disease activity, with synergistic effect, Especially proportioning is obvious 1: 5~10: 1 synergistic effect, can effectively delay the generation (being shown in Table 13) of fenfuram resistance.
The picarbutrazox of table 13 is with fenfuram mixture to phytophthora capsici virulence
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 0.280 / /
II fenfurams 0:1 2.923 / /
I∶II 1:20 1.298 2.017 1.554
I∶II 1:10 0.984 1.573 1.599
I∶II 1:5 0.664 1.136 1.711
I∶II 1:1 0.287 0.511 1.781
I∶II 10:1 0.168 0.305 1.816
I∶II 20:1 0.165 0.293 1.773
I∶II 80:1 0.162 0.283 1.748
Biologicall test example 7：
Rhizoctonia cerealis (Rhizoctonia cerealis) activity test
Test method：Reference《People's Republic of China (PRC) agricultural industry criteria NY/T1156.2-2006》Mycelial growth rate method.
Result of the test shows：Picarbutrazox has synergistic effect with carboxin mixed ratio in the range of 1: 10~80: 1, Especially match has notable synergistic to act at 1: 1~10: 1, and picarbutrazox can be reduced after being applied in combination with carboxin Consumption (is shown in Table 14).
The picarbutrazox of table 14 is with carboxin mixture to rhizoctonia cerealis virulence
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 8.421 / /
II carboxins 0:1 0.563 / /
I∶II 1:20 0.385 0.589 1.531
I∶II 1:10 0.386 0.615 1.594
I∶II 1:5 0.410 0.667 1.627
I∶II 1:1 0.573 1.055 1.842
I∶II 10:1 2.117 3.712 1.753
I∶II 20:1 3.160 5.059 1.601
I∶II 80:1 4.717 7.183 1.523
Biologicall test example 8：
Soybean rust bacterium (Phakopsora pachyrhizi Sydow) activity test
Test method：With reference to reference《People's Republic of China (PRC) agricultural industry criteria NY/T1156.11-2008》Pot-culture method.
Result of the test shows：Picarbutrazox is substantially carried with benodanil, oxycarboxin, benzo alkene fluorine bacterium azoles mixture activity Height, there is good synergistic effect, especially matches the synergy at 1: 5~10: 1 notable (being shown in Table 15, table 16, table 17).
The picarbutrazox of table 15 is with benodanil mixture to soybean rust bacterium power
The picarbutrazox of table 16 is with oxycarboxin mixture to soybean rust bacterium power
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 29.220 / /
II oxycarboxins 0:1 15.792 / /
I∶II 1:10 9.913 16.481 1.663
I∶II 1:5 9.953 17.102 1.718
I∶II 1:1 11.342 20.503 1.808
I∶II 10:1 14.661 27.123 1.850
I∶II 20:1 16.127 28.083 1.741
I∶II 80:1 17.419 28.916 1.660
The picarbutrazox of table 17 is with benzo alkene fluorine bacterium azoles mixture to soybean rust bacterium power
Treatment Proportioning Actual measurement EC50(mg/L) Theoretical EC50(mg/L) Synergy ratio (SR)
I picarbutrazox 1:0 29.220 / /
II benzo alkene fluorine bacterium azoles 0:1 0.789 / /
I∶II 1:10 0.526 0.866 1.646
I∶II 1:5 0.556 0.942 1.694
I∶II 1:1 0.859 1.537 1.789
I∶II 10:1 3.542 6.834 1.929
I∶II 20:1 5.785 10.759 1.860
I∶II 80:1 12.473 20.223 1.621
Biologicall test example 9：
Sclerotinia sclerotiorum (Sclerotinia sclerotiorum) activity test
Test method：Reference《People's Republic of China (PRC) agricultural industry criteria NY/T1156.2-2006》Mycelial growth rate method.
Result of the test shows：Picarbutrazox and isofetamid mixture activity is significantly improved, and has good synergistic effect, especially The synergy at 1: 5~10: 1 of its proportioning is notable (being shown in Table 18).
The picarbutrazox of table 18 is with isofetamid mixtures to Sclerotinia sclerotiorum virulence
Field test embodiment
Picarbutrazox can prepare various formulations, and following field test embodiment is mixed using 20% suspending agent (SC) Experiment.
There is same or analogous characteristic selected from the compound in Fungicidal active compound II, such compound each component variable rate technology Go out same or analogous effect, therefore, citing is only carried out to amount of activated compound in field test embodiment proves its effect, Other compositions do not have this field test effect in not representing same class compound.
1st, 50% Boscalid WG+20%picarbutrazox SC：
Preventing and treating gray mold of cucumber
Test method：Reference《National Standard of the People's Republic of China GB/T 17980.28-2000》Carry out field control effectiveness test.
Active material Threshold retention Disease index Prevention effect (%)
A: 20%picarbutrazox SC 300 mg/kgs 29.97 51.97
B: 50% Boscalid WG 400 mg/kgs 11.95 80.85
A+B The mg/kg of 250 mg/kg+250 10.25 83.57
A+B The mg/kg of 200 mg/kg+300 9.72 84.42
A+B The mg/kg of 150 mg/kg+350 8.93 85.69
Blank Clear water 62.40 /
2nd, 20% flutolanil WP+20%picarbutrazox SC：
Prevent and treat rice sheath blight disease
Test method：Field control effectiveness test is carried out with reference to GB GB/T 17980.20-2000.
Active material Threshold retention Disease index Prevention effect (%)
A: 20%picarbutrazox SC 400 mg/kgs 25.57 64.43
B: 20% flutolanil WP 150 grams/ha 17.18 76.10
A+B 300+50 grams/ha of mg/kgs 12.54 82.56
A+B 250+80 grams/ha of mg/kgs 11.17 84.46
A+B 200+100 grams/ha of mg/kgs 10.32 85.64
Blank Clear water 71.89 /
3rd, 41.7% fluopyram SC+20%picarbutrazox SC：
Preventing and treating grape grey mould
Test method：Field control effectiveness test is carried out with reference to other crop gray mold field control effectiveness test methods.
Active material Threshold retention Disease index Prevention effect (%)
A: 20%picarbutrazox SC 400 mg/kgs 26.53 58.43
B: 41.7% fluopyram SC 80 grams/ha 15.59 75.57
A+B 350+30 grams/ha of mg/kgs 12.48 80.45
A+B 300+50 grams/ha of mg/kgs 11.96 81.26
A+B 250+70 grams/ha of mg/kgs 10.13 84.13
Blank Clear water 63.82 /
4th, 20% fluxapyroxad SC+20%picarbutrazox SC：
Prevent and treat rice sheath blight disease
Test method：Field control effectiveness test is carried out with reference to GB GB/T 17980.20-2000.
Active material Threshold retention Disease index Prevention effect (%)
A: 20%picarbutrazox SC 400 mg/kgs 31.17 53.30
B: 20% fluxapyroxad SC 100 grams/ha 14.03 78.98
A+B 350+30 grams/ha of mg/kgs 12.77 80.87
A+B 300+60 grams/ha of mg/kgs 11.06 83.43
A+B 250+90 grams/ha of mg/kgs 10.39 84.43
Blank Clear water 66.74 /
5th, 24% thifluzamide SC+20%picarbutrazox SC：
Prevent and treat rice sheath blight disease
Test method：Field control effectiveness test is carried out with reference to GB GB/T 17980.20-2000.
Active material Threshold retention Disease index Prevention effect (%)
A: 20%picarbutrazox SC 500 mg/kgs 31.14 54.43
B: 24% thifluzamide SC 60 grams/ha 12.18 82.18
A+B 400+10 grams/ha of mg/kgs 11.36 83.38
A+B 350+30 grams/ha of mg/kgs 10.14 85.16
A+B 300+50 grams/ha of mg/kgs 9.48 86.13
Blank Clear water 68.34 /
6th, 20% fluorine azoles bacterium aniline SC+20%picarbutrazox SC：
Prevent and treat rice sheath blight disease
Test method：Field control effectiveness test is carried out with reference to GB GB/T 17980.20-2000.
Active material Threshold retention Disease index Prevention effect (%)
A: 20%picarbutrazox SC 500 mg/kgs 28.16 58.79
B: 20% fluorine azoles bacterium aniline SC 90 grams/ha 14.34 79.02
A+B 400+30 grams/ha of mg/kgs 11.08 83.79
A+B 350+50 grams/ha of mg/kgs 10.44 84.72
A+B 300+60 grams/ha of mg/kgs 10.03 85.32
Blank Clear water 68.34 /
7th, 10% isopyrazam SC+20%picarbutrazox SC：
Prevent and treat powdery mildew of cucumber
Test method：Reference《National Standard of the People's Republic of China GB/T 17980.30-2000》Carry out field control effectiveness test.
Active material Threshold retention Disease index Prevention effect (%)
A: 20%picarbutrazox SC 500 mg/kgs 29.01 57.53
B: 10% isopyrazam SC 80 mg/kgs 12.19 82.15
A+B The mg/kg of 400 mg/kg+30 11.64 82.96
A+B The mg/kg of 350 mg/kg+50 10.04 85.30
A+B The mg/kg of 300 mg/kg+70 9.32 86.36
Blank Clear water 68.31 /
8th, 50% pyrrole metsulfovax EW+20%picarbutrazox SC：
Preventing and treating cucumber downy mildew
Test method：Reference《National Standard of the People's Republic of China GB/T 17980.26-2000》Carry out field control effectiveness test.
Active material Threshold retention Disease index Prevention effect (%)
A: 20%picarbutrazox SC 500 mg/kgs 12.56 81.23
B: 50% pyrrole metsulfovax EW 400 mg/kgs 16.71 75.03
A+B The mg/kg of 400 mg/kg+150 11.99 82.08
A+B The mg/kg of 350 mg/kg+200 10.02 85.02
A+B The mg/kg of 300 mg/kg+250 9.11 86.38
Blank Clear water 66.91 /
9th, 50% fluorine azoles ring bacterium amine SC+20%picarbutrazox SC：
Prevent and treat downy mildew of garpe, powdery mildew
Test method：Prevent and treat downy mildew of garpe reference《National Standard of the People's Republic of China GB/T 17980.122-2004》Enter Row field control effectiveness test；Preventing and treating uncinula necator reference《National Standard of the People's Republic of China GB/T 17980.121-2004》 Carry out field control effectiveness test.
10th, 20% carboxin EC+20%picarbutrazox SC：
Preventing and treating maize head smut
Test method：Reference《National Standard of the People's Republic of China GB/T 17980.106-2004》Carry out field control effectiveness test.
Applicant uses the mode of two kinds of components " bucket mix " and carries out in above-mentioned field test, why adopts in this way, Reason is that these test objectives are to find to have Synergistic with picarbutrazox in magnanimity Fungicidal active compound The component of effect, and be completed in before the application complex composition prepares embodiment, those skilled in the art understand " bucket mix " It is that the clear and definite technology for preparing complex composition is guided, applicant exactly realizes technical side of the invention under the guide of such technology Case, has reached desired technique effect, and the complex composition for finally preparing not only has the stability of unitary agent, and tool There is the outstanding bactericidal property shown by above-mentioned data.
Although Fungicidal active compound I and II special in the present invention is known compound, and the bactericidal property of each component and kills Bacterium is composed by those skilled in the art's basic understanding, but above-claimed cpd is compounded to realize to the effective of SDHI series bactericidal agents Delaying drug resistance and energy notable synergistic, it is ensured that the effect controlled a medicine is then non-obvious for those skilled in the art more.Application People has paid substantial amounts of creative work in the process of the test for seeking suitably compounding component, and have passed through biological test and medicine many times Effect experiment, the result of the test of bactericidal composition defined herein is encouraging.

Claims (10)

1. a kind of bactericidal composition, said composition includes Fungicidal active compound I and Fungicidal active compound II, and the Fungicidal active compound I is picarbutrazox, and the Fungicidal active compound II is succinate dehydrogenase inhibitors class（SDHI）At least one in bactericide, including following bactericide：Flutolanil（flutolanil）, Boscalid（boscalid）, fluopyram（fluopyram）, isopyrazam（isopyrazam）, fluorine azoles ring bacterium amine（sedaxane）, fluxapyroxad（fluxapyroxad）, thifluzamide（thifluzamide）, biphenyl pyrrole bacterium amine（bixafen）, pyrrole metsulfovax（penthiopyrad）, fluorine azoles bacterium aniline（penflufen）, furametpyr（furametpyr）, fenfuram（fenfuram）, benodanil（benodanil）, mebenil（mepronil）, oxycarboxin（oxycarboxin）, carboxin（carboxin）, benzo alkene fluorine bacterium azoles（benzovindiflupyr）And isofetamid.
2. a kind of bactericidal composition according to claim 1, it is characterised in that：The mass ratio of Fungicidal active compound I and Fungicidal active compound II is 100: 1~1: 100；Preferably 1: 10~80: 1；It is further preferably 1: 1~10: 1.
3. a kind of bactericidal composition preparation, said preparation includes the bactericidal composition and preparation auxiliary material described in claim 1 or 2, and bactericidal composition described by percentage to the quality accounts for the 1~90% of total amount；Preferably, described bactericidal composition accounts for the 5~60% of total amount.
4. a kind of bactericidal composition preparation according to claim 3, it is characterised in that：Said preparation is solid-like or liquid preparation, a kind of in wettable powder of the solid-like preparation including powdery, pulvis, Seed Treatment dry powder doses, Seed Treatment dispersible pulvis, water dispersible granules and granule, liquid preparation includes one kind in suspending agent, suspension emulsion, microcapsule suspending agent, Seed Treatment suspending agent, Seed Treatment microcapsule suspending agent and suspension seed-coating agent.
5. a kind of bactericidal composition preparation according to claim 3, it is characterised in that：The auxiliary element include wetting agent, emulsifying agent, dispersant, thickener, solvent, antifreezing agent, film forming agent, cyst material, pH acid-base modifiers, disintegrant, preservative, stabilizer, defoamer, colouring agent, filler and water and other be beneficial to active ingredient in the formulation stablize or reactive compound play known substance.
6. a kind of bactericidal composition preparation according to claim 5, it is characterised in that：
Described wetting agent is selected from EO/PO block polyethers, AEO, tallow ethyoxyl ammonium salt, alkylnaphthalene sulphur
One or more in hydrochlorate, fatty alcohol polyoxyethylene ether sulfate and acyl group glutamate；
Described emulsifying agent is selected from APES, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyethenoxy ether, fat
Alcohol APEO, phenethyl phenol polyethenoxy ether polyethenoxy ether, aliphatic amine polyoxyethylene ether, castor oil oxirane
Addition product and its derivative, polyol fatty acid ester and its ethylene oxide adduct, alkylbenzenesulfonate, alkylsulfonate,
Dialkyl succinylsuccinate sulfonated ester, alkyl biphenyl base ether sulfonate, naphthalene sulfonic acid-formaldehyde condensation product, aliphatic alcohol sulfate, alkyl
Phenol polyethenoxy ether sulfate, aralkyl phenol polyethenoxy ether sulfate, APES phosphate, phenethyl
Phenol polyethenoxy ether phosphate, polyoxyethylene carboxylate phosphate, ethoxylated fatty amines phosphate, alkyl phosphoric acid
Salt, APES formaldehyde condensation product, aralkyl phenol polyethenoxy ether formaldehyde condensation products, biphenyl phenol polyethenoxy
Ether formaldehyde condensation products, polyoxyethylene polyoxypropylene block copolymer, alkyl naphthalene sulfonic acid formaldehyde condensation products, phenol formaldehyde condensate
Sulfonate, APES formaldehyde condensation products sulfat, contracting methylcellulose and its derivative, alkylammonium salt,
Amino alcohol fatty acid derivatives, polyamines derivative of fatty acid, quaternary ammonium salt, tallow ethyoxyl ammonium salt, alkylnaphthalene sulfonate,
One or more in amino acid, amine oxide, glycine betaine, fatty alcohol polyoxyethylene ether sulfate and acyl group glutamate；
The dispersant be selected from naphthalene sulfonic acid condensate sodium salt, phenolsulfonic acid condensation product sodium salt, methyl naphthalene sulfonate formaldehyde condensate,
Sodium lignin sulfonate, sodium metnylene bis-naphthalene sulfonate, acrylate homopolymer sodium salt, polymeric polycarboxylic acid salt, dioctyl sulfo group
One or more in butanedioic acid sodium salt, EO/PO block polyethers and maleic acid-acrylic acid copolymer sodium salt；
The thickener is selected from xanthans, Magnesiumaluminumsilicate, sodium carboxymethylcellulose, starch phosphate sodium, ocentyl succinic and forms sediment
One or more in powder sodium and polyvinyl alcohol；
The solvent is selected from one or more in dimethylbenzene, turpentine-based vegetable oil, methyl oleate and heavy aromatic solvent oil；
The antifreezing agent is selected from one or more in ethylene glycol, propane diols, glycerine, isopropanol and urea；
The film forming agent is selected from polyvinyl alcohol, polyvinyl acetate, polyethylene glycol, polymethylacrylic acid glycol ester, carboxylic
In the high molecular polymer with caking property and film forming such as methylcellulose, gum arabic, xanthans and starch one
Plant or various；
The cyst material is carbamide resin；It is by interface polymerization reaction by isocyanate-monomer with polyalcohol or polyamine
It is obtained；Isocyanates includes toluene di-isocyanate(TDI), 4,4- methyl diphenylene diisocyanates, the multiple methylene of many phenyl
Polyisocyanates, polyphenyl polymethylene polyisocyanates etc.；
The pH acid-base modifiers are selected from the one kind in citric acid, glacial acetic acid, hydrochloric acid, ammoniacal liquor, triethanolamine and diethylenetriamine
Or it is various；Institute's expense is to adjust the pH value of final products to be advisable to stability range；
The disintegrant is selected from one or more in sodium chloride, ammonium chloride, ammonium sulfate, sodium sulphate and soluble starch；
The preservative is selected from the one kind or many in Kathon CG, formaldehyde, phenyl salicylate, butyl p-hydroxybenzoate and potassium sorbate
Kind；
The stabilizer is selected from epoxidized soybean oil, epoxychloropropane, triphenyl phosphite, glycidol ether and pentaerythrite
One or more；
The defoamer is selected from organic silicon defoamer and/or polyether antifoam agent；
The colouring agent is selected from one or more in iron oxide, titanium oxide and azo dyes；
Described filler is selected from one or more in kaolin, diatomite, talcum powder, precipitated calcium carbonate and white carbon；
The water is running water, deionized water or distilled water.
7. the application of a kind of bactericidal composition preparation described in a kind of bactericidal composition according to claim 1~2 any one claim or 3~6 any one claims, it is characterised in that for preventing and treating plant pathogenic fungi and oomycetes disease.
8. application according to claim 7, it is characterised in that the application is used to prevent and treat one or more in following germ：
Sac fungus in disease fungus：Venturia (Venturia), powdery mildew (Erysiphales), Gibberella (Gibberella), Sclerotinia（Sclerotinia）；
Basidiomycetes in disease fungus（Basidiomycetes）：Ustilago（Ustilago）, rest fungus（Uredinales)；
In oomycetes downy mildew (Peronosporales)：Phytophthora（Phytophthora）, pythium（Pythium), Plasmopara（Plasmopara）；
Fungi Imperfecti in disease fungus（Deuteromyces）：Rhizoctonia（Rhizoctonia）, Fusarium (Fusarium), Botrytis（Botrytis）, Pyricularia Sacc.（Pyricularia）, Cercospora（Cercospora）, bipolaris（Bipolaris）, colletotrichum (Colletotrichum)。
9. application according to claim 7, it is characterised in that crop includes following species：Cereal wheat, barley, paddy rice, sorghum；Fruit tree kind apple, pears, peach, oranges and tangerines, grape, lichee, banana, longan, mango, loquat；Greengrocery cucumber, watermelon, potyvirus, sponge gourd, muskmelon, spinach, celery, tomato, capsicum, eggplant, ginger, green onion, garlic, leek, wild cabbage, Chinese cabbage, strawberry, asparagus lettuce, Kidney bean, cowpea, broad bean, radish, carrot, potato, Chinese yam, taro, lotus rhizome, water chestnut, wild rice stem, sweet potato；Sugar plant class beet, sugarcane；Oil crops class soybean, peanut, rape, sesame, sunflower；Or tobacco, tea.
10. application according to claim 7, it is characterised in that the application is used to prevent and treat one or more in following crop disease：
Phytophthora (Pyhtophthora) potato, the late blight of tomato that strain causes；
Downy mildew (Peronosporales) downy mildew of garpe that causes；
Powdery mildew (Erysiphales) tobacco, sesame, sunflower and the melon powdery mildew that cause；
Gibberella (Gibberella) Wheat And Barley that causes of strain and the various grass head blight of corn, bakanae disease of rice；
Venturia ( Venturia ) apple that strain causes or pears scab；
Sclerotinia ( Sclerotinia) the various plants sclerotiniose that causes of strain；
Ustilago (Ustilago) the wheat loose smut that causes of strain；
Botrytis (Botrytis ) gray mold of various plants that causes of strain；
Pyricularia Sacc. (Pyricularia ) rice blast that causes of strain；
Cercospora (Cercospora ) the strain beet cercospora leaf spot, the cercospora brown spot of peanut that cause；
Bipolaris (Bipolaris) the strain corn southern leaf blight, the water rice brown spot that cause；
Rhizoctonia (Rhizoctonia ) cotton seedling blight that causes of strain and rice sheath blight disease；
Colletotrichum (Colletotrichum) strain cause apple, pears, cotton, grape, wax gourd, cucumber, capsicum and
The many planting fruit-trees of eggplant and the anthracnose of vegetables.
CN201511015593.XA 2015-12-29 2015-12-29 Compositions of the picarbutrazox with succinate dehydrogenase inhibitors series bactericidal agent and its preparation and application Pending CN106922708A (en)

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CN106922703A (en) * 2015-12-30 2017-07-07 江苏龙灯化学有限公司 A kind of bactericidal composition
CN106922699A (en) * 2015-12-30 2017-07-07 江苏龙灯化学有限公司 a bactericidal composition
CN107372532A (en) * 2017-08-11 2017-11-24 北京科发伟业农药技术中心 The bactericidal composition of the urethane of pyrrole containing tetrazolium
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CN109380233A (en) * 2017-08-07 2019-02-26 江苏龙灯化学有限公司 A kind of bactericidal composition
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CN110301450A (en) * 2018-03-20 2019-10-08 江苏龙灯化学有限公司 Tetrazolium pyrrole urethane is reducing or preventing the purposes in crop disease
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US20110159110A1 (en) * 2008-03-24 2011-06-30 Nippon Soda Co., Ltd. Plant disease control agent

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CN106922703A (en) * 2015-12-30 2017-07-07 江苏龙灯化学有限公司 A kind of bactericidal composition
CN107410322A (en) * 2017-04-17 2017-12-01 北京科发伟业农药技术中心 The bactericidal composition of the fluorine bacterium azoles of alkene containing benzo
CN109380233A (en) * 2017-08-07 2019-02-26 江苏龙灯化学有限公司 A kind of bactericidal composition
CN107372532A (en) * 2017-08-11 2017-11-24 北京科发伟业农药技术中心 The bactericidal composition of the urethane of pyrrole containing tetrazolium
CN110301445A (en) * 2018-03-20 2019-10-08 江苏龙灯化学有限公司 Application of a bactericidal composition containing tetrazopyramid and oxamid in reducing or preventing crop diseases
CN110301450A (en) * 2018-03-20 2019-10-08 江苏龙灯化学有限公司 Tetrazolium pyrrole urethane is reducing or preventing the purposes in crop disease
CN110301445B (en) * 2018-03-20 2022-05-13 江苏龙灯化学有限公司 Application of sterilization composition containing fentrazazole-ethyl and hymexazol in reducing or preventing crop diseases
CN109221148A (en) * 2018-09-27 2019-01-18 广东省农业科学院植物保护研究所 A kind of composition pesticide of Fluxapyroxad-containsterilization and propamidine
CN109221148B (en) * 2018-09-27 2021-02-12 广东省农业科学院植物保护研究所 Pesticide composition containing fluxapyroxad and propamidine
WO2023180909A1 (en) * 2022-03-22 2023-09-28 Upl Limited An agrochemical composition
CN116172012A (en) * 2023-02-27 2023-05-30 广西壮族自治区农业科学院 A bactericidal composition for preventing and treating bitter gourd powdery mildew
CN116172012B (en) * 2023-02-27 2024-06-28 广西壮族自治区农业科学院 A kind of bactericidal composition for preventing and controlling powdery mildew of bitter melon

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