CN1072012C - New process for extracting danshensu from red sage root and protocatechualdehyde - Google Patents
New process for extracting danshensu from red sage root and protocatechualdehyde Download PDFInfo
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- CN1072012C CN1072012C CN99109604A CN99109604A CN1072012C CN 1072012 C CN1072012 C CN 1072012C CN 99109604 A CN99109604 A CN 99109604A CN 99109604 A CN99109604 A CN 99109604A CN 1072012 C CN1072012 C CN 1072012C
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- red sage
- sage root
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Abstract
The present invention relates to a new extraction process of danshensu and protocatechuic aldehyde in red sage roots, which comprises the following steps that the red sage root is pulverized, and after the red sage root is processed by using alkaline lye, the red sage root is extracted for three times in water, extraction liquid is merged, and a red sage root dry ointment is obtained by concentration and spray drying. Concentrated liquid can also be extracted in alcohol firstly before spray drying, and then, the alcohol extraction liquid is concentrated. The present invention has the advantage of greatly enhanced extraction rate of the danshensu and the protocatechuic aldehyde. The content of the protocatechuic aldehyde and the danshensu of the product extracted by the present invention is respectively 3 to 168 times and 4 to 22.6 times of the content of the protocatechuic aldehyde and the danshensu of similar products at present. The effective ingredients in the medicinal material of the red sage root are sufficiently utilized, the resources are saved, and simultaneously, specific medicine with good therapeutic effect and low cost can be produced.
Description
The present invention relates to the novel technology for extracting of danshensu and protocatechualdehyde in the Radix Salviae Miltiorrhizae.
Radix Salviae Miltiorrhizae tool stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the relieving restlessness effect clears away heart-fire, be to treat one of coronary heart disease and anginal active drug clinically, the annual whole nation of its use amount is more than one hundred million tons, at present in a lot of prescribed preparations, as all being to feed intake in FUFANG DANSHEN PIAN, FUFANG DANSHEN DIWAN, compound Salviae Miltiorrhizae buccal tablet, Radix Salviae Miltiorrhizae Tabellae, the Radix Salviae Miltiorrhizae Injection etc. as monarch drug.But its traditional extraction process is not a water to be carried, and water is carried after the first exactly alcohol extraction.
Water extraction technology is: Radix Salviae Miltiorrhizae, to pulverize, and water is carried 3 times, merges aqueous solution, and the water extract concentrates, extractum.
Alcohol water extraction method technology is: Radix Salviae Miltiorrhizae, to pulverize, and high concentration ethanol extracts, and low-concentration ethanol extracts, water extraction, merge extractive liquid, reclaims ethanol, concentrates extractum.
No matter be water carry or first alcohol extraction after water carry all can not Radix Salviae Miltiorrhizae is contained effective ingredient danshensu and protocatechualdehyde extract effectively, only proposed about the 10-20% of its content.For more than one hundred million tons red rooted salvia, be undoubtedly a kind of great waste, also only produce the product of unsatisfactory curative effect simultaneously.
The objective of the invention is at above-mentioned shortcoming of the prior art, and provide a kind of and can increase substantially extraction ratio, produce the novel technology for extracting of danshensu and protocatechualdehyde in the Radix Salviae Miltiorrhizae that therapeutic effect is good, cost is low.
The present invention is achieved through the following technical solutions:
Radix Salviae Miltiorrhizae is pulverized, and after handling with alkali liquor, water is carried three times, and temperature is 80-100 ℃, merge extractive liquid,, and concentrated, spray drying gets the dried cream of Radix Salviae Miltiorrhizae.
Can also before spray drying, earlier concentrated solution be carried out ethanol extraction, concentrate ethanol extract then.
Principle of the present invention is to be weakly acidic material according to danshensu and protocatechualdehyde, be dissolved in the alkali salify, increase dissolubility in its water, and the character that chemical compound tends towards stability behind the salify, inquired into out the novel technology for extracting of danshensu and protocatechualdehyde effective ingredient in the Radix Salviae Miltiorrhizae.
Advantage of the present invention is as follows:
1, increased substantially the extraction ratio of danshensu and protocatechualdehyde:
The product that the present invention obtained through refining, the content of its protocatechualdehyde are 3-168 times of present like product, 34.4 times of average out to.The content of its danshensu is 4-22.6 times of like product, 9.2 times of average out to (for details see attached table reaching accompanying drawing).
2, made full use of the active ingredient in the red rooted salvia, energy savings 900%:
Annual national Radix Salviae Miltiorrhizae consumption is more than one hundred million tons, if extract by traditional handicraft, reach content of the present invention and will throw several times to tens times red rooted salvia more, and medical material per ton will be saved several ten million RMB to more than one hundred million units for country by 1000 yuan.Have huge social benefit and economic benefit.
3, the present invention can provide the specific drug that therapeutic effect is good, cost is low for cardio-cerebral vascular disease patient, and therapeutic effect will improve several times to tens of times.
Embodiments of the invention are as follows:
Get a Radix Salviae Miltiorrhizae goods, the inspection decontamination is removed silt, is ground into thick piece, after handling with alkali liquor, adds water at 80-100 ℃, extracts merge extractive liquid, 3 times.
It is 1.10-1.3 that merge extractive liquid, is evaporated to proportion.
Concentrated solution adds an amount of ethanol extraction, gets ethanol extract.
Behind the ethanol extract decompression recycling ethanol, spray drying gets the dried cream of Radix Salviae Miltiorrhizae.
Compound Salviae Miltiorrhizae series of products danshensu and former youngster's aldehyde measurement result are relatively
(the compound Salviae Miltiorrhizae buccal tablet of producing with product Anguo Pharmaceutical of the present invention group is contrast, compares)
| The name of an article | Producer | Lot number | Protocatechualdehyde content mg/ sheet | Product content of the present invention is its multiple | Danshensu (in protocatechualdehyde) mg/ sheet | Product of the present invention is its multiple | Red rooted salvia g/ sheet |
| The compound Salviae Miltiorrhizae buccal tablet | Anguo Pharmaceutical group | 990612 | 0.50 | 0.68 | 0.45 | ||
| FUFANG DANSHEN PIAN | White Cloud Mountain pharmaceutical factory | 980305-607 | 0.096 | 11.6 | 0.21 | 7.2 | 1 |
| FUFANG DANSHEN PIAN | White Cloud Mountain pharmaceutical factory | 940402-602 | 0.071 | 15.6 | 0.148 | 10.2 | 1 |
| FUFANG DANSHEN PIAN | The Guangzhou flower city | 940321-4 | 0.113 | 9.8 | 0.213 | 7.1 | 1 |
| FUFANG DANSHEN PIAN | The Guangdong Longchuan | 950606 | 0.030 | 37 | 0.126 | 12 | 1 |
| FUFANG DANSHEN PIAN | Longhua, the military region, Guangdong | 94-7034 | 0.054 | 20.6 | 0.225 | 6.7 | 1 |
| FUFANG DANSHEN PIAN | The Xi'an pharmaceutical factory of traditional Chinese medicine | 920604 | 0.118 | 9.4 | 0.394 | 3.8 | 1 |
| FUFANG DANSHEN PIAN | Shi Shi Longhua | 990305 | 0.0066 | 168.3 | 0.067 | 22.6 | 1 |
| FUFANG DANSHEN DIWAN | Sky, the Tianjin Alliance Phamaceutical Corp. of exerting all one's strength | 980912 | 0.032 | 3.1 | 0.034 | 4 | 0.09 |
| X | 34.4 | 9.2 |
Accompanying drawing and drawing explanation:
Fig. 1-6 is that danshensu and protocatechualdehyde composition are measured collection of illustrative plates in the compound Salviae Miltiorrhizae series of products, among each figure, about 8 minutes the peak what be that danshensu goes out the peak about 1,15 minute is protocatechualdehyde 2.
Fig. 1 is the mensuration collection of illustrative plates of protocatechualdehyde standard reference material, concentration: 0.0188mg/ml.
The mensuration collection of illustrative plates of the dried cream of Radix Salviae Miltiorrhizae that Fig. 2 makes for the present invention.Concentration: be equivalent to 18mg red rooted salvia/ml.
Fig. 3 is the mensuration collection of illustrative plates of commercially available FUFANG DANSHEN PIAN (Guangdong Longchuan pharmaceutical factory 050606).Concentration: be equivalent to 20mg medical material/ml.
Fig. 4 is the mensuration collection of illustrative plates of commercially available FUFANG DANSHEN PIAN (Huacheng Pharmaceutical Factory, Gaungzhou 940321-4).Concentration: be equivalent to 20mg medical material/ml.
Fig. 5 is the mensuration collection of illustrative plates in commercially available FUFANG DANSHEN PIAN (the imperial pharmaceutical factory 990305 of Shijiazhuang China).Concentration: be equivalent to 20mg medical material/ml.
Fig. 6 is the mensuration collection of illustrative plates of commercially available FUFANG DANSHEN PIAN (980305-607 of Chinese Traditional Medicine Factory of Baiyunshan Pharmaceutical Gneral Factory).Concentration: be equivalent to 20mg medical material/ml.
Claims (3)
1, the extraction process of danshensu and protocatechualdehyde in the Radix Salviae Miltiorrhizae, it include with Radix Salviae Miltiorrhizae pulverize, water extraction three times, temperature is 80-100 ℃, merge extractive liquid,, concentrated, spray drying gets the dried cream of Radix Salviae Miltiorrhizae, it is characterized in that in advance the Radix Salviae Miltiorrhizae of pulverizing being handled with alkali liquor at water.
2, technology according to claim 1 is characterized in that before spray drying, earlier concentrated solution was carried out ethanol extraction, concentrated ethanol extract then.
3, technology according to claim 2 is characterized in that it is 1.10-1.30 that merge extractive liquid, is concentrated into proportion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99109604A CN1072012C (en) | 1999-06-30 | 1999-06-30 | New process for extracting danshensu from red sage root and protocatechualdehyde |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99109604A CN1072012C (en) | 1999-06-30 | 1999-06-30 | New process for extracting danshensu from red sage root and protocatechualdehyde |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1237439A CN1237439A (en) | 1999-12-08 |
| CN1072012C true CN1072012C (en) | 2001-10-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99109604A Expired - Fee Related CN1072012C (en) | 1999-06-30 | 1999-06-30 | New process for extracting danshensu from red sage root and protocatechualdehyde |
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| CN (1) | CN1072012C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100378088C (en) * | 2005-10-12 | 2008-04-02 | 正大青春宝药业有限公司 | A kind of preparation method of salvianolic acid |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002045680A1 (en) * | 2000-12-06 | 2002-06-13 | Genomine Inc. | Composition for whitening of skin containing protocatechuic aldehyde as an effective component |
| CN100450501C (en) * | 2004-03-17 | 2009-01-14 | 天津天士力制药股份有限公司 | Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases and preparing process thereof |
| CN1303052C (en) * | 2004-03-18 | 2007-03-07 | 中国科学院大连化学物理研究所 | Process for preparing Danshensu |
-
1999
- 1999-06-30 CN CN99109604A patent/CN1072012C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 华西药学杂志1998,13(2) 1998.2.28 唐昌炯，丹参素担取工艺的探索 * |
| 华西药学杂志1998,13(2) 1998.2.28 唐昌炯，丹参素担取工艺的探索;药学通报1981,16(11) 1981.11.30 丹参水溶性有效成分——丹参素的提取分离和注射剂的试剂 * |
| 药学通报1981,16(11) 1981.11.30 丹参水溶性有效成分——丹参素的提取分离和注射剂的试剂 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100378088C (en) * | 2005-10-12 | 2008-04-02 | 正大青春宝药业有限公司 | A kind of preparation method of salvianolic acid |
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| Publication number | Publication date |
|---|---|
| CN1237439A (en) | 1999-12-08 |
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Free format text: FORMER OWNER: ZHAO ZHIJUN LIU TIEGANG Effective date: 20050923 Owner name: ZHOU YU Free format text: FORMER OWNER: HAN GUIRU |
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Effective date of registration: 20050923 Address after: 071000 No. 419 North Street, the Great Wall, Hebei, Baoding Patentee after: Zhou Yu Address before: 050011 Hebei Provincial Institute for drug control, 44 Fu Qiang street, Hebei, Shijiazhuang Co-patentee before: Zhao Zhijun Patentee before: Han Guiru Co-patentee before: Liu Tiegang |
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