CN107249523B - 治疗剂的电动脉络膜上注射 - Google Patents

治疗剂的电动脉络膜上注射 Download PDF

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Publication number
CN107249523B
CN107249523B CN201580061178.XA CN201580061178A CN107249523B CN 107249523 B CN107249523 B CN 107249523B CN 201580061178 A CN201580061178 A CN 201580061178A CN 107249523 B CN107249523 B CN 107249523B
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China
Prior art keywords
needle
cannula
eye
actuation
actuation assembly
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Active
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CN201580061178.XA
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English (en)
Chinese (zh)
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CN107249523A (zh
Inventor
D·W·普莱斯
I·J·科汉
B·J·奥伯基尔彻
S·索科罕沃尔
D·J·亚赛瓦克
M·布鲁威尔
L·R·索菲
M·T·卡特
G·W·约翰森
M·拉梅阿尼费尔德
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Genentech Inc
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Orbit Biomedical Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1585—Needle inserters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1586—Holding accessories for holding infusion needles on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Prostheses (AREA)
CN201580061178.XA 2014-09-11 2015-09-10 治疗剂的电动脉络膜上注射 Active CN107249523B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462049118P 2014-09-11 2014-09-11
US62/049,118 2014-09-11
US14/840,622 2015-08-31
US14/840,622 US10064752B2 (en) 2014-09-11 2015-08-31 Motorized suprachoroidal injection of therapeutic agent
PCT/US2015/049430 WO2016040635A1 (en) 2014-09-11 2015-09-10 Motorized suprachoroidal injection of therapeutic agent

Publications (2)

Publication Number Publication Date
CN107249523A CN107249523A (zh) 2017-10-13
CN107249523B true CN107249523B (zh) 2020-09-22

Family

ID=55453677

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580061178.XA Active CN107249523B (zh) 2014-09-11 2015-09-10 治疗剂的电动脉络膜上注射

Country Status (14)

Country Link
US (1) US10064752B2 (2)
EP (1) EP3191033B1 (2)
JP (1) JP6541162B2 (2)
KR (1) KR20170063697A (2)
CN (1) CN107249523B (2)
AU (1) AU2015315044A1 (2)
BR (1) BR112017004828B1 (2)
CA (1) CA2960649A1 (2)
MX (1) MX2017003260A (2)
PH (1) PH12017500443A1 (2)
RU (1) RU2017112036A (2)
SG (1) SG11201701968QA (2)
WO (1) WO2016040635A1 (2)
ZA (1) ZA201702514B (2)

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BR112016018570B1 (pt) 2014-02-12 2022-08-30 Gyroscope Therapeutics Limited Aparelho para a liberação de agente terapêutico em um olho
US10064752B2 (en) 2014-09-11 2018-09-04 Orbit Biomedical Limited Motorized suprachoroidal injection of therapeutic agent
US10258502B2 (en) 2014-09-18 2019-04-16 Orbit Biomedical Limited Therapeutic agent delivery device
CN107249522B (zh) 2014-09-19 2021-04-20 奥叙拉尔有限公司 眼科递送装置
US11154420B2 (en) 2015-09-17 2021-10-26 Oxular Limited Ophthalmic injection device
US10478553B2 (en) 2016-03-09 2019-11-19 Orbit Biomedical Limited Apparatus for subretinal administration of therapeutic agent via a curved needle
WO2017158365A2 (en) 2016-03-16 2017-09-21 Oxular Limited Ophthalmic delivery device and ophthalmic active agent containing compositions
SG11201808426XA (en) 2016-04-15 2018-10-30 Univ Pennsylvania Compositions for treatment of wet age-related macular degeneration
US10806629B2 (en) 2016-06-17 2020-10-20 Gyroscope Therapeutics Limited Injection device for subretinal delivery of therapeutic agent
US11000410B2 (en) 2016-06-17 2021-05-11 Gyroscope Therapeutics Limited Guide apparatus for tangential entry into suprachoroidal space
US10646374B2 (en) 2016-06-17 2020-05-12 Orbit Biomedical Limited Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent
US20190216645A1 (en) * 2016-09-23 2019-07-18 The Regents Of The University Of California Surgical device for ab-externo sub-retinal fluid drainage
US11273072B2 (en) 2017-01-13 2022-03-15 Gyroscope Therapeutics Limited Suprachoroidal injection device
US11076984B2 (en) 2017-03-13 2021-08-03 Gyroscope Therapeutics Limited Method of performing subretinal drainage and agent delivery
US11033427B2 (en) 2017-04-13 2021-06-15 Alcon Inc. Vitreoretinal instruments for fluid aspiration
US11027061B2 (en) 2017-05-08 2021-06-08 Medtronic Minimed, Inc. Flexible cannula insertion device, system and process
EP3681471B1 (en) * 2017-09-15 2025-03-05 Oxular Limited Ophthalmic delivery device
EP3687464A4 (en) * 2017-09-27 2021-09-29 REGENXBIO Inc. TREATMENT OF EYE DISEASES WITH A TOTALLY HUMAN POST-TRANSLATION MODIFIED ANTI-VEGF FAB
US12558434B2 (en) 2018-02-20 2026-02-24 The Trustees Of The University Of Pennsylvania Compositions for treatment of wet age-related macular degeneration
CN109224190B (zh) * 2018-07-20 2020-11-03 陈红雨 一种用于患儿头部注射的固定器
CN109200384A (zh) * 2018-10-31 2019-01-15 中国人民解放军陆军特色医学中心 一种留置针
US11759355B1 (en) 2019-02-26 2023-09-19 Gyroscope Therapeutics Limited Method of delivering leading blebs and agent to subretinal space
WO2020206098A1 (en) * 2019-04-03 2020-10-08 Regenxbio Inc. Gene therapy for eye pathologies
US11690974B2 (en) 2019-04-25 2023-07-04 Warsaw Orthopedic, Inc. Methods and devices for delivering therapeutic materials to the intervertebral disc
EP4017561A1 (en) * 2019-08-22 2022-06-29 Boston Scientific Scimed, Inc. Systems and methods for controlling needle penetration
CN114502197A (zh) 2019-08-26 2022-05-13 再生生物股份有限公司 用全人经翻译后修饰的抗VEGF Fab治疗糖尿病性视网膜病变
WO2021071835A1 (en) 2019-10-07 2021-04-15 Regenxbio Inc. Adeno-associated virus vector pharmaceutical composition and methods
CA3155564A1 (en) 2019-10-11 2021-04-15 Gyroscope Therapeutics Limited Dose clip assembly for syringe
AU2021358781A1 (en) 2020-10-07 2023-05-18 Tern Therapeutics, Llc Gene therapy for ocular manifestations of cln2 disease
WO2022171771A1 (en) 2021-02-12 2022-08-18 Boehringer Ingelheim International Gmbh Complement c3 antigen binding proteins
CR20240265A (es) 2021-12-22 2024-10-16 Boehringer Ingelheim Int Anticuerpos anti-c3 y fragmentos de unión al antígeno de estos y sus usos para tratar enfermedades oftálmicas u oculares
US20250249127A1 (en) 2022-04-14 2025-08-07 Regenxbio Inc. Gene therapy for treating an ocular disease
KR20250065626A (ko) 2022-09-06 2025-05-13 제넨테크, 인크. 이중-곡선 니들을 통해 치료제를 망막하 투여하기 위한 장치
WO2024059794A1 (en) * 2022-09-16 2024-03-21 Cvrx, Inc. System, devices, and methods for guidewire delivery
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JP2026500975A (ja) 2023-01-13 2026-01-09 ジェネンテック， インコーポレイテッド シリンジのための投与ドック
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TW202602405A (zh) 2024-03-27 2026-01-16 美商建南德克公司 用於視網膜下注射裝置的扭矩環
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CN2045634U (zh) * 1989-01-11 1989-10-11 晁三万 多功能微调眼科手术刀
CN2409937Y (zh) * 2000-02-03 2000-12-13 李根林 视网膜移植器
US6309374B1 (en) * 1998-08-03 2001-10-30 Insite Vision Incorporated Injection apparatus and method of using same
WO2002017986A2 (en) * 2000-08-31 2002-03-07 Mpnb Ltd. Microsurgical injection and/or distending instrument

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US10064752B2 (en) 2014-09-11 2018-09-04 Orbit Biomedical Limited Motorized suprachoroidal injection of therapeutic agent

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
CN2045634U (zh) * 1989-01-11 1989-10-11 晁三万 多功能微调眼科手术刀
US6309374B1 (en) * 1998-08-03 2001-10-30 Insite Vision Incorporated Injection apparatus and method of using same
CN2409937Y (zh) * 2000-02-03 2000-12-13 李根林 视网膜移植器
WO2002017986A2 (en) * 2000-08-31 2002-03-07 Mpnb Ltd. Microsurgical injection and/or distending instrument

Also Published As

Publication number Publication date
SG11201701968QA (en) 2017-04-27
PH12017500443A1 (en) 2017-07-31
JP6541162B2 (ja) 2019-07-10
MX2017003260A (es) 2018-02-12
AU2015315044A1 (en) 2017-03-30
US20160074217A1 (en) 2016-03-17
EP3191033A1 (en) 2017-07-19
BR112017004828A2 (pt) 2017-12-12
KR20170063697A (ko) 2017-06-08
EP3191033B1 (en) 2019-11-06
JP2017526478A (ja) 2017-09-14
US10064752B2 (en) 2018-09-04
CN107249523A (zh) 2017-10-13
CA2960649A1 (en) 2016-03-17
ZA201702514B (en) 2019-07-31
BR112017004828B1 (pt) 2021-12-14
RU2017112036A (ru) 2018-10-11
WO2016040635A1 (en) 2016-03-17

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