CN107922498A - 具有整合可控功能的嵌合抗原受体 - Google Patents

具有整合可控功能的嵌合抗原受体 Download PDF

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Publication number
CN107922498A
CN107922498A CN201680048318.4A CN201680048318A CN107922498A CN 107922498 A CN107922498 A CN 107922498A CN 201680048318 A CN201680048318 A CN 201680048318A CN 107922498 A CN107922498 A CN 107922498A
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leu
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ligand binding
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亚历山大·朱耶拉特
菲利普·迪沙泰奥
劳伦特·普瓦罗
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Cellectis SA
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A—HUMAN NECESSITIES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/23—On/off switch
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    • C07K2319/00—Fusion polypeptide
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680048318.4A 2015-08-24 2016-08-24 具有整合可控功能的嵌合抗原受体 Pending CN107922498A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201570545 2015-08-24
DKPA201570545 2015-08-24
EP15202592 2015-12-23
EP15202592.0 2015-12-23
PCT/EP2016/069918 WO2017032777A1 (en) 2015-08-24 2016-08-24 Chimeric antigen receptors with integrated controllable functions

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Publication Number Publication Date
CN107922498A true CN107922498A (zh) 2018-04-17

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CN201680048318.4A Pending CN107922498A (zh) 2015-08-24 2016-08-24 具有整合可控功能的嵌合抗原受体

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US (1) US10988542B2 (2)
EP (1) EP3341410B1 (2)
JP (1) JP6894430B2 (2)
KR (1) KR20180042361A (2)
CN (1) CN107922498A (2)
AU (1) AU2016313082B2 (2)
BR (1) BR112018002189A2 (2)
CA (1) CA2995632C (2)
IL (1) IL257138A (2)
MX (1) MX2018001533A (2)
RU (1) RU2018109426A (2)
WO (1) WO2017032777A1 (2)

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CN110678480A (zh) * 2017-03-28 2020-01-10 细胞设计实验室股份有限公司 嵌合多肽和改变它们的在细胞膜中的定位的方法
CN112512557A (zh) * 2018-04-27 2021-03-16 克里斯珀医疗股份公司 用于浆细胞耗竭的抗bcma car-t-细胞
CN112566941A (zh) * 2018-08-13 2021-03-26 奥托路斯有限公司 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞
CN115087670A (zh) * 2019-12-11 2022-09-20 西拉格国际有限责任公司 包含ltbr和edb结合结构域的多特异性结合分子及其用途
CN119638840A (zh) * 2023-09-15 2025-03-18 东莞市朋志生物科技有限公司 一种抗糖类抗原153的抗体及其应用

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110678480A (zh) * 2017-03-28 2020-01-10 细胞设计实验室股份有限公司 嵌合多肽和改变它们的在细胞膜中的定位的方法
CN112512557A (zh) * 2018-04-27 2021-03-16 克里斯珀医疗股份公司 用于浆细胞耗竭的抗bcma car-t-细胞
CN112566941A (zh) * 2018-08-13 2021-03-26 奥托路斯有限公司 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞
CN115087670A (zh) * 2019-12-11 2022-09-20 西拉格国际有限责任公司 包含ltbr和edb结合结构域的多特异性结合分子及其用途
CN119638840A (zh) * 2023-09-15 2025-03-18 东莞市朋志生物科技有限公司 一种抗糖类抗原153的抗体及其应用

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US10988542B2 (en) 2021-04-27
BR112018002189A2 (pt) 2018-09-18
RU2018109426A3 (2) 2020-02-28
US20180237533A1 (en) 2018-08-23
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MX2018001533A (es) 2018-03-15
IL257138A (en) 2018-03-29
CA2995632A1 (en) 2017-03-02
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EP3341410A1 (en) 2018-07-04
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